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Search Results for " p11 "

28

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1879L1	P11 acetate	Integrin	Cytoskeletal Signaling
	P11 acetate 是一种整合素 αvβ3-玻连蛋白相互作用拮抗剂 (IC50 = 2.74 nM)。
TP2326L	Oligopeptide P11-4 acetate Oligopeptide P11-4 acetate(593266-60-5 free base)	Others	Others
	Oligopeptide P11-4 acetate(593266-60-5 free base) 是一种肽。
T34081	Piromelatine NEU-P-11,NEU-P 11,NEU-P11	P2X Receptor; 5-HT Receptor; MT Receptor; Sodium Channel; TRP/TRPV Channel	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Piromelatine 是褪黑激素 MT1/MT2 受体、5-HT1A 和 5-HT1D 的激动剂，也是 5-HT2B 的拮抗剂。Piromelatine 具有抗痛觉活性，对 P2X3、TRPV1 和 Nav1.7 通道有抑制作用，可用于促进睡眠、缓解疼痛、抗神经退行性疾病和抗抑郁疾病的研究。
TP1879	HSDVHK-NH2 P11
	Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.
T24586	PAFAH1b2 PAFAH-1-b-2,3-IN-P11,3INP11,3 IN P11,PAFAH 1 b 2
	PAFAH1b2 is a selective platelet-activating factor acetylhydrolases 1b2 and 1b3 inhibitor that acts by impairing cancer cell survival.
T10922	CYP11B2-IN-1	P450	Metabolism
	CYP11B2-IN-1 是一种有效的选择性 CYP11B2 抑制剂，对 CYP11B2 和 CYP11B1 的 IC50 分别为 2.3 nM 和 142 nM。
T9596	AP1189 acetate	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	AP1189 acetate 是黑皮质素 1 和黑皮质素 3 受体的偏向激动剂。
T16422	P110δ-IN-1 PWT-143	PI3K	PI3K/Akt/mTOR signaling
	P110δ-IN-1 (PWT-143) 是一种有效的、选择性的P110δ抑制剂，其 IC50=8.4 nM。
T3969	I-CBP112	Epigenetic Reader Domain; Histone Acetyltransferase	Chromatin/Epigenetic
	I-CBP112 是一种特异性的乙酰赖氨酸竞争性蛋白质-蛋白质相互作用抑制剂，靶向 CBP/p300 溴结构域，增强 p300 的乙酰化作用。
T4472	NMS-P118	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	NMS-P118是可口服的高选择性PARP-1抑制剂，用于癌症治疗，在HeLa 细胞中的IC50值为0.04 μM。
T7334	NP118809 39-1B4,1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	NP118809 (39-1B4) 是 N 型钙通道阻滞剂，IC50值为 0.11 μM。它较弱地抑制 L 型钙通道，IC50值为 12.2 μM。
T24437	MCP110 MCP-110,MCP 110	Raf; Ras	GPCR/G Protein; MAPK
	MCP110 是 Ras 与 Raf-1 相互作用的抑制剂，可用于治疗人类肿瘤的研究。
T4247	I-CBP112 hydrochloride	Epigenetic Reader Domain	Chromatin/Epigenetic
	I-CBP112 hydrochloride 是含溴结构域转录因子的选择性抑制剂，靶向 CBP/p300 溴结构域。在体内外，它以剂量依赖性方式显着降低 MLL-AF9(+) 急性髓细胞白血病细胞的白血病起始潜力，还增加 BET 溴结构域抑制剂 JQ1 以及阿霉素的细胞毒活性。
TP1947L	P110 TFA	Others	Others
	P110 TFA 是一种 dynamin-related protein 1 (Drp1) 抑制剂，抑制 Drp1 GTPase 活性。
T64249	CYP11B1-IN-2
	CYP11B1-IN-2 (compound 7aa) 是一种选择性的、口服具有活力的 CYP11B1 抑制剂，能够作用于 human CYP11B1 (IC50: 9 nM) 和 rat CYP11B1 (IC50: 25 nM)。CYP11B1-IN-2 能够用于研究皮质醇过量所致疾病。
T15783	LP117	Others	Others
	LP117 is a novel and effective inhibitor of 5-Lipoxygenase (5-LO) product synthesis (IC50: 1.1 μM).
T61329	HP1142
	HP1142 is a highly effective and specific inhibitor targeting the FLT3 receptor tyrosine kinase, with a particular affinity for its mutant variant FLT3/ITD. It exhibits a benzoimidazole scaffold-based structure, making it a promising compound for investigating and studying the FLT3/ITD mutation in the context of leukemia research [1].
T40850	[D-Trp11]-Neurotensin [D-Trp11]-Neurotensin
	[D-Trp11]-Neurotensin is a compound that functions as a selective antagonist of Neurotensin (NT) in perfused rat hearts, while exhibiting full agonist properties in guinea pig atria and rat stomach strips. Additionally, this compound can inhibit hypotension induced by NT.
T78204	CYP11A1-IN-1
	CYP11A1-IN-1（化合物30）是一种针对CYP11A1的抑制剂，其IC50为201-2000 nM。该化合物主要应用于类固醇受体研究，尤其适用于雄激素受体依赖性疾病，例如前列腺癌的研究。
T72397	PARP11 inhibitor ITK7 ITK7
	PARP11 inhibitor ITK7 (ITK7) 为高效选择性的PARP11抑制剂，IC50为14 nM，主要用于针对PARP11的细胞定位研究。
T78033	SDP116
	SDP116为合成的GPR116 Stachel肽衍生物，具备ADGRF5激动剂功能。
T80291	PP113
	PP113是一种具有广谱抗菌性的抗菌肽，能有效作用于多种革兰氏阴性及革兰氏阳性细菌。对E.coli (MIC: 73.3 uM)、B. subtilis (MIC: 23.3 uM)、S. aureus (MIC: 13 uM)、S. lutea (MIC: 16.7 uM)及B. pumilus (MIC: 23.3 uM)表现出不同程度的最小抑菌浓度(MIC)。
T68254	WP1193
	WP1193 is an inhibitor of the JAK2/STAT3 pathway.
T38005	P11149
	P11149 is a competitive, BBB-penetarated weakly, orally active and selective inhibitor of AChE. P11149 exhibits an IC50 of 1.3 μM for rat BChE/AChE. P11149, a Galanthamine derivative, demonstrates central cholinergic activity, behavioral efficacy and safety. P11149 is used in the study for Alzheimer’s disease[1]. P11149 is a GAL analog that is rapidly hydrolyzed in vivo to yield the potent AChE inhibitor, 6-DMG[1].P11149 exhibits greater s.c. bioavailability than p.o. [1].Oral P11149 in mice pr...
TP1947	P110
	Dynamin-related protein 1 (Drp1) inhibitor, inhibits Drp1 GTPase activity. Displays no effect on dynamin 1 or other mitochondrial dynamics-related proteins. Inhibits mitochondrial fission, dysfunction and reactive oxygen species (ROS) production in vitro.
T10387	ASP1126	Others	Others
	ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist (EC50s: 7.12 nM, 517 nM for hS1P1 and hS1P3).
T14940	CGP11952	Others	Others
	CGP11952 is same the benzodiazepines in its pharmacological action and it also is an experimental benzodiazepine derivative.
T23491	UBP1112	Others	Others
	group III mGlu receptor antagonist

化合物

Cat.No: TP1879L1

Target: Integrin

Oligopeptide P11-4 acetate

Cat.No: TP2326L

Synonym: Oligopeptide P11-4 acetate(593266-60-5 free base)

Target: Others

Cat.No: T34081

Synonym: NEU-P-11,NEU-P 11,NEU-P11

Target: P2X Receptor, 5-HT Receptor, MT Receptor, Sodium Channel, TRP/TRPV Channel

Cat.No: TP1879

Synonym: P11

Cat.No: T24586

Synonym: PAFAH-1-b-2,3-IN-P11,3INP11,3 IN P11,PAFAH 1 b 2

Cat.No: T10922

Target: P450

Cat.No: T9596

Target: Melanocortin Receptor

Cat.No: T16422

Synonym: PWT-143

Target: PI3K

Cat.No: T3969

Target: Epigenetic Reader Domain, Histone Acetyltransferase

Cat.No: T4472

Target: PARP

Cat.No: T7334

Synonym: 39-1B4,1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮

Target: Calcium Channel

Cat.No: T24437

Synonym: MCP-110,MCP 110

Target: Raf, Ras

I-CBP112 hydrochloride

Cat.No: T4247

Target: Epigenetic Reader Domain

Cat.No: TP1947L

Target: Others

Cat.No: T64249

Cat.No: T15783

Target: Others

Cat.No: T61329

[D-Trp11]-Neurotensin

Cat.No: T40850

Synonym: [D-Trp11]-Neurotensin

Cat.No: T78204

PARP11 inhibitor ITK7

Cat.No: T72397

Synonym: ITK7

Cat.No: T78033

Cat.No: T80291

Cat.No: T68254

Cat.No: T38005

Cat.No: TP1947

Cat.No: T10387

Target: Others

Cat.No: T14940

Target: Others

Cat.No: T23491

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T19328	Fructo-oligosaccharide DP11/GF10	Others	Others
	Fructo-oligosaccharide DP11/GF10 is a fructooligosaccharide (FOS) compound with a degree of polymerization (DP) equal to 11. FOS consists of 10 fructose units connected by (2→1)-β-glycosidic bonds, with a single D-glucosyl unit present at the non-reducing end.

天然产物

Fructo-oligosaccharide DP11/GF10

Cat.No: T19328

Target: Others

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