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Cat. No.	Product Name	Target	Signaling Pathways
T6830	Epoxomicin BU-4061T,BU-4061T,Aids010837,环氧酶素	Apoptosis; Proteasome	Apoptosis; Proteases/Proteasome; Ubiquitination
	Epoxomicin (BU-4061T,Aids010837) 是一种含环氧酮的天然产物，可穿越血脑屏障，并具有很强的抗肿瘤和抗炎活性。它是一种选择性不可逆的蛋白酶体抑制剂，抑制类胰凝乳蛋白酶的活性。
TN2755	2-Desoxy-4-epi-pulchellin	Anti-infection	Microbiology/Virology
	2-Desoxy-4-epi-pulchellin 是分离自 Polygonum hydropiper 的二氯甲烷可溶部分的一种化合物。
TN2923	3'-Deoxy-4-O-methylsappanol	Tyrosinase	Proteases/Proteasome
	3'-Deoxy-4-O-methylsappanol shows moderate cytotoxicities against cultured human melanoma HMV-II cells with the IC50 value of 872.0 uM ± 2.4.
TN2490	1,3-Diacetylvilasinin	Others	Others
	1,3-Diacetylvilasinin shows marginal cytotoxicities against certain human tumor cell lines. It also shows antifeeding activity towards insects.
TN2492	1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone	Others	Others
	1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone has moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacks antifungal activity against Candida albicans.
TN4172	Guajadial B	Topoisomerase	DNA Damage/DNA Repair
	Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. Guajadial B shows cytotoxicities against five human cancer cell lines, it is the most effective having an IC50 value of 150 nM toward A549 cells.
TN2695	2,3-Dihydroamentoflavone 7,4'-dimethyl ether	Others	Others
	2,3-Dihydroamentoflavone 7,4'-dimethyl ether exhibits cytotoxicities (ED50 values < 4 microg/mL) against P-388 and/or HT-29 cell lines in vitro.
TN4630	Nemoralisin	Others	Others
	Nemoralisin exhibits weak cytotoxicities (IC50>10 uM) against HepG2, AGS, MCF-7, and A-549 cancer cell lines.
TN1173	1-Hydroxyrutaecarpine	Others	Others
	1-Hydroxyrutaecarpine exhibits cytotoxicities (ED50 values < 4 microg/mL) against P-388 or HT-29 cell lines in vitro.
TN5012	Shizukaol C	HIV Protease; Antifection	Microbiology/Virology; Proteases/Proteasome
	1. Shizukaol C shows anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains. <br/> 2. Shizukaol C has significant cytotoxicities against C8166 cells. <br/>
TN3009	4',5,7-Trihydroxy-6-prenylflavone	Others	Others
	6-Prenylapigenin(4',5,7-Trihydroxy-6-prenylflavone) shows potent inhibitory activity on melanin formation, it may be potential sources for skin whitening agents. It also shows moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarci
TN4864	Pungiolide A	Others	Others
	Pungiolide A exhibits moderate cytotoxicities with IC50 values in the range of 0.90-6.84 uM.
TN4215	Hispidanin B	Others	Others
	Hispidanin B shows significant cytotoxicities against tumor cell lines SGC7901, SMMC7721, and K562, with IC50 values of 10.7, 9.8, and 13.7 uM, respectively.
TN2493	1,4,5,6-Tetrahydroxy-7-prenylxanthone	Others	Others
	1,4,5,6-Tetrahydroxy-7-prenylxanthone has anti-cancer activity, it shows moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines; it also exhibits moderate activities with GI50 (Growth inhibitory) values of 2.
T81170	Shishijimicin A
	Shishijimicin A是一款从子囊菌Didemnum proliferum中分离出的新型抗肿瘤剂，具备突出的细胞毒性及抗肿瘤活性。作为点击化学试剂，Shishijimicin A内含Alkyne基团，能够与含Azide基团的分子通过铜催化的叠氮-炔环加成反应(CuAAc)进行作用。
T81168	Shishijimicin C
	Shishijimicin C 是由子囊菌 Didemnum proliferum 分离得到的一种新型抗肿瘤剂，具有显著的细胞毒性和抗肿瘤活性。作为点击化学试剂，Shishijimicin C 含有Alkyne基团，能够通过铜催化的叠氮-炔环加成反应（CuAAc）与含Azide基团的分子反应。
TN5011	Shizukaol B	ERK; IL Receptor; p38 MAPK; TNF; NOS; NF-κB; COX; HIV Protease; DNA/RNA Synthesis; Prostaglandin Receptor; JNK	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome
	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production in lipopolysaccharide (LPS)-stimul
TN5153	Torilin	MMP; ERK; IκB/IKK; p38 MAPK; NF-κB; Tyrosinase; Reductase; DNA/RNA Synthesis; JNK	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Endocrinology/Hormones; MAPK; Metabolism; NF-κB; Proteases/Proteasome
	Torilin 是一种睾酮5α还原酶抑制剂，它（IC50=31.7+/-4.23μM）对5α还原酶的抑制作用强于α-亚麻酸（IC50=160.3+/-24.62μM），但弱于非那雄胺（IC50=0.38+/-0.06μM）。Torilin 具有免疫调节、肝脏保护和抗炎特性，它通过限制 TAK1介导的 MAP 激酶和 NF-βB 活化来抑制炎症，它可以减轻关节炎的严重程度，改变 dLN 或关节中的白细胞活化，并恢复血清和脾细胞细胞因子失衡。托利林抑制α-黑素细胞刺激激素激活的 B16黑色素瘤细胞中的黑色素生成，IC（50）值为25μM。Torilin 对枯草芽孢杆菌 ATCC 6633孢子和营养细胞表现出优异的抗菌活性。Torilin 在体内和体外都具有强大的抗血管生成活性，它可能通过抑制肿瘤侵袭来抑制肿瘤发生，逆转癌细胞的多药耐药性，它可以增强阿霉素、长春碱、紫杉醇和秋水仙碱对多药耐药 KB-V1和 MCF7/ADR 细胞的细胞毒性。

天然产物

Cat.No: T6830

Synonym: BU-4061T,BU-4061T,Aids010837,环氧酶素

Target: Apoptosis, Proteasome

2-Desoxy-4-epi-pulchellin

Cat.No: TN2755

Target: Anti-infection

3'-Deoxy-4-O-methylsappanol

Cat.No: TN2923

Target: Tyrosinase

1,3-Diacetylvilasinin

Cat.No: TN2490

Target: Others

1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone

Cat.No: TN2492

Target: Others

Cat.No: TN4172

Target: Topoisomerase

2,3-Dihydroamentoflavone 7,4'-dimethyl ether

Cat.No: TN2695

Target: Others

Cat.No: TN4630

Target: Others

1-Hydroxyrutaecarpine

Cat.No: TN1173

Target: Others

Cat.No: TN5012

Target: HIV Protease, Antifection

4',5,7-Trihydroxy-6-prenylflavone

Cat.No: TN3009

Target: Others

Cat.No: TN4864

Target: Others

Cat.No: TN4215

Target: Others

1,4,5,6-Tetrahydroxy-7-prenylxanthone

Cat.No: TN2493

Target: Others

Shishijimicin A

Cat.No: T81170

Shishijimicin C

Cat.No: T81168

Cat.No: TN5011

Target: ERK, IL Receptor, p38 MAPK, TNF, NOS, NF-κB, COX, HIV Protease, DNA/RNA Synthesis, Prostaglandin Receptor, JNK

Cat.No: TN5153

Target: MMP, ERK, IκB/IKK, p38 MAPK, NF-κB, Tyrosinase, Reductase, DNA/RNA Synthesis, JNK

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