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Search Results for " histidine "

56

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9372	D-Histidine	Mitochondrial Metabolism	Metabolism
	D-Histidine 是一种 L-histidine 的对映体。其中 L-histidine 是婴儿必需的氨基酸，是一种线粒体谷氨酰胺转运的抑制剂。
T40122	L-Histidine benzyl ester bistosylate	Others	Others
	L-Histidine benzyl ester bistosylate可作为HutP（一种RNA结合蛋白）的激活剂。
T32080	Histidine oxoglurate Histidine alpha-ketoglutarate
	Histidine oxoglurate is a bioactive chemical.
T81677	N-Formyl-L-histidine Formyl-L-histidine
	N-Formyl-L-histidine 通过与组氨酸-tRNA合成酶结合展示其活性，其Ki值为4.6 μM。此外，N-Formyl-L-histidine作为L-组氨酸解氨酶的竞争性抑制剂，具有4.26 mM的Ki值，能够有效抑制该酶对L-组氨酸的解氨反应，阻止尿苷酸的生成。
T20382	Diglycyl-histidine NSC334195,NSC-334195,Gly-gly-his,Glycylglycyl-L-histidine,NSC 334195
	Diglycyl-histidine is a tripeptide complexed with cupric ion designed to mimic specific Cu(II) transport site of ascorbate on albumin molecule.
T67981	Copper histidine
	Copper histidine 抑制了Ctr1介导的奥沙利铂在体外的细胞摄取，而不会改变奥沙利铂在体内DRG 组织中的铂或神经毒性的积累。Copper histidine 通过口服治疗 Menkes 疾病。
T68950	Hepta-histidine
	Hepta-histidine is a novel inhibitor of Tau aggregation against Tau-related neurodegenerative diseases including Alzheimer's disease (AD).
T33702	N-Mercaptoacetyl-L-histidine SA 120,L-Histidine, N-(mercaptoacetyl)-,SA120,SA-120
	N-Mercaptoacetyl-L-histidine is a peptide.
T66645	Fmoc-His-OH (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-imidazol-4-yl)propanoic acid,(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-histidine,FMOC-L-Histidine
	(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-imidazol-4-yl)propanoic acid 是一种组氨酸衍生物。
T9494	Imidazole-5-propionic acid Imidazolylpropionic acid,3-(咪唑-4-基)丙酸,SALOR-INT L480258-1EA,Deamino-histidine	Dehydrogenase	Metabolism
	Imidazole-5-propionic acid (Imidazolylpropionic acid) 是组氨酸代谢的产物，可能涉及氧化或转氨作用。它是 G. candidum 组氨醇脱氢酶的有效抑制剂，IC50 值低至 3.17 microM。
T32735	L-Histidine S-malate
	L-Histidine S-malate is a bioactive chemical.
T3937	Methyl L-histidinate dihydrochloride L-Histidine methyl ester dihydrochloride,L-组氨酸甲酯二盐酸盐	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Methyl L-histidinate dihydrochloride (L-Histidine methyl ester dihydrochloride) 在Sprague-Dawley 大鼠胃中组氨酸脱羧酶的抑制作用被评估为 14CO2 产生减少，活性值为 1.8 μM。
T66788	DL-Histidine

T33760	N-Stearoylhistidine N-Stearoyl-L-histidine
	N-Stearoylhistidine is a bioactive chemical.
T24974	2-Iodohistidine 2-Iodo-L-histidine
	2-Iodohistidine shows potent antimalarial activity.
T65767	N-Cbz-L-histidine
	N-Cbz-L-histidine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T65767。
T66680	Fmoc-1-methyl-L-histidine
	Fmoc-1-methyl-L-histidine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66680，CAS号为 202920-22-7。
TP1088	N-Acetylcarnosine N-Acetyl-L-carnosine,N-乙酰肌肽	Others	Others
	N-Acetylcarnosine (N-Acetyl-L-carnosine) 是一种含有组氨酸的天然二肽，是药理学上主要的 L-carnosine 的来源。它是一种眼科药物，对人类白内障具有潜在的应用价值。
T83633	1-N-Methyl-4-mercaptohistidine disulfide	Others	Others
	1-N-Methyl-4-mercaptohistidine disulfide 是一种潜在的杜氏菌叶绿体偶联因子1氧化还原调节剂，是氧化形式的卵硫醇A，抑制光触发的CF1 ATP酶活性。
T26374	(S)-alpha-Fluoromethylhistidine 2 HCl
	(S)-alpha-Fluoromethylhistidine 2 HCl is a potent irreversible inhibitor of histidine decarboxylase (HDC) and glutathione S-transferase.
T80908	Tyrosylhistidine
	Tyrosylhistidine是由酪氨酸和组氨酸构成的二肽(Tyr-His)。作为一种口服降血压肽，它能够降低自发性高血压模型小鼠的血压。
T34033	Phosphohistidine 3-Phosphohistidine
	Phosphohistidine is a eukaryotic enzyme dephosphorylating proteins and peptides.
T34208	Pyroglutamylhistidine Pglu-his
	Pyroglutamylhistidine is a dipeptide.
T33611	N-Carbethoxyhistidine
	N-Carbethoxyhistidine can be used to protect amine functional groups.
TP1401	HAE His-Ala-Glu	Others	Others
	HAE (His-Ala-Glu) 由组氨酸、丙氨酸和谷氨酸组成。
TP1280	Hexa-His	Others	Others
	Hexa-His 是融合蛋白的金属结合位点，是一种由 6 个组氨酸构成的六肽。
T6605	NH125	CaMK; Virus Protease; PKA; Antibacterial; PKC; Autophagy; Antifungal	Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; Neuroscience; Tyrosine Kinase/Adaptors
	NH125 是一种真核延长因子 2 激酶(eEF-2K/CaMKIII)的高效选择性抑制剂，诱导 eEF2 磷酸化，对 eEF-2K 作用的 IC50值为 60 nM。
T65118	DEPC Diethyl pyrocarbonate	Others	Others
	DEPC (Diethyl pyrocarbonate) 是一种有效的、不可逆的含有组氨酸残基的 RNase 抑制剂。DEPC 可用碳氧基化修饰组氨酸残基从而导致酶失活，可用于防止RNA 酶降解RNA。DEPC 对兔子的中枢化学敏感性具有抑制作用。DEPC 可以修饰 His，Tyr，Ser 和 Thr 残基。
T15650	KDM5A-IN-1	Histone Demethylase	Chromatin/Epigenetic
	KDM5A-IN-1 是一种可口服且具有高效性和选择性的泛组氨酸赖氨酸脱甲基酶 5 KDM5 抑制剂，抑制 KDM5A，KDM5B，KDM5C，IC50 值分别为 45 nM，56 nM 和 55 nM。KDM5A-IN-1 抑制 PC9 H3K4Me3，可用于研究癌症。
T32098L	Homocarnosine acetate	GABA Receptor; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Homocarnosine acetate 是大脑特有的二肽，由 γ-氨基丁酸 (GABA) 和组氨酸组成。它具有抗氧化和抗炎作用、预防 DNA 损伤和抑制晚期糖基化终产物形成
T7454	4-Bromo-3-hydroxybenzoic acid	Decarboxylase; Endogenous Metabolite	Metabolism; Others
	4-Bromo-3-hydroxybenzoic acid 是一种组氨酸脱羧酶抑制剂，是一种 Brocresine 的代谢产物，对大鼠胎儿和大鼠胃HDC 的IC50均为 1 mM。它还能够在体外抑制猪肾脏和大鼠胃粘膜中的芳香族 L-氨基酸脱羧酶，两种酶的IC50均为 1 mM。
T22243	Anserine L-鹅肌肽,L-Anserine	Endogenous Metabolite	Metabolism
	Anserine (L-Anserine) 是 Carnosine 的甲基化形式，是口服具有活性的天然二肽，存在于脊椎动物的骨骼肌。它不会被血清肌肽酶裂解，能够作为生化缓冲液，螯合剂，抗糖化剂和抗氧化剂。它能够改善阿尔茨海默氏病模型小鼠的记忆功能。
T26480	A331440 A-331440,A331440 free base,A 331440
	A331440 is an modulator of L-histidine and histamine H3 receptor.
T31851	Formiminoglutamic acid NSC-334078,NSC334078,NSC 334078
	Formiminoglutamic acid is used to indicate folic acid deficiency and megaloblastic anemia of pregnancy with the measurement in the urine after oral administration of histidine.
T33440	MK785 MK-785,MK 785
	MK785 is part of the association between inhibition of aortic histamine formation, aortic albumin permeability, and atherosclerosis. Aortic histamine synthesis was inhibited by partial inhibition of aortic histidine decarboxylase (HD) by application of MK
TP1401L	HAE acetate(64111-99-5 free base)	Others	Others
	HAE acetate(64111-99-5 free base) 是由组氨酸、丙氨酸和谷氨酸组成的3个氨基酸肽。
T38472	Phosphoribosyl pyrophosphate pentasodium PRPPpentasodium,磷酸核糖焦磷酸
	Phosphoribosyl pyrophosphate (PRPP) pentasodium is a vital metabolite essential for the biosynthesis of purine and pyrimidine nucleotides, as well as the amino acids histidine and tryptophan. It also acts as a precursor for the important cofactors NAD and NADP.
T37547	trans-Urocanic Acid
	trans-Urocanic acid is a major epidermal chromophore for the immunosuppressive effects of UV radiation that is produced in mammalian stratum corneum by the action of histidine ammonialyase on L-histidine. It contributes to the acidification of the surface of the stratum corneum, and its function has been proposed as that of an endogenous sunscreen, endowing a low-level of protection (SPF ~ 1.5) against UV-induced DNA damage and excessive keratinocyte apoptosis. Upon UVB exposure, trans-urocanic ...
T17166	Tritoqualine Hypostamine,酞茂异喹,Inhibostamin	Decarboxylase	Metabolism; Others
	Tritoqualine is used as an inhibitor of histidine decarboxylase.
T38382	8Br-HA
	8Br-HA is an inhibitor of fragile histidine triad diadenosine triphosphatase (FHIT; IC50= 0.12 μM).1It inhibits the growth of HCC827 and H460 lung cancer cells (GI50s = 0.87 and 5.9 μM, respectively). 1.Kawaguchi, M., Sekimoto, E., Ohta, Y., et al.Synthesis of fluorescent probes targeting tumor-suppressor protein FHIT and Identification of apoptosis-inducing FHIT inhibitorsJ. Med. Chem.64(13)9567-9576(2021)
T27995	MDK-3046 HK-inhibitor-2,MDK3046,HK inhibitor 2
	MDK-3046 is a YycG histidine kinase (HK) inhibitor with potent antibiofim activity against Staphylococcus epidermidis.
T82863	Biotin-X-NTA
	Biotin-X-NTA，用于定性检测硝基纤维素膜上固定的组氨酸标记蛋白。
TP2181	Hexa His tag peptide	Others	Others
	Hexa His is an amino acid sequence consisting of 6 His residues in a row, it is also known as Hexa histidine-tag, 6 x His-tag, and by the trademarked name His-tag.
T36973	5-Phospho-D-ribose 1-diphosphate (sodium salt hydrate)
	5-Phospho-D-ribose 1-diphosphate (PRPP) is a natural intermediate involved in the pentose phosphate pathway leading to purine, pyrimidine, and histidine metabolism. It is also an intermediate in the synthesis of plant hormones, alkaloids, and other secondary metabolites from glucose. Several phosphoribosyltransferases (PRTases) use PRPP as a substrate to add a 5-phosphoribosyl group to another substrate, as in the production of adenosine monophosphate from adenine and PRPP by adenine PRTase. N/A
T17274	YM022	CCR	Immunology/Inflammation; Microbiology/Virology
	YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo. YM022 shows the Ki values of 68 pM and 63 nM for CCK-B and CCK-A receptor, respectively.
T76577	Antiulcer Agent 2
	Antiulcer Agent 2 是一种四肽，组成包括天冬氨酸、丙氨酸、组氨酸和赖氨酸，存在于人白蛋白N端，并在溃疡及活性氧生成中显示出潜在应用。
T76585	Hepcidin-20 (human)
	Hepcidin-20 (human) 是一种β-折叠结构肽，含有组氨酸和丰富的半胱氨酸，具备抗真菌活性，并能抑制多糖细胞间粘附素 (PIA) 阳性及阴性菌株的生物膜形成及细菌细胞代谢[3]。
TP1088L	N-Acetylcarnosine acetate N-Acetyl-L-carnosine acetate,N-Acetyl carnosine acetate,N-乙酰肌肽醋酸盐	Others	Others
	N-Acetylcarnosine acetate (N-Acetyl-L-carnosine acetate) 是一种天然的，含有组氨酸的二肽，是药理学上主要的 L-carnosine 的来源。N-Acetylcarnosine 是一种有效的眼科药物，有用于人类白内障的潜力。
T77105	Odesivimab
	Odesivimab 是一种人源化单克隆抗体，靶向埃博拉病毒糖蛋白，重组组氨酸标记的马科纳毒株埃博拉病毒糖蛋白胞外域蛋白的 KD 值为 7.74 nM。Odesivimab 可用于埃博拉病毒感染的研究。
T35646	4-oxo-2-Nonenal 4-oxo-2-Nonenal,4-ONE
	4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid. [1] [2] It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.[1][2][3] 4-oxo-2-Nonenal is a more recently identified product of lipid peroxidation.[4][5][6] It actively modifies histidine and lysine residues on prot...

化合物

Cat.No: T9372

Target: Mitochondrial Metabolism

L-Histidine benzyl ester bistosylate

Cat.No: T40122

Target: Others

Histidine oxoglurate

Cat.No: T32080

Synonym: Histidine alpha-ketoglutarate

N-Formyl-L-histidine

Cat.No: T81677

Synonym: Formyl-L-histidine

Diglycyl-histidine

Cat.No: T20382

Synonym: NSC334195,NSC-334195,Gly-gly-his,Glycylglycyl-L-histidine,NSC 334195

Copper histidine

Cat.No: T67981

Hepta-histidine

Cat.No: T68950

N-Mercaptoacetyl-L-histidine

Cat.No: T33702

Synonym: SA 120,L-Histidine, N-(mercaptoacetyl)-,SA120,SA-120

Cat.No: T66645

Synonym: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-imidazol-4-yl)propanoic acid,(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-histidine,FMOC-L-Histidine

Imidazole-5-propionic acid

Cat.No: T9494

Synonym: Imidazolylpropionic acid,3-(咪唑-4-基)丙酸,SALOR-INT L480258-1EA,Deamino-histidine

Target: Dehydrogenase

L-Histidine S-malate

Cat.No: T32735

Methyl L-histidinate dihydrochloride

Cat.No: T3937

Synonym: L-Histidine methyl ester dihydrochloride,L-组氨酸甲酯二盐酸盐

Target: HDAC

Cat.No: T66788

N-Stearoylhistidine

Cat.No: T33760

Synonym: N-Stearoyl-L-histidine

2-Iodohistidine

Cat.No: T24974

Synonym: 2-Iodo-L-histidine

N-Cbz-L-histidine

Cat.No: T65767

Fmoc-1-methyl-L-histidine

Cat.No: T66680

N-Acetylcarnosine

Cat.No: TP1088

Synonym: N-Acetyl-L-carnosine,N-乙酰肌肽

Target: Others

1-N-Methyl-4-mercaptohistidine disulfide

Cat.No: T83633

Target: Others

(S)-alpha-Fluoromethylhistidine 2 HCl

Cat.No: T26374

Tyrosylhistidine

Cat.No: T80908

Phosphohistidine

Cat.No: T34033

Synonym: 3-Phosphohistidine

Pyroglutamylhistidine

Cat.No: T34208

Synonym: Pglu-his

N-Carbethoxyhistidine

Cat.No: T33611

Cat.No: TP1401

Synonym: His-Ala-Glu

Target: Others

Cat.No: TP1280

Target: Others

Cat.No: T6605

Target: CaMK, Virus Protease, PKA, Antibacterial, PKC, Autophagy, Antifungal

Cat.No: T65118

Synonym: Diethyl pyrocarbonate

Target: Others

Cat.No: T15650

Target: Histone Demethylase

Homocarnosine acetate

Cat.No: T32098L

Target: GABA Receptor, Endogenous Metabolite

4-Bromo-3-hydroxybenzoic acid

Cat.No: T7454

Target: Decarboxylase, Endogenous Metabolite

Cat.No: T22243

Synonym: L-鹅肌肽,L-Anserine

Target: Endogenous Metabolite

Cat.No: T26480

Synonym: A-331440,A331440 free base,A 331440

Formiminoglutamic acid

Cat.No: T31851

Synonym: NSC-334078,NSC334078,NSC 334078

Cat.No: T33440

Synonym: MK-785,MK 785

HAE acetate(64111-99-5 free base)

Cat.No: TP1401L

Target: Others

Phosphoribosyl pyrophosphate pentasodium

Cat.No: T38472

Synonym: PRPPpentasodium,磷酸核糖焦磷酸

trans-Urocanic Acid

Cat.No: T37547

Cat.No: T17166

Synonym: Hypostamine,酞茂异喹,Inhibostamin

Target: Decarboxylase

Cat.No: T38382

Cat.No: T27995

Synonym: HK-inhibitor-2,MDK3046,HK inhibitor 2

Cat.No: T82863

Hexa His tag peptide

Cat.No: TP2181

Target: Others

5-Phospho-D-ribose 1-diphosphate (sodium salt hydrate)

Cat.No: T36973

Cat.No: T17274

Target: CCR

Antiulcer Agent 2

Cat.No: T76577

Hepcidin-20 (human)

Cat.No: T76585

N-Acetylcarnosine acetate

Cat.No: TP1088L

Synonym: N-Acetyl-L-carnosine acetate,N-Acetyl carnosine acetate,N-乙酰肌肽醋酸盐

Target: Others

Cat.No: T77105

4-oxo-2-Nonenal

Cat.No: T35646

Synonym: 4-oxo-2-Nonenal,4-ONE

Cat. No.	Product Name	Target	Signaling Pathways
T2A2532	L-Histidine Glyoxaline-5-alanine,L-(-)-Histidine,L-组氨酸,histidine,组氨酸,L-Hisidine	Mitochondrial Metabolism; Endogenous Metabolite	Metabolism
	L-Histidine (L-(-)-Histidine) 是人类生长和组织修复所需的一种半必需氨基酸(儿童应从食物中获得)。 L-Histidine 是线粒体谷氨酰胺转运的抑制剂。
T4934	1-Methyl-L-histidine 1-甲基-L-组氨酸,3-(1-Methylimidazol-4-yl)-L-alanine,Nτ-Methyl-L-histidine	Endogenous Metabolite	Metabolism
	1-Methyl-L-histidine (3-(1-Methylimidazol-4-yl)-L-alanine)，一种人内源性代谢物，是肉类和外源性 3-methylhistidine 摄入的客观生物标记。
T4826	L-Histidine monohydrochloride monohydrat	Others; Endogenous Metabolite	Metabolism; Others
	L-Histidine monohydrochloride monohydrat 是一种 α-氨基酸。 L-异构体是 22 种蛋白质氨基酸之一，即蛋白质的组成部分。
T8274	3-Methyl-L-histidine	Endogenous Metabolite	Metabolism
	3-Methyl-L-histidine 是一种肉类尤其是鸡肉摄入和大豆制品摄入的生物标记。
T4732	L-Carnosine Karnozin,L-肌肽,beta-Alanyl-L-histidine	Antioxidant; Endogenous Metabolite	Metabolism; oxidation-reduction
	L-Carnosine (Karnozin) 是由beta-丙氨酸和组氨酸组成的二肽，具有抑制衰老的作用。
T38094	N-Acetyl-L-histidine monohydrate
	N-Acetyl-L-histidine monohydrate 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 T38094，CAS号为 39145-52-3。
T37298	Spinacine	Endogenous Metabolite	Metabolism
	Spinacine 是人内源性代谢产物。
T8790	1-Methylhistamine dihydrochloride	Endogenous Metabolite	Metabolism
	1-Methylhistamine dihydrochloride 是组胺代谢物。
T0965	Histamine Ergamine,组胺	5-HT Receptor; Endogenous Metabolite; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Histamine (Ergamine) 是通过组胺的酶促脱羧衍生的胺。它是一种强大的胃分泌兴奋剂、支气管平滑肌的收缩剂、血管扩张剂以及中枢作用的神经递质。
T19443L	N-Acetylhistamine acetate	Endogenous Metabolite; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	N-Acetylhistamine acetate 是一种组胺代谢物。它可用作过敏反应的组氨酸代谢的潜在生物标志物。
TN4505	Masticadienolic acid	Others	Others
	Masticadienolic acid is a specific competitive inhibitor of secreted phospholipase A2, it not only protects the active site histidine from alkylation but also inhibits the action of secreted from pancreas, synovial fluid, and bee venom. Masticadienolic ac

天然产物

Cat.No: T2A2532

Synonym: Glyoxaline-5-alanine,L-(-)-Histidine,L-组氨酸,histidine,组氨酸,L-Hisidine

Target: Mitochondrial Metabolism, Endogenous Metabolite

1-Methyl-L-histidine

Cat.No: T4934

Synonym: 1-甲基-L-组氨酸,3-(1-Methylimidazol-4-yl)-L-alanine,Nτ-Methyl-L-histidine

Target: Endogenous Metabolite

L-Histidine monohydrochloride monohydrat

Cat.No: T4826

Target: Others, Endogenous Metabolite

3-Methyl-L-histidine

Cat.No: T8274

Target: Endogenous Metabolite

Cat.No: T4732

Synonym: Karnozin,L-肌肽,beta-Alanyl-L-histidine

Target: Antioxidant, Endogenous Metabolite

N-Acetyl-L-histidine monohydrate

Cat.No: T38094

Cat.No: T37298

Target: Endogenous Metabolite

1-Methylhistamine dihydrochloride

Cat.No: T8790

Target: Endogenous Metabolite

Cat.No: T0965

Synonym: Ergamine,组胺

Target: 5-HT Receptor, Endogenous Metabolite, Histamine Receptor

N-Acetylhistamine acetate

Cat.No: T19443L

Target: Endogenous Metabolite, Histamine Receptor

Masticadienolic acid

Cat.No: TN4505

Target: Others

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