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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0692	Allopurinol Zyloric,别嘌醇,Zyloprim,Lopurin,别嘌呤醇	ROS; Xanthine Oxidase	Immunology/Inflammation; Metabolism
	Allopurinol (Zyloric) 是一种黄嘌呤氧化酶(XO)抑制剂，IC50=7.82±0.12 μM。
T6376	Allopurinol Sodium 1H-吡唑并[3,4-D]嘧啶-4-醇单钠盐,Allopurinol sodium salt,Sodium allopurinol	ROS	Immunology/Inflammation
	Allopurinol Sodium 是黄嘌呤氧化酶抑制剂，其IC50= 0.2~50 μM。它能够抗利什曼原虫，也可用于研究痛风以及高尿酸血症。
T62574	Antileishmanial agent-6
	Antileishmanial agent-6 是一种有效的抗利什曼虫剂。Antileishmanial agent-6 对Leishmania donovani 和 L-6 具有抗利什曼虫活性 (IC50: 0.54 μM) 和细胞毒性 (IC50: 10.2 μM) 作用。
T62330	Antileishmanial agent-12
	Antileishmanial agent-12 (compound 5a) 是一种有效的抗利什曼原虫剂，对 Leishmania brazilensis (IC50: 14.9 μM)、Leishmania infantum (IC50: 21.3 μM) 和 T. cruzi (IC50: 9.3 μM) 具有抗原虫作用。
T76070	Defensin HNP-1 human TFA
	Defensin HNP-1 human TFA，一种人中性粒细胞肽(HNPs)，在早期动脉粥样硬化发展中涉及内皮细胞功能障碍。该化合物展现出广泛的抗菌及抗利什曼原虫活性。
T78973	DCN-83	Parasite	Microbiology/Virology
	DCN-83，作为一种抗利什曼虫试剂，在靶向无鞭毛体形式方面表现最佳，其半抑制浓度(IC50)为0.71 μM。该化合物显示出穿越血脑屏障并进入中枢神经系统的潜力。

化合物

Allopurinol

Cat.No: T0692

Synonym: Zyloric,别嘌醇,Zyloprim,Lopurin,别嘌呤醇

Target: ROS, Xanthine Oxidase

Allopurinol Sodium

Cat.No: T6376

Synonym: 1H-吡唑并[3,4-D]嘧啶-4-醇单钠盐,Allopurinol sodium salt,Sodium allopurinol

Target: ROS

Antileishmanial agent-6

Cat.No: T62574

Synonym:

Target:

Antileishmanial agent-12

Cat.No: T62330

Synonym:

Target:

Defensin HNP-1 human TFA

Cat. No.	Product Name	Target	Signaling Pathways
TN4660	Niranthin	Anti-infection; HBV; PAFR; Topoisomerase	DNA Damage/DNA Repair; GPCR/G Protein; Microbiology/Virology
	Niranthin 是一种木脂素，具有广泛的药理活性。它是L. donovaniIB 拓扑异构酶的非竞争性抑制剂，可用于研究耐药利什曼病的治疗。
TN1432	Bacopasaponin C (-)-假马齿苋皂苷 C,假马齿苋皂苷C	Anti-infection; GABA Receptor; NMDAR	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Bacopasaponin C 是一种分离自Bacopa monniera 中的天然糖苷，具有抗肿瘤和抗利什曼原虫作用。
T2P2806	Hederacolchiside A1 黑海常春藤苷A1,革叶常春藤皂苷 A1,Raddeanoside R13	Apoptosis; ERK; MEK; Akt; PI3K; Parasite; mTOR	Apoptosis; Cytoskeletal Signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Hederacolchiside A1 (Raddeanoside R13) 是从白头翁中分离的一种有抗利什曼原虫和抗肿瘤增殖活性的天然产物。
TN3729	Cuniloside B	Antifection	Microbiology/Virology
	Cuniloside B shows anti-leishmanial activity.
TN4470	Lyoniside	Antifection	Microbiology/Virology
	Lyoniside and saracoside are cytotoxic to promastigotes and intracellular amastigotes, they demonstrate strong anti-leishmanial efficacies in BALB/c mice model of leishmaniasis, suggests that these two compounds potential anti-leishmanial candidates. The
TN1409	Asimilobine	AChR; Antifection	Microbiology/Virology; Neuroscience
	(-)-Asimilobine shows antioxidative, anti-acetylcholinesterase (AChE), anti-α±-glucosidase, anti-leishmanial and anti-fungal activities; it displays weak inhibition against Streptococcus mutans (ATCC 25175), with a minimum inhibition concentration (MIC) o