39
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11465 |
Lenacapavir
GS-6207 |
Others; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Lenacapavir (GS-6207) 是一种有效的靶向衣壳的 HIV 复制抑制剂。 Lenacapavir 在 MT-4 细胞中显示出抗 HIV 活性,EC50 为 100 pM。 | |||
T2578 |
Didanosine
ddI,去羟肌苷,2',3'-Dideoxyinosine |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Didanosine (ddI) 是一种逆转录酶抑制剂,IC50为490nM。 | |||
T19963 |
Alizarin Complexone
Alizarin Fluorine Blue,Alizarin-3-methyliminodiacetic acid,茜素络合指示剂 |
Reverse Transcriptase | Microbiology/Virology |
Alizarin Complexone (Alizarin-3-methyliminodiacetic acid) 是 Rous 相关病毒 2 逆转录酶的抑制剂。 Alizarin Complexone 可用作生物研究的钙示踪剂和螯合剂。 | |||
T6098 |
Cabotegravir
GSK744,GSK-1265744,卡博特韦,S/GSK1265744 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Cabotegravir (S/GSK1265744) 是一种HIV 整合酶抑制剂,可研究艾滋病。它抑制OAT1 和OAT3,IC50值为 0.81 和0.41 μM。 | |||
T4326 |
AG 555
Tyrphostin B46,Tyrphostin AG 555 |
EGFR; Reverse Transcriptase | Angiogenesis; JAK/STAT signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors |
AG 555 (Tyrphostin B46)是一种选择性EGFR 的有效抑制剂,可阻断Cdk2活化。它是一种抗逆转录病毒药。 | |||
T1404 |
Stavudine
d4T,Sanilvudine,BMY-27857,NSC 163661,司他夫定 |
Apoptosis; Nucleoside Antimetabolite/Analog; HIV Protease; NOD-like Receptor (NLR); Reverse Transcriptase; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Stavudine (BMY-27857) 是一种口服活性核苷逆转录酶抑制剂,还抑制线粒体 DNA 的复制,具有抗HIV-1和HIV-2的活性。它降低 NLRP3 炎症小体激活,调节淀粉样 β 自噬,诱导细胞凋亡。 | |||
T27154 |
Dexelvucitabine
D-D-4FC,DPC-817,RVT,beta-D-D-4FC,DFC |
Reverse Transcriptase | Microbiology/Virology |
Dexelvucitabine (RVT) 是一种胞苷类似物,一种口服有活性的核苷逆转录酶抑制剂。它是一种 2'-脱氧胞苷抗逆转录病毒剂。它是一种有效的抗 HIV-1病毒剂,这些病毒聚合酶中含有胸苷类似物和/或 M184V 突变。 | |||
T30047 |
Ancriviroc
Schering C,SCH-351125,[3H]ancriviroc,CHEMBL336672,AC1NUILE |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Ancriviroc(CHEMBL336672) 是一种具有强抗逆转录病毒活性的肟米哌啶基-哌啶酰胺,是一种有效的CCR5抑制剂,可用于研究HIV。 | |||
T8238 |
Fosamprenavir Calcium Salt
福沙那伟钙,Diallyl Trisulfide,GW433908G |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Fosamprenavir Calcium Salt (GW433908G) 是抗逆转录病毒蛋白酶抑制剂 Amprenavir 的磷酸酯前药,具有改善的溶解性和抗HIV 感染作用。 | |||
T5949 |
Dideoxyadenosine
|
||
2',3'-Dideoxyadenosine 是HIV 复制抑制剂,具有抗逆转录病毒活性和抗病毒的作用[1]。 | |||
T1595 |
Nevirapine
NSC 641530,奈韦拉平,BI-RG 587,奈伟拉平,NVP |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Nevirapine (NVP) 是一种 HIV-1逆转录酶非核苷抑制剂,Ki 值为 270 μM,可用于研究 HIV/AIDS。 | |||
T14313 |
Apricitabine
AVX754,SPD754 |
HIV Protease; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome |
Apricitabine (SPD754) 是一种具有高选择性和口服活性的HIV-1逆转录酶抑制剂(Ki=0.08μM),是2′-脱氧-3′-氧-4′-硫代胞苷(dOTC)的(-)对映体 。 Apricitabine 对DNA 聚合酶α、β和γ具有抑制作用,Ki 值分别为300μM、12μM 和112.25μM。Apricitabine 在抗逆转录病毒HIV 感染者中显示出良好的抗逆转录病毒治疗效果,具有良好的耐受性和较低的选择性抗性。 | |||
T2409 |
Tenofovir alafenamide
替诺福韦艾拉酚胺,替诺福韦,GS-7340 |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Tenofovir alafenamide (GS-7340) 是一种核苷酸逆转录酶抑制剂和抗逆转录病毒替诺福韦的新型酯类前药。 | |||
T7779 |
Nelfinavir
AG1341,甲磺酸萘非那韦 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Nelfinavir (AG1341) 是一种口服活性的 HIV-1 蛋白酶抑制剂,用于抑制 HIV 感染,是一种广谱抗癌剂。 | |||
T7903 |
Saquinavir
Ro 31-8959,沙奎那韦 |
SARS-CoV; HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Saquinavir (Ro 31-8959) 是一种 HIV 蛋白酶抑制剂,可研究逆转录病毒。它也是 SARS-CoV 3CLpro 抑制剂,IC50为 1.36 μM。 | |||
T11538 |
Hck-IN-1
|
HIV Protease; Src; Hck | Angiogenesis; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Hck-IN-1 是二苯基吡唑啉化合物,选择性的 Nef 依赖性 Hck 抑制剂。它是广泛的 HIV-1 Nef 直接拮抗剂,对于野生型 HIV-1 复制的IC50为 100-300 nM。它结合口袋残基 Asn126,具有抗逆转录病毒活性。 | |||
T80644 |
DNA polymerase-IN-1
|
Antiviral; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation |
DNA polymerase-IN-1 作为DNA聚合酶抑制剂,展现出对肿瘤细胞的抗增殖活性,其半抑制浓度(IC50)为20.7 μM。DNA polymerase-IN-1 抑制 Taq DNA 聚合酶,IC 值低于 250μM。DNA polymerase-IN-1 通过RT-PCR检测在体外显示出抗逆转录病毒活性,可用于研究氧化损伤和结直肠癌。 | |||
T28946 |
Tenofovir exalidex
Tenofovir,HDP-Tenofovir,CMX-157,CMX157,CMX 157 |
Antiviral | Immunology/Inflammation |
Tenofovir exalidex (CMX 157) 是一种非环核苷酸类似物 Tenofovir 的脂质结合物,对野生型和抗逆转录病毒耐药的 HIV 毒株,包括多药核苷/核苷酸类似物耐药病毒,都有活性。Tenofovir exalidex 对人外周血单个核细胞中所有主要的HIV-1和HIV-2亚型以及单核细胞来源的巨噬细胞中所有 HIV-1 菌株具有活性,EC50 范围在 0.2 和 7.2 nM 之间。Tenofovir exalidex 具有口服活性,无明显毒性。Tenofovir exalidex 对 HBV 也有活性。 | |||
T7212L |
Delavirdine
Rescriptor,DLV,U 90152,地拉韦啶,BHAP-U 90152 |
||
Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine is part of Highly Active Antiretroviral Therapy (HAART), which can be used to treat human immunodeficiency virus (HIV) type 1. | |||
T25535 |
Indinavir, threo-
Threo-indinavir,Indinavir sulfate specified impurity C |
||
Indinavir, threo- is a protease inhibitor utilized as a component of highly active antiretroviral treatment to HIV/AIDS. | |||
T79837 |
Bavtavirine
|
||
Bavtavirine为一强效NNRTIs,构成HAART方案关键组分。该化合物主用于HIV相关疾病研究。 | |||
T5863L |
Indinavir
茚地那韦,MK-639,L 735 524,Crixivan |
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Indinavir (IDV) is an inhibitor of protease that is used as part of highly active antiretroviral therapy for the treatment of HIV/AIDS. | |||
T68666 |
Benfluron Hydrochloride
|
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Benfluron Hydrochloride is an inhibitor of HIV-1 Rev function which also acts as a cytostatic agent with substantial antiretroviral activity. | |||
T8156 |
Saquinavir mesylate
沙奎拉韦,沙奎那韦甲磺酸盐,Ro 31-8959/003 |
HIV Protease; Autophagy | Autophagy; Microbiology/Virology; Proteases/Proteasome |
Saquinavir mesylate (Ro 31-8959/003) 是一种 HIV 蛋白酶抑制剂,可研究逆转录病毒。 | |||
T68376 | Indinavir lactone | ||
Indinavir lactone is a protease inhibitor used as a component of highly active antiretroviral therapy to treat HIV/AIDS. | |||
T24839 |
Stampidine
HI-113,HI 113,HI113 |
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Stampidine can prevent the sexual transmission of HIV-1. It exhibited remarkable subnanomolar to low nanomolar in vitro antiretroviral potency against nucleoside reverse transcriptase inhibitor-resistant primary clinical HIV isolates, non-nucleoside RT-re | |||
T4555 |
Fosamprenavir
GW 433908,福沙那韦,Amprenavir phosphate |
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Fosamprenavir (Amprenavir phosphate; GW 433908) 是抗逆转录病毒蛋白酶抑制剂 Amprenavir 的磷酸酯前药,与母体分子相比具有更高的溶解度。具有抗HIV 感染作用。 | |||
T71518 | Zidovudine diphosphate | ||
Zidovudine diphosphate is an antiretroviral medication used to prevent and treat HIV/AIDS. It is of the nucleoside analog reverse-transcriptase inhibitor (NRTI) class. Zidovudine inhibits the enzyme (reverse transcriptase) that HIV uses to synthesize DNA, thus preventing viral DNA from forming. | |||
T71983 |
Zidovudine glucuronide
|
||
Zidovudine glucuronide is an antiretroviral medication used to prevent and treat HIV/AIDS. It is of the nucleoside analog reverse-transcriptase inhibitor (NRTI) class. Zidovudine inhibits the enzyme (reverse transcriptase) that HIV uses to synthesize DNA, thus preventing viral DNA from forming. | |||
T82536 | DNA polymerase-IN-4 | ||
DNA polymerase-IN-4 (Compd 5c),香豆素衍生物,显示出抗逆转录病毒活性,IC50为134.22 μM。 | |||
TP1332 |
Enfuvirtide
|
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Enfuvirtide (INN) is an HIV fusion inhibitor, the first of a class of antiretroviral drugs used in combination therapy for the treatment of HIV-1 infection. | |||
T70596 |
Emtricitabine triphosphate
(-)-Emtricitabine triphosphate |
||
Emtricitabine triphosphate ((-)-Emtricitabine triphosphate) 是恩曲他滨 的磷酸化合成代谢物。Emtricitabine 是一种核苷逆转录酶抑制剂。Emtricitabine 是一种抗逆转录病毒试剂,用于抵抗 HIV 和 HBV 感染。 | |||
T73837 | AZT triphosphate tetraammonium | ||
AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) tetraammonium 是一种 Zidovudine (AZT) 的活性三磷酸酯代谢产物。AZT triphosphate tetraammonium 具有抗逆转录病毒的活性,并抑制 HIV 复制。AZT triphosphate tetraammonium 还可抑制 HBV 的 DNA 聚合酶。AZT triphosphate tetraammonium 可激活线粒体介导的凋亡 (apoptosis) 途径。 | |||
T80621 |
Semzuvolimab
UB421 |
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Semzuvolimab是靶向T细胞表面抗原T4/Leu-3,即p55 (CD4)的鼠IgG1κ类抗体。该CD4抗体具备中和HIV感染的能力,潜在用于抑制HAART稳定型HIV感染。 | |||
T76292 |
Tifuvirtide
|
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Tifuvirtide (T-1249) 是一种肽类人类免疫缺陷病毒 1 型(HIV-1)融合抑制剂。Tifuvirtide 是一种合成设计的杂合逆转录病毒包膜多肽。Tifuvirtide 具有抗逆转录病毒活性。Tifuvirtide 可用于HIV 感染的研究。 | |||
T62328 |
Cabotegravir sodium
|
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Cabotegravir sodium 是一种 HIV 整合酶的高效抑制剂,能够作用于 HIVADA (IC50: 2.5 nM)。Cabotegravir sodium 主要由尿苷二磷酸葡萄糖醛酸转移酶 (UGT) 1A1 代谢,与其他抗逆转录病毒药物 (ARVs) 相互作用的可能性较小。 | |||
T36490 | AZT triphosphate TEA | ||
AZT triphosphate TFA (3'-Azido-3'-deoxythymidine-5'-triphosphate TFA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TFA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TFA also inhibits the DNA polymerase of HBV. AZT triphosphate TFA activates the mitochondria-mediated apoptosis pathway[1][2][3]. Treatment with 100 μM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in ... | |||
T61311 |
HIV-1 inhibitor-30
|
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HIV-1 inhibitor-30 (compound 10i) is a potent inhibitor of HIV-1, specifically targeting the RT DNA polymerase enzyme. It exhibits strong antiretroviral activity, with an EC 50 value of 40 nM and an IC 50 value of 80 nM. Furthermore, HIV-1 inhibitor-30 demonstrates significant effectiveness against seven NNRTI-resistant strains of HIV-1 (RT-K103N; RT-Y181C; RT-K103N, Y181C; RT-L100I, K103N; RT-Y188L; RT-K103N, G190A; RT-K103N, V108I), with IC 50 values ranging from 0.04 to 1.42 μM. This compound... | |||
T83732 |
Tat-CBD3A6K TFA
|
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Tat-CBD3A6K是一种肽类化合物,为N型电压门控钙通道Cav2.2以及collapsin response mediator protein 2 (CRMP2) 蛋白-蛋白相互作用抑制剂Tat-CBD3的衍生物。Tat-CBD3A6K (10 mg/kg) 能够阻止由d4T (stavudine)引发的大鼠抗逆转录病毒神经病痛模型中爪撤回阈值的下降,并减少同一大鼠分离的背根神经节(DRG)神经元的动作电位数量。通过硬膜途径给予Tat-CBD3A6K (30 µM/animal) 能够减少由萜类生物碱辣椒素引发的大鼠硬脑膜血流增加。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2830 |
Betulinic acid
白桦脂酸,桦木酸,ALS-357,Lupatic acid,Betulic acid |
Apoptosis; Mitophagy; NF-κB; HIV Protease; Topoisomerase; Endogenous Metabolite; Aminopeptidase; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome |
Betulinic acid (ALS-357) 是从白桦树皮中分离出来的一种五环三萜类天然产物,是真核细胞拓扑异构酶 I 的抑制剂,IC50值为 5 μM,具有抗逆转录病毒、抗疟疾、抗癌和抗炎特性。 | |||
TN2115 |
Pseudohypericin
|
Others; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Others |
Pseudohypericin has photocytotoxic, and antiretroviral activities, it has potential therapeutic value in diseases such as AIDS. |