19
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Cat. No. | Product Name | Target | Signaling Pathways |
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T5424 |
Etosalamide
依托柳胺,Ethosalamide |
Others | Others |
Etosalamide (Ethosalamide) 是一种解热缓解疼痛的试剂。它具有抗炎作用,可用于研究过敏性疾病。 | |||
T5310 |
TR-14035
MDK-1191 |
Integrin | Cytoskeletal Signaling |
TR-14035 (MDK-1191) 是一种具有口服活性的 α4β7/α4β1整合素双重抑制剂,对 α4β7和 α4β1作用的 IC50值分别为 7 和 87 nM,可用于炎症和自体免疫疾病的研究。 | |||
T0059 |
Diphenylpyraline hydrochloride
盐酸双苯比拉林,4-Diphenylmethoxy-1-methylpiperidine hydrochloride |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Diphenylpyraline hydrochloride (4-Diphenylmethoxy-1-methylpiperidine hydrochloride) 是一种组胺 H1 受体的拮抗剂,抑制多巴胺的吸收。它是可口服的抗组胺试剂,具有抗胆碱和抗过敏作用,可用于缓解过敏性疾病,如鼻炎、花粉热和瘙痒性皮肤疾病等。 | |||
T21060L |
NPC 567 acetate
NPC 567 acetate(109333-26-8 Free base) |
Bradykinin Receptor | GPCR/G Protein |
NPC 567 acetate 是一种缓激肽 B2 拮抗剂,可用于治疗过敏性气道疾病的研究。 | |||
T16476 |
PF-03654746
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
PF-03654746 是组胺 H3 受体的选择性拮抗剂。 PF-03654746 提高了阿尔茨海默病的认知功效和疾病改善作用。 PF-03654746 可用于治疗过敏性鼻炎的研究。 | |||
T72031 |
BI 1015550
|
PDE | Metabolism |
BI 1015550 是一种具有口服活性的PDE4B 抑制剂,IC50值为 7.2 nM。BI 1015550 具有良好的安全性,在炎症、过敏疾病、肺纤维化和慢性阻塞性肺疾病 (COPD) 中有潜在应用。 | |||
T31072 |
CP-664511
UNII-W1AEF8025F,CP664511 |
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CP-664511 is an alpha4beta1/ vascular cell adhesion molecule-1 (VCAM-1) inhibitor with therapeutic potential for allergic airway disease. | |||
T70333 |
PM-43I
|
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PM-43I is a potent inhibitor of both STAT5- and STAT6-dependent allergic airway disease in mice. | |||
T13263 |
COX/5-LO-IN-1
Atreleuton analog |
COX | Immunology/Inflammation; Neuroscience |
COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states. | |||
T74646 |
PM-81I
|
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PM-81I为一种高效STAT6抑制剂(针对SH2结构域),可显著减少STAT6的磷酸化水平。适用于研究过敏性肺病、过敏性鼻炎、慢性阻塞性肺病或癌症。 | |||
T60864 | Sequifenadine | ||
Sequifenadine 具有研究过敏症状的炎症性眼病潜力,它是一种 H1 抗组胺药。 | |||
T26628 |
Andolast
CR2039,CR-2039,CR 2039 |
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Andolast, also known as CR-2039, an anti-allergic agent for the treatment of bronchial asthma, chronic obstructive pulmonary disease (COPD). Andolast acts at different cellular levels to inhibit immunoglobulin E synthesis. Andolast proved to be significan | |||
T73129 |
STAT6-IN-1
|
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STAT6-IN-1(化合物19a)是一种针对STAT6的SH2结构域表现出较高亲和力(IC50=0.028 µM)的STAT6抑制剂。该化合物主要用于研究过敏性肺病、过敏性鼻炎、慢性阻塞性肺病或癌症。 | |||
T68280 |
Adriforant
|
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Adriforant, also known as ZPL-3893787, PF-3893787 and ZPL-389, is a novel histamine H4 receptor antagonist. Adriforant shows an excellent in vitro profile that warrants their further investigation in relevant models of human disease. Histamine H4 receptor (H4R) has become a promising target for immuno-inflammatory diseases, such as allergic rhinitis, asthma or dermal allergies. | |||
T35836 |
PMX-205 (trifluoroacetate salt)
|
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PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50= 31 nM).1It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma.2,3PMX-205 is also brain penetrant and reduces neuroinflammation and neurodegeneration in an animal model of Alzheimer's disease.4 1.March, D.R., Proctor, L.M., Stoermer, M.J., et al.Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Rela... | |||
T69918 |
Adriforant tartrate hydrate
|
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Adriforant tartrate hydrate, also known as ZPL-3893787 tartrate hydrate, PF-3893787 tartrate hydrate and ZPL-389 tartrate hydrate, is a novel histamine H4 receptor antagonist. Adriforant tartrate hydrate shows an excellent in vitro profile that warrants their further investigation in relevant models of human disease. Histamine H4 receptor (H4R) has become a promising target for immuno-inflammatory diseases, such as allergic rhinitis, asthma or dermal allergies. | |||
T71329 |
Theophylline-d6
|
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Theophylline-d6 is intended for use as an internal standard for the quantification of theophylline by GC- or LC-MS. Theophylline is an inhibitor of phosphodiesterase. It is also an adenosine A1 and A2 receptor antagonist. Theophylline induces relaxation of isolated cat bronchial smooth muscle segments precontracted with acetylcholine. It inhibits ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic asthma. F... | |||
T70247 |
Clemizole sulfate
|
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Clemizole sulfate is a drug in clinical development for the treatment of hepatitis C virus (HCV) infection. Clemizole is a novel inhibitor of TRPC5 channels. Clemizole is an H1 antagonist. Clemizole, an antihistamine drug that was once widely used for treatment of allergic disease, was recently discovered to be a potent inhibitor (IC50, 24 nM) of the interaction between an HCV protein (NS4B) and HCV RNA. Although clemizole was widely used during the 1950s and 1960s, this was before contemporary ... | |||
T83763 |
EPI-X4 TFA
Endogenous Peptide Inhibitor of CXCR4 |
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EPI-X4是一种源于人血清白蛋白408-423氨基酸的内源性肽段,是趋化因子(C-X-C基序)受体4 (CXCR4)的拮抗剂。在0.8至1,000µM的浓度范围内,EPI-X4能抑制表达CXCR4的HEK293细胞中由趋化因子(C-X-C基序)配体12 (CXCL12)诱发的钙离子动员和受体内化。EPI-X4还能抑制CXCL12诱导的Jurkat T细胞和人类CD34+造血干细胞的迁移。体内实验中,EPI-X4(16µmol/kg)在急性过敏性气道高嗜酸性粒细胞疾病的小鼠模型中减少了Cxcr4依赖的炎症细胞气道浸润。慢性肾脏病患者尿液中EPI-X4的水平增高,并与肾小球滤过率(GFR)成反比。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1416 |
Ayanin
|
IL Receptor; P450; PARP; PDE | Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism |
Ayanin 是从Croton schiedeanus Schlecht 中分离得到的黄酮类物质。它是非选择性的磷酸二酯酶抑制剂,在呼吸道疾病中有研究的价值,如过敏性哮喘等。 | |||
T3S1612 |
kuwanon G
桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G |
Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase | GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience |
Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂,具有杀菌作用。 | |||
TN2511 |
Britannilactone diacetate
1,6-O,O-Diacetylbritannilactone |
IL Receptor; PARP; ROS; MAPK; Caspase; JAK; JNK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; JAK/STAT signaling; MAPK; Proteases/Proteasome; Stem Cells |
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic activity, it reduces leukotriene C4 pro | |||
T75499 | Maceneolignan H | ||
Maceneolignan H (Compound 8)是一种新的木脂素化合物,从肉豆蔻假种皮中分离而来。它表现为选择性CCR3拮抗剂(EC50=1.4 μM),具有研究过敏性疾病潜力。 |