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Search Results for " ntri "

Targets Recommended: Others Parasite Autophagy

32

抑制剂 & 化合物

9

天然产物

5

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T3266	Lumefantrine Benflumetol,dl-Benflumelol,苯芴醇	Others; Parasite; Autophagy	Autophagy; Microbiology/Virology; Others
	Lumefantrine (dl-Benflumelol) 是一种抗疟药，用于治疗急性单纯性疟疾。与Artemether 联用，可提高疗效。
T16809	Rupintrivir AG-7088,AG7088,Rupintrivirvr	Virus Protease; Antiviral	Immunology/Inflammation; Microbiology/Virology
	Rupintrivirvr (AG7088) 是一种选择性鼻病毒 (HRV) 3C 半胱氨酸蛋白酶的拟肽抑制剂，具有抗病毒活性和免疫调节活性。Rupintrivirvr 抑制 EV71 和 EV-D68 复制，可用于研究病毒感染。
T14927	Centrinone LCR-263	PLK; Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	Centrinone (LCR-263) 是 polo 样激酶 4 的可逆抑制剂，对PLK4的Ki 值为0.16 nM。
T8515	Osoresnontrine BI-409306	PDE	Metabolism
	Osoresnontrine (BI-409306) 是选择性的PDE9A 抑制剂，IC50=52 nM，对其他 PDE 的活性较弱。它可用于中枢神经系统障碍疾病中提高记忆力的研究。
T71691	Pumafentrine BY 343	PDE	Metabolism
	Pumafentrine（BY 343）是 PDE3/PDE4双重抑制剂，可降低小鼠实验性结肠炎的临床评分和 TNF 表达。
T61833	Tovinontrine IMR-687	PDE	Metabolism
	Tovinontrine (IMR-687) 是一种针对镰状细胞病治疗设计的强效且选择性的磷酸二酯酶-9 (PDE9) 抑制剂。其展现出高效能，对PDE9A1和PDE9A2的IC 50 值分别为8.19 nM和9.99 nM [1]。
T8333	Aurintricarboxylic acid ATA,NSC-4056,NSC4056,金精三羧酸,NSC 4056	Apoptosis; P2X Receptor; Influenza Virus; Topoisomerase	Apoptosis; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Aurintricarboxylic acid (NSC-4056) 是高效的αβ-亚甲基-ATP 敏感选择性P2X1Rs 和P2X3Rs 变构拮抗剂。它是核糖核酸酶和拓扑异构酶 II 的有效抑制剂，可阻止核酸与酶结合。
TN6963	Hentriacontane	NF-κB	NF-κB
	Hentriacontane 是一种天然产物，具有多种药理作用，包括抗炎、抗肿瘤和抗菌活性。
T11991	Mefentrifluconazole	P450; Antifungal	Metabolism; Microbiology/Virology
	Mefentrifluconazole 是一种有效的、选择性的和具有口服活性的真菌 CYP51 (Kd= 0.5 nM) 抑制剂，但对人芳香酶的抑制活性较低，IC50值为0.92 μM。它是一种新型唑类衍生物，用作农用广谱抗真菌剂。
T25376	Ensifentrine Ensifentrina,Ensifentrinum	PDE	Metabolism
	Ensifentrine (Ensifentrinum) 是首创的吸入式磷酸二酯酶 3 (PDE3) 和PDE4双重抑制剂，IC50分别为 0.4 nM 和 1479 nM。它具有支气管保护和抗炎作用，可用于研究慢性阻塞性肺疾病 (COPD) 。
T25101	Antrimycin Antrimycin A,Cirratiomycin B
	Antrimycin is an antibiotic.
T15460	Halofantrine hydrochloride WR-171669,SKF-102886	Others	Others
	Halofantrine hydrochloride is a blocker of delayed rectifier potassium current. Halofantrine hydrochloride also via the inhibition of the human-ether-a-go-go-related gene (HERG) channel and a potent antimalarial agent.
T33922	Pentrinitrol W-2197,W 2197,W2197
	Pentrinitrol is a biochemical.
T38899	Irsenontrine E2027,Irsenontrine
	Irsenontrine (E2027) is a selective and orally active inhibitor of phosphodiesterase 9 (PDE9), primarily used for researching neurological diseases.
T35062	Vintriptol Vintriptolum
	Vintriptol is a biochemical.
T39586	Cantrixil TRX-E-002-1
	Cantrixil (TRX-E-002-1) is a second-generation super-benzopyran (SBP) compound, derived from TRX-E-002. It elicits an increase in phosphorylated c-Jun levels, leading to caspase-mediated apoptosis in ovarian cancer cells. Cantrixil exhibits potent pan anti-cancer activity against various cancer phenotypes.
T39108	Irsenontrine maleate E2027 maleate
	Irsenontrine (E2027) maleate is a selective and orally active inhibitor of phosphodiesterase 9 (PDE9). It can be utilized in the study of neurological diseases.
T33603	Nb-enantride
	Nb-enantride is a novel chiral trialkylborohydride for the asymmetric reduction of ketones.
T63393	Halofantrine
	Halofantrine 是一种抗疟活性物质，具有高度亲脂性，并对 HERG 钾通道具有阻断作用，能够对抗耐 Chloroquine 的恶性疟原虫 Plasmodium falciparum。
T26767	Benafentrine dimaleate Benafentrine
	Benafentrine dimaleate is a platelet activating factor receptor (PAFR) antagonists and phosphodiesterase (PDE) 3/4 inhibitors.
T19275	Desbutyl Lumefantrine D9 Desbutyl-benflumetol D9	Others	Others
	Desbutyl Lumefantrine D9, a deuterium-labeled metabolite of Lumefantrine, exhibits the incorporation of deuterium atoms.
T29314	Lumefantrine Impurity A 2-(Dibutylamino)-2-(2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl)ethanol, (RS, Z)-
	2-(Dibutylamino)-2-(2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl)ethanol, (RS, Z)- is a bioactive chemical.
T69491	(E/Z)-Ensifentrine
	(E/Z)-Ensifentrine is a potent and selective PDE3/4 inhibitor. (E/Z)-Ensifentrine acts as a long-acting inhibitor of the phosphodiesterase enzymes PDE-3 and PDE-4, producing both bronchodilator and antiinflammatory effects. It is being developed by Verona Pharma as a potential treatment for asthma and hay fever, and is currently in clinical trials.
T61770	(R)-Irsenontrine
	(R)-Irsenontrine ((R)-E2027) 是Irsenontrine 的 R 型异构体，是一种有效的磷酸二酯酶 9 (PDE9) 抑制剂，抑制其IC50值为 0.041 μM。(R)-Irsenontrine 可用于神经系统疾病的研究。
T31745	Fantridone HCl Fantridone hydrochloride,AGN-616,AGN616,AGN 616
	Fantridone HCl is a biochemical.
T10999	Desbutyl Lumefantrine Desbutyl-benflumetol	Others	Others
	Desbutyl Lumefantrine is a metabolite of lumefantrine with antimalarial activity.
T69075	Dicentrine HCl
	Dicentrine HCl is the salt form of Dicentrine, an alpha 1-adrenoceptor antagonist effective against human hyperplastic prostates.
T33279	Meliantriol
	Meliantriol is an active compound in Azadirachta indica (Neem). It can bind to PBP2A and PVL toxin with the binding energies of -6.02 kcal/mol and -8.94 kcal/mol, respectively.
T11891	Lumefantrine-d18 Benflumetol D18,苯芴醇 D18,Lumefantrine D18	Others	Others
	Lumefantrine D18 is an antimalarial drug, and is the deuterium labeled Lumefantrine.
T25485	Halofantrine, (-)- L-WR-171669
	Halofantrine, (-)- is an antimalarial agent.
T26565	Adentri BG-9719,BG9719,BG 9719,CVT124,CVT-124,CVT 124
	Adentri is a novel antagonist of adenosine A1 receptor with unique diuretic activity.
T14926	Centrinone-B LCR-323	Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	Centrinone-B (LCR-323) is a potent and highly selective inhibitor of PLK4 (Ki: 0.59 nM).

化合物

Cat.No: T3266

Synonym: Benflumetol,dl-Benflumelol,苯芴醇

Target: Others, Parasite, Autophagy

Cat.No: T16809

Synonym: AG-7088,AG7088,Rupintrivirvr

Target: Virus Protease, Antiviral

Cat.No: T14927

Synonym: LCR-263

Target: PLK, Aurora Kinase

Cat.No: T8515

Synonym: BI-409306

Target: PDE

Cat.No: T71691

Synonym: BY 343

Target: PDE

Cat.No: T61833

Synonym: IMR-687

Target: PDE

Aurintricarboxylic acid

Cat.No: T8333

Synonym: ATA,NSC-4056,NSC4056,金精三羧酸,NSC 4056

Target: Apoptosis, P2X Receptor, Influenza Virus, Topoisomerase

Cat.No: TN6963

Target: NF-κB

Mefentrifluconazole

Cat.No: T11991

Target: P450, Antifungal

Cat.No: T25376

Synonym: Ensifentrina,Ensifentrinum

Target: PDE

Cat.No: T25101

Synonym: Antrimycin A,Cirratiomycin B

Halofantrine hydrochloride

Cat.No: T15460

Synonym: WR-171669,SKF-102886

Target: Others

Cat.No: T33922

Synonym: W-2197,W 2197,W2197

Cat.No: T38899

Synonym: E2027,Irsenontrine

Cat.No: T35062

Synonym: Vintriptolum

Cat.No: T39586

Synonym: TRX-E-002-1

Irsenontrine maleate

Cat.No: T39108

Synonym: E2027 maleate

Cat.No: T33603

Cat.No: T63393

Benafentrine dimaleate

Cat.No: T26767

Synonym: Benafentrine

Desbutyl Lumefantrine D9

Cat.No: T19275

Synonym: Desbutyl-benflumetol D9

Target: Others

Lumefantrine Impurity A

Cat.No: T29314

Synonym: 2-(Dibutylamino)-2-(2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl)ethanol, (RS, Z)-

(E/Z)-Ensifentrine

Cat.No: T69491

(R)-Irsenontrine

Cat.No: T61770

Cat.No: T31745

Synonym: Fantridone hydrochloride,AGN-616,AGN616,AGN 616

Desbutyl Lumefantrine

Cat.No: T10999

Synonym: Desbutyl-benflumetol

Target: Others

Cat.No: T69075

Cat.No: T33279

Lumefantrine-d18

Cat.No: T11891

Synonym: Benflumetol D18,苯芴醇 D18,Lumefantrine D18

Target: Others

Halofantrine, (-)-

Cat.No: T25485

Synonym: L-WR-171669

Cat.No: T26565

Synonym: BG-9719,BG9719,BG 9719,CVT124,CVT-124,CVT 124

Cat.No: T14926

Synonym: LCR-323

Target: Aurora Kinase

Cat. No.	Product Name	Target	Signaling Pathways
T20225	Dicentrine, (-)- L-Dicentrine,荷包牡丹碱,NSC 251699,NSC251699,NSC-251699	Others	Others
	Dicentrine, (-)- (NSC-251699) 是一种在几种植物物种中发现的非卟啉生物碱，在小鼠内脏痛的急性模型中显示出显著的镇痛活性。
TN3547	Bullatantriol	Antifection	Microbiology/Virology
	Bullatantriol has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts. It may have weak antibacterial activities.
TN5690	Carpinontriol A
	Carpinontriol A 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5690，CAS号为 473451-72-8。
TN1577	Dicentrine 荷苞牡丹碱,荷包牡丹碱	Others	Others
	Dicentrine, a selective α±(1)-adrenoceptor antagonist with potent antiarrhythmic and antihypertensive activities, it also has antinociception in different models of chemical pain.
TN3603	Carpinontriol B	IL Receptor; Antifection	Immunology/Inflammation; Microbiology/Virology
	Carpinontriol B has antimicrobial activity, it at 40 ug/disk caused the formation of zones of inhibition. It also has anti-inflammatory activity, it shows considerable inhibition on the production of nitric oxide and reduces the production of interleukin-6 in dose-dependent manner in RAW 264.7 cells.
TN3337	Acantrifoside E	Others	Others
	Acantrifoside E是一种天然产物，属于伞形科阿魏属，其产品编号为 TN3337，CAS号为 645414-25-1。Acantrifoside E可用作对照参考。
TN3336	Acantrifoic acid A	Others	Others
	Acantrifoic acid A is a natural product from Acanthopanax trifoliatus.
TN1559	Dehydrodicentrine	AChR	Neuroscience
	Dehydrodicentrine showed strong acetylcholinesterase (AChE) inhibitory effects with the IC50 value of 2.98 μM.
T11365	Ganodermanontriol	Others	Others
	Ganodermanontriol, a sterol derived from Ganoderma lucidum, showcases hepatoprotective activity and possesses anti-inflammatory properties in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells through the upregulation of HO-1 expression.

天然产物

Dicentrine, (-)-

Cat.No: T20225

Synonym: L-Dicentrine,荷包牡丹碱,NSC 251699,NSC251699,NSC-251699

Target: Others

Cat.No: TN3547

Target: Antifection

Carpinontriol A

Cat.No: TN5690

Cat.No: TN1577

Synonym: 荷苞牡丹碱,荷包牡丹碱

Target: Others

Carpinontriol B

Cat.No: TN3603

Target: IL Receptor, Antifection

Acantrifoside E

Cat.No: TN3337

Target: Others

Acantrifoic acid A

Cat.No: TN3336

Target: Others

Dehydrodicentrine

Cat.No: TN1559

Target: AChR

Ganodermanontriol

Cat.No: T11365

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00357	HNT/NTM Protein, Human, Recombinant (His) HNT,NTRI,IGLON2,neurotrimin	Human	HEK293
	NTM (Neurotrimin) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. IgLONs have been associated with psychiatric disorders, intelligence, body weight, heart disease, and tumors. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. Neurotrimin is a mem...
TMPY-00355	HNT/NTM Protein, Human, Recombinant (hFc) neurotrimin,NTRI,IGLON2,HNT	Human	HEK293
	NTM (Neurotrimin) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. IgLONs have been associated with psychiatric disorders, intelligence, body weight, heart disease, and tumors. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. Neurotrimin is a mem...
TMPY-03221	Intrinsic Factor Protein, Human, Recombinant (His) IF,IFMH,gastric intrinsic factor (vitamin B synthes...	Human	HEK293
	Gastric intrinsic factor, also known as GIF, belongs to the of the cobalamin transport protein family. It is a glycoprotein produced by the parietal cells of the stomach. Gastric intrinsic factor plays a key role in the absorption of vitamin B12 on in the small intestine. Vitamin B12 bounds to haptocorrin after entry into the stomach. The resulting complex enters the duodenum, where pancreatic enzymes digest haptocorrin. In the less acidic environment of the small intestine, B12 can then bind to...
TMPY-00530	Centrin 2 Protein, Human, Recombinant (His) CEN2,centrin, EF-hand protein, 2,CALT	Human	HEK293
	Centrin 2 Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 21.2 kDa. Accession number: P41208
TMPH-03145	Thanatin Protein, Podisus maculiventris, Recombinant (His & KSI)	Podisus maculiventris	E. coli
	Insect defense peptide with a broad spectrum of activity against Gram-positive and Gram-negative bacteria and fungi. No activity against S.aureus. Stops respiration in bacteria but does not permeabilize their inner membranes.

重组蛋白

HNT/NTM Protein, Human, Recombinant (His)

Cat.No: TMPY-00357

Species: Human

Expression System: HEK293

HNT/NTM Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00355

Species: Human

Expression System: HEK293

Intrinsic Factor Protein, Human, Recombinant (His)

Cat.No: TMPY-03221

Species: Human

Expression System: HEK293

Centrin 2 Protein, Human, Recombinant (His)

Cat.No: TMPY-00530

Species: Human

Expression System: HEK293

Thanatin Protein, Podisus maculiventris, Recombinant (His & KSI)

Cat.No: TMPH-03145

Species: Podisus maculiventris

Expression System: E. coli

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