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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1485L |
Calcineurin substrate acetate
|
Autophagy | Autophagy |
Calcineurin substrate acetate 来自 cAMP 依赖性蛋白激酶的调节 RII 亚基。 | |||
TP2054L |
Calcineurin Autoinhibitory Peptide acetate
|
Phosphatase | Metabolism |
Calcineurin Autoinhibitory Peptide acetate 是一种选择性的钙调磷酸酶抑制剂 (IC50 ~ 10 μM)。它可用于保护神经元免受兴奋性神经元死亡。 | |||
TP1485 |
Calcineurin substrate
|
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Calcineurin Substrate is a Peptide from the regulatory RII subunit of cAMP-dependent protein kinase. | |||
TP1398 |
Calcineurin substrate (TFA)
|
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Calcineurin substrate (TFA) is a polypeptide derived from the regulatory RII subunit of camp-dependent protein kinase.Calcineurin substrate (TFA) can be used to determine the activity of Calcineurin. | |||
TP2054 |
Calcineurin Autoinhibitory Peptide
|
||
Selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 μM). Does not inhibit PP1, PP2A or CaM kinase II (IC50 > 100 mM). | |||
T75864 |
Calcineurin autoinhibitory peptide TFA
|
||
Calcineurin autoinhibitory peptide TFA 为选择性Ca2+/钙调蛋白依赖性蛋白磷酸酶(钙调神经磷酸酶)抑制剂,IC50约为10 μM。该化合物能够保护神经元不受兴奋性神经元死亡影响。 | |||
T75740 |
Calcineurin substrate TFA
|
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Calcineurin substrate (TFA) 是来自 cAMP 依赖性蛋白激酶调节性RII 亚基的多肽。Calcineurin substrate (TFA) 可用于钙调神经磷酸酶活力的测定。 | |||
T50103 |
NFAT Inhibitor-2
|
Others | Others |
NFAT Inhibitor-2 是一种化学合成中的砌块。 | |||
T2648 |
Pimecrolimus
SDZ-ASM 981,ASM 981,吡美莫司 |
Others | Others |
Pimecrolimus (SDZ-ASM 981) 是一种免疫亲和素配体,能与胞质受体特异性的结合。 | |||
T6459 |
Cyclosporine
|
Phosphatase | Metabolism |
Cyclosporine 是一种钙调神经磷酸酶通路抑制剂,用作免疫抑制剂以防止器官移植中的排斥反应。 | |||
T21807 |
INCA-6
Triptycene-1,4-quinone |
Others | Others |
INCA-6 (Triptycene-1,4-quinone) 是细胞渗透性的 NFAT 抑制剂。INCA-6 通过特异性阻断 NFAT 底物靶向钙调神经磷酸酶位点,有效抑制calcineurin (CN)-NFAT 信号传导。 | |||
TP1015 |
NFAT Inhibitor
VIVIT peptide |
Others | Others |
NFAT Inhibitor (VIVIT peptide) 是NFAT 的细胞渗透性肽抑制剂,能够选择性抑制钙调磷酸酶介导的NFAT 脱磷酸作用。 | |||
T1784 |
Everolimus
依维莫司,RAD001,SDZ-RAD |
Apoptosis; Others; mTOR; Autophagy | Apoptosis; Autophagy; Others; PI3K/Akt/mTOR signaling |
Everolimus (SDZ-RAD) 是 Rapamycin 的衍生物,也是一种口服活性的mTOR1选择性抑制剂。它与FKBP-12结合可产生免疫抑制复合物,还抑制肿瘤细胞增殖并诱导细胞凋亡和自噬,有免疫抑制和抗癌活性。 | |||
T3097 |
Mycophenolic Acid Impurity
马替麦考酚酸杂质,5,7-dihydroxy-4-methylphthalide |
Others | Others |
Mycophenolic Acid Impurity (5,7-dihydroxy-4-methylphthalide) 是一种免疫抑制药物和有效的抗增殖剂,可用于代替旧的抗增殖剂 azathioprine。它通常用作三联疗法的一部分,包括钙调神经磷酸酶抑制剂(ciclosporin 或 tacrolimus)和prednisolone。它还可用于研究选择表达编码 XGPRT(黄嘌呤鸟嘌呤磷酸核糖基转移酶)的大肠杆菌基因的动物细胞。 | |||
T34973 |
Tyrphostin 8
4-Hydroxybenzylidenemalononitrile |
EGFR; GTPase | Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) 是一种有效的 GTP 酶抑制剂,对 EGFR 激酶有抑制作用, IC50 值为 560 μM。Tyrphostin 8 可抑制蛋白丝氨酸/苏氨酸钙调磷酸酶 (IC50=21 μM),增强 Caco-2 细胞中转铁蛋白受体介导的转吞作用,并增加口服胰岛素 - 转铁蛋白的降血糖作用。 | |||
T76220 |
Cyclosporin A-Derivative 3
|
||
Cyclosporin A-Derivative 3 是 Cyclosporin A 的衍生物,具有钙调神经磷酸酶抑制作用。 | |||
TP1665 |
Cyclosporin D
|
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Cyclosporin D is a metabolite of cyclosporin A, an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells. | |||
TP1387 |
Cyclosporin A-Derivative 2
|
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Derivative 2 is A novel Derivative of Cyclosporin A.Cyclosporin A is an immunosuppressant that binds to cyclophilin and inhibits calcineurin. | |||
T78217 |
(R)-Azasetron besylate
SENS-401 |
Phosphatase | Metabolism |
(R)-Azasetron besylate (SENS-401)是一种口服活性的钙调神经磷酸酶抑制剂,能够减轻Cisplatin引发的听力损失和耳蜗损害。 | |||
T5339 |
YZ129
|
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YZ129 是一种抗胶质母细胞瘤的HSP90-磷酸酶-NFAT 通路的抑制剂,直接与热休克蛋白 (HSP90)结合,对NFAT 核易位的IC50值为820 nM。YZ129 在 G2/M 期诱导GBM 细胞周期阻滞,促进细胞凋亡,抑制肿瘤细胞增值和迁移。 | |||
T35892 |
Q134R
Q134R |
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Q134R, a neuroprotective hydroxyquinoline derivative that suppresses nuclear factor of activated T cell (NFAT) signaling. Q134R can across blood-brain barrier. Q134R has the potential for Alzheimer’s disease (AD) and aging-related disorders research[1]. Q134R (1-10 μM) suppresses NFAT signaling, without inhibiting calcineurin activity. Q134R partially inhibits NFAT activity in primary rat astrocytes, but does not prevent calcineurin-mediated dephosphorylation of a non-NFAT target, either in vivo... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0945 |
Cyclosporin A
环孢素,Cyclosporine A,Ciclosporin,Cyclosporine,环孢菌素 |
Phosphatase; Antibiotic; Complement System | Immunology/Inflammation; Metabolism; Microbiology/Virology |
Cyclosporin A 属于天然产物,是一种真菌的活性代谢产物,一种环状多肽。Cyclosporin A 是一种能与亲环素结合的免疫抑制剂,可以抑制 calcineurin (IC50=7 nM)。 | |||
T3777 |
Praeruptorin A
(+)-Praeruptorin A,白花前胡甲素 |
CaMK; NF-κB | Neuroscience; NF-κB |
Praeruptorin A ((+)-Praeruptorin A) 是一种白花前胡的主要生物活性成分。它能够抑制 NF-κB 活化,发挥抗炎作用。 | |||
T20879 |
Tacrolimus monohydrate
FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506 |
Phosphatase; Others; Antibacterial; Antibiotic; Autophagy | Autophagy; Metabolism; Microbiology/Virology; Others |
Tacrolimus monohydrate (LCP-Tacro) 是大环内酯类化合物,它与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶,从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。 | |||
T4S1419 |
(±)-Praeruptorin A
Praeruptorin A,(±)-白花前胡甲素,白花前胡甲素,(-)-Praeruptorin A |
p38 MAPK; Calcium Channel; Akt | Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling |
(±)-Praeruptorin A 是来自白花前胡的干燥根中的一种主要成分,用于研究伴有厚痰和呼吸困难的咳嗽,非天生性咳嗽和上呼吸道感染。它是顺式-内酯 (CKL) 的二酯化产物,可作为 Ca2+-反流阻滞剂,用于高血压的研究。 | |||
T2481 |
Ascomycin
FK520,Immunomycin,子囊霉素,FR-900520 |
Phosphatase; Others; Antibiotic; Parasite; Antifungal | Metabolism; Microbiology/Virology; Others |
Ascomycin (Immunomycin) 是 Tacrolimus 的乙基类似物,具有免疫抑制特性。它也是一种大环聚酮类抗生素,具有抗疟疾、抗真菌和抗痉挛等多种生物活性。它可防止移植排斥,并具有用于各种皮肤病研究的潜力。 | |||
T70221 |
Dibefurin
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Dibefurin is a metabolite that inhibits the activity of calcineurin, a calcium/calmodulin-dependent protein phosphatase involved in the activation of T lymphocytes. | |||
T36845 |
Isogarcinol
|
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Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 μM) and suppressing the proliferation of T cells. Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental auto... |