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Search Results for " pdgfr-β "

Targets Recommended: EGFR FGFR PDGFR Src

18

抑制剂 & 化合物

1

天然产物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T23127	PD-161570 PD 161570	EGFR; FGFR; PDGFR; Src	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PD-161570 是一种有效的 ATP 竞争性人 FGF-1 受体抑制剂，IC50 为 39.9 nM，Ki 为 42 nM。它还是骨形态发生蛋白 (BMPs) 和TGF-β信号抑制剂。它抑制PDGF 刺激的自磷酸化和FGF-1受体磷酸化，IC50分别为 450 和 622 nM。它抑制 PDGFR、EGFR 和 c-Src 酪氨酸激酶，IC50 值分别为 310、240 和 44 nM。
T3476	JI-101 CGI-1842,JI 101	VEGFR; PDGFR; Ephrin Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	JI-101 (CGI-1842) 是一种有口服活性的多靶点激酶抑制剂，能够抑制VEGFR2，PDGFRβ和EphB4，具有抗癌作用。
T6036	Brivanib BMS-540215,布立尼布	EGFR; VEGFR; FGFR; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Brivanib (BMS-540215) 是一种针对 VEGFR2 的 ATP 竞争性抑制剂，IC50 为 25 nM。它对 VEGFR-1 和 FGFR-1 具有中等效力，对 VEGFR2 的选择性是对 PDGFR-β 的 240 倍。
T15616	JNJ-10198409 3-氟-N-(6,7-二甲氧基-2,4-二氢茚并[1,2-C〕吡唑-3-基苯基胺,JNJ-10198409	PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	JNJ-10198409 是相对选择性的、ATP 竞争性的、具有口服活性的血小板衍生生长因子受体酪氨酸激酶抑制剂，其IC50=2 nM。它对PDGFR-β激酶 (IC50=4.2 nM) 和PDGFR-α激酶 (IC50=45 nM) 有较好的抑制作用。它是双重机制的抗血管生成和肿瘤细胞的抗增殖剂。
T4349	Sitravatinib MG516,MGCD516	Discoidin Domain Receptor (DDR); VEGFR; FLT; Trk receptor; TAM Receptor; c-Kit; Ephrin Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	Sitravatinib (MGCD516) 是一种有口服活性的受体酪氨酸激酶抑制剂。它单独使用即具有有效的抗肿瘤功效，且通过促进抗肿瘤免疫微环境增强了 PD-1 阻断的活性。
T1792L	Regorafenib monohydrate	Raf; VEGFR; c-RET; PDGFR; c-Kit; Autophagy	Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors
	Regorafenib monohydrate 是一种新型口服多激酶抑制剂，对VEGFR1/2/3、PDGFRβ、Kit、RET 和Raf-1的IC50分别为 13、4.2、46、22、7、1.5 和 2.5 nM。
T6091	CP-673451	VEGFR; PDGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	CP673451 是选择性的血小板源生长因子受体 (PDGFR) 抑制剂，能够抑制 PDGFRα (IC50:10 nM) 和 PDGFRβ (IC50:1 nM) 的活性。
T6711	Tyrphostin AG1296 Tyrphostin AG 1296,AG 1296	Apoptosis; FGFR; FLT; PDGFR; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Tyrphostin AG1296 (Tyrphostin AG 1296) 抑制人PDGF α和β受体以及相关干细胞因子受体的信号传导，是一种选择性血小板衍生生长因子受体抑制剂，IC50值为 0.8 μM。
T3463	NVP-ACC789 ACC-789,ZK202650	VEGFR; PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	NVP-ACC789 (ZK202650) 是一种人VEGFR-1，VEGFR-2(鼠VEGFR-2)，VEGFR-3 和 PDGFR-β 的抑制剂，它们的 IC50 值分别为 0.38，0.02 (0.23)，0.18 和 1.4 μM。
T3211	Midostaurin 米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱	Others; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Others
	Midostaurin (PKC412) 是一种多靶点蛋白激酶抑制剂，有抗肿瘤活性，对 PKCα/β/γ、Syk、Flk-1、Akt、PKA、c-Kit、c-Fgr、c-Src、FLT3、PDFRβ和VEGFR1/2的IC50值范围为 22 到500 nM 之间。
T71576	SIM010603
	SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor. SIM010603 inhibited stem cell factor receptor (Kit), vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor-β (PDGFR-β), glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), and Fms-like tyrosine kinase-3 (FLT3) with IC(50) values between 5.0 and 68.1 nmol/l. SIM010603 inhibited the phosphorylation of PDGFR-β and VEGFR-2. Mor...
T23660	AG1433 Tyrphostin AG-1433,Tyrphostin AG1433,AG-1433,Tyrphostin AG 1433,AG 1433
	AG1433 is a tyrosine kinases inhibitor that acts as a direct and selective inhibitor of photosynthetic PEP carboxylase and an inhibitor of PDGFR-β, Flk-1, and angiogenesis.
T71897	Vatalanib succinate
	Vatalanib succinate is a VEGFR, PDGFR-β, c-Kit, c-Fms, and aromatase inhibitor.
T79530	SA-PA	PROTACs	PROTAC
	SA-PA是一种细胞内自组装PROTAC，以叠氮化物和炔烃为基础。它在U87细胞中可选择性降解VEGFR-2、PDGFR-β和EphB4蛋白，并可利用肿瘤组织中的内源性铜通过点击化学反应转化为PROTAC。
T28874	SU11652 SU-11652,SU 11652
	SU11652 is a potent cell-permeable pyrrole-indolinone compound. SU11652 acts as an ATP-competitive tyrosine kinase receptor and angiogenic inhibitor with greater selectivity for PDGFR-β (PDGFRβ, IC50 = 3 nM), Flk-1 (VEGFR2, IC50 = 27 nM), FGFR1 (IC50= 170
TMIH-0393	Nintedanib-13C-d3
	Nintedanib-13C-d3 是 Nintedanib 的 13C 和氘代化合物。Nintedanib 的 CAS 号为 656247-17-5。Nintedanib 是一种有效的三重血管激酶抑制剂，能够抑制VEGFR1 (IC50:34 nM)、VEGFR2 (IC50:13 nM)、VEGFR3 (IC50:13 nM)，FGFR1 (IC50:69 nM)、FGFR2 (IC50:37 nM)、FGFR3 (IC50:108 nM)，PDGFRα (IC50:59 nM)、PDGFRβ (IC50:65 nM)。
T29542	AC708 AC 708,AC-708
	AC708 is a small molecule CSF1R inhibitor that effectively inhibits CSF1R phosphorylation mediated by CSF-1 (IC50 = 26 nM) and IL-34 (IC50 = 33 nM). It also inhibited the activity of growth factor-dependent cells cultured in CSF-1 (IC50 = 38 nM) or IL-34
T67442	CGP-53716
	The growth factors, platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) play major roles in enhanced smooth muscle cells growth in rodent blood vessels after vascular injury. Tyrosine kinase inhibition has been shown to be effective in blocking tyrosine phosphorylation at the PDGF and bFGF receptors in cultured fibroblast and vascular smooth muscle cells which in turn inhibits their proliferation[1]. CGP 53716 is a specific PDGFR tyrosine kinase inhibitor on SMC (smoo...

化合物

Cat.No: T23127

Synonym: PD 161570

Target: EGFR, FGFR, PDGFR, Src

Cat.No: T3476

Synonym: CGI-1842,JI 101

Target: VEGFR, PDGFR, Ephrin Receptor

Cat.No: T6036

Synonym: BMS-540215,布立尼布

Target: EGFR, VEGFR, FGFR, Autophagy

Cat.No: T15616

Synonym: 3-氟-N-(6,7-二甲氧基-2,4-二氢茚并[1,2-C〕吡唑-3-基苯基胺,JNJ-10198409

Target: PDGFR

Cat.No: T4349

Synonym: MG516,MGCD516

Target: Discoidin Domain Receptor (DDR), VEGFR, FLT, Trk receptor, TAM Receptor, c-Kit, Ephrin Receptor

Regorafenib monohydrate

Cat.No: T1792L

Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Autophagy

Cat.No: T6091

Target: VEGFR, PDGFR, c-Kit

Tyrphostin AG1296

Cat.No: T6711

Synonym: Tyrphostin AG 1296,AG 1296

Target: Apoptosis, FGFR, FLT, PDGFR, c-Kit

Cat.No: T3463

Synonym: ACC-789,ZK202650

Target: VEGFR, PDGFR

Cat.No: T3211

Synonym: 米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱

Target: Others, PKC

Cat.No: T71576

Cat.No: T23660

Synonym: Tyrphostin AG-1433,Tyrphostin AG1433,AG-1433,Tyrphostin AG 1433,AG 1433

Vatalanib succinate

Cat.No: T71897

Cat.No: T79530

Target: PROTACs

Cat.No: T28874

Synonym: SU-11652,SU 11652

Nintedanib-13C-d3

Cat.No: TMIH-0393

Cat.No: T29542

Synonym: AC 708,AC-708

Cat.No: T67442

Cat. No.	Product Name	Target	Signaling Pathways
T2734	Sennoside B 番泻苷 B,番泻苷B	PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Sennoside B 是在番泻叶的叶子和豆荚中大量发现的蒽醌苷。它可通过与 PDGF-BB 及其受体结合并下调 PDGFR-β 信号传导途径来抑制 PDGF 刺激的细胞增殖。

天然产物

Cat.No: T2734

Synonym: 番泻苷 B,番泻苷B

Target: PDGFR

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00481	PDGF R beta/CD140b Protein, Cynomolgus, Recombinant (His) PDGF R beta,PDGFRB,PDGFR-2,PDGF-R-β	Cynomolgus	HEK293 Cells
	Platelet-derived growth factor receptor (PDGFR) signaling is involved in proliferation and survival in a wide array of cell types.PDGFR-β signalling, via TGF-β signalling, may be crucial for restoration of BBB integrity after cerebral ischemia and therefore represents a novel potential therapeutic target.
TMPK-00422	PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi), Biotinylated PDGFR-2,PDGF R β/CD140b,PDGFR1,CD...	Human	HEK293 Cells
	PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 59 kDa and the accession number is P09619.
TMPK-00421	PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi) PDGFR1,CD140B,PDGFR-2,PDGF R β/CD...	Human	HEK293 Cells
	PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 59 kDa and the accession number is P09619.
TMPK-01050	PDGF R beta/CD140b Protein, Canine, Recombinant (His) JTK12,PDGF R β,PDGFR-β,PDGFR<...	Canine	HEK293 Cells
	PDGF R beta/CD140b Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 57.25 kDa and the accession number is Q6QNF3.
TMPY-05497	PDGFRB Protein, Human, Recombinant (hFc) PDGFR,CD140B,PENTT,JTK12,KOGS,platelet-derived grow...	Human	HEK293 Cells
	PDGFRB Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82.8 kDa and the accession number is P09619-1.
TMPY-04937	PDGFRB Protein, Human, Recombinant (His), Biotinylated platelet-derived growth factor receptor, beta polypeptide,CD...	Human	HEK293 Cells
	PDGFRB Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.6 kDa and the accession number is P09619-1.
TMPY-01207	PDGFRB Protein, Human, Recombinant (His) CD140B,IMF1,KOGS,PDGFR,PDGFR-1,platelet-de...	Human	HEK293 Cells
	PDGFRB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.6 kDa and the accession number is P09619-1.
TMPY-05358	PDGFRB Protein, Human, Recombinant PENTT,platelet-derived growth factor receptor, beta polypept...	Human	HEK293 Cells
	PDGFRB Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 56.2 kDa and the accession number is P09619-1.
TMPK-01178	PDGFD Protein, Cynomolgus, Recombinant (His) IEGF,SCDGFB,PDGF-D,SCDGF-B	Cynomolgus	HEK293 Cells
	Platelet‑derived growth factor D (PDGF‑D) is a new member of the PDGF family that binds the PDGFR‑β homodimer. PDGF‑D promotes the angiogenic capacity of EPCs, including proliferation, migration, adhesion and tube formation, and thereby contributes to angiogenesis.

重组蛋白

PDGF R beta/CD140b Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00481

Species: Cynomolgus

Expression System: HEK293 Cells

PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00422

Species: Human

Expression System: HEK293 Cells

PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00421

Species: Human

Expression System: HEK293 Cells

PDGF R beta/CD140b Protein, Canine, Recombinant (His)

Cat.No: TMPK-01050

Species: Canine

Expression System: HEK293 Cells

PDGFRB Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05497

Species: Human

Expression System: HEK293 Cells

PDGFRB Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-04937

Species: Human

Expression System: HEK293 Cells

PDGFRB Protein, Human, Recombinant (His)

Cat.No: TMPY-01207

Species: Human

Expression System: HEK293 Cells

PDGFRB Protein, Human, Recombinant

Cat.No: TMPY-05358

Species: Human

Expression System: HEK293 Cells

PDGFD Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01178

Species: Cynomolgus

Expression System: HEK293 Cells

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