31
4
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T15052 |
Dapansutrile
|
NOD-like Receptor (NLR); NOD | Immunology/Inflammation; NF-κB |
Dapansutrile 是一种口服有活性的 NLRP3 炎性小体选择性抑制剂。它具有抗炎特性,可用于研究缓解疼痛。 | |||
T15050 |
Danicamtiv
MYK-491,SAR 440181 |
Myosin | Cytoskeletal Signaling |
Danicamtiv (MYK-491) 是一种正性肌力药物,也是一种心肌肌球蛋白的选择性变构激活剂,可增加心脏收缩功能并保持机械效率。 | |||
TP2058L |
Catestatin acetate
Catestatin acetate(142211-96-9 free base) |
Endogenous Metabolite; AChR | Metabolism; Neuroscience |
Catestatin acetate 是 nAChR 的非竞争性拮抗剂,可抑制儿茶酚胺的释放。 Catestatin acetate 调节心脏功能和血压。 | |||
T31640 |
Enrasentan
SB-217242,SB 217242,SB217242 |
Endothelin Receptor | GPCR/G Protein |
Enrasentan(sb-217242)是一种 ET(A) 和 ET(B) 受体的混合拮抗剂,可降低血压、防止心肌肥大和保护心肌功能。 | |||
T9232 |
Mitochondrial fusion promoter M1
|
Mitochondrial Metabolism | Metabolism |
Mitochondrial fusion promoter M1 是一种线粒体动态调节剂,能够保持线粒体功能并促进细胞呼吸,减轻心肌缺血/再灌注大鼠的心脏损伤和大脑损伤。 | |||
T14875 |
Indocyanine green
Cardiogreen,IC Green,Foxgreen,吲哚菁绿 |
Others | Others |
Indocyanine green (Cardiogreen) 是低毒性荧光剂,普遍用于医学诊断,包括确定心输出量,肝功能和肝血流量,以及用于眼科血管造影。 | |||
T68037L |
CBS-1114 HCl
N-Phenylbenzamidrazone hydrochloride,cbs-1114 HCl(46721-85-1 Free base) |
Lipoxygenase | Metabolism |
CBS-1114 HCl (N-Phenylbenzamidrazone hydrochloride) 是一种5-脂氧合酶抑制剂,是一种良好眼睛渗透型号的抗炎化合物。CBS-1114 HCl 可以保持和改善心脏功能,减轻心功能障碍,以及减少患有心血管疾病的受试者的心外膜脂肪组织和/或心包脂肪组织。 | |||
TP1937L1 |
RFRP-1 (human) acetate(311309-25-8 free base)
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
RFRP-1 (human) acetate(311309-25-8 free base) 是一种有效的内源性 NPFF 受体激动剂(NPFF2 和 NPFF1 的 EC50 值分别为 0.0011 和 29 nM)。它减弱离体大鼠和兔心肌细胞的收缩功能。降低心率、每搏输出量、射血分数和心输出量,并增加大鼠的血浆催乳素水平。 GnIH 同系物。 | |||
T36569 |
KR-32568
|
Sodium Channel | Membrane transporter/Ion channel |
KR-32568是一种钠/氢交换器1(NHE-1)抑制剂(IC50:230 nM)。KR-32568具有强大的心脏保护作用。当使用浓度为10μM 时,它能在离体的缺血大鼠心脏模型中恢复心脏收缩功能。KR-32568(0.3mg/kg)在缺血和再灌注损伤的大鼠模型中减少了心肌梗死的大小。 | |||
T33451 |
ML 7
ML7,ML-7 |
||
ML 7 is an inhibitor of myosin light chain kinase that protects cardiac function from ischemia/reperfusion (I/R) injury. | |||
T70699 |
SAR296968
|
||
SAR296968 is a novel selective NCX inhibitor, improving cardiac function and restoring sympathovagal balance in heart failure. | |||
T75947 |
RFRP-1(human) TFA
|
||
RFRP-1(human) TFA, an endogenous NPFF receptor agonist, exhibits potent activity with EC50 values of 0.0011 nM for NPFF2 and 29 nM for NPFF1. It significantly diminishes the contractile function of isolated rat and rabbit cardiac myocytes. Moreover, it decreases heart rate, stroke volume, ejection fraction, and cardiac output, while elevating plasma prolactin levels in rats. | |||
TP1937 |
RFRP-1(human)
RFRP-1 (human) |
||
Potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac out | |||
T70280 |
KB-R7785
|
||
KB-R7785 is a novel ADAM12 and MMP inhibitor, ameliorating cardiac function in a transverse aortic constriction (TAC) model by inhibiting the proteolytic activation of HB-EGF signaling, exerting its antidiabetic effect by ameliorating insulin sensitivity through the inhibition of TNF-alpha production. | |||
TP1827L |
Neuronostatin-13 human acetate
Neuronostatin-13 human acetate(1096485-24-3 free base) |
Others | Others |
Neuronostatin-13 human acetate(1096485-24-3 free base) 是一种 13 个氨基酸的肽类激素,在调节激素和心脏功能中起重要作用。 | |||
T60377 |
CXL-1020
|
||
CXL-1020 是一种硝酰 (HNO) 前体药物。CXL-1020 改善舒张异常大鼠的心肌收缩性/舒张性和 Ca2+循环。CXL-1020 在犬模型中诱导血管舒张并改善心脏功能。CXL-1020 已被用于研究收缩期心力衰竭和稳定期心力衰竭。 | |||
T82778 |
Cardioexcitatory peptide 1
|
||
Cardioexcitatory peptide 1为从非洲大蜗牛(Achatina)心房分离的心兴奋性神经肽。该化合物对心脏具有显著的兴奋效应,并能影响肌肉组织的运动及神经活动。 | |||
T39587 |
APJ receptor agonist 4
|
||
APJ Receptor Agonist 4 is a potent, orally active apelin receptor (APJ) agonist, demonstrating an EC50 of 0.06 nM and a Ki of 0.07 nM. It exhibits excellent pharmacokinetic profiles in rodent heart failure (HF) models and has shown an acceptable safety profile in preclinical toxicology studies. This compound effectively improves cardiac function, making it valuable for research into HF disease. | |||
T35839 |
3-Iodothyronamine (hydrochloride)
|
||
3-Iodothyronamine is derived from the deiodination and decarboxylation of endogenous thyroxine. It activates the G protein-coupled receptor known as trace amine-associated receptor 1 at nanomolar concentrations whereupon it rapidly influences thyroid hormone actions including body temperature, heart rate, and cardiac output. It has also been reported to function in controlling lipid and glucose utilization, hormonal secretion, and neuronal function, and has been considered for use in chemically-... | |||
TP1209 |
BNP (1-32), rat TFA (133448-20-1 free base)
Brain Natriuretic Peptide (BNP) (1-32), rat TFA,BNP (1-32), rat TFA |
||
Acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeostasis. Helps restore the body\'s sa | |||
T81837 |
MCaE12A
|
||
MCaE12A作为RyR2的高亲和调节剂,提高了RyR2对细胞质Ca2+浓度的敏感性,并促使通道开启。该化合物是在RyR2从结构到功能研究中的关键工具,同时用于控制心肌细胞Ca2+的稳态和动态。 | |||
T75878 |
Catestatin TFA
|
||
Catestatin TFA,一个含有21个氨基酸残基、阳离子性疏水性肽,作为内源性肽,调节心脏功能及血压。它通过烟碱型乙酰胆碱受体(nAChRs)以非竞争性方式抑制儿茶酚胺释放,功能为烟碱类拮抗剂。 | |||
TP2000 |
MM 07
|
||
Apelin biased agonist; exhibits bias for the G protein pathway. Stimulates endothelial NOS phosphorylation and expression, promotes proliferation, and attenuates apoptosis of human pulmonary arterial endothelial cells in vitro. Shows positive inotropic an | |||
T76044 |
Elabela(19-32) TFA
|
||
Elabela(19-32) TFA 是ELABELA(ELA)与apelin受体(APJ)结合的活性片段,能激活Gαi1和β-arrestin-2信号通路,EC50值分别为8.6 nM和166 nM。该化合物可诱导受体内在化,降低动脉压,并对心脏具有正性肌力作用。 | |||
T64266 | KR-39038 | ||
KR-39038 是一种口服具有活力的 GRK5 (G 蛋白偶联受体激酶 5) 抑制剂 (IC50: 0.02 μM)。KR-39038 能够抑制新生儿心肌细胞的 HDAC5 通路,明显抑制血管紧张素 II 诱导的细胞肥大,具有显著的抗心肌肥厚和改善心功能作用。KR-39038 能够用于进行心力衰竭的研究。 | |||
T68499 | F15845 HBr | ||
F 15845 is a blocker of the persistent sodium current prevents consequences of hypoxia in rat femoral artery. F15845 has been shown to selectively inhibit the persistent sodium current of Nav1.5[1] exerting cardioprotective effects following ischemia. In vitro testing showed minimal effects of F15845 on other important ion channels of the heart, including major Ca2+ and K+ channels.[1] This characteristic is thought to account for the limited effect of F15845 to change other heart parameters suc... | |||
T63153 | APJ receptor agonist 5 | ||
APJ receptor agonist 5 (compound 3) 是一种有效的、口服具有活力的 apelin 受体 (APJ) 激动剂 (EC50: 0.4 nM)。APJ receptor agonist 5 在啮齿动物心力衰竭 (HF) 模型中具有出色的药代动力学特征,在临床前毒理学研究中也具有可接受的安全性。APJ receptor agonist 5 能够改善心脏功能,可用于 HF 疾病的研究。 | |||
T76223 | NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) | ||
NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) (化合物 39) 作为APJ激动剂表现出高亲和力,其Ki值为0.6 nM。该化合物能有效激活Gαi1,具有EC50值0.8 nM,并能募集β-arrestin2,相关EC50值为31 nM。同时,NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) 对心脏功能具有显著的延长作用。 | |||
T31657 |
Epothilone F
|
||
Epothilone F is a derivative or analogue of Epothilone D. Epothilone F is also an active metabolite of Epothilone D. In molecule of Epothilone F, a hydroxymethyl group is on the thiazole ring. Like taxanes, Epothilone F prevents cancer cells from dividing | |||
T82663 |
CU06-1004
Sac-1004 |
||
CU06-1004 (Sac-1004) 是一种口服活性的内皮功能障碍阻滞剂。它通过降低过度的渗透性和炎症来改善内皮功能障碍,有效抑制了包括糖尿病视网膜病变、中风、癌症和炎症性肠病在内的多种动物模型中的血管渗漏和炎症。此外,CU06-1004 对CDAA 诱导的 NASH 模型的小鼠也具有改善作用,并能够提升心脏功能。 | |||
T65994 |
(6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
|
||
Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TCO2745 |
Cyclic AMP
Adenosine 3',5'-cyclophosphate,cAMP,腺苷环磷酸酯,环磷腺苷,Cyclic 3',5'-monophosphate adenosine,3',5'-AMP,Adenosine Cyclophosphate |
Others; Endogenous Metabolite | Metabolism; Others |
Cyclic AMP (cAMP)(Adenosine 3',5'-cyclophosphate) 是有丝分裂信使,可以促进 G1期到 S 期的细胞周期进程。 | |||
T2750 |
Ginkgolide C
银杏内酯C,BN-52022 |
MMP; Sirtuin; Endogenous Metabolite; AMPK | Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Ginkgolide C (BN-52022) 是从银杏叶中分离到的一种黄酮类天然产物,可增强体内大鼠的心脏功能,具有减少血小板聚集,改善阿尔兹海默症等作用。 | |||
T3893 |
Forsythoside B
连翘酯苷 B,连翘脂苷B |
TNF; NF-κB | Apoptosis; NF-κB |
Forsythoside B 是传统中药植物独一味叶子中分离的一种苯乙醇苷。它可抑制 TNF-alpha,IL-6,IκB, 调节 NF-κB。它抑制炎症反应,具有抗氧化和神经保护作用。 | |||
T16332 |
NKH477
Colforsin dapropate hydrochloride |
NMDAR | Neuroscience |
NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 shows an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute |