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Search Results for " gastric ulcers "

37

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4981	Anisotropine Methylbromide	Prostaglandin Receptor; AChR	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Anisotropine Methylbromide 是一种抗胆碱能药物，已用于缓解胃肠道痉挛和抑制胃酸分泌。
T1756L	Ilaprazole IY81149,艾普拉唑,IY 81149,IY-81149	Proton pump; TOPK	MAPK; Membrane transporter/Ion channel
	Ilaprazole (IY-81149) 是一种具有口服活性质子泵抑制剂，以剂量依赖性方式不可逆地抑制H+/K+-ATPase，在兔壁细胞制剂中的IC50为 6 μM。它也是一种有效的T 细胞起源蛋白激酶(TOPK)抑制剂，用于胃溃疡的研究。
T1756	Ilaprazole sodium IY-81149 sodium,艾普拉唑钠	Proton pump; TOPK	MAPK; Membrane transporter/Ion channel
	Ilaprazole sodium (IY-81149 sodium) 是一种具有口服活性质子泵抑制剂，以剂量依赖性方式不可逆地抑制 H+/K+-ATPase，在兔壁细胞制剂中的 IC50为 6 μM。它也是一种有效的 T 细胞起源蛋白激酶(TOPK)抑制剂，用于胃溃疡的研究。
T14975	CJ-42794 CJ-042794	Others	Others
	CJ-42794 (CJ-042794)是前列腺素受体 EP4的选择性拮抗剂, 抑制[3H]-PGE2与 EP4受体结合的平均 pKi 为8.5, 对 EP4选择性比 EP1, EP2和 EP3高200多倍。
T28136	NC-1300-B NC1300B,NC 1300 B	ATPase	Membrane transporter/Ion channel
	NC-1300-B 抑制 H（+）-K（+）-ATP 酶，可用于研究胃溃疡。
T19826	Rabeprazole LY307640	Potassium Channel; STAT	JAK/STAT signaling; Membrane transporter/Ion channel; Stem Cells
	Rabeprazole (LY307640) 是一种 H+/K+-ATPase 抑制剂，通过靶向 STAT3 介导的糖酵解来抑制胃上皮细胞中的细胞增殖，可用于研究胃溃疡。
T13145	Thiazolidinone-Derivatives-1	Others	Others
	Thiazolidinone-Derivatives-1 抑制胃酸分泌，可用于研究胃和十二指肠溃疡的治疗。
T15687	Thioflosulide L-745337	COX	Immunology/Inflammation; Neuroscience
	Thioflosulide (L-745337) 是一种具有选择性和高效性的 COX2 抑制剂（IC50：2.3 nM），具有抗炎活性，可用于研究胃溃疡。
T7099	Gefarnate	Others	Others
	Gefarnate 是一种胃炎和胃溃疡的研究药物，目前也用于研究干眼症。
T14546	Bermoprofen AD-1590,AJ-1590	Others	Others
	Bermoprofen (AD-1590) 是一种口服活性非甾体抗炎化合物，具有抗炎镇痛活性，可用于研究胃溃疡。
T68100	Mifentidine DA 4577	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Mifentidine (DA 4577) 是一种可口服的 H2 受体拮抗剂，可用于研究胃排空和实验性胃和十二指肠溃疡。
T3610	Ranitidine 雷尼替丁,HSDB 3925,Ranitidin	P450; Antibacterial; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience
	Ranitidine (HSDB 3925) 是一种选择性的，具有口服活性的组胺 H2 受体拮抗剂，IC50为 3.3 μM。它还一种是CYP2C19和CYP2C9的弱抑制剂，可抑制胃液分泌。
T33846	Oxyphenonium bromide Spasmophen,Oxifenon,奥芬溴铵,Oxyfenon,Atrenyl,Oxyphenon	Others	Others
	Oxyphenonium bromide (Oxyfenon) 具有抗胆碱能活性，可用于治疗胃和十二指肠溃疡以及缓解内脏痉挛的研究。
T0674	Lansoprazole 兰索拉唑,A-65006,AG-1749	Proton pump; Phospholipase; Antibacterial	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Lansoprazole (A-65006) 是一种可抑制胃酸生成的质子泵抑制剂。它是中性鞘磷脂酶的外泌体抑制剂。
T1651	Rabeprazole sodium Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,雷贝拉唑钠,Rebeprazole sodium,Aciphex Sodium	Apoptosis; Proton pump	Apoptosis; Membrane transporter/Ion channel
	Rabeprazole sodium (Habeprazole Sodium) 是一种质子泵抑制剂，不可逆地抑制胃 H+/K+-ATPase，可研究胃溃疡和胃食管反流。它诱导细胞凋亡，也抑制尿苷核苷核糖水解酶，IC50为 0.3 μM。
T10221	Abeprazan hydrochloride DWP14012 hydrochloride,Fexuprazan hydrochloride	Proton pump	Membrane transporter/Ion channel
	Abeprazan hydrochloride (Fexuprazan hydrochloride) 是一种有效的、可逆的、具有口服活性的potassium-competitive acid 阻滞剂，通过竞争性的与钾离子结合抑制 H+，K+- ATPase，而无需酸激活。Abeprazan hydrochloride 是一种质子泵抑制剂(PPI)，通过减少胃酸的产生而起作用，可用于治疗胃酸相关疾病，如胃食管反流病(GERD)和消化性溃疡。
T1052	Proglumide 二丙谷酰胺	cholecystokinin	GPCR/G Protein
	Proglumide (Binoside) 是一种非肽的、口服具有活性的胆囊收缩素(CCK)-A/B 受体拮抗剂。它能够选择性阻断 CCK 在中枢神经系统中的作用。它能够抑制胃分泌，具有保护胃十二指肠粘膜的能力，并表现出抗癫痫和抗氧化活性。
T77599	Methyl retinoate Retinoic acid, methyl ester	Others	Others
	Methyl retinoate (Retinoic acid, methyl ester) 在体内实验中会诱导给部位发生无菌炎症，会使血液中白细胞数量增加，而红细胞和Hb含量减少。Methyl retinoate 可促进自发性白血病的产生。Methyl retinoate 可用于治疗因维生素A缺乏而产生的胃肥大和溃疡。
T69805	AU-006
	AU-006 is an anti-ulcer drug which is effective in the treatment of gastric ulcers by inhibiting gastric acid secretion.
T70135	Nepaprazole sodium dihydrate
	Nepaprazole sodium dihydrate is a proton pump inhibitor potentially for treatment of gastric ulcers.
T32224	Isopropamide Priazimide,Dipramide,Piaccamide,Chloroisopropamide,Dipramid
	Isopropamide (R5) is a long-acting anticholinergic drug. It is used to treat peptic ulcers and other gastrointestinal disorders involving excess gastric acid (gastrointestinal acidosis) and hyperactivity.
T26090	Rioprostil TR 4698,TR4698,Rioprostilum,TR-4698
	Rioprostil is a methyl prostaglandin E1 analog that decreases gastric acid secretion and enhances the gastric mucus-bicarbonate barrier. It is effective in the treatment of gastric ulcers and gives significant protection against NSAID-induced gastric muco
T12047	Misoprostol acid	Others	Others
	Misoprostol acid is an active metabolite of Misoprostol,can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers.
T68200	Roxatidine hydrochloride
	Roxatidine hydrochloride is an anti-ulcer agent and histamine antagonist that suppresses gastric acid secretion. It effectively heals duodenal and gastric ulcers and reduces ulcer pain. Roxatidine acetate has an improved safety profile compared to other similar drugs, in part because lower doses of roxatidine acetate are therapeutically effective.
T25375	Enprostil RS-84135,RS 84135,Gardrin,RS84135
	Enprostil is a synthetic PGE2 analog that has an inhibitory effect on gastric acid secretion, a mucoprotective effect, and a postprandial lowering effect on gastrin. It has efficient and safe in the therapy of gastroduodenal ulcers.
T78237	Urease-IN-6
	Urease-IN-6为一种高效Urease抑制剂，IC50值为14.2 μM，适用于消化性溃疡和胃溃疡研究。
T37470	Bismuth subcarbonate
	Bismuth subcarbonate, also known as bismuth carbonate oxide, is a versatile semiconductor compound based on bismuth, commonly utilized for its antibacterial properties, as well as in various applications such as sensors, super capacitors, and photocatalysts. Additionally, bismuth subcarbonate serves as a protective agent against gastric acid erosion, particularly in the treatment of gastric ulcers[1][2].
T33314	Methantheline Bromide Frenogastrico,Dixamone bromide,Banthine,Asabaine,Methanthelinium bromide
	Methantheline Bromide is a synthetic spasmolytic used to relieve cramps or spasms of the stomach, bowel, and bladder. It is also useful for intestinal or gastric ulcers (peptic ulcer disease), intestinal problems, pancreatitis, gastritis, biliary dysmotil
T61228	Pirenzepine
	Pirenzepine (LS 519 free base) is a selective antagonist of the M1 muscarinic acetylcholine receptor (mAChR). It effectively inhibits gastric acid secretion and reduces muscle spasm, making it a valuable compound for investigating peptic ulcers. Additionally, Pirenzepine exhibits anti-proliferative activity against cancer cells [1] [2].
T60584	Cimetidine hydrochloride
	Cimetidine (SKF-92334) hydrochloride 是一种具有口服活性的，可逆的组胺H2受体拮抗剂 (Ki = 0.6 μM)。Cimetidine hydrochloride 显示出抗癌和抗炎活性。Cimetidine hydrochloride 是一种胃酸减少剂，它可用于十二指肠和胃溃疡的相关研究。
T71801	Arbaprostil
	Arbaprostil is a synthetic prostaglandin E analog that protects gastric mucosa, prevents ulceration, and promotes healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and can inhibit the growth of experimental tumors. Arbaprostil is a prodrug for the potent PGE2.
T79656	Urease-IN-8
	Urease-IN-8 (Compound 5e) 为一竞争性脲酶 (Urease) 抑制剂，具IC50值为3.51 μM，Ki值为3.11 μM，主要用于消化性溃疡与胃溃疡研究。
T63227	Hydrocortisone phosphate sodium
	Hydrocortisone phosphate (sodium) (Hydrocortisone 21-phosphate (sodium)) 是一种具有较弱抗炎作用的软类固醇，作用时间短，能够用于研究几种眼部疾病和胃溃疡。
T79652	Urease-IN-7
	Urease-IN-7 (Compound 5k)，作为竞争性Urease抑制剂，具有IC50为3.33 μM和Ki值为3.62μM。该化合物可用于消化性溃疡和胃溃疡研究。
T71772	Bicifadine free base
	Bicifadine, also known as DOV-220075, CL 220,075, is a SNDR inhibitor potentially for the treatment of lower back pain. Bicifadine has a non-opioid, non-NSAID mechanism for the treatment of pain, which should have less abuse potential than opioid drugs and less propensity to cause gastric ulcers than NSAID drugs. While the drug is purported to be a serotonin (SERT) and noradrenaline transporter (NET) inhibitor, it also has effects at the dopamine transporter (DAT), effectively making it a broad...
T80287	KLTWQELYQLKYKGI	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	KLTWQELYQLKYKGI (QK) 是一种与VEGF受体结合并同VEGF竞争的VEGF模拟肽。在口服或全身给药时，该化合物对啮齿类动物胃溃疡的愈合展现了活性。此外，KLTWQELYQLKYKGI 在体外具有诱导毛细血管形成和组织的能力。
T27752	KT109 KT-109,KT 109
	KT109 is a selective inhibitor of DAGLβ (IC50 = 42 nM). KT109-treated wild-type mice displayed reductions in LPS-induced allodyni as well as in DAGL-β (-/-) micea. Repeated KT109 administration prevented the expression of LPS-induced allodynia, without ev

化合物

Anisotropine Methylbromide

Cat.No: T4981

Target: Prostaglandin Receptor, AChR

Cat.No: T1756L

Synonym: IY81149,艾普拉唑,IY 81149,IY-81149

Target: Proton pump, TOPK

Ilaprazole sodium

Cat.No: T1756

Synonym: IY-81149 sodium,艾普拉唑钠

Target: Proton pump, TOPK

Cat.No: T14975

Synonym: CJ-042794

Target: Others

Cat.No: T28136

Synonym: NC1300B,NC 1300 B

Target: ATPase

Cat.No: T19826

Synonym: LY307640

Target: Potassium Channel, STAT

Thiazolidinone-Derivatives-1

Cat.No: T13145

Target: Others

Cat.No: T15687

Synonym: L-745337

Target: COX

Cat.No: T7099

Target: Others

Cat.No: T14546

Synonym: AD-1590,AJ-1590

Target: Others

Cat.No: T68100

Synonym: DA 4577

Target: Histamine Receptor

Cat.No: T3610

Synonym: 雷尼替丁,HSDB 3925,Ranitidin

Target: P450, Antibacterial, Histamine Receptor

Oxyphenonium bromide

Cat.No: T33846

Synonym: Spasmophen,Oxifenon,奥芬溴铵,Oxyfenon,Atrenyl,Oxyphenon

Target: Others

Cat.No: T0674

Synonym: 兰索拉唑,A-65006,AG-1749

Target: Proton pump, Phospholipase, Antibacterial

Rabeprazole sodium

Cat.No: T1651

Synonym: Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,雷贝拉唑钠,Rebeprazole sodium,Aciphex Sodium

Target: Apoptosis, Proton pump

Abeprazan hydrochloride

Cat.No: T10221

Synonym: DWP14012 hydrochloride,Fexuprazan hydrochloride

Target: Proton pump

Cat.No: T1052

Synonym: 二丙谷酰胺

Target: cholecystokinin

Methyl retinoate

Cat.No: T77599

Synonym: Retinoic acid, methyl ester

Target: Others

Cat.No: T69805

Nepaprazole sodium dihydrate

Cat.No: T70135

Cat.No: T32224

Synonym: Priazimide,Dipramide,Piaccamide,Chloroisopropamide,Dipramid

Cat.No: T26090

Synonym: TR 4698,TR4698,Rioprostilum,TR-4698

Misoprostol acid

Cat.No: T12047

Target: Others

Roxatidine hydrochloride

Cat.No: T68200

Cat.No: T25375

Synonym: RS-84135,RS 84135,Gardrin,RS84135

Cat.No: T78237

Bismuth subcarbonate

Cat.No: T37470

Methantheline Bromide

Cat.No: T33314

Synonym: Frenogastrico,Dixamone bromide,Banthine,Asabaine,Methanthelinium bromide

Cat.No: T61228

Cimetidine hydrochloride

Cat.No: T60584

Cat.No: T71801

Cat.No: T79656

Hydrocortisone phosphate sodium

Cat.No: T63227

Cat.No: T79652

Bicifadine free base

Cat.No: T71772

KLTWQELYQLKYKGI

Cat.No: T80287

Target: VEGFR

Cat.No: T27752

Synonym: KT-109,KT 109

Cat. No.	Product Name	Target	Signaling Pathways
TN2078	Pinocembrin chalcone 2',4',6'-Trihydroxychalcone,Pinocembrinchalcone	Calcium Channel; Tyrosinase; Antibacterial; Antifection	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Proteases/Proteasome
	Pinocembrin chalcone 是一种具有抗诱变作用的酪氨酸酶抑制剂。 Pinocembrin 查尔酮可用于预防胃溃疡的研究。
TN4465	Luvangetin	COX; Prostaglandin Receptor; Antifection	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection against pylorus-ligated and aspirin-induced gastric ulcers in rats and cold restraint stress-induced
T83258	7(18)-Dehydroschisandro A
	7(18)-Dehydroschisandro A (化合物2) 是从Schizandra chinensis Baill分离得到的木脂素，对激性胃溃疡显示出抑制效果。
T83257	7(8)-Dehydroschisandrol A
	7(8)-Dehydroschisandrol A (Compound 4a)为从Schizandra chinensis Baill分离的木脂素，对激性胃溃疡表现出较弱抑制效果。
T75507	1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone
	1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone 对幽门螺杆菌菌株 51 表现出有效的抗菌活性，MIC50 值和 MIC90 值分别为 22 µM 和 50 µM。该化合物展现了在研究胃及十二指肠溃疡方面的潜力。

天然产物

Pinocembrin chalcone

Cat.No: TN2078

Synonym: 2',4',6'-Trihydroxychalcone,Pinocembrinchalcone

Target: Calcium Channel, Tyrosinase, Antibacterial, Antifection

Cat.No: TN4465

Target: COX, Prostaglandin Receptor, Antifection

7(18)-Dehydroschisandro A

Cat.No: T83258

7(8)-Dehydroschisandrol A

Cat.No: T83257

1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone

Cat.No: T75507

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