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40

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4502	BISMUTH SUBGALLATE 次没食子酸铋,Dermatol Puder,Bismuth Gallate	Others	Others
	Bismuth subgallate (Dermatol Puder) 是一种止血剂，可作用于凝血因子 XII ，促使凝血级联的激活，改善纤维蛋白凝块的早期形成。
T19786	Hematin Ferrihemate,Ferriheme hydroxide,Ferriheme,Ferrihemic acid,羟高铁血红素	Others	Others
	Hematin (Ferrihemic acid) 是含铁卟啉，可以结合止血蛋白诱导其失活，降低凝血因子的活性以及阻碍纤维蛋白凝块的溶解。它可用于研究急性卟啉症和癌症。
T0182L	Clopidogrel hydrogen sulfate 硫酸氢氯吡格雷,(S)-(+)-Clopidogrel hydrogen sulfate,(S)-(+)-Clopidogrel bisulfate,SR-25990C,Clopidogrel,硫酸氯吡格雷	P450; P2Y Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) 是一种抗血小板药物，可防止血栓形成。它抑制 CYP2B6和 CYP2C19，IC50分别为 18.2 和 524 nM。它是一种选择性的高亲和力 P2Y12 受体拮抗剂，可抑制纤维蛋白原与血小板的结合以及血小板的粘附和聚集。
TP2068L	Cyclotraxin B acetate(1203586-72-4 free base)	Trk receptor	Tyrosine Kinase/Adaptors
	Cyclotraxin B acetate(1203586-72-4 free base) 是 TrkB 受体的拮抗剂；抑制 BDNF 诱导的 TrkB 活性 (IC50 = 0.30 nM)。变构改变 TrkB 受体构象但不改变 BDNF 结合。防止 BDNF 引起的小鼠冷异常性疼痛。还显示在小鼠中表现出推定的抗焦虑特性。
T21153	Clothianidin TI435,TI-435,TI 435,噻虫胺,Celero	AChR	Neuroscience
	Clothianidin (TI 435) 是一种杀虫剂，作为乙酰胆碱的激动剂，可刺激 nAChR，从而激活突触后乙酰胆碱受体，但不抑制 AChE。
T4573	Cyclothiazide	GluR	Neuroscience
	Cyclothiazide 是AMPA 受体的正变构调节剂，可快速抑制 AMPA 受体脱敏，并缓慢增强 AMPA 电流。它可以阻断天然和异源表达的AMPA 受体脱敏。
T0506	Clotrimazole 克霉唑,BAY b 5097,FB 5097	Antibacterial; Antibiotic; Antifection; Autophagy; Antifungal	Autophagy; Microbiology/Virology
	Clotrimazole (FB 5097) 是咪唑衍生物，有抗真菌和抗菌活性，是 P450抑制剂。
T26804	Biclotymol	Others	Others
	Biclotymol 可用于感染性口咽疾病研究。
T11852	Linaclotide	Guanylate cyclase	GPCR/G Protein
	Linaclotide 是一种有效的选择性鸟苷酸环化酶 C 激动剂，可用于治疗便秘型肠易激综合征 (IBS-C) 和慢性便秘的研究。
T13620	Clothixamide Clotixamide	Others	Others
	Clothixamide（Clotixamide）是一种噻吨类衍生物，具有抗精神失常活性。
T23900	Clothiapine LW 2159,HF2159,氯噻平,HF-2159,HF 2159,S-805C
	Clothiapine is an atypical antipsychotic of the dibenzothiazepine chemical class.
T6581	Methyclothiazide Duretic,Enduron,甲氯噻嗪,Aquatensen	Others; Carbonic Anhydrase	Metabolism; Others
	Methyclothiazide (Aquatensen) 是一种具有口服活性的利尿剂，也是一种降压剂。它能够拮抗体外的电压依赖性钙通道的 (VDCC) 活性，也可以抑制内源性血管收缩刺激导致的血管反应。
TP2403	Recanaclotide IW 9179,IW-9179,IW9179
	Recanaclotide can be used to treat Gastroparesis, Functional Dyspepsia, and Other Gastrointestinal Disorders.
T69054	Ciclotizolam
	Ciclotizolam is a drug which is a thienotriazolodiazepine derivative. It is a partial agonist for the benzodiazepine site of the GABAA receptor, with similar binding affinity to related compounds like brotizolam, but a low efficacy.
T69204	Octoclothepin maleate salt
	Octoclothepin maleate salt is a D2 dopamine receptor antagonist and 5-HT2 serotonin receptor antagonist.
T66283	1,4-Bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene octahydrobromide
	1,4-Bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene octahydrobromide 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66283，CAS号为 155148-32-6。
T39264	Cyclotriazadisulfonamide CADA,Cyclotriazadisulfonamide
	Cyclotriazadisulfonamide (CADA) is a specific inhibitor of HIV entry that targets CD4. It functions by preventing the co-translational translocation of human CD4 (huCD4) into the endoplasmic reticulum (ER) lumen through a mechanism dependent on the signal peptide (SP).
T23924	Cyclothialidine Ro 09-1437
	Cyclothialidine is an inhibitor of DNA gyrase.
TP2068	Cyclotraxin B
	Antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic p
T39264L	Cyclotriazadisulfonamide hydrochloride Cyclotriazadisulfonamide hydrochloride (182316-44-5 Free base)	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Cyclotriazadisulfonamide hydrochloride 是 CD4 靶向 HIV 进入的选择性抑制剂，并以信号肽依赖性方式抑制人 CD4 共翻译易位进入 ER 腔。
T68735	Ciclotropium (free base)
	Ciclotropium (free base) is quaternary ammonium compound with anticholinergic and parasympatholytic activity. Oral Cyclotropium bromide inhibited fasting and meal-stimulated colonic motility significantly without causing adverse side effects. After cyclotropium bromide, there was a significant correlation between antral contraction amplitude and gastric emptying.
T11852L	Linaclotide acetate MM 416775,MM416775 MD-1100 acetate,Linzess,MM-416775
	Linaclotide acetate is used as an oral guanylate cyclase C agonist linaclotide; 14 amino acid peptide for the potential treatment of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation.
T76231	Cyclotheonellazole A
	Cyclotheonellazole A为一天然大环肽类化合物，对弹性蛋白酶具显著的抑制效果（IC50=0.034 nM），且对糜蛋白酶亦有抑制作用，IC50值达0.62 nM。
T75832	Cyclotraxin B TFA
	Cyclotraxin B TFA 是一种环肽，是一种高效且选择性的 TrkB 抑制剂，且不会改变 BDNF 的结合。Cyclotraxin B TFA 非竞争性地抑制 BDNF 诱导的 TrkB 活性，IC50值为 0.30 nM。Cyclotraxin B TFA 可以穿越血脑屏障，并具有止痛和抗焦虑的行为作用。
T17204	UNC0321	Histone Methyltransferase	Chromatin/Epigenetic
	UNC0321 是一种有效的组蛋白甲基转移酶 G9a 抑制剂，在 ECSD 和 CLOT 测定中，Ki 为 63 pM，IC50 分别为 9 nM 和 6 nM。 UNC0321 抑制 GLP，在 ECSD 和 CLOT 试验中 IC50 分别为 15 nM 和 23 nM。
T31206	Darexaban YM 150,Darexaban, Tanexaban,YM150	Factor Xa	Metabolism
	Darexaban (Tanexaban, YM-150) 是选择性的、口服具有活力的 Xa 因子 (FXa) 抑制剂，IC50=54.6 nM。它对其他相关丝氨酸蛋白酶(如胰蛋白酶、凝血酶和激肽释放酶)具有高选择性。它具有抗凝和抗血栓形成作用。
T23764	AZ3976 AZ 3976,AZ-3976	PAI-1	Metabolism
	AZ3976 是一种纤溶酶原激活物抑制剂-1抑制剂，在血浆凝块溶解试验中的 IC50为16μM。AZ3976 显示促纤维蛋白溶解活性。
T22600	BC 11 hydrobromide	Others	Others
	The compound is a selective urokinase inhibitor (IC50 = 8.2 μM). It also inhibits clot lysis with no effect on clot formation.
T78367	Fibrinogen (Bovine)
	Fibrinogen (Bovine)为特异性蛋白质水解酶，通过凝血酶激活过程组装成纤维蛋白凝块。
T36773	12(S)-HETrE
	12(S)-HETrE is produced by 12-lipoxygenase oxidation of dihomo-γ-linolenic acid (DGLA). 12(S)-HETrE is reported to inhibit agonist-mediated platelet activation (IC50 = 40 μM), α granule secretion, integrin αIIbβ3 activation, Rap1 activation, and thrombin-induced clot retraction in vitro.
T75152	ARC19499
	ARC19499 是一种核酸适配体，与组织因子通路抑制剂(TFPI)特异性结合，阻断 TFPI 对factor Xa 和 TF/factor VIIa 复合物的抑制作用。ARC19499 纠正血友病A 和B 血浆中的凝血酶生成，并恢复凝血。
T35583	Hirudin (54-65; non-sulfated) (trifluoroacetate salt)
	Hirudin (54-65; non-sulfated) is a desulfated peptide fragment of hirudin, an anticoagulant produced byH. medicinalis.1It inhibits fibrin clot formation induced by isolated bovine thrombin with an IC50value of 3.7 μM.2 1.Niehrs, C., Huttner, W.B., Carvallo, D., et al.Conversion of recombinant hirudin to the natural form by in vitro tyrosine sulfation. Differential substrate specificities of leech and bovine tyrosylprotein sulfotransferasesJ. Biol. Chem.265(16)9314-9318(1990) 2.Payne, M.H., Krste...
T70810	THR-18
	THR-18 is an 18-mer peptide derived from the sequence of human plasminogen activator inhibitor 1 (PAI-1), having the ability to bind to a site of tissue plasminogen activator (tPA) distal to its catalytic site and uncouple the beneficial clot-dissolving properties of tPA from its deleterious non-fibrinolytic effects.
T73855	Thromboxane B1
	Thromboxane B1 (TXB1) 是TXB家族中的一员，属于类花生酸脂质家族。该家族因参与血栓形成而得名。
T82063	Integrin signaling inhibitor, mP13
	Integrinsignaling inhibitor, mP13 是抑制整合素信号传导，阻止内向外和外向内信号传递，涉及纤维蛋白原结合、血小板粘附及凝块收缩的化合物。
T26657	AR-H067637
	AR-H067637 is a rapid-binding, reversible and potent (inhibition constant K(i) = 2-4 nM), competitive inhibitor of thrombin, as well as of thrombin bound to fibrin (clot-bound thrombin) or to thrombomodulin. The total amount of free thrombin generated in
T35579	PKSI-527
	PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM). It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 μM, respectively). PKSI-527 reduces bradykinin generation induced by kaolin and λ-carrageenan ex vivo in human plasma. It also prolongs partial thromboplastin and euglobulin clot lysis times. In vivo, PKSI-527 (300 mg/kg per day) reduces hyperplasia, pannus formation, and infiltration of in...
T75589	Bitis Cornuta Venom
	Bitis Cornuta Venom (Many-horned Adder Venom) 是从 Bitis Cornuta 提取的蛇毒，含有sPLA2毒素，该毒素具有通过抑制凝血酶原复合物以发挥抗凝活性的能力，并能促使凝血酶原转化为凝血酶，引发凝块形成。
T72113	6-Aminocaproic acid hydrochloride EACA hydrochloride,EACA hydrochloride ; Epsilon-Amino-n-caproic Acid hydrochloride ; 6-Aminohexanoic acid hydrochloride,6-Aminohexanoic acid hydrochloride,Epsilon-Amino-n-caproic Acid hydrochloride
	6-Aminocaproic acid hydrochloride，一种单氨基羧酸，作为有效及口服活性的纤溶酶和纤溶酶原抑制剂，具备显著的抗纤溶能力。通过竞争性结合纤溶酶原上的赖氨酸残基，6-Aminocaproic acid hydrochloride 阻止血块溶解，抑制纤溶酶生成，减少纤维蛋白溶解，用于出血性疾病研究。
T80119	Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)	Thrombin	Proteases/Proteasome
	Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) 是一种具有高亲和力的Hirugen类肽，其与凝血酶的KD值小于100 nM。作为抗血栓剂，它能有效抑制凝血酶诱导的纤维蛋白凝块生成，其IC50值为0.087 μM。

化合物

BISMUTH SUBGALLATE

Cat.No: T4502

Synonym: 次没食子酸铋,Dermatol Puder,Bismuth Gallate

Target: Others

Cat.No: T19786

Synonym: Ferrihemate,Ferriheme hydroxide,Ferriheme,Ferrihemic acid,羟高铁血红素

Target: Others

Clopidogrel hydrogen sulfate

Cat.No: T0182L

Synonym: 硫酸氢氯吡格雷,(S)-(+)-Clopidogrel hydrogen sulfate,(S)-(+)-Clopidogrel bisulfate,SR-25990C,Clopidogrel,硫酸氯吡格雷

Target: P450, P2Y Receptor

Cyclotraxin B acetate(1203586-72-4 free base)

Cat.No: TP2068L

Target: Trk receptor

Cat.No: T21153

Synonym: TI435,TI-435,TI 435,噻虫胺,Celero

Target: AChR

Cat.No: T4573

Target: GluR

Cat.No: T0506

Synonym: 克霉唑,BAY b 5097,FB 5097

Target: Antibacterial, Antibiotic, Antifection, Autophagy, Antifungal

Cat.No: T26804

Target: Others

Cat.No: T11852

Target: Guanylate cyclase

Cat.No: T13620

Synonym: Clotixamide

Target: Others

Cat.No: T23900

Synonym: LW 2159,HF2159,氯噻平,HF-2159,HF 2159,S-805C

Methyclothiazide

Cat.No: T6581

Synonym: Duretic,Enduron,甲氯噻嗪,Aquatensen

Target: Others, Carbonic Anhydrase

Cat.No: TP2403

Synonym: IW 9179,IW-9179,IW9179

Cat.No: T69054

Octoclothepin maleate salt

Cat.No: T69204

1,4-Bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene octahydrobromide

Cat.No: T66283

Cyclotriazadisulfonamide

Cat.No: T39264

Synonym: CADA,Cyclotriazadisulfonamide

Cyclothialidine

Cat.No: T23924

Synonym: Ro 09-1437

Cat.No: TP2068

Cyclotriazadisulfonamide hydrochloride

Cat.No: T39264L

Synonym: Cyclotriazadisulfonamide hydrochloride (182316-44-5 Free base)

Target: HIV Protease

Ciclotropium (free base)

Cat.No: T68735

Linaclotide acetate

Cat.No: T11852L

Synonym: MM 416775,MM416775 MD-1100 acetate,Linzess,MM-416775

Cyclotheonellazole A

Cat.No: T76231

Cyclotraxin B TFA

Cat.No: T75832

Cat.No: T17204

Target: Histone Methyltransferase

Cat.No: T31206

Synonym: YM 150,Darexaban, Tanexaban,YM150

Target: Factor Xa

Cat.No: T23764

Synonym: AZ 3976,AZ-3976

Target: PAI-1

BC 11 hydrobromide

Cat.No: T22600

Target: Others

Fibrinogen (Bovine)

Cat.No: T78367

Cat.No: T36773

Cat.No: T75152

Hirudin (54-65; non-sulfated) (trifluoroacetate salt)

Cat.No: T35583

Cat.No: T70810

Cat.No: T73855

Integrin signaling inhibitor, mP13

Cat.No: T82063

Cat.No: T26657

Cat.No: T35579

Bitis Cornuta Venom

Cat.No: T75589

6-Aminocaproic acid hydrochloride

Cat.No: T72113

Synonym: EACA hydrochloride,EACA hydrochloride ; Epsilon-Amino-n-caproic Acid hydrochloride ; 6-Aminohexanoic acid hydrochloride,6-Aminohexanoic acid hydrochloride,Epsilon-Amino-n-caproic Acid hydrochloride

Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)

Cat.No: T80119

Target: Thrombin

Cat. No.	Product Name	Target	Signaling Pathways
T0881	6-Aminocaproic acid 氨基己酸,EACA,6-氨基己酸,6-Aminohexanoic acid,Epsilon-Amino-n-caproic Acid,(6-)ε-Aminocaproic acid	Others	Others
	6-Aminocaproic acid (EACA) 是一种单氨基羧酸，是一种有效的、具有口服活性的纤溶酶和纤溶酶原的抑制剂。它是一种有效的抗纤维蛋白溶解剂，能够竞争性结合纤溶酶原上的赖氨酸残基，防止血块溶解，并抑制纤溶酶的形成，减少纤维蛋白溶解。它可用于出血性疾病的研究。
T31141	Cyclotheonamide A
	Cyclotheonamide A is a cyclic peptide isolated from the marine sponge Theonella.

天然产物

6-Aminocaproic acid

Cat.No: T0881

Synonym: 氨基己酸,EACA,6-氨基己酸,6-Aminohexanoic acid,Epsilon-Amino-n-caproic Acid,(6-)ε-Aminocaproic acid

Target: Others

Cyclotheonamide A

Cat.No: T31141

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