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Search Results for " tricyclic antidepressant "

41

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3086	Mesoridazine Besylate Mesoridazine benzenesulfonate,Serentil,苯磺酸美索达嗪	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Mesoridazine Besylate (Serentil) 是一种哌啶类精神安定药，属于称为吩噻嗪类的药物，用于治疗精神分裂症。它是硫利达嗪的代谢物。
T4274	Melitracen hydrochloride 盐酸美利曲辛,盐酸美力他欣,Thymeol hydrochloride,Melixeran	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Melitracen hydrochloride (Thymeol hydrochloride) 是一种可口服的双相抗抑郁药和抗焦虑药。它可以通过突触前膜抑制去甲肾上腺素和5-羟色胺(5-HT)的吸收，从而诱导突触空间中单胺递质的增加。
T1327	Nortriptyline hydrochloride Desitriptyline HCl,EN-7048 hydrochloride,盐酸去甲替林,Desmethylamitriptyline hydrochloride,ELF-101 hydrochloride,去甲替林	Apoptosis; Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; AChR; Norepinephrine; Autophagy; Histamine Receptor; Drug Metabolite	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Nortriptyline hydrochloride (ELF-101 hydrochloride) 是一种三环类抗抑郁药，用于缓解抑郁症的症状。它是 Amitriptyline 的主要活性代谢产物，是有效自噬抑制剂。
T37015	Iprindole	5-HT Receptor	GPCR/G Protein; Neuroscience
	Iprindole，一种三环吲哚类抗抑郁化合物，是去甲肾上腺素和5-羟色胺摄取的双重弱抑制剂[1]。
T0172	Maprotiline hydrochloride Maprotiline HCl,盐酸马普替林,Psymion,Deprilept,Ludiomil	5-HT Receptor; Adrenergic Receptor; AChR; Norepinephrine; Autophagy; Histamine Receptor	Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Maprotiline hydrochloride (Psymion) 是一种桥环四环类抗抑郁药，是去甲肾上腺素重吸收抑制剂。
T12232	Nitroxazepine CIBA 2330Go	Serotonin Transporter	Neuroscience
	Nitroxazepine (CIBA 2330Go) 是三环抗抑郁化合物，是一种 5-羟色胺去甲肾上腺素再摄取抑制剂，可用于抗抑郁的研究。
T7941	Imipramine hydrochloride 盐酸丙咪嗪,Imipramine (hydrochloride),Tofranil,G 22355,Imipramine HCl,Melipramine	Serotonin Transporter	Neuroscience
	Imipramine hydrochloride (Imipramine HCl) 可抑制血清素转运蛋白，IC50=32 nM。它可阻止胰酶的易位，阻碍 MV 和外泌体的分泌。
T21013	Clomipramine Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina,氯米帕明	5-HT Receptor	GPCR/G Protein; Neuroscience
	Clomipramine (Clomicalm) 是一种三环类抗抑郁药，能够有效阻断 5-HT 再摄取 (IC50:1.5 nM) ，可用于研究强迫症 (OCD) 及抑郁症。
T0255	Clomipramine hydrochloride Clomipramine HCl,Anafranil,盐酸氯米帕明	Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Norepinephrine; GST	GPCR/G Protein; Neuroscience; oxidation-reduction
	Clomipramine hydrochloride (Anafranil) 是一种5-羟色胺转运体(Ki:0.14 nM)、去甲肾上腺素转运体(Ki:54 nM)和多巴胺转运体(Ki:3 nM)阻断剂。
T0678	Amitriptyline hydrochloride Amitriptyline HCl,Tryptizol,盐酸阿米替林,Domical,Annoyltin	Trk receptor; Sigma receptor; 5-HT Receptor; Serotonin Transporter; Sodium Channel; Adrenergic Receptor; AChR; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; Tyrosine Kinase/Adaptors
	Amitriptyline hydrochloride (Annoyltin) 是血清素再摄取转运体和去甲肾上腺素再摄取转运体抑制剂，还与多巴胺再摄取转运体结合，其Ki 为 2.58 μM。它也抑制肾上腺素能受体、毒蕈碱受体、组胺受体、5-羟色胺受体。它是TrkA 和TrkA 受体的激动剂，具有强神经营养活性和有抗抑郁作用。
T0991	Desipramine hydrochloride NSC-114901,Desmethylimipramine,盐酸去甲咪嗪,JB-8181,EX-4355,Norimipramine,G-35020	Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Desipramine hydrochloride (Norimipramine) 是一种二苯并氮杂类衍生物三环类抗抑郁药，可作为选择性去甲肾上腺素再摄取抑制剂。它还显示出较弱的 5-羟色胺再摄取抑制、α1 阻断、抗组胺和抗胆碱能作用。
T60330	Metapramine
	Metapramine (19560 RP) 是一种三环类抗抑郁剂。Metapramine 抑制去甲肾上腺素 (norepinephrine) 的再摄取，而不影响血清素或多巴胺的再摄取。Metapramine 是 N-methyl-D-aspartic acid (NMDA) 受体复合物通道的低亲和力拮抗剂。
T1568	Amoxapine 阿莫沙平,CL-67772	GlyT	Neuroscience
	Amoxapine (CL-67772) 是一种dibenzoxazepine 家族的四环抗抑郁药，常被归类为仲胺三环类抗抑郁药。
T15773	Lofepramine Gamanil,洛非帕明,Amplit,Leo 640,Lopramine	5-HT Receptor; Norepinephrine	GPCR/G Protein; Neuroscience
	Lofepramine (Leo 640) 是一种有效的三环抗抑郁药，广泛地代谢为 Desipramine。它能够抑制摄取促进去甲肾上腺素能神经传递，以及抑制神经元摄取 5-羟色胺和色氨酸吡咯酶，增强 5-羟色胺能神经传递，进而发挥其抗抑郁作用。它还具有显著的抗焦虑效果。
T68070	Fezolamine	Norepinephrine	Neuroscience
	Fezolamine 是一种新型可口服的非三环类化合物，具有抗抑郁活性。它在体外阻断[3H]去甲肾上腺素的突触体摄取方面的选择性是摄取[4H]3-羟色胺或[3H]多巴胺的3至2倍。在使用单胺耗尽动物的经典行为测试中，它阻止了利血平和四苯的抑制作用。
T25248	Cianopramine Ro 112465,Ro-112465,Ro112465
	Cianopramine is a tricyclic antidepressant and a potent neuronal serotonin (5-HT) uptake inhibitor in animals.
T15132L	Dimetacrine tartrate Linostil,Istonil,Istonyl,Miroistonil,MO 709
	Dimetacrine tartrate is a tricyclic antidepressant (TCA) used for the therapy of depression in Europe and formerly in Japan.
T20017	Melitracen Melitracene
	Melitracen is a tricyclic antidepressant.
T13377	(Z)-10-Hydroxynortriptyline (Z)-10-Hydroxy Nortriptyline	IL Receptor	Immunology/Inflammation
	(Z)-10-Hydroxy Nortriptyline is a Nortriptyline metabolite, and is a tricyclic antidepressant,and is used to relieve the symptoms of depression.
T82804	Butriptyline Butriptylene
	Butriptyline (Butriptylene)，三环抗抑郁剂，具有口服生物活性。
T69579	Dothiepin HCl
	Dothiepin HCl is a Tricyclic antidepressant (TCA), acting as a serotonin–norepinephrine reuptake inhibitor (SNRI) and also having other activities including antihistamine, antiadrenergic, antiserotonergic, anticholinergic, and sodium channel-blocking effects.
T37307	Nordoxepin hydrochloride
	Doxepin is a tricyclic antidepressant. Desmethyldoxepin is the primary metabolite of doxepin, produced by metabolism at the liver. The metabolism of tricyclic antidepressants, including doxepin, is affected by a variety of factors, including age, genetics, and drug-drug interactions.
T69620	Demexiptiline
	Demexiptiline is a tricyclic antidepressant used in France for the treatment of depression. It acts primarily as a norepinephrine reuptake inhibitor similarly to desipramine.
T74205	Imipramine N-oxide
	Imipramine N-oxide 是 Imipramine 的代谢物。Imipramine 是一种叔胺三环类抗抑郁药。
T71773	Levomepromazine Maleate
	Levomepromazine Maleate is a Tricyclic antidepressant (TCA), acting as a serotonin–norepinephrine reuptake inhibitor (SNRI) and also having other activities including antihistamine, antiadrenergic, antiserotonergic, anticholinergic, and sodium channel-blocking effects.
T38131	(E)-10-Hydroxynortriptyline
	(E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline . Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1]. [1]. Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8. [2]. Shimoda K, et al. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology ...
T11135	(E)-10-Hydroxynortriptyline maleate (E)-10-Hydroxy Nortriptyline maleate	Others	Others
	(E)-10-Hydroxy Nortriptyline maleate, a metabolite of Nortriptyline, serves as a key active metabolite of the tricyclic antidepressant Amitriptyline, primarily utilized in alleviating depression symptoms.
T22240	Amitriptyline	Sigma receptor; 5-HT Receptor; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Amitriptyline 是一种具有镇痛特性的三环类抗抑郁药 (TCA)。它广泛用于治疗抑郁症和神经性疼痛。
T11008	Desmethylnortriptyline	Others	Others
	Desmethylnortriptyline is a metabolite of nortriptyline. Nortriptyline is a tricyclic antidepressant. It is the main active metabolite of amitriptyline and is used to relieve depressive symptoms.
T61376	Opipramol
	Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) that primarily acts as a sigma (σ) receptor agonist, exhibiting potent interaction with sigma recognition sites (K i value of 50 nM). It can be employed in the research of generalized anxiety disorder (GAD) [1] [2].
T61741	Azaphen dihydrochloride monohydrate
	Pipofezine(Azafen，Azaphen)是5-羟色胺重吸收抑制剂。
T70487	Tofenacin (free base)
	Tofenacin (free base) is an antidepressant drug with a tricyclic-like structure. It acts as a serotonin-norepinephrine reuptake inhibitor, and based on its close relation to orphenadrine, may also possess anticholinergic and antihistamine properties. Tofenacin is also the major active metabolite of orphenadrine and likely plays a role in its beneficial effects against depressive symptoms seen in Parkinson's disease patients.
T69943	Citalopram oxalate
	Citalopram oxalate is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition.
T78564	Depramine GP 31406
	Depramine (GP 31406) 是三环抗抑郁剂，具药理活性。该化合物可抑制乙酰胆碱酯酶、Mg2+-ATPase 与 Na+/K+ ATPase 活性。
T71537	Tofenacin hydrochloride
	Tofenacin hydrochloride is an antidepressant drug with a tricyclic-like structure. It acts as a serotonin-norepinephrine reuptake inhibitor, and based on its close relation to orphenadrine, may also possess anticholinergic and antihistamine properties. Tofenacin is also the major active metabolite of orphenadrine and likely plays a role in its beneficial effects against depressive symptoms seen in Parkinson's disease patients.
T11088	Doxepin D3 Hydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Doxepin D3 Hydrochloride is a deuterium-labeled doxepin hydrochloride.Doxepin hydrochloride is an oral active tricyclic antidepressant used as a sedative.Doxepin hydrochloride is also an effective CYP450 inhibitor, significantly inhibiting CYP450 2C19 and
T0204	Protriptyline hydrochloride 盐酸普罗替林,Protriptyline HCl	5-HT Receptor; AChE	GPCR/G Protein; Neuroscience
	Protriptyline hydrochloride (Protriptyline HCl) 是一种含有一个仲胺的三环结构抗抑郁试剂，可以用于抑郁和 ADHD 的相关研究。它使动物精力充沛起激励作用，并且有时用于嗜睡症的相关研究。
T60445	Desipramine
	Desipramine 是一种具有抗抑郁活性的三环类化合物。Desipramine 可抑制中枢神经系统的去甲肾上腺素再摄取受体，减少睡眠相关的腮舌肌活性丧失，可用于改善咽塌陷的研究。
T60521	Doxepin
	作为三环类抗抑郁药，Doxepin 抑制血清素和去甲肾上腺素的再摄取。Doxepin 具有抗炎作用，可减少抗氧化应激。Doxepin 显示出对特应性皮炎和慢性荨麻疹的治疗效果，并且能改善认知过程和保护中枢神经系统。
T74582	Trimipramine N-oxide
	Trimipramine N-oxide 为三环抗抑郁药trimipramine的活性代谢物，其对人去甲肾上腺素单胺转运体(hNAT)、血清素(hSERT)、多巴胺(hDAT)以及人体有机阳离子转运蛋白(hOCT1与hOCT2)的IC50值分别为11.7、3.59、9.4、9.35及27.4 nM。因此，Trimipramine N-oxide在忧郁和焦虑研究中有应用价值。
T70960	Maprotiline-d3 hydrochloride
	Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET) and is selective for NET over the serotonin and dopamine transporters. Maprotiline also binds to the serotonin (5-HT) receptor subtype 5-HT2A, as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors. In vivo, maprotiline inhibits norepinephrine reuptake in r...

化合物

Mesoridazine Besylate

Cat.No: T3086

Synonym: Mesoridazine benzenesulfonate,Serentil,苯磺酸美索达嗪

Target: Dopamine Receptor, 5-HT Receptor

Melitracen hydrochloride

Cat.No: T4274

Synonym: 盐酸美利曲辛,盐酸美力他欣,Thymeol hydrochloride,Melixeran

Target: Dopamine Receptor, 5-HT Receptor

Nortriptyline hydrochloride

Cat.No: T1327

Synonym: Desitriptyline HCl,EN-7048 hydrochloride,盐酸去甲替林,Desmethylamitriptyline hydrochloride,ELF-101 hydrochloride,去甲替林

Target: Apoptosis, Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, AChR, Norepinephrine, Autophagy, Histamine Receptor, Drug Metabolite

Cat.No: T37015

Target: 5-HT Receptor

Maprotiline hydrochloride

Cat.No: T0172

Synonym: Maprotiline HCl,盐酸马普替林,Psymion,Deprilept,Ludiomil

Target: 5-HT Receptor, Adrenergic Receptor, AChR, Norepinephrine, Autophagy, Histamine Receptor

Cat.No: T12232

Synonym: CIBA 2330Go

Target: Serotonin Transporter

Imipramine hydrochloride

Cat.No: T7941

Synonym: 盐酸丙咪嗪,Imipramine (hydrochloride),Tofranil,G 22355,Imipramine HCl,Melipramine

Target: Serotonin Transporter

Cat.No: T21013

Synonym: Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina,氯米帕明

Target: 5-HT Receptor

Clomipramine hydrochloride

Cat.No: T0255

Synonym: Clomipramine HCl,Anafranil,盐酸氯米帕明

Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Norepinephrine, GST

Amitriptyline hydrochloride

Cat.No: T0678

Synonym: Amitriptyline HCl,Tryptizol,盐酸阿米替林,Domical,Annoyltin

Target: Trk receptor, Sigma receptor, 5-HT Receptor, Serotonin Transporter, Sodium Channel, Adrenergic Receptor, AChR, Norepinephrine, Histamine Receptor

Desipramine hydrochloride

Cat.No: T0991

Synonym: NSC-114901,Desmethylimipramine,盐酸去甲咪嗪,JB-8181,EX-4355,Norimipramine,G-35020

Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Adrenergic Receptor

Cat.No: T60330

Cat.No: T1568

Synonym: 阿莫沙平,CL-67772

Target: GlyT

Cat.No: T15773

Synonym: Gamanil,洛非帕明,Amplit,Leo 640,Lopramine

Target: 5-HT Receptor, Norepinephrine

Cat.No: T68070

Target: Norepinephrine

Cat.No: T25248

Synonym: Ro 112465,Ro-112465,Ro112465

Dimetacrine tartrate

Cat.No: T15132L

Synonym: Linostil,Istonil,Istonyl,Miroistonil,MO 709

Cat.No: T20017

Synonym: Melitracene

(Z)-10-Hydroxynortriptyline

Cat.No: T13377

Synonym: (Z)-10-Hydroxy Nortriptyline

Target: IL Receptor

Cat.No: T82804

Synonym: Butriptylene

Cat.No: T69579

Nordoxepin hydrochloride

Cat.No: T37307

Cat.No: T69620

Imipramine N-oxide

Cat.No: T74205

Levomepromazine Maleate

Cat.No: T71773

(E)-10-Hydroxynortriptyline

Cat.No: T38131

(E)-10-Hydroxynortriptyline maleate

Cat.No: T11135

Synonym: (E)-10-Hydroxy Nortriptyline maleate

Target: Others

Cat.No: T22240

Target: Sigma receptor, 5-HT Receptor, Norepinephrine, Histamine Receptor

Desmethylnortriptyline

Cat.No: T11008

Target: Others

Cat.No: T61376

Azaphen dihydrochloride monohydrate

Cat.No: T61741

Tofenacin (free base)

Cat.No: T70487

Citalopram oxalate

Cat.No: T69943

Cat.No: T78564

Synonym: GP 31406

Tofenacin hydrochloride

Cat.No: T71537

Doxepin D3 Hydrochloride

Cat.No: T11088

Target: Histamine Receptor

Protriptyline hydrochloride

Cat.No: T0204

Synonym: 盐酸普罗替林,Protriptyline HCl

Target: 5-HT Receptor, AChE

Cat.No: T60445

Cat.No: T60521

Trimipramine N-oxide

Cat.No: T74582

Maprotiline-d3 hydrochloride

Cat.No: T70960

Cat. No.	Product Name	Target	Signaling Pathways
T1045	Trimipramine maleate Surmontil maleate,马来酸三甲丙咪嗪,三甲丙咪嗪马来酸盐	Dopamine Receptor; 5-HT Receptor; Antibacterial; Adrenergic Receptor; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Trimipramine maleate (Surmontil maleate) 是一种 5-HT 受体拮抗剂，对 5-HT1C、5-HT2和 5-HT1A 受体的 pKi 值分别为 6.39、8.10和 4.66。
T0185	Escitalopram Seroplex,依他普仑,S-(+)-Citalopram,艾司西酞普兰,(S)-Citalopram	Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Adrenergic Receptor; AChR; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Escitalopram (Seroplex) 是一种外消旋 Citalopram 的 S-对映体，是一种选择性 5-羟色胺再摄取抑制剂，Ki=0.89 nM，比 R(-)-enantiomer 结合亲和力高 30 倍。它对多巴胺转运体和去甲肾上腺素转运体均有选择性，是一种研究抑郁症的抗抑郁药。
T73844	Nortriptyline
	Nortriptyline (Desmethylamitriptyline) 是三环类抗抑郁药，是 Amitriptyline 的主要活性代谢产物，用于缓解抑郁症症状。Nortriptyline 是有效自噬 (autophagy) 抑制剂。

天然产物

Trimipramine maleate

Cat.No: T1045

Synonym: Surmontil maleate,马来酸三甲丙咪嗪,三甲丙咪嗪马来酸盐

Target: Dopamine Receptor, 5-HT Receptor, Antibacterial, Adrenergic Receptor, Norepinephrine, Histamine Receptor

Cat.No: T0185

Synonym: Seroplex,依他普仑,S-(+)-Citalopram,艾司西酞普兰,(S)-Citalopram

Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Adrenergic Receptor, AChR, Norepinephrine, Histamine Receptor

Cat.No: T73844

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