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Search Results for " aminopeptidase "

59

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9345	Aminopeptidase M	Others	Others
	Aminopeptidase M 抑制对多种疾病（例如高度血管化的癌症类型）具有重要意义。
T61278	Aminopeptidase-IN-1	Aminopeptidase	Metabolism
	Aminopeptidase-IN-1 是一种有效的胰岛素调节氨肽酶 (IRAP) 抑制剂（Ki： 7.7 μM）。Aminopeptidase-IN-1 可用于认知和记忆障碍的研究。
T36943	Aminopeptidase N Inhibitor
	Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM.
TQ0047	DG051	Aminopeptidase	Metabolism
	DG051 是有效的白三烯 A4 水解酶抑制剂，IC50=47 nM。
T76568	Aminopeptidase N Ligand (CD13) NGR peptide
	AminopeptidaseN Ligand (CD13) NGR peptide 是靶向CD13的多肽，常见于癌症研究中，用作细胞内传递的载体介质。
T21859	ARM1	Aminopeptidase; Epoxide Hydrolase	Metabolism
	ARM1 是氨基肽酶和环氧化物水解酶抑制剂，IC50分别为为7.61 µM 和12.4 µM。
T11221	ERAP1-IN-1	Others	Others
	ERAP1-in-1 是一种内质网氨基肽酶 1 (ERAP1) 抑制剂，能竞争性地抑制 ERAP1 对代表性生物底物九聚物肽的作用。
T6301	Tosedostat CHR-2797,托舍多特	Aminopeptidase; AChR	Metabolism; Neuroscience
	Tosedostat (CHR-2797) 是一种具有口服活性的氨基肽酶(aminopeptidase) 抑制剂，对多种肿瘤细胞系均具有抗增殖作用。
T3715	Acebilustat 阿西鲁司特,CTX-4430	Aminopeptidase; LTR	Immunology/Inflammation; Metabolism
	Acebilustat (CTX-4430) 是一种具有口服活性的白三烯 A4 水解酶抑制剂，可用于炎症研究。
T16684	Puromycin aminonucleoside 维生素E醋酸酯,NSC 3056	Apoptosis; Proteasome; Aminopeptidase; Antibacterial; Antibiotic	Apoptosis; Metabolism; Microbiology/Virology; Proteases/Proteasome; Ubiquitination
	Puromycin aminonucleoside (NSC-3056) 是一种氨基核苷类抗生素，是嘌呤霉素类似物。它可逆抑制二肽基肽酶和胞浆丙氨酸氨基肽酶。它通过以氧化应激依赖性方式调节 ZO-1 来增加足细胞通透性。它诱导细胞凋亡。
T28482	Firibastat QGC 001,QGC-001,RB-150,RB150,QGC001,RB 150	Aminopeptidase	Metabolism
	Firibastat (RB150) 是一种具有口服活性的 EC33 前体药物。Firibastat 是一种首创的脑氨基肽酶 A(APA) 抑制剂 (Ki=200 nM)，选择性地抑制高血压大鼠脑血管紧张素 II 转化为血管紧张素 III，降低血压。
T21696	SC-57461A N -甲基- N -[3 - [4 - (苯甲基)苯氧基]丙基Β-丙氨酸盐酸盐	Aminopeptidase	Metabolism
	SC-57461A 是一种口服有活力的非肽类白三烯 A4 (LTA4) 水解酶选择性抑制剂，它能够抑制重组人 (IC50: 2.5 nM) 、小鼠 (IC50: 3 nM) 和小鼠LTA4水解酶 (IC50: 23 nM) 。
TP1181	Bradykinin (2-9) Des-Arg1-bradykinin	Bradykinin Receptor	GPCR/G Protein
	Bradykinin (2-9) (Des-Arg1-bradykinin)，是Bradykinin的一种氨基端截短肽类代谢物，通过Aminopeptidase P的切割作用形成。
T5652	L(+)-Leucinol	Aminopeptidase	Metabolism
	L(+)-Leucinol 是一种有效的亮氨酸氨基肽酶抑制剂。
T60021	ecMetAP-IN-1	Others	Others
	ecMetAP-IN-1 可用作 QSAR 模型，以使用多元线性回归研究蛋氨酸氨基肽酶抑制剂作为抗癌剂。
T64341	H-β-Ala-AMC TFA	Others	Others
	H-β-Ala-AMC TFA 是氨基肽酶的底物之一。
T18997	GPDA Glycylproline p-nitroanilide tosylate,GPN	Others	Others
	GPDA (Glycylproline p-nitroanilide tosylate) 是一种酶促反应检测底物，用于检测脯氨酰二肽氨基肽酶。
TP1917L1	Sar-[D-Phe8]-des-Arg9-Bradykinin acetate Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base)	Bradykinin Receptor	GPCR/G Protein
	Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base) 是一种有效的选择性缓激肽 B1 受体激动剂（兔主动脉中的 EC50 = 9.02 nM），对氨肽酶、激肽酶 I 和 II (ACE) 以及中性内肽酶切割具有抗性。在体内表现出降血压和血管生成活性。
T22255	Amastatin	Others	Others
	Amastatin is a non-toxic inhibitor of aminopeptidase A and leucine aminopeptidase, and its Ki for aminopeptidase A is 1 µM .
T24431	Matlystatin A
	Matlystatin A is an inhibitor of aminopeptidase. It shows multiple inhibitory activities against both aminopeptidase N and matrix metalloproteinases.
T25987	Probestin
	Probestin is an aminopeptidase M inhibitor, isolated from Streptomyces azureus MH663-2F6.
T32676	Leucylmethionine Leu-met
	Leucylmethionine is a substrate for aminopeptidase M.
T37062	L-Leucine-7-amido-4-methylcoumarin hydrochloride
	L-Leu-AMC is a fluorogenic substrate for leucine aminopeptidase.1Upon enzymatic cleavage by leucine aminopeptidase, AMC is released and its fluorescence can be used to quantify leucine aminopeptidase activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. 1.Izquierdo, M., Lin, D., O’Neill, S., et al.Development of a high-throughput screening assay to identify inhibitors of the major M17-leucyl aminopeptidase from Trypanosoma cruzi using rapidfire mass spectrometryS...
T29485	7-Lysylalanyl-4-methylcoumarinamide
	7-Lysylalanyl-4-methylcoumarinamide is a Fluorogenic substrate for dipeptidyl aminopeptidase.
T25940	Phebestin
	Phebestin is an aminopeptidase N inhibitor, produced by Streptomyces sp. MJ716-m3.
T15479	HFI-142	Others	Others
	HFI-142 is an inhibitor of insulin-regulated aminopeptidase (IRAP) (Ki: 2.01 μM).
T25675	Leucinal L-Leucinal
	Leucinal inhibits the activity of brain aminopeptidase and potentiates analgesia induced by leu-enkephalen.
T28037	Microginin 527
	Microginin 527, a compound found in Microcystis, is an inhibitor of protein phosphatase, ACE, and leucine aminopeptidase.
T68911	LAF-153
	LAF-153 is a reversible Methionine Aminopeptidase‑2 (MetAP-2) Inhibitor.
T19665	Amastatin hydrochloride 氨肽酶抑制剂盐酸盐,BIMI-1803,Amastatin HCl,ZX-AFC000547,ZXAFC000547,BIMI1803,J-000280,J000280
	Amastatin HCl is an inhibitor of aminopeptidase. It also induces vasoconstriction.
T78002	Spinorphin TFA LVV-hemorphin-4 TFA
	Spinorphin TFA是一种脑啡肽降解酶抑制剂，能够抑制氨基肽酶、二肽基氨基肽酶III、血管紧张素转换酶以及脑非肽酶，常用于缓解疼痛研究中。
T26048	RB 101 RB101,RB-101
	RB 101 suppresses enkephalinase and aminopeptidases; biologically cleaved at disulfide to produce inhibitors of both aminopeptidase N and neutral endopeptidase.
T25897	OH-Ubenimex p-Hydroxyubenimex,p-Hydroxybestatin
	OH-Ubenimex is an orally active aminopeptidase inhibitor that has an immunomodulating action.
T13188	TP-004	Others	Others
	TP-004 is a potent and reversible methionine aminopeptidase 2 (MetAP2) inhibitor (IC50: 6 nM).
T17110	TNP-470 AGM-1470	Others	Others
	TNP-470 is a methionine aminopeptidase-2 inhibitor. TNP-470 is also an angiogenesis inhibitor.
T71626	Epibestatin Hydrochloride
	Epibestatin Hydrochloride is a stabilizer of 14-3-3 PPIs, as well as a diastereoepimer of aminopeptidase inhibitor bestatin.
T76589	H-Leu-Trp-Met-Arg-OH
	H-Leu-Trp-Met-Arg-OH是一种四肽，可作为氨基肽酶(aminopeptidase)介导水解研究的底物。
T63915	Sitagliptin fenilalanil
	Sitagliptin fenilalanil 是一种二肽氨基肽酶 (DPP-4)抑制剂。
T40839	H-Val-βNA L-Valine β-naphthylamide,H-Val-βNA
	H-Val-βNA, also known as L-Valine β-naphthylamide, serves as a substrate for aminopeptidase and Valine arylamidase activities.
T68605	JNJ-4929821
	JNJ-4929821 is a potent, reversible methionine aminopeptidase-2 (MetAP-2) inhibitor with IC50 of 8 nM.
T20445	L-Leucine-p-nitroanilide
	L-Leucine-p-nitroanilide is a substrate. It is used for the colorimetric determination of leucine aminopeptidase.
T39488	Relzomostat
	Relzomostat is a MetAP2 inhibitor, specifically targeting methionine aminopeptidase 2. It holds potential in research concerning obesity, type 2 diabetes, and other conditions associated with obesity.
T25573	Ketomethylenebestatin
	Ketomethylenebestatin is a carba-analog of bestatin，the aminopeptidase (AP) inhibitor. Ketomethylenebestatin is 10 fold less effective as an inhibitor of aminopeptidases than bestatin.
T68382	Fumarranol
	Fumarranol is an angiogenesis inhibitor. It also interacts with P. falciparum methionine aminopeptidase 2 to inhibit malaria parasite growth in vitro and in vivo.
T11930	M8891	Others	Others
	M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor(IC50 :54nM;Ki:4.33 nM).M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral acti
T76608	H-D-Ala-D-Ala-D-Ala-D-Ala-OH
	H-Ala-D-Ala-D-Ala-D-Ala-OH 是 D-氨肽酶的底物。
T69346	A-357300
	A-357300 is a potent, selective, reversible MetAP2 inhibitor with IC50 of 0.12 uM. Methionine aminopeptidase 2 inhibition is an effective treatment strategy for neuroblastoma in preclinical models.
T61258	HFI-419
	HFI-419 is a potent inhibitor of insulin-regulated aminopeptidase (IRAP) with a K i value of 0.48 μM. It is utilized in research pertaining to cognitive and memory impairments, including Alzheimer's disease, brain trauma, and stroke [1].
TP1771	NGR peptide Trifluoroacetate
	NGR peptide Trifluoroacetate containing the asparagine-glycine-arginine (NGR) motif is recognized by CD13/aminopeptidase N (APN) receptor isoforms that are selectively overexpressed in tumor neovasculature.
T82836	Bombinin
	Bombinin为Bombina variegata所产生的抗菌肽，能够保护对氨基肽酶。

化合物

Aminopeptidase M

Cat.No: T9345

Target: Others

Aminopeptidase-IN-1

Cat.No: T61278

Target: Aminopeptidase

Aminopeptidase N Inhibitor

Cat.No: T36943

Cat.No: TQ0047

Target: Aminopeptidase

Aminopeptidase N Ligand (CD13) NGR peptide

Cat.No: T76568

Cat.No: T21859

Target: Aminopeptidase, Epoxide Hydrolase

Cat.No: T11221

Target: Others

Cat.No: T6301

Synonym: CHR-2797,托舍多特

Target: Aminopeptidase, AChR

Cat.No: T3715

Synonym: 阿西鲁司特,CTX-4430

Target: Aminopeptidase, LTR

Puromycin aminonucleoside

Cat.No: T16684

Synonym: 维生素E醋酸酯,NSC 3056

Target: Apoptosis, Proteasome, Aminopeptidase, Antibacterial, Antibiotic

Cat.No: T28482

Synonym: QGC 001,QGC-001,RB-150,RB150,QGC001,RB 150

Target: Aminopeptidase

Cat.No: T21696

Synonym: N -甲基- N -[3 - [4 - (苯甲基)苯氧基]丙基Β-丙氨酸盐酸盐

Target: Aminopeptidase

Bradykinin (2-9)

Cat.No: TP1181

Synonym: Des-Arg1-bradykinin

Target: Bradykinin Receptor

Cat.No: T5652

Target: Aminopeptidase

Cat.No: T60021

Target: Others

H-β-Ala-AMC TFA

Cat.No: T64341

Target: Others

Cat.No: T18997

Synonym: Glycylproline p-nitroanilide tosylate,GPN

Target: Others

Sar-[D-Phe8]-des-Arg9-Bradykinin acetate

Cat.No: TP1917L1

Synonym: Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base)

Target: Bradykinin Receptor

Cat.No: T22255

Target: Others

Cat.No: T24431

Cat.No: T25987

Leucylmethionine

Cat.No: T32676

Synonym: Leu-met

L-Leucine-7-amido-4-methylcoumarin hydrochloride

Cat.No: T37062

7-Lysylalanyl-4-methylcoumarinamide

Cat.No: T29485

Cat.No: T25940

Cat.No: T15479

Target: Others

Cat.No: T25675

Synonym: L-Leucinal

Cat.No: T28037

Cat.No: T68911

Amastatin hydrochloride

Cat.No: T19665

Synonym: 氨肽酶抑制剂盐酸盐,BIMI-1803,Amastatin HCl,ZX-AFC000547,ZXAFC000547,BIMI1803,J-000280,J000280

Cat.No: T78002

Synonym: LVV-hemorphin-4 TFA

Cat.No: T26048

Synonym: RB101,RB-101

Cat.No: T25897

Synonym: p-Hydroxyubenimex,p-Hydroxybestatin

Cat.No: T13188

Target: Others

Cat.No: T17110

Synonym: AGM-1470

Target: Others

Epibestatin Hydrochloride

Cat.No: T71626

H-Leu-Trp-Met-Arg-OH

Cat.No: T76589

Sitagliptin fenilalanil

Cat.No: T63915

Cat.No: T40839

Synonym: L-Valine β-naphthylamide,H-Val-βNA

Cat.No: T68605

L-Leucine-p-nitroanilide

Cat.No: T20445

Cat.No: T39488

Ketomethylenebestatin

Cat.No: T25573

Cat.No: T68382

Cat.No: T11930

Target: Others

H-D-Ala-D-Ala-D-Ala-D-Ala-OH

Cat.No: T76608

Cat.No: T69346

Cat.No: T61258

NGR peptide Trifluoroacetate

Cat.No: TP1771

Cat.No: T82836

Cat. No.	Product Name	Target	Signaling Pathways
T1257	Bestatin Ubenimex,乌苯美司	Others; Aminopeptidase; Antibacterial; Antibiotic; LTR	Immunology/Inflammation; Metabolism; Microbiology/Virology; Others
	Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂，可用于癌症研究。
T7958	Methyl arachidate 花生酸甲酯,Methyl Icosanoate	Others; Aminopeptidase	Metabolism; Others
	Methyl arachidate (Methyl Icosanoate) 是一种天然化合物，具有白三烯 A4 水解酶 (LTA4H) 抑制活性。
T3529	Bestatin hydrochloride 盐酸乌苯美司,Ubenimex hydrochloride,苯丁抑制素	Integrin; Aminopeptidase; Antibacterial; Antibiotic	Cytoskeletal Signaling; Metabolism; Microbiology/Virology
	Bestatin hydrochloride (Ubenimex hydrochloride) 是CD13(Aminopeptidase N)/APN 和leukotriene A4 hydrolase 抑制剂，可研究癌症。
T4755	2,3-Diaminopropanoic acid hydrochloride DL-2,3-Diaminopropionic acid monohydroch,3-Amino-DL-alanine monohydrochloride,DL-2,3-二胺基丙酸盐酸盐	Others; Endogenous Metabolite	Metabolism; Others
	2,3-Diaminopropanoic acid hydrochloride (3-Amino-DL-alanine monohydrochloride) 是内源性代谢产物的一种。
T6841	Fumagillin NSC9168,烟曲霉素,Amebacilin	Others; HIV Protease; Antibiotic; Parasite	Microbiology/Virology; Others; Proteases/Proteasome
	Fumagillin (Amebacilin) 由烟曲霉菌中提取的一种抗菌药，有抗阿米巴活性。它通过抑制 HIV-1 viral protein R 活性来抑制 HIV‐1感染。
T2830	Betulinic acid 白桦脂酸,桦木酸,ALS-357,Lupatic acid,Betulic acid	Apoptosis; Mitophagy; NF-κB; HIV Protease; Topoisomerase; Endogenous Metabolite; Aminopeptidase; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Betulinic acid (ALS-357) 是从白桦树皮中分离出来的一种五环三萜类天然产物，是真核细胞拓扑异构酶 I 的抑制剂，IC50值为 5 μM，具有抗逆转录病毒、抗疟疾、抗癌和抗炎特性。
T11203	Enocyanin	Others	Others
	Enocyanin, an anthocyanin extracted from grapes, exhibits inhibitory effects on leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase, and esterase activity.
T14121	Actinonin (-)-Actinonin	Aminopeptidase	Metabolism
	Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM, it also is an apoptosis inducer. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase, it also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5].
T62258	Bestatin trifluoroacetate
	Bestatin trifluoroacetate (Ubenimex trifluoroacetate) 是一种 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂，经常用于研究癌症。

天然产物

Cat.No: T1257

Synonym: Ubenimex,乌苯美司

Target: Others, Aminopeptidase, Antibacterial, Antibiotic, LTR

Methyl arachidate

Cat.No: T7958

Synonym: 花生酸甲酯,Methyl Icosanoate

Target: Others, Aminopeptidase

Bestatin hydrochloride

Cat.No: T3529

Synonym: 盐酸乌苯美司,Ubenimex hydrochloride,苯丁抑制素

Target: Integrin, Aminopeptidase, Antibacterial, Antibiotic

2,3-Diaminopropanoic acid hydrochloride

Cat.No: T4755

Synonym: DL-2,3-Diaminopropionic acid monohydroch,3-Amino-DL-alanine monohydrochloride,DL-2,3-二胺基丙酸盐酸盐

Target: Others, Endogenous Metabolite

Cat.No: T6841

Synonym: NSC9168,烟曲霉素,Amebacilin

Target: Others, HIV Protease, Antibiotic, Parasite

Cat.No: T2830

Synonym: 白桦脂酸,桦木酸,ALS-357,Lupatic acid,Betulic acid

Target: Apoptosis, Mitophagy, NF-κB, HIV Protease, Topoisomerase, Endogenous Metabolite, Aminopeptidase, Autophagy

Cat.No: T11203

Target: Others

Cat.No: T14121

Synonym: (-)-Actinonin

Target: Aminopeptidase

Bestatin trifluoroacetate

Cat.No: T62258

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