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Cat. No.	Product Name	Target	Signaling Pathways
T28001	MDK-6983 MDK-6983,Compound 6k,Autophagy inhibitor 6k,MDK6983	Autophagy	Autophagy
	MDK-6983 (MDK-6983) 是一种自噬抑制剂，可破坏人黑色素瘤细胞中肌动蛋白细胞骨架的动力学。
T19765	MDK-4025	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	MDK-4025 是锥体神经元中高压激活 (HVA) Ca2+ 电流的抑制剂。
T5310	TR-14035 MDK-1191	Integrin	Cytoskeletal Signaling
	TR-14035 (MDK-1191) 是一种具有口服活性的 α4β7/α4β1整合素双重抑制剂，对 α4β7和 α4β1作用的 IC50值分别为 7 和 87 nM，可用于炎症和自体免疫疾病的研究。
T25779	MDK-4683 MDK 4683,CA IX/XII Inhibitor
	MDK-4683, also known as CA IX/XII Inhibitor, is a hCA IX and hCA XII inhibitor.
T33261	MDK-5432 AMPA stabilizer (R,R)-2a,MDK 5432
	MDK-5432, also known as AMPA stabilizer (R,R)-2a, is the most potent AMPA stabilizer.
T25780	MDK-4823 LMPTP-IN-23,LMPTP-IN 23,MDK4823,LMPTP-IN23,MDK 4823
	MDK-4823, also known as LMPTP inhibitor1, is a potent low-molecular-weight tyrosine phosphatase (LMPTP) inhibitor. LMPTP is highly expressed in insulin-target tissues. LMPTP promotes diabetes and insulin resistance in obesity.
T27998	MDK-4204 Anticancer AgentI,MDK 4204,Anticancer Agent I,MDK4204,Anticancer Agent-I
	MDK-4204, an anticancer agent, shows significant anti-cancer activity with IC50 values of 8.8 µM and 9.5 µM in PC-3 and DU-145 cells, respectively.
T27997	MDK-3345 MDK 3345,Mcl-1 Inhibitor11,Mcl-1 Inhibitor 11,Mcl-1 Inhibitor-11
	MDK-3345 is a reversible covalent inhibitor for Mcl-1.
T5093	Pim1/AKK1-IN-1 LKB1/AAK1 dual inhibitor,MDK-2275	Pim; Hippo pathway	Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) 是多种酶抑制剂，能够作用于Pim1、AKK1、MST2 和 LKB1，Kd 值分别为 35、53、75 和 380 nM，还抑制 MPSK1 和 TNIK。
T9033	BTYNB MDK6620,BTYNB IMP1 Inhibitor	Others; c-Myc; NF-κB	Cell Cycle/Checkpoint; NF-κB; Others
	BTYNB (MDK6620) 是IMP1结合 c-Myc mRNA 的有效选择性抑制剂，IC50为 5 μM。它下调 β-TrCP1 mRNA 并减少NF-κB 的激活。它通过损害 IGF2 mRNA 结合蛋白 1 结合来破坏这种增强子功能，可用于癌症研究。
T27991	MDK-0757 Hsp90-IN-89,MDK0757
	MDK-0757 is a novel inhibitor of heat shock protein 90 (Hsp90).
T8412	(S,R,S)-AHPC VH032-NH2,MDK7526,VHL ligand 1	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC (VH032-NH2) 是一种 VH032-based VHL ligand，可用于募集 von Hippel-Lindau (VHL)蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。
T27990	MDK-0738 AKR1C3-IN-14a,AKR1C3 IN 14a
	MDK-0738 is a potent and selective aldo-keto reductase 1C3 inhibitor.
T27995	MDK-3046 HK-inhibitor-2,MDK3046,HK inhibitor 2
	MDK-3046 is a YycG histidine kinase (HK) inhibitor with potent antibiofim activity against Staphylococcus epidermidis.
T27999	MDK-4624 AMPKα1 activator C13,C13, Compound 13
	MDK-4624 is a AMPKα1 activator. MDK-4624 inhibits Helicobacter pylori-induced oxidative stresses and gastric epithelial cell apoptosis. MDK-4624 attenuates dexamethasone-induced osteoblast cell death. MDK-4624 potently inhibits melanoma cell proliferation
T27994	MDK-2959 PTPsigma inhibitor2,PTPsigma inhibitor 2,PTPsigmainhibitor2
	MDK-2959 is a potent inhibitor of protein tyrosine phosphatase sigma (PTPsigma).
T27996	MDK-3298 Mcl-1 Inhibitor-5,Mcl-1 Inhibitor 5,MDK3298,Mcl-1 Inhibitor5
	MDK-3298 is a reversible covalent inhibitor of Mcl-1, a target of protein-protein interaction (PPI).
T27992	MDK08445 MDK-08445,MDK 08445
	MDK08445 is an important intermediate or precursor for the synthesis of Cefiderocol, a potent siderophore cephalosporin antibiotic.
T28000	MDK49781 MDK-49781,MDK 49781
	MDK49781 is a useful chemical intermediate for drug synthesis.
T28004	MDK8228 PF-CBP/BRD4,MDK-8228,MDK 8228
	MDK8228 is an inhibitor of CBP/p300 and BRD4 bromodomain. MDK8228 downregulates IL-6, IL-ß and IFN-ß in macrophages.
T1772	MDK83190 Apoptosis Activator 2	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	MDK83190 (Apoptosis Activator 2) 是一种细胞凋亡激活剂，可诱导 caspase-3 激活、Apaf-1 寡聚化、PARP 切割和 DNA 片段化。
T28002	MDK71803 MDK-71803,Cefiderocol-intermediate, Cefiderocol-precursor,MDK 71803
	MDK71803 is an important intermediate or precursor for the synthesis of Cefiderocol, a potent siderophore cephalosporin antibiotic with a catechol moiety on the 3-position side chain.
T24438	MDK5466 MDK-5466,MDK 5466,E21,Flt3-IN-III,Flt3 Inhibitor III
	MDK5466 is an Flt3 inhibitor that acts by preventing glutamate-induced cell death.
T70601	MDK03855
	MDK03855, also known as A2AR antagonist 19, is an adenosine A2A receptor (A2AR) antagonist. MDK03855 has CAS#1454903-85-5. The last five digit of CAS# was used for name.
T70141	MDK80908
	MDK80908, also known as PPARalpha/gamma agonist N15, is a dual PPARα/γ agonist, ameliorating insulin resistance and gluconeogenesis in vivo and vitro. MDK80908 has CAS#1821380-90-8.
T70069	MDK6465
	MDK6465, also known as PCSK9-IN-8b, is a novel liver-targeted inhibitor of ribosomal synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9). MDK6465 has CAS#1900686-46-5. the last 4 digits are used in its name.
T69916	MDK3673
	MDK3673, also known as Olfr895-Agonist-10, is a novel specific agonist of odorant receptor 895 (Olfr895).
T28003	MDK7677 Cathepsin B Inhinitor-17,MDK 7677
	MDK7677 is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities.
T9460	iMDK	PI3K	PI3K/Akt/mTOR signaling
	iMDK 是PI3K 抑制剂，能够抑制生长因子MDK。它能够与 MEK 抑制剂协同抑制非小细胞肺癌，而不会伤害正常细胞和小鼠。
T16529	BEBT-908 PI3Kα inhibitor 1,MDK9521	PI3K; HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	BEBT-908 (PI3Kα inhibitor 1) 是一种选择性的PI3Kα抑制剂(IC50<0.1 μM)，也抑制 HDAC (0.1 μM≤IC50≤1 μM)。
T27989	MDK0734 Cathepsin B Inhinitor-42
	MDK0734 is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities.
T70599	Asem F-18
	Asem F-18 is a radiolabeled antagonist for imaging the α7-nicotinic acetylcholine receptor with PET .
T69915	GX-585
	GX-585 is a novel potent inhibitor of NaV1.7 and highly selective against NaV1.5, having limited selectivity against NaV1.1 and NaV1.2.
T68559	OUN58101
	OUN58101, also known as MDK-8101, also known as BI-D, is a RSV L-protein inhibitor. OUN58101 was first reported in patnet WO 2005042530. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
T70068	AT-1015 hydrochloride monohydrate
	AT-1015 hydrochloride monohydrate is a serotonin (5-HT)2 receptor antagonist that blocks vascular and platelet 5-HT2A receptors.
T3190	PIK-inhibitors MDK34597	PI3K	PI3K/Akt/mTOR signaling
	PIK-inhibitors (MDK34597) 是一种泛 PI3K 抑制剂，是 PI-103 的类似物。
T70140	D 22888
	D 22888 is a PDE4 inhibitor.
T4198	T.cruzi-IN-1 MDK1088,T.cruzi Inhibitor	Antibiotic; Parasite	Microbiology/Virology
	T.cruzi-IN-1 (MDK1088) 是一种克氏锥虫抑制剂，IC50为 8 nM。它是一种 4-三氟甲基取代的类似物，有潜力治疗南美锥虫病的急性和慢性阶段。
T24439	MDK6204 CLK1/2 IN 2,CLK1/2IN2,CLK1/2-inhibitor-2,CLK1/2-IN-2,CLK1/2 inhibitor 2
	MDK6204 is a selective inhibitor of CLK1 and CLK2.
T61627	iMDK quarterhydrate
	iMDK quarterhydrate, a potent PI3K inhibitor, is effective in inhibiting the growth factor MDK (also known as midkine or MK) while demonstrating suppression of non-small cell lung cancer (NSCLC). In combination with a MEK inhibitor, iMDK quarterhydrate demonstrates cooperative inhibition of NSCLC without causing harm to normal cells and mice [1].
T7082	HDAC8-IN-1	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC8-IN-1 是一种 HDAC8 抑制剂，在癌细胞系中的 IC50 为 27.2 nM，有抗增殖作用。

化合物

Cat.No: T28001

Synonym: MDK-6983,Compound 6k,Autophagy inhibitor 6k,MDK6983

Target: Autophagy

Cat.No: T19765

Target: Calcium Channel

Cat.No: T5310

Synonym: MDK-1191

Target: Integrin

Cat.No: T25779

Synonym: MDK 4683,CA IX/XII Inhibitor

Cat.No: T33261

Synonym: AMPA stabilizer (R,R)-2a,MDK 5432

Cat.No: T25780

Synonym: LMPTP-IN-23,LMPTP-IN 23,MDK4823,LMPTP-IN23,MDK 4823

Cat.No: T27998

Synonym: Anticancer AgentI,MDK 4204,Anticancer Agent I,MDK4204,Anticancer Agent-I

Cat.No: T27997

Synonym: MDK 3345,Mcl-1 Inhibitor11,Mcl-1 Inhibitor 11,Mcl-1 Inhibitor-11

Cat.No: T5093

Synonym: LKB1/AAK1 dual inhibitor,MDK-2275

Target: Pim, Hippo pathway

Cat.No: T9033

Synonym: MDK6620,BTYNB IMP1 Inhibitor

Target: Others, c-Myc, NF-κB

Cat.No: T27991

Synonym: Hsp90-IN-89,MDK0757

Cat.No: T8412

Synonym: VH032-NH2,MDK7526,VHL ligand 1

Target: Others, Ligand for E3 Ligase

Cat.No: T27990

Synonym: AKR1C3-IN-14a,AKR1C3 IN 14a

Cat.No: T27995

Synonym: HK-inhibitor-2,MDK3046,HK inhibitor 2

Cat.No: T27999

Synonym: AMPKα1 activator C13,C13, Compound 13

Cat.No: T27994

Synonym: PTPsigma inhibitor2,PTPsigma inhibitor 2,PTPsigmainhibitor2

Cat.No: T27996

Synonym: Mcl-1 Inhibitor-5,Mcl-1 Inhibitor 5,MDK3298,Mcl-1 Inhibitor5

Cat.No: T27992

Synonym: MDK-08445,MDK 08445

Cat.No: T28000

Synonym: MDK-49781,MDK 49781

Cat.No: T28004

Synonym: PF-CBP/BRD4,MDK-8228,MDK 8228

Cat.No: T1772

Synonym: Apoptosis Activator 2

Target: Apoptosis, Caspase

Cat.No: T28002

Synonym: MDK-71803,Cefiderocol-intermediate, Cefiderocol-precursor,MDK 71803

Cat.No: T24438

Synonym: MDK-5466,MDK 5466,E21,Flt3-IN-III,Flt3 Inhibitor III

Cat.No: T70601

Cat.No: T70141

Cat.No: T70069

Cat.No: T69916

Cat.No: T28003

Synonym: Cathepsin B Inhinitor-17,MDK 7677

Cat.No: T9460

Target: PI3K

Cat.No: T16529

Synonym: PI3Kα inhibitor 1,MDK9521

Target: PI3K, HDAC

Cat.No: T27989

Synonym: Cathepsin B Inhinitor-42

Cat.No: T70599

Cat.No: T69915

Cat.No: T68559

AT-1015 hydrochloride monohydrate

Cat.No: T70068

Cat.No: T3190

Synonym: MDK34597

Target: PI3K

Cat.No: T70140

Cat.No: T4198

Synonym: MDK1088,T.cruzi Inhibitor

Target: Antibiotic, Parasite

Cat.No: T24439

Synonym: CLK1/2 IN 2,CLK1/2IN2,CLK1/2-inhibitor-2,CLK1/2-IN-2,CLK1/2 inhibitor 2

iMDK quarterhydrate

Cat.No: T61627

Cat.No: T7082

Target: HDAC

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