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Search Results for " thymidylate synthase "

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Cat. No.	Product Name	Target	Signaling Pathways
T2627	Nolatrexed dihydrochloride 盐酸诺拉曲塞,Thymitaq,AG 337	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Nolatrexed dihydrochloride (Thymitaq) 是一种非竞争性的胸苷酸合酶抑制剂，能够在癌细胞 S 期诱导细胞周期停滞，具有抗癌活性。它与该酶的叶酸辅因子结合位点相互作用，对人胸苷酸合酶的Ki 值为 11 nM。
T33762	Fosifloxuridine nafalbenamide NUC-3373,NUC3373,NUC 3373	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Fosifloxuridine nafalbenamide (NUC 3373) 是一种胸腺嘧啶合酶抑制剂，属于嘧啶核苷酸类似物，具有抗癌活性。它能诱发宿主免疫反应，有潜力增强免疫治疗。
T3658	Trifluridine/tipiracil hydrochloride mixture Trifluridine-tipiracil hydrochloride mixture,TAS102,TAS-102,TAS 102	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Trifluridine/tipiracil hydrochloride mixture (TAS-102) 是一种新型口服组合药物，含有摩尔比为 2:1 的曲氟尿苷(TFT) 和盐酸替吡嘧啶 (TTP)。它主要通过抑制胸苷酸合酶 (TS) 和掺入 DNA 来显示抗肿瘤活性。
T6632	Raltitrexed ZD1694,雷替曲塞,D1694,ICI-D1694,Tomudex	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Raltitrexed (D1694) 是一种抗代谢药物，通过抑制胸苷酸合成酶起作用，可用于化疗。
T1428	Trifluridine 曲氟尿苷,NSC 529182,Trifluorothymidine,5-Trifluorothymidine,NSC 75520,曲氟胸苷,Viroptic,Trifluridina	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Trifluridine (NSC-75520) 是一种氟化胸苷类似物，具有潜在的抗肿瘤活性，还具有抗病毒活性。它掺入 DNA 并抑制胸苷酸合酶，从而抑制 DNA 合成、抑制蛋白质合成和细胞凋亡。
T4228	Nolatrexed	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Nolatrexed 是一种胸苷酸合成酶抑制剂，具有潜在的抗癌活性。
T27399	Galocitabine RO 091390,RO-091390,RO091390,RO-09-1390,Neofrutulon	Others	Others
	Galocitabine (Neofrutulon) 是一种胸苷酸合成酶抑制剂，可能用于治疗癌症。
T0189	Pemetrexed Pemetrexed acid,培美曲塞,LY231514,培美曲唑,LY-231514 Disodium Hydrate	DHFR; DNA/RNA Synthesis; Antifolate; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Pemetrexed (LY-231514 Disodium Hydrate) acid 是一种鸟嘌呤衍生的抗肿瘤药物，可结合并抑制胸苷酸合酶、二氢叶酸还原酶和甘氨酰胺核苷酸甲酰转移酶的 Ki 分别为 1.3 nM、7.2 nM 和 65 nM。
T0964	Floxuridine 氟尿苷,5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640	Apoptosis; Nucleoside Antimetabolite/Analog; Others; DNA/RNA Synthesis; Antibacterial; HSV	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Floxuridine (FUDR) 是一种嘧啶类似物，也是一种抗肿瘤代谢物。它抑制胸苷酸合成酶，导致 DNA 合成中断和细胞毒性。它是一种可诱导细胞凋亡的金黄色葡萄球菌感染抑制剂，具有抗HSV 和CMV 病毒的作用。
T19833	5-Fluoroorotic acid	DNA/RNA Synthesis; Antifungal	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	5-Fluoroorotic 是一种胸苷酸合成酶的抑制剂，是酵母分子遗传学中的一种选择性试剂。它具有与 5-fluorocytosine 相近的良好表达的抗念珠菌作用，以及适度的抗皮肤真菌作用。
T0984	5-Fluorouracil 5-FU,Fluorouracil,5-氟脲嘧啶,NSC 19893,5-Fluoracil,氟尿嘧啶	Apoptosis; Nucleoside Antimetabolite/Analog; HIV Protease; DNA/RNA Synthesis; Endogenous Metabolite	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Proteases/Proteasome
	5-Fluorouracil (5-FU) 是一种尿嘧啶类似物，一种 DNA 合成抑制剂。5-Fluorouracil 具有抗肿瘤活性，通过抑制胸苷酸合成酶影响嘧啶的合成。5-Fluorouracil 可以引起细胞凋亡和自噬。
T4382	Proguanil hydrochloride Paludrine hydrochloride,盐酸氯胍,Chlorguanide hydrochloride,Chloroquanil	Others; Dehydrogenase; DNA/RNA Synthesis; Antifolate; Parasite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Others
	Proguanil hydrochloride (Chloroquanil) 是一种双胍类抗疟疾剂，在体内代谢形成环胍。它还是一种二氢叶酸还原酶抑制剂。
T21314	Amsilarotene TAC-101,TAC 101,TAC101	CDK	Cell Cycle/Checkpoint
	Amsilarotene (TAC101) 是口服有活性的合成类视黄醇，对视黄酸受体 α (RAR-α) 具有选择性亲和力，对 RAR-α 和 RAR-β 的 Ki=为 2.4 nM 和 400 nM。它可造成人胃癌、卵巢癌细胞及肝细胞癌的凋亡，可用于研究癌症。
T1852	Rac-Belinostat NSC726630,PXD101,PX-105684	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Rac-Belinostat (PX-105684) 是一种具有抗肿瘤活性的新型异羟肟酸型组蛋白脱乙酰酶 (HDAC) 抑制剂。 Belinostat 靶向 HDAC 酶，从而抑制肿瘤细胞增殖、诱导细胞凋亡、促进细胞分化和抑制血管生成。这种药物可以使耐药肿瘤细胞对其他抗肿瘤药物敏感，可能是通过一种涉及胸苷酸合酶下调的机制。
T30761	CB 3703 CB3703,NSC 289522,CB-3703
	CB 3703 is an inhibitor of dihydrofolate reductase and thymidylate synthase.
T24454	Metesind Glucuronate AG 331,AG331,AG-331
	Metesind Glucuronate is an antineoplastic. It also is a specific thymidylate synthase inhibitor.
T24991	8-Deazahomofolic acid
	8-Deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor and other folate related enzymes inhibitor.
T28023	Metesind AG331,AG-341,AG-331,AG341
	Metesind, a thymidylate synthase inhibitor, is used potentially for the treatment of brain cancer and solid tumours.
T30760	CB 30900 CB30900,CB-30900
	CB30900 is a novel and effective thymidylate synthase inhibitor.
T25519	ICI 198583 CB 3819,ICI198583,ICI-198583
	ICI 198583 is an inhibitor of antifolate thymidylate synthase.
T12674	(Rac)-Plevitrexed (Rac)-ZD 9331,(Rac)-BGC9331	Others	Others
	(Rac)-Plevitrexed is a racemate of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).
T30763	CB 3731 CB3731,CB-3731
	CB 3731 is used in fluorine-19 nuclear magnetic resonance studies of binary and ternary complexes of thymidylate synthase.
T27349	Fosfluridine tidoxil HDP 990006,HDP990006,HDP-990006
	Fosfluridine tidoxil, a thymidylate synthase inhibitor, is used potentially for the treatment of colorectal cancer, and breast cancer.
T71623	ICI-M247496
	ICI-M247496 is a non-polyglutamated analog of CB3717 and quinazoline-based inhibitor of thymidylate synthase.
T12635	(R)-Plevitrexed (R)-ZD 9331,(R)-BGC9331,(R)-普来曲塞	Others	Others
	(R)-Plevitrexed is a less active enantiomer of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).
T21315	Folitixorin ANX-510
	ANX-510 is a folate-based biomodulator. It stabilizes the covalent binding of the fluorouracil metabolite FdUMP to thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituen
T24981	5,6,7,8-Tetrahydro-8-deazahomofolic acid 5,6,7,8-Tdfa
	5,6,7,8-Tetrahydro-8-deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor and other folate related enzymes inhibitor.
T24572	OSI-7904L free acid OSI 7904,OSI-7904L,OSI7904,OSI 7904L,OSI7904L,OSI-7904
	OSI-7904L is a folate-based thymidylate synthase inhibitor. It also has antimalarial and antitumor properties.
T62996	10-Formyl-5,8-dideazafolic acid
	10-Formyl-5,8-dideazafolic acid 是一种胸苷酸合成酶 (thymidylate synthase) 抑制剂。
T69268	BGC-638
	BGC-638, an analogue of BGC-945, is a thymidylate synthase inhibitor specifically transported into α-folate receptor (α-FR)Â–overexpressing tumors.
T70583	Pemetrexed Diethyl Ester
	Pemetrexed Diethyl Ester is a protected intermediate in the synthesis of Pemetrexed, a multi-targeted anti-folate that inhibits thymidylate synthase as well as other folate dependent enzymes.
T12635L	Plevitrexed BGC9331,ZD 9331	Others	Others
	Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is an orally active and effective thymidylate synthase (TS) inhibitor (Ki: 0.44 nM). Plevitrexed is used for gastric cancer in clinical.
T38490	ONX 0801 trisodium Idetrexedtrisodium,BGC 945 trisodium,CB300945trisodium
	ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.
T63401	EGFR/HER2/TS-IN-1
	EGFR/HER2/TS-IN-1 是 EGFR、HER2和TS (Thymidylate synthase)抑制剂，他们的IC50值分别为 0.203、0.088 和 0.168 μM，具有诱导 MCF7 细胞凋亡（apoptosis）的作用。
T66032	Pemetrexed disodium heptahydrate
	Pemetrexed disodium is a guanine-derived antineoplastic agent that functions as a nucleic acid synthesis inhibitor through its binding to, and inhibition of, thymidylate synthase.
T36895	5-Fluorouracil-13C,15N2 5-Fluorouracil-13C,15N2
	5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis.
T60780	Tegafur-Uracil
	Tegafur-Uracil 是可用于抗实体肿瘤相关研究的，具有口服活性的氟尿嘧啶类抗癌剂，可抑制胸苷酸合成酶。
T78751	DG1
	DG1（化合物8Nc）是一种Thymidylate Synthase（TS）抑制剂，具有抑制NSCLC细胞的血管生成和代谢重编程作用。此外，DG1还能有效下调CD26、ET-1、FGF-1和EGF的表达，并在A549异种移植小鼠模型中显著抑制肿瘤组织的增殖。
T77237	N,O-Didansyl-L-tyrosine cyclohexylammonium
	N,O-Didansyl-L-tyrosine cyclohexylammonium 是一种有效的选择性胸苷酸合成酶 (TS) 抑制剂，作用于Escherichia coli，Lactobacillus casei 和人的 TS 的IC50值分别是 5.0，3.4 和 119 μM。
T36096	Thiocoraline
	Thiocoraline is a depsipeptide and DNAbis-intercalator originally isolated fromMicromonosporawith antibacterial and anticancer activities.1,2It is active against the Gram-positive bacteriaS. aureus,B. subtilis, andM. luteus(MICs = 0.05, 0.05, and 0.03 μg/ml, respectively) but not Gram-negativeE. coli,K. pneumoniae, orP. aeruginosa(MICs = >100 μg/ml for all).1Thiocoraline inhibits RNA and DNA polymerase and thymidylate synthase (IC50s = 6, 6, and 15 μg/ml, respectively), as well as RNA and DNA sy...

化合物

Nolatrexed dihydrochloride

Cat.No: T2627

Synonym: 盐酸诺拉曲塞,Thymitaq,AG 337

Target: DNA/RNA Synthesis

Fosifloxuridine nafalbenamide

Cat.No: T33762

Synonym: NUC-3373,NUC3373,NUC 3373

Target: DNA/RNA Synthesis

Trifluridine/tipiracil hydrochloride mixture

Cat.No: T3658

Synonym: Trifluridine-tipiracil hydrochloride mixture,TAS102,TAS-102,TAS 102

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Cat.No: T6632

Synonym: ZD1694,雷替曲塞,D1694,ICI-D1694,Tomudex

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Cat.No: T1428

Synonym: 曲氟尿苷,NSC 529182,Trifluorothymidine,5-Trifluorothymidine,NSC 75520,曲氟胸苷,Viroptic,Trifluridina

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, HSV

Cat.No: T4228

Target: DNA/RNA Synthesis

Cat.No: T27399

Synonym: RO 091390,RO-091390,RO091390,RO-09-1390,Neofrutulon

Target: Others

Cat.No: T0189

Synonym: Pemetrexed acid,培美曲塞,LY231514,培美曲唑,LY-231514 Disodium Hydrate

Target: DHFR, DNA/RNA Synthesis, Antifolate, Autophagy

Cat.No: T0964

Synonym: 氟尿苷,5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640

Target: Apoptosis, Nucleoside Antimetabolite/Analog, Others, DNA/RNA Synthesis, Antibacterial, HSV

5-Fluoroorotic acid

Cat.No: T19833

Target: DNA/RNA Synthesis, Antifungal

Cat.No: T0984

Synonym: 5-FU,Fluorouracil,5-氟脲嘧啶,NSC 19893,5-Fluoracil,氟尿嘧啶

Target: Apoptosis, Nucleoside Antimetabolite/Analog, HIV Protease, DNA/RNA Synthesis, Endogenous Metabolite

Proguanil hydrochloride

Cat.No: T4382

Synonym: Paludrine hydrochloride,盐酸氯胍,Chlorguanide hydrochloride,Chloroquanil

Target: Others, Dehydrogenase, DNA/RNA Synthesis, Antifolate, Parasite

Cat.No: T21314

Synonym: TAC-101,TAC 101,TAC101

Target: CDK

Cat.No: T1852

Synonym: NSC726630,PXD101,PX-105684

Target: HDAC

Cat.No: T30761

Synonym: CB3703,NSC 289522,CB-3703

Metesind Glucuronate

Cat.No: T24454

Synonym: AG 331,AG331,AG-331

8-Deazahomofolic acid

Cat.No: T24991

Cat.No: T28023

Synonym: AG331,AG-341,AG-331,AG341

Cat.No: T30760

Synonym: CB30900,CB-30900

Cat.No: T25519

Synonym: CB 3819,ICI198583,ICI-198583

(Rac)-Plevitrexed

Cat.No: T12674

Synonym: (Rac)-ZD 9331,(Rac)-BGC9331

Target: Others

Cat.No: T30763

Synonym: CB3731,CB-3731

Fosfluridine tidoxil

Cat.No: T27349

Synonym: HDP 990006,HDP990006,HDP-990006

Cat.No: T71623

(R)-Plevitrexed

Cat.No: T12635

Synonym: (R)-ZD 9331,(R)-BGC9331,(R)-普来曲塞

Target: Others

Cat.No: T21315

Synonym: ANX-510

5,6,7,8-Tetrahydro-8-deazahomofolic acid

Cat.No: T24981

Synonym: 5,6,7,8-Tdfa

OSI-7904L free acid

Cat.No: T24572

Synonym: OSI 7904,OSI-7904L,OSI7904,OSI 7904L,OSI7904L,OSI-7904

10-Formyl-5,8-dideazafolic acid

Cat.No: T62996

Cat.No: T69268

Pemetrexed Diethyl Ester

Cat.No: T70583

Cat.No: T12635L

Synonym: BGC9331,ZD 9331

Target: Others

ONX 0801 trisodium

Cat.No: T38490

Synonym: Idetrexedtrisodium,BGC 945 trisodium,CB300945trisodium

EGFR/HER2/TS-IN-1

Cat.No: T63401

Pemetrexed disodium heptahydrate

Cat.No: T66032

5-Fluorouracil-13C,15N2

Cat.No: T36895

Synonym: 5-Fluorouracil-13C,15N2

Cat.No: T60780

Cat.No: T78751

N,O-Didansyl-L-tyrosine cyclohexylammonium

Cat.No: T77237

Cat.No: T36096

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