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Search Results for " renin "

92

抑制剂 & 化合物

15

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T35880	Renin Fluorogenic Substrate
	The renin fluorogenic substrate consists of the normal peptide substrate for renin which has been linked to the fluorophore EDANS at one end and to a non-fluorescent quenching molecule (Dabcyl) at the other. After cleavage by renin, the product (peptide-EDANS) is brightly fluorescent and can be easily analyzed using an excitation wavelength of 340 nm and emission wavelengths of 485-510 nm.
T38900	Renin FRET Substrate I
	Renin FRET Substrate I is a specific compound that functions as a substrate for human renin. It is specifically designed to contain the exact cleavage site found in the N-terminal peptide of human angiotensinogen.
TP2351	Renin inhibitory peptide Pro-his-pro-phe-his-phe-phe-val-tyr-lys
	Renin inhibitory peptide is an analog of angiotensinogen.
TP2351L	Renin inhibitory peptide, statine SCRIP,Iva-his-pro-phe-his-sta-leu-phe-NH2
	Renin inhibitory peptide, statine is a effective, specific statine-containing renin inhibitor.
T80244	Renin inhibitor peptide,rat
	Renin inhibitorpeptide,rat 是一种特定的大鼠肾素抑制剂，具有生物活性的肽。
T76443	Renin substrate 1
	Reninsubstrate 1 是一种对酶具有高亲和力的肾素 (renin) 底物。
T62138	Renin inhibitor-1
	Renin inhibitor-1 (compound 26) 是一种有效的、口服具有活力的肾素抑制剂，能够作用于 rh-renin (IC50: 0.9 nM) 和 hPRA (IC50: 1.8 nM)。Renin inhibitor-1 具有抗高血压作用，具有潜力进行高血压和心血管/肾脏疾病的研究。
T26127	R-PEP 27 Renin inhibitory peptide, R-pep-27,Pro-his-pro-phe-his-statine-ile-phe-NH2
	R-PEP 27 is an inhibitor of potent renin, decreased plasma angiotensin II, and blood pressure in normal volunteers.
TP1929L1	Saralasin acetate(34273-10-4 free base)	RAAS	Endocrinology/Hormones
	Saralasin acetate(34273-10-4 free base) 是一种非选择性血管紧张素 II 拮抗剂。
T7714	Temocapil	Tyrosinase	Proteases/Proteasome
	Temocapil 是一种酪氨酸激酶抑制剂。
T1520	Aliskiren hemifumarate 阿利克仑半富马酸盐,CGP 60536,SPP 100,CGP60536B	RAAS; Autophagy	Autophagy; Endocrinology/Hormones
	Aliskiren hemifumarate (CGP60536B) 一种可口服非肽肾素抑制剂，IC50为1.5 nM，具有抗高血压活性。
T3064	VTP-27999 VTP27999	RAAS	Endocrinology/Hormones
	VTP-27999是烷基胺肾素抑制剂，它已用于研究肾功能基础科学的试验。
T7668	VTP-27999 TFA N-[2-[(R)-(3-氯苯基)[(3R)-1-[[[(2S)-2-(甲基氨基)-3-[(3R)-四氢-2H-吡喃-3-基]丙基]氨基]羰基]-3-哌啶基]甲氧基]乙基]氨基甲酸甲酯 2,2,2-三氟乙酸盐	RAAS	Endocrinology/Hormones
	VTP-27999 TFA 是烷基胺肾素抑制剂(IC50:0.47 nM)。
T6666	Sevelamer Carbonate	Others	Others
	Sevelamer carbonate 是一种口服具有活力的非钙基磷酸盐结合剂，能有效降低体内血清磷水平，但对体内血清钙、氯水平影响极小，可用于研究慢性肾脏病的高磷血症。它被认为是七氟乙烯的一种改进的缓冲形式。
T6698	Temocapril hydrochloride CS-622 HCl,Acecol,Temocapril HCl,CS-622,盐酸替莫普利	RAAS	Endocrinology/Hormones
	Temocapril hydrochloride (CS-622 HCl) 是血管紧张素转化酶 (ACE) 抑制剂。Temocapril HCl 能够用于充血性心力衰竭、急性心肌梗死、高血压、胰岛素抵抗和肾脏疾病的研究。
T37683	3-Hydroxykynurenine 3-hydroxy-DL-Kynurenine,DL-3-Hydroxykynurenine	Others	Others
	3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) 是色氨酸的活性代谢物，可抑制酵母和大鼠肝脏醛脱氢酶 97% 和 69%。
T71760	4-Chlorokynurenine
	4-Chlorokynurenine is a prodrug of 7-Cl-kynurenic acid (7-Cl-KYNA), a potent, selective antagonist of the NMDA/glycine receptor.
T70549	Kadsurenin L
	Kadsurenin L is a neolignan originally isolated from Piper kadsura. It has a role as a platelet-activating factor receptor antagonist and a plant metabolite.
T125390	Glisoprenin D
	Glisoprenin D 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125390，CAS号为 205594-89-4。
T124831	Scillarenin
	Scillarenin 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T124831，CAS号为 465-22-5。
T72430	L-Kynurenine sulfate
	L-Kynurenine sulfate 是一种芳香烃受体AHR 激动剂，可激活 AHR 导向的初始T 细胞极化至抗炎 Treg 表型。
T3011L	Kynurenine sulfate monohydrate L-Kynurenine sulfate monohydrate
	Kynurenine sulfate monohydrate is a precursor of kynurenic acid which is the only recognized endogenous excitatory amino acid receptor antagonist agent in the central nervous system. L-Kyn is known to be a pigment generating component in animals. In mamma
T34194	Puntarenine
	Puntarenine is an alkaloid of the isohomoprotoberberine family that has shown marginal activity against the dermatophytic fungus Trichophyton mentagrophytes and the yeast Saccharomyces cerevisiae.
T32361	Karenin
	Karenin is a bioactive chemical.
T4313	Tinoridine hydrochloride 盐酸替诺立定,Nonflamin,Y-3642 hydrochloride	COX; Glutathione Peroxidase	Immunology/Inflammation; Metabolism; Neuroscience
	Tinoridine hydrochloride (Y-3642 hydrochloride) 是非甾体抗炎药，具有显著的自由基清除和抗过氧化物特性。
T28950	Terlakiren CP 80794,CP-80,794	RAAS	Endocrinology/Hormones
	Terlakiren (CP-80,794) 是一种具有口服活性和高效性的肾素 (Renin) 抑制剂，抑制人肾素的效能，可用于研究高血压类的神经系统疾病。
TP1842L	Angiotensinogen (1-14), human acetate	Endogenous Metabolite	Metabolism
	Angiotensinogen (1-14), human acetate 是血管紧张素原的片段，它是肾素-血管紧张素系统的被动底物。
T3695	Pepstatin 抑肽素,Pepstatin A,Pepsin Inhibitor S 735A,Ahpatinin C	Amino Acids and Derivatives; Proteasome; HIV Protease; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Proteases/Proteasome; Ubiquitination
	Pepstatin (Pepsin Inhibitor S 735A) 是由放线菌类产生的特异性天冬氨酸蛋白酶抑制剂，可抑制 HIV 蛋白酶的活性。
T2639	LY2811376	Beta Amyloid; Beta-Secretase; BACE	Neuroscience
	LY2811376 是可口服的非肽段β-secretase (BACE1)抑制剂，IC50=239 nM-249 nM，能够降低 Aβ 蛋白的分泌，EC50=300 nM。
T37496L	Alamandine TFA	RAAS	Endocrinology/Hormones
	Alamandine TFA 是肾素-血管紧张素系统 (RAS) 的成员，是一种血管活性肽，是 G 蛋白偶联受体 MrgD 的内源性配体。它通过抗高血压作用来保护肾脏和心脏。
TP1295	Angiotensin I (human, mouse, rat) Angiotensin 1 Human,血管紧张素 1 (人)	Others	Others
	Angiotensin I (human, mouse, rat) 是血管紧张素Ⅱ的前体物质，在血管紧张素转化酶 (ACE) 的参与下裂解成血管紧张素Ⅱ。
T22574L	Angiotensin 1/2 (5-7) acetate	RAAS	Endocrinology/Hormones
	Angiotensin 1/2 (5-7) acetate 是一种具有 H2N-Ile-His-Pro-OH 序列的肽。血管紧张素是一种寡肽，是一种激素和一种强大的双肽原。它来源于前体分子血管紧张素原，一种在肝脏中产生的血清球蛋白。它在肾素-血管紧张素系统中起重要作用。
T14123	ACT 178882	RAAS	Endocrinology/Hormones
	ACT 178882 is a new Renin inhibitor (IC50: 1.4 nM).
T19187	Aliskiren D6 hemifumarate CGP 60536 D6 hemifumarate,SPP 100 D6 hemifumarate,CGP60536B D6 hemifumarate	RAAS	Endocrinology/Hormones
	Aliskiren (CGP 60536) D6 hemifumarate is a deuterium-labeled Aliskiren hemifumarate. Aliskiren hemifumarate is a direct and orally active renin inhibitor (IC50: 1.5 nM).
T26431	A 65317 A-65317,A65317
	A 65317 is a selective renin inhibitor that causes a blockade of the renin-angiotensin system.
T25369	Emd 52297 Emd-52297,Emd52297
	Emd 52297 is an inhibitor of renin.
T25233	CH 66 CH66,Piv-his-pro-phe-leu(OH)leu-tyr-tyr-ser-NH2,CH-66
	CH 66 is an inhibitor of renin.
T71318	H 218-54
	H 218-54 is a renin inhibitor.
T25370	Emd 55068 Emd-55068,Emd55068
	Emd 55068 is a synthetic antagonist of renin.
T25368	Emd 51921 Emd51921,Emd-51921,Emd-51,921,Emd 51,921,Emd 51 921
	Emd 51921 is a linear peptide renin inhibitor.
T25386	ES 6864 ES-6864,ES6864
	ES 6864 is an orally active inhibitor of renin.
T30921	CI 992 CI-992,CI992
	CI 992 is a novel potent inhibitor of primate renin.
T34285	Remikiren D09038,C07465,126222-34-2,AC1O44IV,CHEMBL31601
	Remikiren is a highly specific renin inhibitor with oral activity for the treatment of hypertensio.
T26215	SQ 30774 SQ-30774,SQ 30,774,SQ30774,SQ30,774,SQ-30,774
	SQ 30774 is a representative of the imidazole alcohols-a novel class of renin inhibitors.
T26426	A 62198 A62198,A-62198
	A 62198 is a potent and selective renin inhibitor with potential as a hypotensive agent.
T29204	Zankiren A72517,A-72517,A 72617
	Zankiren is a renin inhibitor. Zankiren can reduce blood pressure, plasma renin activity, and angiotension II.
T62618	SPH3127
	SPH3127 (DRI 18) 是一种强有效的、口服具有活力的、新型的 direct renin 抑制剂，其对 recombinant human-renin，human plasma renin activity 的 IC50 值分别为0.4 nM 和 0.45 nM。SPH3127具有抗高血压效果，能够用于研究高血压。
T25479	H 142 H142,H-142
	H 142 is a human renin decapeptide inhibitor.
T20477	Cgp 29287 Cgp29,287,Cgp29287,Cgp 29,287,Cgp-29,287,Cgp-29287
	Cgp 29287 is a primate-specific renin inhibitor. It also has a prolonged duration of action.
T26439	A 74273 A-74273,A74273
	A 74273, a nonpeptidic and renin inhibitor, may be used to treat cardiovascular diseases due to renin inhibition.

化合物

Renin Fluorogenic Substrate

Cat.No: T35880

Renin FRET Substrate I

Cat.No: T38900

Renin inhibitory peptide

Cat.No: TP2351

Synonym: Pro-his-pro-phe-his-phe-phe-val-tyr-lys

Renin inhibitory peptide, statine

Cat.No: TP2351L

Synonym: SCRIP,Iva-his-pro-phe-his-sta-leu-phe-NH2

Renin inhibitor peptide,rat

Cat.No: T80244

Renin substrate 1

Cat.No: T76443

Renin inhibitor-1

Cat.No: T62138

Cat.No: T26127

Synonym: Renin inhibitory peptide, R-pep-27,Pro-his-pro-phe-his-statine-ile-phe-NH2

Saralasin acetate(34273-10-4 free base)

Cat.No: TP1929L1

Target: RAAS

Cat.No: T7714

Target: Tyrosinase

Aliskiren hemifumarate

Cat.No: T1520

Synonym: 阿利克仑半富马酸盐,CGP 60536,SPP 100,CGP60536B

Target: RAAS, Autophagy

Cat.No: T3064

Synonym: VTP27999

Target: RAAS

Cat.No: T7668

Synonym: N-[2-[(R)-(3-氯苯基)[(3R)-1-[[[(2S)-2-(甲基氨基)-3-[(3R)-四氢-2H-吡喃-3-基]丙基]氨基]羰基]-3-哌啶基]甲氧基]乙基]氨基甲酸甲酯 2,2,2-三氟乙酸盐

Target: RAAS

Sevelamer Carbonate

Cat.No: T6666

Target: Others

Temocapril hydrochloride

Cat.No: T6698

Synonym: CS-622 HCl,Acecol,Temocapril HCl,CS-622,盐酸替莫普利

Target: RAAS

3-Hydroxykynurenine

Cat.No: T37683

Synonym: 3-hydroxy-DL-Kynurenine,DL-3-Hydroxykynurenine

Target: Others

4-Chlorokynurenine

Cat.No: T71760

Cat.No: T70549

Cat.No: T125390

Cat.No: T124831

L-Kynurenine sulfate

Cat.No: T72430

Kynurenine sulfate monohydrate

Cat.No: T3011L

Synonym: L-Kynurenine sulfate monohydrate

Cat.No: T34194

Cat.No: T32361

Tinoridine hydrochloride

Cat.No: T4313

Synonym: 盐酸替诺立定,Nonflamin,Y-3642 hydrochloride

Target: COX, Glutathione Peroxidase

Cat.No: T28950

Synonym: CP 80794,CP-80,794

Target: RAAS

Angiotensinogen (1-14), human acetate

Cat.No: TP1842L

Target: Endogenous Metabolite

Cat.No: T3695

Synonym: 抑肽素,Pepstatin A,Pepsin Inhibitor S 735A,Ahpatinin C

Target: Amino Acids and Derivatives, Proteasome, HIV Protease, Autophagy

Cat.No: T2639

Target: Beta Amyloid, Beta-Secretase, BACE

Cat.No: T37496L

Target: RAAS

Angiotensin I (human, mouse, rat)

Cat.No: TP1295

Synonym: Angiotensin 1 Human,血管紧张素 1 (人)

Target: Others

Angiotensin 1/2 (5-7) acetate

Cat.No: T22574L

Target: RAAS

Cat.No: T14123

Target: RAAS

Aliskiren D6 hemifumarate

Cat.No: T19187

Synonym: CGP 60536 D6 hemifumarate,SPP 100 D6 hemifumarate,CGP60536B D6 hemifumarate

Target: RAAS

Cat.No: T26431

Synonym: A-65317,A65317

Cat.No: T25369

Synonym: Emd-52297,Emd52297

Cat.No: T25233

Synonym: CH66,Piv-his-pro-phe-leu(OH)leu-tyr-tyr-ser-NH2,CH-66

Cat.No: T71318

Cat.No: T25370

Synonym: Emd-55068,Emd55068

Cat.No: T25368

Synonym: Emd51921,Emd-51921,Emd-51,921,Emd 51,921,Emd 51 921

Cat.No: T25386

Synonym: ES-6864,ES6864

Cat.No: T30921

Synonym: CI-992,CI992

Cat.No: T34285

Synonym: D09038,C07465,126222-34-2,AC1O44IV,CHEMBL31601

Cat.No: T26215

Synonym: SQ-30774,SQ 30,774,SQ30774,SQ30,774,SQ-30,774

Cat.No: T26426

Synonym: A62198,A-62198

Cat.No: T29204

Synonym: A72517,A-72517,A 72617

Cat.No: T62618

Cat.No: T25479

Synonym: H142,H-142

Cat.No: T20477

Synonym: Cgp29,287,Cgp29287,Cgp 29,287,Cgp-29,287,Cgp-29287

Cat.No: T26439

Synonym: A-74273,A74273

Cat. No.	Product Name	Target	Signaling Pathways
T4S0290	Araloside A Chikusetsusaponin IV,竹节参皂苷IV	RAAS; Fas/FasL	Apoptosis; Endocrinology/Hormones
	Araloside A (Chikusetsusaponin IV) 是竹节参中的一种成分，对肾素renin 具有低抑制活性(IC50:77.4 μM)。
T10938	D-Kynurenine D-尿嘧啶,(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid,ZINC901103	GPR; AhR; Endogenous Metabolite	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism
	D-Kynurenine (ZINC901103) 是 D-色氨酸的代谢物和 GPR109B 的激动剂。 D-Kynurenine 激活 AhR 并促进上皮细胞向间充质的转化。 D-Kynurenine 在 D-氨基酸氧化酶的荧光分析中用作底物。
T4928	L-Kynurenine L-犬尿氨酸,(S)-Kynurenine	AhR; Aryl Hydrocarbon Receptor; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	L-Kynurenine ((S)-Kynurenine) 是L-色氨酸的代谢物，是芳香烃受体激动剂，可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。
TN6778	Umbelliprenin 伞形花醚,7-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl]oxy]-2H-1-benzopyran-2-oneUmbelliprenin	IL Receptor	Immunology/Inflammation
	Umbelliprenin (7-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl]oxy]-2H-1-benzopyran-2-oneUmbelliprenin) 可减轻神经性疼痛，并降低血清 IL-6 水平和氧化应激。
T79948	Kadsurenin B
	Kadsurenin B为PAF（platelet-activating factor）拮抗剂，展现出神经保护作用。该化合物在药理学领域显示出广泛的研究潜力，包括抗菌、抗炎、神经保护、抗氧化、抗血小板聚集、细胞毒性和抗寄生虫等效能。
TN4302	Isokadsurenin D	Others	Others
	Isokadsurenin D是一种天然产物，属于五味子科南五味子属，其产品编号为 TN4302，CAS号为 147976-35-0。Isokadsurenin D可用作对照参考。
T2S1727	Lycorenine	Antifection	Microbiology/Virology
	Lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity. The development of tachyph
TN3054	4-O-Demethylisokadsurenin D	Others	Others
	4-O-Demethylisokadsurenin D 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3054，CAS号为 89104-59-6。
T3S0804	Worenine 甲基黄连碱,Worenin	Others	Others
	Worenine (Worenin) 是一种从黄连中提取的物质。它在大鼠体内第一阶段代谢中显示出脱氢，氢化，羟基化和脱亚甲基反应。在大鼠体内 II 期代谢中显示为硫酸化和葡萄糖醛酸化反应。
T81994	Kadsurenin A
	Kadsurenin A是一种生物活性木脂素，具有潜在的药用价值。
TN4365	Kadsurenin D	Others	Others
	Kadsurenin D 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4365，CAS号为 140669-89-2。
TN3055	4-O-Demethylkadsurenin D	Others	Others
	4-O-Demethylkadsurenin D 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3055，CAS号为 127179-70-8。
T0522	Diammonium Glycyrrhizinate 甘草酸二铵,Glycyrrhizin	Dehydrogenase	Metabolism
	Diammonium Glycyrrhizinate (Glycyrrhizin) 是分离自甘草中的化合物，有抗炎作用。
T19186	Aldosterone	Others	Others
	Aldosterone is the primary mineralocorticoid. Aldosterone is synthesized and secreted in response to renin-angiotensin system activation or high dietary potassium by the zona glomerulosa of the adrenal cortex.
T38649	Lyciumin A
	Lyciumin A, a cyclic octapeptide, possesses inhibitory properties against proteases, renin, and angiotensin-converting enzyme. It holds potential for hypertension research.

天然产物

Cat.No: T4S0290

Synonym: Chikusetsusaponin IV,竹节参皂苷IV

Target: RAAS, Fas/FasL

Cat.No: T10938

Synonym: D-尿嘧啶,(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid,ZINC901103

Target: GPR, AhR, Endogenous Metabolite

Cat.No: T4928

Synonym: L-犬尿氨酸,(S)-Kynurenine

Target: AhR, Aryl Hydrocarbon Receptor, Endogenous Metabolite

Cat.No: TN6778

Synonym: 伞形花醚,7-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl]oxy]-2H-1-benzopyran-2-oneUmbelliprenin

Target: IL Receptor

Cat.No: T79948

Isokadsurenin D

Cat.No: TN4302

Target: Others

Cat.No: T2S1727

Target: Antifection

4-O-Demethylisokadsurenin D

Cat.No: TN3054

Target: Others

Cat.No: T3S0804

Synonym: 甲基黄连碱,Worenin

Target: Others

Cat.No: T81994

Cat.No: TN4365

Target: Others

4-O-Demethylkadsurenin D

Cat.No: TN3055

Target: Others

Diammonium Glycyrrhizinate

Cat.No: T0522

Synonym: 甘草酸二铵,Glycyrrhizin

Target: Dehydrogenase

Cat.No: T19186

Target: Others

Cat.No: T38649

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