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41

抑制剂 & 化合物

13

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9190	NAG-thiazoline GlcNAc-thiazoline,N-乙酰 - 葡糖胺基噻唑啉	Others	Others
	NAG-thiazoline (GlcNAc-thiazoline) 是一种 O-GlcNAcase 抑制剂，Ki 值为 180 nM。它对 V. campbellii 有效，MIC 值为 0.5 µM。
T72482	Dazostinag disodium	STING	Immunology/Inflammation
	Dazostinag disodium (TAK-676) 是一种新型干扰素基因刺激剂（STING）激动剂，也是一种免疫系统调节剂，具有抗肿瘤活性，可激活树突状细胞、自然杀伤细胞和 T 细胞。
T68053	Denagliptin GW823093	DPP-4	Proteases/Proteasome
	Denagliptin是一种小分子二肽基肽酶IV（DPP-4）抑制剂，可用于治疗内分泌于代谢疾病，可用于研究2型糖尿病。
T1782	Canagliflozin 卡格列净,JNJ 24831754ZAE,JNJ 28431754AAA,TA 7284,JNJ 28431754	SGLT	GPCR/G Protein
	Canagliflozin (JNJ 28431754AAA) 是SGLT2的选择性抑制剂，在表达 mSGLT2，rSGLT2 和 hSGLT2 的 CHO 细胞上，IC50分别为 2 nM，3.7 nM 和 4.4 nM。
T6390	Anagrelide hydrochloride BMY 26538-01,盐酸阿那格雷,Anagrelide HCl,Agrylin,BL4162A	PDE	Metabolism
	Anagrelide hydrochloride (BL4162A) 能够有效治疗血小板增多症。
T7133	Anagliptin SK-0403,阿拉格列汀	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Anagliptin (SK-0403) 是一种选择性的二肽酰肽酶 4 抑制剂，IC50=3.8 nM，对 DPP-8/9 的选择性相对较弱，IC50分别为 68 和 60 nM。
T0160	Anagrelide Anagrelida,Xagrid,Anagrelidum,阿那格雷	PDE	Metabolism
	Anagrelide (Xagrid) 是III 型磷酸二酯酶(PDEIII)抑制剂 (IC50=36 nM)，是咪唑喹唑啉衍生物。它能够抑制血小板生成，以及抗血栓形成作用，可用作血小板聚集抑制剂。
T16009L	Managlinat dialanetil MB06322,MB 6322,CS-917	Phosphatase	Metabolism
	Managlinat dialanetil (MB06322) 是一种可口服且具有有效性的 fructose 1,6-bisphosphatase (FBPase) 抑制剂，具有降糖活性，可用于研究 2 型糖尿病。
T67795	Camonagrel
	Camonagrel 是一种化合物，对Prostaglandin E2具有抑制作用。
T0191	Linagliptin BI 1356,利格列汀,利拉利汀	Ferroptosis; Proteasome; DPP-4; Autophagy	Apoptosis; Autophagy; Proteases/Proteasome; Ubiquitination
	Linagliptin (BI 1356) 是一种有效的、可口服的、基于二氢嘌呤二酮的二肽基肽酶 4 抑制剂，具有降血糖活性。
T67852	Linagliptin Methyldimer	Proteasome	Proteases/Proteasome; Ubiquitination
	Linagliptin Methyldimer 是一种强效的二肽基肽酶 IV 抑制剂，IC50=6 pM。
T1782L	Canagliflozin hemihydrate JNJ28431754,TA 7284,TA7284,TA-7284,JNJ 28431754,JNJ-28431754	SGLT	GPCR/G Protein
	Canagliflozin hemihydrate (TA 7284) (JNJ28431754 hemihydrate) 是一种选择性的 SGLT2 抑制剂，作用于表达 mSGLT2，rSGLT2 和 hSGLT2 的 CHO 细胞，IC50 分别为 2 nM，3.7 nM 和 4.4 nM。
T124826	N-Methylhernagine
	N-Methylhernagine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T124826，CAS号为 4668-25-1。
T39489	Ulevostinag Ulevostinag,MK-1454
	Ulevostinag (MK-1454) is a STING agonist.
T20949	NAGKi NAGK-i,NAGK i,3-O-Methyl-N-acetyl-D-glucosamine
	NAGKi is an inhibitor of N-acetylmannosamine kinase (NAMK) and N-acetylglucosamine kinase (NAGK).
T10669	Canagliflozin-d4 Canagliflozin D4	Others	Others
	Canagliflozin D4 is a deuterium-labeled Canagliflozin. Canagliflozin is an SGLT2 inhibitor.
T71081	Nagstatin
	Nagstatin is an inhibitor of N-acetyl-beta-D-glucosaminidase and is produced by Streptomyces amakusaensis MG846-fF3.
T75293	Anagrelide hydrochloride monohydrate
	Anagrelide hydrochloride monohydrate 是一种咪唑并喹唑啉制剂。Anagrelide hydrochloride monohydrate 可降低血液中血小板的水平，防止血栓形成。Anagrelide hydrochloride monohydrate 可用于研究原发性血小板增多症 (ET) 和与真性红细胞增多症 (PV) 相关的血小板增多症。
T39682	Gunagratinib ICP-192
	Gunagratinib (ICP-192) is a potent and selective, orally active pan-FGFR (fibroblast growth factor receptors) inhibitor with low toxicity, exhibiting irreversible covalent binding to effectively inhibit FGFR activities. It is particularly suitable for cancer research purposes.
T75405	GlcNAc kinase (EcNagK)
	GlcNAc kinase (EcNagK) (N-Acetylglucosamine kinase) 为GlcNAc代谢过程中的关键酶。通过将ATP的γ-磷酰基转移到GlcNAc的C-6位羟基，生成GlcNAc-6-P。
T24898	Trifenagrel BW-325U,BW 325U,BW325U
	Trifenagrel is an antithrombotic. It has been found to produce less gastric irritation and fecal blood loss in humans.
T131025	Anagallosaponin IX
	Anagallosaponin IX 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131025。
T32058	Henagliflozin SHR3824,SHR 3824,SHR-3824
	Henagliflozin (SHR3824) is an effective, oral, and selective SGLT2 inhibitor that effectively inhibits human SGLT2 in vitro, but has very weak inhibitory effects on human SGLT1.
T12605	Quinagolide hydrochloride 盐酸喹高利特,CV205-502 hydrochloride	Others	Others
	Quinagolide hydrochloride is a selective agonist of dopamine D2 receptor.
T16009	(Rac)-Managlinat dialanetil CS-917,(Rac)-MB06322,MB06322,(Rac)-CS-917	Others; DHFR	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	(Rac)-Managlinat dialanetil ((Rac)-MB06322) 是 Managlinat dialanetil 的外消旋体，Managlinat dialanetil 是一种可口服且具有有效性的 fructose 1,6-bisphosphatase (FBPase) 抑制剂，可用于研究 2 型糖尿病。
T75086	Dazostinag
	Dazostinag (TAK-676 free base) 为干扰素基因刺激剂 (STING) 蛋白的激动剂，展现出抗肿瘤活性。它能作为有效载荷 (payload) 用于合成抗体偶联活性分子 (ADC) 的构建。
T37695	NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQ
	NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQ, an ACE2-related peptide, serves as a valuable research tool for comprehending ACE2 functions.
T28397	Phenaglycodol Atadiol,Felixin,Puasital,Sedapsin,Acalmid
	Chlordimeform Hydrochloride is an acaricide.
T25270	Conagenin
	Conagenin is a small molecular immunomodulator isolated by Streptomyces roseosporus.
T76263	Beinaglutide
	Beinaglutide 是一种重组人 GLP-1(rhGLP-1) 多肽，与人 GLP-1(7-36) 具有几乎 100% 的同源性。Beinaglutide 在血糖控制、抑制食物摄入和胃排空和促进体重减轻方面表现出依赖于剂量的作用。Beinaglutide 具有研究超重/肥胖和非酒精性脂肪性肝炎 (NASH) 的潜力。
T62213	Anagliptin hydrochloride
	Anagliptin (SK-0403) hydrochloride 是一种有效的、高度选择性的、口服具有活力的二肽酰肽酶 4 (DPP-4) 抑制剂 (IC50: 3.8 nM)，对 DPP-8 (IC50: 68 nM) 和 DDP-9 (IC50: 60 nM) 的选择性相对较弱。
T31378	Denagliptin tosylate GSK-823093,GSK 823093,GW-823093,GW 823093,GSK823093,GW823093
	Denagliptin (GW823093 or GSK-823093) is a dipeptidyl peptidase IV (DPP-IV) inhibitor.
T32758	Linagliptin mixture with metformin Jentadueto Xr,Linagliptin / metformin,Jentadueto
	Linagliptin mixture with metformin is used for the treatment of type 2 diabetes.
T68483	Quinagolide Free Base
	Quinagolide Free Base is a non-ergot dopamine D(2)-agonist.
T81708	Nagrestipen
	Nagrestipen 是一种人巨噬细胞炎症蛋白-1α 变体，也称为 ECI 301，主要用于癌症、肿瘤、转移、放射肿瘤学以及肿瘤转移研究试验，具有显著的抗肿瘤活性。
TF0019	2,6-Dimethyl-4-Heptyl-β-D-Maltopyranoside, Anagrade
	2,6-Dimethyl-4-Heptyl-β-D-Maltopyranoside, Anagrade 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TF0019，CAS号为 869638-31-3。
T28971	Tianagliflozin
	Tianagliflozin, a sodium/glucose cotransporter 2 (SGLT-2) inhibitor, is used potentially for the treatment of type 2 diabetes.
T0755	Carglumic Acid Carbaglu,N-Carbamylglutamate,N-Carbamyl-L-glutamic acid,氨甲酰谷氨酸,Carbamylglutamic acid,Carbamino-L-glutamic acid,Ureidoglutaric acid	Others	Others
	Carglumic Acid (Ureidoglutaric acid) 是一种 N-乙酰谷氨酸 (NAG) 的功能类似物和氨甲酰磷酸合成酶 1(CPS1)的活化剂，可用于与 N-乙酰谷氨酸合成酶 (NAGS) 缺陷相关的急性和慢性高氨血症的研究。
T29090	Valibose
	Valibose An α-glucosidase inhibitor. Valibose ameliorated metabolic disturbance of glucose and lipids. valibose markedly reduced level of serum BUN and NAG, and decreased the weight index of kidney.
T38225	N-Arachidonoyl-3-hydroxy-γ-Aminobutyric Acid
	Several different arachidonoyl amino acids, including N-arachidonoyl-3-hydroxy-γ-aminobutyric acid (NAG-3H-ABA), have been isolated and characterized from bovine brain. The glycine congener was further characterized and found to suppress formalin-induced pain in rats. NAG-3H-ABA was also found in rat brain by LC-MS techniques, but has not been fully characterized to date. Most arachidonoyl amino acids are poor ligands for the CB1 receptor.
T73993	Fazirsiran
	Fazirsiran (ARO-AAT) 是第二代 RNA 干扰 (RNAi) 活性分子。Fazirsiran 由胆固醇偶联的 RNAi 触发器 (chol-RNAi) 组成，通过 RNAi 选择性降解 AAT mRNA，以及与 N-乙酰半乳糖胺 (NAG) 偶联的蜂毒肽衍生肽配制成赋形剂 EX1，促进肝细胞内 chol RNAi 的内体逃逸。

化合物

NAG-thiazoline

Cat.No: T9190

Synonym: GlcNAc-thiazoline,N-乙酰 - 葡糖胺基噻唑啉

Target: Others

Dazostinag disodium

Cat.No: T72482

Target: STING

Cat.No: T68053

Synonym: GW823093

Target: DPP-4

Cat.No: T1782

Synonym: 卡格列净,JNJ 24831754ZAE,JNJ 28431754AAA,TA 7284,JNJ 28431754

Target: SGLT

Anagrelide hydrochloride

Cat.No: T6390

Synonym: BMY 26538-01,盐酸阿那格雷,Anagrelide HCl,Agrylin,BL4162A

Target: PDE

Cat.No: T7133

Synonym: SK-0403,阿拉格列汀

Target: Proteasome, DPP-4

Cat.No: T0160

Synonym: Anagrelida,Xagrid,Anagrelidum,阿那格雷

Target: PDE

Managlinat dialanetil

Cat.No: T16009L

Synonym: MB06322,MB 6322,CS-917

Target: Phosphatase

Cat.No: T67795

Cat.No: T0191

Synonym: BI 1356,利格列汀,利拉利汀

Target: Ferroptosis, Proteasome, DPP-4, Autophagy

Linagliptin Methyldimer

Cat.No: T67852

Target: Proteasome

Canagliflozin hemihydrate

Cat.No: T1782L

Synonym: JNJ28431754,TA 7284,TA7284,TA-7284,JNJ 28431754,JNJ-28431754

Target: SGLT

N-Methylhernagine

Cat.No: T124826

Cat.No: T39489

Synonym: Ulevostinag,MK-1454

Cat.No: T20949

Synonym: NAGK-i,NAGK i,3-O-Methyl-N-acetyl-D-glucosamine

Canagliflozin-d4

Cat.No: T10669

Synonym: Canagliflozin D4

Target: Others

Cat.No: T71081

Anagrelide hydrochloride monohydrate

Cat.No: T75293

Cat.No: T39682

Synonym: ICP-192

GlcNAc kinase (EcNagK)

Cat.No: T75405

Cat.No: T24898

Synonym: BW-325U,BW 325U,BW325U

Anagallosaponin IX

Cat.No: T131025

Cat.No: T32058

Synonym: SHR3824,SHR 3824,SHR-3824

Quinagolide hydrochloride

Cat.No: T12605

Synonym: 盐酸喹高利特,CV205-502 hydrochloride

Target: Others

(Rac)-Managlinat dialanetil

Cat.No: T16009

Synonym: CS-917,(Rac)-MB06322,MB06322,(Rac)-CS-917

Target: Others, DHFR

Cat.No: T75086

NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQ

Cat.No: T37695

Cat.No: T28397

Synonym: Atadiol,Felixin,Puasital,Sedapsin,Acalmid

Cat.No: T25270

Cat.No: T76263

Anagliptin hydrochloride

Cat.No: T62213

Denagliptin tosylate

Cat.No: T31378

Synonym: GSK-823093,GSK 823093,GW-823093,GW 823093,GSK823093,GW823093

Linagliptin mixture with metformin

Cat.No: T32758

Synonym: Jentadueto Xr,Linagliptin / metformin,Jentadueto

Quinagolide Free Base

Cat.No: T68483

Cat.No: T81708

2,6-Dimethyl-4-Heptyl-β-D-Maltopyranoside, Anagrade

Cat.No: TF0019

Cat.No: T28971

Cat.No: T0755

Synonym: Carbaglu,N-Carbamylglutamate,N-Carbamyl-L-glutamic acid,氨甲酰谷氨酸,Carbamylglutamic acid,Carbamino-L-glutamic acid,Ureidoglutaric acid

Target: Others

Cat.No: T29090

N-Arachidonoyl-3-hydroxy-γ-Aminobutyric Acid

Cat.No: T38225

Cat.No: T73993

Cat. No.	Product Name	Target	Signaling Pathways
T4514	N-Acetyl-D-Glucosamine N-乙酰-D-氨基葡萄糖,NAG,N-Acetyl-2-amino-2-deoxyglucose,Marine Sweet,N-Acetyl-2-amino-2-deoxy-D-glucose,N-乙酰氨基葡萄糖,GlcNAc	Endogenous Metabolite	Metabolism
	N-Acetyl-D-Glucosamine (NAG) 是葡萄糖的单糖衍生物。
TN2296	Vinaginsenoside R4 越南参皂苷R4	Others	Others
	Vinaginsenoside R4 是分离自水培人参的叶子中。它能够抑制黑色素的生物合成，并增强斑马鱼的色素沉着，对 melan-a 细胞没有任何细胞毒性作用。
T8198	Visnagin	Others	Others
	Visnagin 是一种抗氧化剂呋喃香豆素衍生物。它具有预防Cerulein 诱导的急性胰腺炎的潜力。它在血管平滑肌中具有良好的血管扩张作用。它具有抗炎作用，可用于缓解疼痛的研究。
TN2297	Vinaginsenoside R8 越南参皂苷R8	Others	Others
	Vinaginsenoside R8 is a natural product
TN6267	Tannagine
	Tannagine 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6267，CAS号为 123750-34-5。
T4416	Vinaginsenoside R3 越南参皂苷 R3	Others	Others
	Vinaginsenoside R3是一种天然产物，属于五加科人参属，其产品编号为 T4416，CAS号为 156012-92-9。Vinaginsenoside R3可用作对照参考。
T73856	Anagyrine hydrochloride
	Anagyrine ((-)-Anagyrine) hydrochloride 是一种存在于Lupinus albus 中的喹啉类生物碱。Anagyrine hydrochloride 可与毒蕈碱和烟碱乙酰胆碱受体 (AChR) 结合，IC50值分别为 132 和 2096 µM。Anagyrine hydrochloride 是一种有效的nAChR 脱敏剂，Anagyrine hydrochloride 可以直接脱敏nAChR，不需要代谢。
TN4623	Nagilactone C	Antifection	Microbiology/Virology
	Nagilactone C and phyllanthoside are novel protein synthesis inhibitors, they are specific for the eukaryotic translation apparatus, function in vivo and in vitro, and interfere with translation elongation. Nagilactone C shows high insecticidal activity against second-instar nymphs of Eocanthecona furcellata. Nagilactone C possesses potent antiproliferative activity against human fibrosarcoma and murine colon carcinoma tumor cell lines exhibiting ED50 values of 2.3 and 1.2 microg/ml, respectivel...
TN1971	Nagarine	Others	Others
	Nagarine has toxic and analgesic effects.
TN3409	Anagyrine	Antifection	Microbiology/Virology
	Anagyrine, is the responsible teratogen from teratogenic lupins, can produce congenital deformities in calves typical of crooked calf disease; it also can induce red cell aplasia, vascular anomaly, and skeletal dysplasia.(-)-Anagyrine and (-)--Methylcytisine have nematicidal activities against Pine Wood Nematodes.
TN5853	Naginata ketone Dehydroelsholtzione
	Naginata ketone 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5853，CAS号为 6138-88-1。
T16264	Nagilactone B	Others	Others
	Nagilactone B is extracted from the root bark of Podocarpus nagi and it also is a liver X receptor (LXR) agonist.
TN4286	Isodunnianol	NOS; NF-κB; ROS; AChR	Immunology/Inflammation; Neuroscience; NF-κB
	Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0.1 to 10 uM in the primary cultured rat cortical neurons. Isodunnianol, dunnianol, and Macrant

天然产物

N-Acetyl-D-Glucosamine

Cat.No: T4514

Synonym: N-乙酰-D-氨基葡萄糖,NAG,N-Acetyl-2-amino-2-deoxyglucose,Marine Sweet,N-Acetyl-2-amino-2-deoxy-D-glucose,N-乙酰氨基葡萄糖,GlcNAc

Target: Endogenous Metabolite

Vinaginsenoside R4

Cat.No: TN2296

Synonym: 越南参皂苷R4

Target: Others

Cat.No: T8198

Target: Others

Vinaginsenoside R8

Cat.No: TN2297

Synonym: 越南参皂苷R8

Target: Others

Cat.No: TN6267

Vinaginsenoside R3

Cat.No: T4416

Synonym: 越南参皂苷 R3

Target: Others

Anagyrine hydrochloride

Cat.No: T73856

Nagilactone C

Cat.No: TN4623

Target: Antifection

Cat.No: TN1971

Target: Others

Cat.No: TN3409

Target: Antifection

Naginata ketone

Cat.No: TN5853

Synonym: Dehydroelsholtzione

Nagilactone B

Cat.No: T16264

Target: Others

Cat.No: TN4286

Target: NOS, NF-κB, ROS, AChR

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