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Targets Recommended: NPC1L1 Bradykinin Receptor

28

抑制剂 & 化合物

4

天然产物

10

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T21060L	NPC 567 acetate NPC 567 acetate(109333-26-8 Free base)	Bradykinin Receptor	GPCR/G Protein
	NPC 567 acetate 是一种缓激肽 B2 拮抗剂，可用于治疗过敏性气道疾病的研究。
T8638	NPC 15199 FMOC-L-Leucine,Fmoc-L-亮氨酸	Others	Others
	NPC 15199 (FMOC-L-Leucine) 是选择性的PPARγ调节剂。它对 PPARγ 的激活效果比罗格列酮低，但二者最大效应相似。它能够改善正常、饮食诱导的葡萄糖不耐受和糖尿病 db/db 小鼠的胰岛素敏感性，一定程度上能够诱导脂肪生成。
T33729	Npc 573 Npc-573,Npc573
	Npc 573 is a bioactive chemical.
T77407	Ensituximab NPC-1C,NEO-102,NEO-101
	Ensituximab (NEO-102) 是一种准对 MUC5AC 变体的选择性 IgG1 单克隆抗体，具有抗肿瘤活性，抑制结直肠癌和胰腺癌。
T70187	NPC-18915
	NPC-18915 is a benzofuran compound, inhibitor of neutophil activation.
T71024	NPC-16731
	NPC-16731 is a Bradykinin antagonist.
T71323	Npc 12626
	Npc 12626 is a N-methyl-D-aspartate receptor antagonist; NPC 17742, the (2R,4R,5S)-isomer, is the most potent isomer in the mixture NPC 12626.
T37480	NPC-15437 (hydrochloride)
	NPC-15437 (盐酸盐) 是一种 PKC 的选择性抑制剂，与酶的调节域相互作用。
T21060	NPC 567
	NPC 567 is an antagonist of the bradykinin receptor.
T18105	m-PEG-NPC (MW 20000)	Others	Others
	m-PEG-NPC (MW 20000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T19553	RPR132595A NPC	Others	Others
	RPR132595A is an active CPT-11 metabolite, it is generated by cytochrome P-450 3A4 (CYP3A4).
T78069	RPR132595A hydrochloride NPC hydrochloride	Drug Metabolite	Metabolism
	RPR132595A (NPC) hydrochloride，CPT-11的活性代谢产物，由细胞色素P-450 3A4 (CYP3A4) 催化产生，经尿液排出体外。
T71321	(S)-VU0637120	Others	Others
	(S)-VU0637120 是一种选择性的神经肽 Y（4）R变构拮抗剂，可用于研究代谢疾病。
T70590	NPC-14695
	NPC-14695 is a smooth muscle-selective muscarinic antagonist with bronchodilating activity.
T70574	NPC 17761
	NPC 17761 is a bradykinin receptor antagonist.
T70576	NPC 17731
	NPC 17731 is a bradykinin receptor antagonist.
T70588	Tazemetostat HCl
	Tazemetostat HCl is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Treatment of xenograft-bearing mice with EPZ-6438 leads to dose-dependent regression of MRTs with correlative diminution of intratumoral trimethylation levels of lysine 27 on histone H3, and prevention of tumor regrowth after dosing cessation. These data demonstrate the dependency of SMARCB1...
T70186	Methazolamide-d6
	Methazolamide-d6 is intended for use as an internal standard for the quantification of methazolamide by GC- or LC-MS. Methazolamide is a carbonic anhydrase inhibitor. It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED50 value of 19.2 mg/kg. It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and re...
T70572	CHF-2060
	CHF-2060 is a novel acetylcholinesterase inhibitor.
T71023	MI-888 free base
	MI-888 is a potent MDM2 inhibitor (Ki = 0.44 nM) with a superior pharmacokinetic profile and enhanced in vivo efficacy. MI-888 is capable of achieving rapid, complete, and durable tumor regression in two types of xenograft models of human cancer with oral administration and represents the most potent and efficacious MDM2 inhibitor reported to date.
T2008	LY294002 LY 294002,NSC 697286,SF 1101	Apoptosis; DNA-PK; Casein Kinase; PI3K; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	LY294002 (SF 1101) 是一种 PI3K 的广谱抑制剂，抑制 PI3Kα、PI3Kδ 和 PI3Kβ (IC50=0.5/0.57/0.97 μM)。LY294002 也是 DNA-PK 抑制剂 (IC50=1.4 μM) 和 CK2 抑制剂 (IC50=98 nM)。LY294002 可以激活凋亡和自噬。
T4079	LY-294002 hydrochloride SF 1101,LY 294002,NSC 697286	PI3K	PI3K/Akt/mTOR signaling
	LY-294002 hydrochloride (NSC 697286) 是一种合成的 PI3Kα/δ/β 分子抑制剂（IC50：0.5/0.57/0.97 μM，在无细胞试验中）；在溶液中比 Wortmannin 更稳定，也是自噬体形成的阻断剂。
TP1847	GLGPNPCRKKCYKRDFLGR
	GLGPNPCRKKCYKRDFLGR is a synthetic peptide.
TP1781	Nuclear pore complex protein Nup98 315-360
	Nuclear pore complex protein Nup98 (315-360) is the 315-360 fragment part of the nuclear pore complex (NPC) protein.
T83667	A11 TFA CPP-EYVQTVKSSKG
	A11是一种细胞穿透肽，由HIV-1 Tat蛋白质转导域与对应于脂联素A1 N末端第20至30残基的11氨基酸肽连接而成。它减少脂联素A1与Eph受体酪氨酸激酶A2(EphA2)的结合，并在HK1鼻咽癌(NPC)细胞中增加EphA2的泛素化。A11（10 µM）抑制HK1和5-8F NPC细胞的增殖、迁移和侵袭。在体内，A11减少5-8F和HK1 NPC小鼠异种移植模型中的肿瘤体积。
T76970	Tagitanlimab
	Tagitanlimab (HBM-9167)，一种人源化抗PD-L1抗体(IgG1κ型)，通过选择性阻断PD-L1与PD-1的相互作用，展现出对研究复发性或转移性鼻咽癌(NPC)的潜力。
T77010	Fiztasovimab
	Fiztasovimab (NPC-21; EV2038) 是一种全人 IgG1λ 单克隆抗体，具有抗人巨细胞病毒 (hCMV) 活性。Fiztasovimab 通过结合 hCMV 包膜上糖蛋白 B 的抗原结构域 1 发挥中和活性。Fiztasovimab 还抑制 hCMV 的细胞间传播。
T81720	N,N'-Dinitrosopiperazine 1,4-Dinitrosopiperazine,DNP
	N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) 为已知致癌物，与鼻咽癌发展及其转移关联。该化合物通过影响包括LYRIC在内的多条信号通路，特别是通过蛋白磷酸化作用于丝氨酸568位，发挥作用。

化合物

NPC 567 acetate

Cat.No: T21060L

Synonym: NPC 567 acetate(109333-26-8 Free base)

Target: Bradykinin Receptor

Cat.No: T8638

Synonym: FMOC-L-Leucine,Fmoc-L-亮氨酸

Target: Others

Cat.No: T33729

Synonym: Npc-573,Npc573

Cat.No: T77407

Synonym: NPC-1C,NEO-102,NEO-101

Cat.No: T70187

Cat.No: T71024

Cat.No: T71323

NPC-15437 (hydrochloride)

Cat.No: T37480

Cat.No: T21060

m-PEG-NPC (MW 20000)

Cat.No: T18105

Target: Others

Cat.No: T19553

Synonym: NPC

Target: Others

RPR132595A hydrochloride

Cat.No: T78069

Synonym: NPC hydrochloride

Target: Drug Metabolite

Cat.No: T71321

Target: Others

Cat.No: T70590

Cat.No: T70574

Cat.No: T70576

Tazemetostat HCl

Cat.No: T70588

Methazolamide-d6

Cat.No: T70186

Cat.No: T70572

MI-888 free base

Cat.No: T71023

Cat.No: T2008

Synonym: LY 294002,NSC 697286,SF 1101

Target: Apoptosis, DNA-PK, Casein Kinase, PI3K, Autophagy

LY-294002 hydrochloride

Cat.No: T4079

Synonym: SF 1101,LY 294002,NSC 697286

Target: PI3K

GLGPNPCRKKCYKRDFLGR

Cat.No: TP1847

Nuclear pore complex protein Nup98 315-360

Cat.No: TP1781

Cat.No: T83667

Synonym: CPP-EYVQTVKSSKG

Cat.No: T76970

Cat.No: T77010

N,N'-Dinitrosopiperazine

Cat.No: T81720

Synonym: 1,4-Dinitrosopiperazine,DNP

Cat. No.	Product Name	Target	Signaling Pathways
TN1854	Lasiodin 毛栲利素,Lasiokaurin	P450; PARP; Caspase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Proteases/Proteasome
	Lasiodin (Lasiokaurin) 是一种来自植物香茶菜的二帖化合物，可抑制 NPC 细胞增殖。 Lasiodin 具有抗氧化、抗肿瘤活性和抗菌活性，可诱导细胞周期组长和凋亡，诱导细胞迁移和侵袭，可用于研究鼻咽癌
TN1405	Arnicolide D 山金车内酯 D,山金车内酯D	Akt; Caspase; PI3K; STAT; mTOR	Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Arnicolide D 是从石胡荽中分离出的一种倍半萜内酯，以浓度和时间依赖性方式抑制鼻咽癌细胞活力。它调节细胞周期，激活 caspase 信号通路并抑制 PI3K/AKT/mTOR 和 STAT3 信号通路。
TN3922	Effusanin E	PARP; NF-κB; Caspase; COX; Antifection	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome
	Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p65 proteins to down-regulate COX-2 expression .
T66078	Cardamonin
	Cardamonin, a chalcone extracted from cardamom spice with anti-inflammatory and anti-tumor activities. Cardamonin decreased viability of NPC(Nasopharyngeal carcinoma ) cells in a concentration-dependent manner. The IC50 values were 16.22 μM(CNE-1), 14.34 μM (CNE-2), 16.50 μM (HONE-1), and 68.12 μM (SUNE-1). Moreover, the expression level of the proapoptotic effector protein Bax and Bid was also markedly increased after treatment with cardamonin（15μM） in CNE-2 cells.In vivo, cardamonin (25 mg/kg ...

天然产物

Cat.No: TN1854

Synonym: 毛栲利素,Lasiokaurin

Target: P450, PARP, Caspase

Cat.No: TN1405

Synonym: 山金车内酯 D,山金车内酯D

Target: Akt, Caspase, PI3K, STAT, mTOR

Cat.No: TN3922

Target: PARP, NF-κB, Caspase, COX, Antifection

Cat.No: T66078

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00131	Niemann Pick C1/NPC1 Protein, Human, Recombinant (His & FLAG) NPC,Niemann-Pick disease, type C1	Human	HEK293 Cells
	Niemann-Pick C1 (NPC1), a host receptor involved in the envelope glycoprotein (GP)-mediated entry of filoviruses into cells, is believed to be a major determinant of cell susceptibility to filovirus infection. Niemann-Pick C1 (NPC1), a membrane protein of lysosomes, is required for the export of cholesterol derived from receptor-mediated endocytosis of LDL. The NPC1 protein is a multipass transmembrane protein whose deficiency causes the autosomal recessive lipid storage disorder Niemann-Pick ty...
TMPK-01298	BST2 Protein, Cynomolgus, Recombinant (His) HM1.24 antigen,PDCA-1,BST2,TETHERIN,BST-2,NPC-A-7,C...	Cynomolgus	HEK293 Cells
	Interferon-induced BST2 (bone marrow stromal cell antigen 2) inhibits viral replication by tethering enveloped virions to the cell surface to restrict viral release and by inducing the NFKB-dependent antiviral immune response. BST2 expression was significantly increased during porcine epidemic diarrhea virus (PEDV) infection of Vero cells by IRF1 targeting its promoter. Both the BST2 and N protein interacted with the E3 ubiquitin ligase MARCHF8/MARCH8 and the cargo receptor.
TMPY-04990	NPC2 Protein, Mouse, Recombinant (His) 2700012J19Rik,HE1,AA408070,AU045843,Niemann-Pick disease, ty...	Mouse	HEK293 Cells
	NPC2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.9 kDa and the accession number is Q9Z0J0.
TMPY-01114	NPC2 Protein, Human, Recombinant (His) HE1,Niemann-Pick disease, type C2,EDDM1	Human	HEK293 Cells
	NPC2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16 kDa and the accession number is P61916-1.
TMPY-00264	NPC2 Protein, Rat, Recombinant (His) Niemann-Pick disease, type C2	Rat	HEK293 Cells
	NPC2 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.9 kDa and the accession number is Q8CHN5.
TMPH-01524	KPNA1 Protein, Human, Recombinant (His)	Human	E. coli
	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta ...
TMPK-01203	TNFRSF19 Protein, Human, Recombinant (hFc) AW123854,TRADE,TAJ α,AL023044,TAJ-α,Taj,TAJ alpha,Toxicity a...	Human	HEK293 Cells
	A novel susceptibility gene TNFRSF19, which encodes an orphan member of the TNF receptor superfamily known to be associated with nasopharyngeal carcinoma (NPC) and lung cancer risk. TNFRSF19, a susceptibility gene for nasopharyngeal carcinoma and other cancers, functions as a potent inhibitor of the TGFβ signaling pathway. TNFRSF19 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 42.22 kDa and the accession number is Q9NS6...
TMPK-01204	TNFRSF19 Protein, Human, Recombinant (His) Taj,TAJ-α,Toxicity and JNK inducer,TAJ-alpha,TRADE,Troy,AW12...	Human	HEK293 Cells
	A novel susceptibility gene TNFRSF19, which encodes an orphan member of the TNF receptor superfamily known to be associated with nasopharyngeal carcinoma (NPC) and lung cancer risk. TNFRSF19, a susceptibility gene for nasopharyngeal carcinoma and other cancers, functions as a potent inhibitor of the TGFβ signaling pathway. TNFRSF19 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 16.55 kDa and the accession number is Q9NS6...
TMPY-02285	Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS2 Protein NS2 Protein	H1N1	E. coli
	Non-structural protein 2 (NS2) plays a crucial role in the hepatitis C virus (HCV) assembly. NS2 was predicted to be composed of three transmembrane (TM) segments. Hepatitis C virus (HCV) nonstructural protein 2 (NS2) is a hydrophobic, transmembrane protein that is required not only for NS2-NS3 cleavage but also for infectious virus production.NS2 protein is essential for hepatitis C virus (HCV) replication. NS2 protein was expressed and purified. Aptamers against NS2 protein were raised and ant...
TMPY-03795	EIF5A2 Protein, Human, Recombinant (His) eIF5AII,eukaryotic translation initiation factor 5A2,EIF-5A2	Human	E. coli
	Eukaryotic translation initiation factor 5A2 (EIF5A2) has been demonstrated to be upregulated in numerous types of human cancer and is associated with cancer progression. Silencing of EIF5A2 in the NSCLC cells resulted in the downregulation of the tumorigenic proteins, apoptosis regulator Bcl-2 and myc proto-oncogene protein, and upregulation of E-cadherin, suggesting that EIF5A2 promotes proliferation and metastasis through these proteins. EIF5A2 may therefore serve as a novel therapeutic targe...

重组蛋白

Niemann Pick C1/NPC1 Protein, Human, Recombinant (His & FLAG)

Cat.No: TMPY-00131

Species: Human

Expression System: HEK293 Cells

BST2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01298

Species: Cynomolgus

Expression System: HEK293 Cells

NPC2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04990

Species: Mouse

Expression System: HEK293 Cells

NPC2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01114

Species: Human

Expression System: HEK293 Cells

NPC2 Protein, Rat, Recombinant (His)

Cat.No: TMPY-00264

Species: Rat

Expression System: HEK293 Cells

KPNA1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01524

Species: Human

Expression System: E. coli

TNFRSF19 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01203

Species: Human

Expression System: HEK293 Cells

TNFRSF19 Protein, Human, Recombinant (His)

Cat.No: TMPK-01204

Species: Human

Expression System: HEK293 Cells

Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS2 Protein

Cat.No: TMPY-02285

Species: H1N1

Expression System: E. coli

EIF5A2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03795

Species: Human

Expression System: E. coli

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