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Search Results for " pca "

29

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T13210	Trombodipine PCA-4230	Others	Others
	Trombodipine is an agent of antithrombotic.
T68644	Pca 4233
	Pca 4233 belongs to a class of selective PAF-receptor antagonists.
T33356	Methylsilanol PCA
	Methylsilanol PCA is a bioactive chemical.
T23123	PCA 4248	Others	Others
	PAF antagonist
T33060	Lysine PCA
	Lysine PCA is a bioactive chemical.
TP1037	D-Lys(Z)-Pro-Arg-pNA diacetate Spectrozyme PCa,Chromozym Pca diacetate
	D-Lys(Z)-Pro-Arg-pNA (diacetate) diacetate is a chromogenic substrate.
TP1196	D-Lys(Z)-Pro-Arg-pNA Chromozym Pca
	D-Lys(Z)-Pro-Arg-pNA is a luminescent substrate of activated protein C (APC).
T9593	Senaparib IMP4297	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Senaparib (IMP4297) 是一种选择性和口服有效的PARP1/2抑制剂，具有强效的抗肿瘤活性。
T3160	HUHS015	Others	Others
	HUHS015 是高效的PCA-1/ALKBH3抑制剂。它对 PCA-1 作用的IC50值为 0.67 μM。
T13812	PCA50941	Others	Others
	PCA50941 is a 1,4-dihydropyridine derivative, treatment for cardiovascular disease.
T0860L	Mefloquine Ro215998,WR 142490,Ro-215998,氟甲喹羟哌啶,Lariam,Ro 215998	Others	Others
	Mefloquine (Ro 215998) 是一种喹啉抗疟药，是一种抗 SARS-CoV-2 进入抑制剂。 Mefloquine 也是一种 K+ 通道 (KvQT1/minK) 拮抗剂，IC50 为 ~1 μM。它可用于疟疾、系统性红斑狼疮和癌症研究。
T21653	1,4-DPCA	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	1,4-DPCA 是一种脯氨酰羟化酶抑制剂，对人源包皮成纤维细胞中胶原羟基化的 IC50 为 2.4 μM，对因子抑制 HIF (FIH) 的 IC50 为 60 μM。
T3049	TPCA-1 GW683965,IKK2 Inhibitor IV,TPCA1	Apoptosis; IκB/IKK; STAT	Apoptosis; JAK/STAT signaling; NF-κB; Stem Cells
	TPCA-1 (TPCA1) 是一种选择性IKK-2抑制剂，IC50值为 17.9 nM。它也是反式激活、DNA 结合以及STAT3磷酸化的一种抑制剂。
T60452	PCAF-IN-2
	PCAF-IN-2 (compound 17) 是一种有效的 PCAF 抑制剂(IC50 = 5.31 µM)。PCAF-IN-2 具有抗肿瘤活性。PCAF-IN-2 诱导细胞凋亡并且阻滞细胞周期在 G2/M 期。
T80282	cPcAMP1/26
	cPcAMP1/26 是一款抗菌肽，能高效清除A.Hydrophila及金黄色葡萄球菌 (S. aureus)。该化合物通过诱导细菌质膜去极化作用并提升细胞内ROS水平，展示其抗菌机制。
T24146	HOCPCA
	HOCPCA is an effective and selective ligand for the GHB binding sites that acts by binding with 27 times better affinity than GHB itself and crossing the blood-brain barrier in vitro and in vivo.
T60762	PCAF-IN-1
	PCAF-IN-1 是用于肿瘤治疗研究的抗肿瘤剂。PCAF-IN-1 是高度选择性的PCAF 抑制剂。
T36796	1,4-DPCA ethyl ester
	1,4-DPCA ethyl ester, the ethyl ester derivative of 1,4-DPCA, acts as an inhibitor of the enzyme factor inhibiting HIF (FIH)[1].
T77552	SLU-PP-1072	Apoptosis; Estrogen/progestogen Receptor	Apoptosis; Endocrinology/Hormones
	SLU-PP-1072 是一种 ERRα和ERRγ 反向双重激动剂，破坏 PCa 细胞代谢，通过细胞周期失调诱导凋亡 (apoptosis)。SLU-PP-1072 用于研究前列腺癌 (PCa) 。
T69564	YK-2-69
	YK-2-69 is a highly selective DYRK2 inhibitor which specifically interacts with Lys-231 and Lys-234 in the co-crystal structure. Especially, YK-2-69 exhibits more potent anti-PCa efficacy than the first-line drug enzalutamide in vivo.
T15594	MKC8866	IRE1	Cell Cycle/Checkpoint
	MKC8866 是一种选择性IRE1 RNase 抑制剂，在体外的IC50为 0.29 μM，是水杨醛类似物。它抑制乳腺癌细胞中的 IRE1 RNase，导致促肿瘤因子的产生减少，并且可以抑制前列腺癌 (PCa) 肿瘤的生长。它强烈抑制二硫苏糖醇诱导的 XBP1s 表达，EC50为 0.52 μM。
T11581	HSR6071	Others	Others
	HSR6071 是一种新型具有口服活性和有效性的抗过敏制剂，能抑制被动皮肤过敏反应 (PCA)。HSR6071 在大鼠实验性哮喘模型中显示出抗哮喘活性。
T40687	1,1,1,3,10,11-Hexachloroundecane
	1,1,1,3,10,11-Hexachloroundecane is a polychlorinated alkane (PCA) characterized by a lengthy carbon chain.
T26832	BKM1740 BKM-1740,BKM 1740
	BKM1740 induced apoptosis in prostate cancer (PCa) cells by repressing survivin at both the mRNA and protein levels in vitro.
T26831	BKM1644 BKM 1644,BKM-1644
	BKM1644 is an effective inhibition of the proliferation of metastatic, castration-resistant PCa (mCRPC) cells.
T78153	PSMA I&T	Others	Others
	PSMAI&T为高效的前列腺特异性膜抗原(PSMA)抑制剂，适用于前列腺癌(PCa)的单光子发射计算机断层扫描(SPECT)/计算机断层扫描(CT)显像及放射性核素研究。
T41175	OB 24 hydrochloride
	OB 24 hydrochloride is a potent and selective heme oxygenase 1 (HO-1) inhibitor (IC50 values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in advanced prostate cancer cells (PCA). Inhibits cell proliferationin vitroand PCA tumor growth and lymph node/lung metastasesin vivo. Synergizes with Taxol.
T38127	pNPS-DHA
	pNPS-DHA is an arylamide derivative of docosahexaenoyl ethanolamide that has anti-allergic activity.1It inhibits degranulation of RBL-2H3 mast cells (IC50= 15 μM).pNPS-DHA (1,000 mg/kg) inhibits IgE-dependent passive cutaneous anaphylaxis (PCA) in mice. 1.Kim, I.-H., Kanayama, Y., Nishiwaki, H., et al.Structure-activity relationships of fish oil derivatives with anti-allergic activity in vitro and in vivoJ. Med. Chem.62(21)9576-9592(2019)
T79674	HDAC-IN-64	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC-IN-64 (Compound 13) 为HDAC抑制剂，对HDAC4/6的IC50值为24 nM及85 nM。其对前列腺癌（PCA）细胞表现出抗增殖与抗迁移效果，并能抑制LNCaP和RWPE-1细胞的生长，GI50值分别达到0.32 μM与1.1 μM。

化合物

Cat.No: T13210

Synonym: PCA-4230

Target: Others

Cat.No: T68644

Methylsilanol PCA

Cat.No: T33356

Cat.No: T23123

Target: Others

Cat.No: T33060

D-Lys(Z)-Pro-Arg-pNA diacetate

Cat.No: TP1037

Synonym: Spectrozyme PCa,Chromozym Pca diacetate

D-Lys(Z)-Pro-Arg-pNA

Cat.No: TP1196

Synonym: Chromozym Pca

Cat.No: T9593

Synonym: IMP4297

Target: PARP

Cat.No: T3160

Target: Others

Cat.No: T13812

Target: Others

Cat.No: T0860L

Synonym: Ro215998,WR 142490,Ro-215998,氟甲喹羟哌啶,Lariam,Ro 215998

Target: Others

Cat.No: T21653

Target: HIF/HIF Prolyl-Hydroxylase

Cat.No: T3049

Synonym: GW683965,IKK2 Inhibitor IV,TPCA1

Target: Apoptosis, IκB/IKK, STAT

Cat.No: T60452

Cat.No: T80282

Cat.No: T24146

Cat.No: T60762

1,4-DPCA ethyl ester

Cat.No: T36796

Cat.No: T77552

Target: Apoptosis, Estrogen/progestogen Receptor

Cat.No: T69564

Cat.No: T15594

Target: IRE1

Cat.No: T11581

Target: Others

1,1,1,3,10,11-Hexachloroundecane

Cat.No: T40687

Cat.No: T26832

Synonym: BKM-1740,BKM 1740

Cat.No: T26831

Synonym: BKM 1644,BKM-1644

Cat.No: T78153

Target: Others

OB 24 hydrochloride

Cat.No: T41175

Cat.No: T38127

Cat.No: T79674

Target: HDAC

Cat. No.	Product Name	Target	Signaling Pathways
T3324	Lycorine Galanthidine,Narcissine,石蒜碱,Amarylline,Belamarine,Licorine,番石榴碱	Apoptosis; Virus Protease; Antibacterial; AChR; Fatty Acid Synthase	Apoptosis; Metabolism; Microbiology/Virology; Neuroscience
	Lycorine (Narcissine) 是从金眼科植物科中提取的一种天然生物碱。它是一种具有口服活性的SCAP 抑制剂，Kd 值 15.24 nM。它也是黑色素瘤血管生成抑制剂，有用于前列腺癌和代谢疾病的研究潜力。
T4814	(R)-5-Oxopyrrolidine-2-carboxylic acid D-Pyroglutamic acid,(R)-(+)-2-Pyrrolidone-5-carboxylic acid,D-焦谷氨酸	Others; Endogenous Metabolite	Metabolism; Others
	(R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) 是内源性代谢产物的一种。
TN1805	Isosilybin B	Apoptosis; Androgen Receptor	Apoptosis; Endocrinology/Hormones
	Isosilybin B 是一种从水飞蓟中提取的黄酮木脂素，具有抗前列腺癌 (PCA) 活性，对癌细胞增殖有抑制作用，促使 G1 期阻滞和凋亡。Isosilybin B 诱导雄激素受体降解。
TN1804	Isosilybin A 异水飞蓟素 A,异水飞蓟宾A,水飞蓟素 B2	Apoptosis; Tyrosinase; PPAR; ABC	Apoptosis; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Proteases/Proteasome
	Isosilybin A 是从水飞蓟中分离出来的一种黄酮木脂素，可抑制癌细胞增殖并诱导 G1 期停滞和凋亡，通过靶向 Akt-NF-κB-雄激素受体轴激活前列腺癌细胞的凋亡机制，具有抗前列腺癌活性。
T4716	Pyrrole-2-carboxylic acid 吡咯-2-羧酸,2-Pyrrolecarboxylic acid,Minaline	Endogenous Metabolite	Metabolism
	Pyrrole-2-carboxylic acid (Minaline) 是一种天然生物碱类，从海洋细菌Pelomonas puraquaesp. Nov 中分离得到。
TN2155	Rhodiocyanoside A	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Rhodiocyanoside A has antiallergic activity, it exhibits inhibitory activity on the histamine release from rat peritoneal exudate cells sensitized with anti-DNP IgE and inhibits the PCA reaction in rats.
T82248	Gymnoside I
	Gymnoside I（化合物1）是糖苷氧基苄基2-异丁基苹果酸，其在小鼠被动皮肤过敏反应（PCA）实验中展现出抗过敏效能。该化合物有望在哮喘、神经衰弱和慢性肝炎治疗研究中应用。

天然产物

Cat.No: T3324

Synonym: Galanthidine,Narcissine,石蒜碱,Amarylline,Belamarine,Licorine,番石榴碱

Target: Apoptosis, Virus Protease, Antibacterial, AChR, Fatty Acid Synthase

(R)-5-Oxopyrrolidine-2-carboxylic acid

Cat.No: T4814

Synonym: D-Pyroglutamic acid,(R)-(+)-2-Pyrrolidone-5-carboxylic acid,D-焦谷氨酸

Target: Others, Endogenous Metabolite

Cat.No: TN1805

Target: Apoptosis, Androgen Receptor

Cat.No: TN1804

Synonym: 异水飞蓟素 A,异水飞蓟宾A,水飞蓟素 B2

Target: Apoptosis, Tyrosinase, PPAR, ABC

Pyrrole-2-carboxylic acid

Cat.No: T4716

Synonym: 吡咯-2-羧酸,2-Pyrrolecarboxylic acid,Minaline

Target: Endogenous Metabolite

Rhodiocyanoside A

Cat.No: TN2155

Target: Histamine Receptor

Cat.No: T82248

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