43
21
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T20971 |
Mefluidide
VEL3973,VEL-3973,VEL 3973,MBR 12325 |
||
Mefluidide is a biochemical. | |||
T2371 |
Emapunil
AC-5216,XBD-173 |
Others | Others |
Emapunil (XBD-173) 是一种选择性的、口服有效的TSPO(一种线粒体苯二氮受体) 的配体。在多种动物模型中,它显示出抗焦虑和抗抑郁特性。 | |||
T2711 |
Chembridge-5861528
TCS 5861528 |
TRP/TRPV Channel | Membrane transporter/Ion channel |
Chembridge-5861528 (TCS 5861528) 是有效的 TRPA1离子通道阻断剂。 | |||
T4976 |
Umbralisib
TGR-1202,RP5264,TGR 1202,TGR1202 |
PI3K | PI3K/Akt/mTOR signaling |
Umbralisib (TGR 1202) 是一种PI3Kδ抑制剂,IC50=22.2 nM,EC50=24.3 nM。它同时可抑制CK1ε,EC50=6.0 μM。 | |||
T1655 |
Ambrisentan
BSF-208075,BSF 208075,安倍生坦,LU 208075 |
Endothelin Receptor | GPCR/G Protein |
Ambrisentan (BSF 208075) 是 ET A 型受体选择性拮抗剂。 | |||
TP1286 |
Carcinoembryonic Antigen CEA
癌胚抗原 |
Others | Others |
Carcinoembryonic Antigen CEA 是一种广谱性肿瘤标志物,是大肠癌组织产生的一种糖蛋白,作为抗原可引起患者的免疫反应。 | |||
T9908 |
Pembrolizumab
|
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
Pembrolizumab 是一种抑制 PD-1 受体的人源化单克隆抗体,是一个 HER2 二聚化抑制剂类,它会削弱 HER2 与 HER 家族其他成员结合的能力。 | |||
T77752 |
HMBR
4-Thiazolidinone, 5-[(4-hydroxy-3-methylphenyl)methylene]-2-thioxo-, (5Z)- |
Others | Others |
HMBR本身不具有荧光,但当与 Y-FAST 结合时,它们在蓝光激发时会发出黄光。 | |||
T28750 |
Sembragiline
RG-1577,EVT-302,RO-4602522,RO4602522,RG1577,EVT302 |
MAO | Metabolism; Neuroscience |
Sembragiline (EVT-302) 是一种具有选择性的 MAO-B 抑制剂,可用于研究阿尔茨海默病(AD)。 | |||
T0920 |
Ambroxol
氨溴索,氨溴索碱,Ambroxolum,NA-872 |
P450; Autophagy | Autophagy; Metabolism |
Ambroxol (NA-872) 是前药溴己辛的活性代谢产物,是一种分泌溶解剂,具有强效祛痰作用,用于治疗与粘液或过多粘液相关的呼吸道疾病。它可诱导肺组织细胞自噬,有用于帕金森氏病和神经性戈谢病的研究潜力。它是一种葡糖脑苷脂酶伴侣,可增加葡糖脑苷脂酶的活性。 | |||
T13140 |
Umbralisib R-enantiomer
TGR-1202 R-enantiomer,RP5264 R-enantiomer |
PI3K | PI3K/Akt/mTOR signaling |
Umbralisib R-enantiomer (RP5264 R-enantiomer) 是 PI3K 的δ型抑制剂,是 TGR-1202 活性较低的对映体。Umbralisib R-enantiomer 对δ型 pi3激酶的 IC50,至少比抑制剂对其他 PI3K 亚型(A, β和γ)的 IC50低20倍。 | |||
T36848 |
Combretastatin A-1
Combretastatin A1 |
Akt; Microtubule Associated | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Combretastatin A-1 是一种有效的微管抑制剂,具有抗肿瘤和抗血管活性,通过微管蛋白解聚介导的 AKT 失活抑制 Wnt/β-catenin 通路发挥作用,可用于研究肝癌。 | |||
T6234 |
Ambroxol hydrochloride
Mucosolvan,Mucoangin,盐酸氨溴索,Ambroxol HCl |
Sodium Channel; Autophagy | Autophagy; Membrane transporter/Ion channel |
Ambroxol hydrochloride (Mucosolvan) 是前药溴己辛的活性代谢产物,是一种葡糖脑苷脂酶伴侣,可增加葡糖脑苷脂酶的活性。它可刺激粘液纤毛作用并清除呼吸道中的空气通道,具有强效祛痰作用。它可诱导肺细胞自噬,有用于帕金森氏病和神经性戈谢病的研究潜力。 | |||
T131083 | Cembratetraene-16,2:19,6-diolide | ||
Cembratetraene-16,2:19,6-diolide 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T131083。 | |||
T32853 |
Lombricine
L-Lombricine |
||
Lombricine, as a phosphodiester of 2-guanidinoethanol and D-serine in structure, is a phosphagen that is unique to earthworms. | |||
T125077 | Mecambridine | ||
Mecambridine 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T125077。 | |||
T124447 | Ambrosic acid | ||
Ambrosic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T124447,CAS号为 6617-14-7。 | |||
T34450 | Rumbrin | ||
Rumbrin is a cytoprotective compound produced by Auxarthron umbrinum. | |||
T17066 |
Umbralisib hydrochloride
RP5264 hydrochloride,TGR-1202 hydrochloride |
PI3K | PI3K/Akt/mTOR signaling |
Umbralisib hydrochloride is a novel PI3Kδ inhibitor (IC50 and EC50 of 22.2 nM and 24.3 nM, respectively). Umbralisib hydrochloride is also active against CK1ε (EC50: 6.0 μM). | |||
T40367 |
Combretastatin A-1 phosphate tetrasodium
Combretastatin A-1 phosphate tetrasodium,OXi-4503 tetrasodium |
||
Combretastatin A-1 phosphate (OXi-4503) tetrasodium, a prodrug of Combretastatin A-1, is a tubulin-binding microtubule polymerization inhibitor that targets the colchicine-binding site. By inducing tubulin depolymerization, Combretastatin A-1 phosphate tetrasodium inhibits the Wnt/β-catenin pathway and leads to the deactivation of AKT. It possesses both anti-tumor and anti-vascular properties. | |||
T81824 |
Membrane-Permeable Sequence, MPS
|
||
Membrane-Permeable Sequence(MPS)是一种CPP,常用于研究跨膜机制。 | |||
T27982 |
MBRI-001
MBRI 001,MBRI001. BPI-2358-d,plinabulin-d,NPI-2358-d |
||
MBRI-001 is a deuterium-substituted plinabulin derivative and a potent anti-cancer agent with better pharmacokinetic characteristics tand lower toxicity. | |||
T29954 |
Ambruticin
W7783,W 7783,W-7783 |
||
Ambruticin is a biochemical. | |||
T124625 |
α-Cembrenediol
|
||
α-Cembrenediol 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124625。 | |||
T124052 | Calophymembranside B | ||
Calophymembranside B 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T124052,CAS号为 869285-60-9。 | |||
T71143 | Ambroxol-d5 | ||
Ambroxol-d5 is intended for use as an internal standard for the quantification of ambroxol by GC- or LC-MS. Ambroxol is an expectorant and active metabolite of bromhexine. It decreases short-circuit currents in electrically stimulated isolated canine tracheal epithelial cells when applied submucosally. Ambroxol decreases IL-13-induced production of mucin 5AC (MUC5AC) in primary human airway epithelial cells and inhibits IL-13-induced decreases in the mucociliary transport rate of endogenous part... | |||
T82476 |
Embramine hydrochloride
|
||
Embramine (hydrochloride) 为具有抗组胺及抗胆碱能特性的单乙醇胺类化合物。 | |||
T69173 | Ambrosin | ||
Ambrosin is a sesquiterpene lactone and a potent NF-κβ inhibitor. It is currently being studied as a potential lead drug for Alzheimer disease therapeutics. | |||
T72182 |
Combretastatin A1 phosphate
Oxi4503,CA1P,Oxi4503 ; CA1P ; Combretastatin A1 diphosphate,Combretastatin A1 diphosphate |
||
Combretastatin A1 phosphate 是一种有效的血管破坏剂。Combretastatin A1 phosphate 对肿瘤具有抗血管生成作用。Combretastatin A1 phosphate 具有用于胰腺神经内分泌肿瘤研究的潜力。 | |||
T80209 |
Human membrane-bound PD-L1 polypeptide
|
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
Human membrane-bound PD-L1 polypeptide 作为抗原,可诱导生成相应的PD-L1抗体。 | |||
T16386 |
Ombrabulin hydrochloride
AVE8062 (hydrochloride),AC7700 (hydrochloride) |
Microtubule Associated | Cytoskeletal Signaling |
Ombrabulin hydrochloride 是一种合成的、具有选择性的 CA-4 磷酸酯或 Ombrabulin 的衍生物,能破坏内皮细胞的微管蛋白细胞骨架,具有抗血管作用。Ombrabulin 是是一种微管蛋白聚合抑制剂,是 combretastatin a -4化合物类的一员,是一种水溶性的微管蛋白解聚肿瘤血管破坏化合物。 | |||
T124967 | D7-Mesembrenone | ||
D7-Mesembrenone 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T124967,CAS号为 35714-44-4。 | |||
T69215 | Ambrein | ||
Ambrein is a triterpene alcohol that is the chief constituent of ambergris, a secretion from the digestive system of the sperm whale, and has been suggested as the possible active component producing the supposed aphrodisiac effects of ambergris. It serves as the biological precursor for a number of aromatic derivatives such as ambroxan and is thought to possess fixative properties for other odorants. It has been shown to act as an analgesic and it has been proven to increase sexual behavior in ... | |||
T72527 |
Umbralisib sulfate
TGR-1202 sulfate ; RP-5264 sulfate,TGR-1202 sulfate,RP-5264 sulfate |
||
Umbralisib (TGR-1202) sulfate 是一种口服有效、选择性的 PI3Kδ和 酪蛋白激酶-1-ε (CK1ε) 双抑制剂,其 EC50分别为 22.2 nM 和 6.0 μM。 Umbralisib sulfate 显示出对慢性淋巴细胞白血病 (CLL) T 细胞独特的免疫调节作用。Umbralisib sulfate 可用于血液系统恶性肿瘤的研究。 | |||
TP2198 |
Platelet Membrane Glycoprotein IIB Peptide (296-306)
|
Others | Others |
GPllb is composed of a 125 Kd heavy chain that is disulfide-linked to a 23 Kd light chain. Hydropathicity analysis of the cDNA sequence indicates that GPllb is anchored to the platelet through a single transmembrane domain located within 20 amino acids of | |||
T16387 |
Ombrabulin
AVE8062,AC7700 |
Microtubule Associated | Cytoskeletal Signaling |
Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells. | |||
T11180 |
Embramine
|
Others | Others |
Embramine, used as an antihistamine and anticholinergic, is a monoethanolamine. | |||
T61921 |
Ambrisentan sodium
|
||
Ambrisentan (BSF 208075) sodium 是选择性的、口服有效的 ET A 型受体 (ETAR) 拮抗剂。 | |||
T126040 | Imbricataflavone A | ||
Imbricataflavone A 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T126040。 | |||
T125582 | Combreglucoside | ||
Combreglucoside 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T125582,CAS号为 173485-48-8。 | |||
T72465 |
Umbralisib tosylate
RP5264 tosylate,TGR-1202 tosylate ; RP5264 tosylate,TGR-1202 tosylate |
||
Umbralisib (TGR-1202) tosylate是一种口服有效、具有选择性的PI3Kδ和酪蛋白激酶-1-ε (CK1ε) 双重抑制剂,EC50值分别为22.2 nM和6.0 μM。该化合物针对慢性淋巴细胞白血病 (CLL) 中的T细胞显示出独特的免疫调节作用,适用于血液系统恶性肿瘤的研究。 | |||
T35434 |
β-Cembrenediol
|
||
β-Cembrenediol (β-CBT) is a natural product from tobacco plants that is found in cigarette smoke condensate. β-CBT inhibits induction of the early antigen of Epstein-Barr virus (EA-EBV) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in vitro (IC50 = 21.9 μM). It inhibits tumor promoting effects of TPA on 7,12-demethylbenz[a]anthracene-induced papilloma formation in vivo. β-CBT is also released into soil by flue-cured tobacco plants and exerts autotoxicity as well as phytotoxic activity against L.... | |||
T31373 |
Dembrexine HCl
Dembroxol |
||
Dembrexine is a bioactive agent. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2S1682 |
Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside
Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-beta-D-glucose,pinocembrin-7-o-3-o-galloyl-4-6-hexahydroxydiphenoyl-beta-d-glucoside |
Amylase | Metabolism |
Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside 可抑制 α-淀粉酶活性,IC50值为0.03 umol/ml。 | |||
T2992 |
Pinocembrin
乔松素,5,7-Dihydroxyflavanone,Dihydrochrysin,Galangin flavanone,松属素 |
NF-κB; Reactive Oxygen Species; Antibacterial; Autophagy | Autophagy; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Pinocembrin (5,7-Dihydroxyflavanone) 是从蜂胶中得到的黄酮类物质,是一种竞争性组氨酸脱羧酶抑制剂,也是抗过敏剂,具有抗氧化、抗菌、抗炎的作用。 | |||
T13514 |
5-MethoxyPinocembroside
|
Others | Others |
5-MethoxyPinocembroside 是一种黄酮类天然产物,存在于辣木 Moringa oleifera 的叶子中。 | |||
TN2078 |
Pinocembrin chalcone
2',4',6'-Trihydroxychalcone,Pinocembrinchalcone |
Calcium Channel; Tyrosinase; Antibacterial; Antifection | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Proteases/Proteasome |
Pinocembrin chalcone 是一种具有抗诱变作用的酪氨酸酶抑制剂。 Pinocembrin 查尔酮可用于预防胃溃疡的研究。 | |||
T7479 |
Ambroxide
降龙涎香醚,(-)-Ambroxide |
Others | Others |
Ambroxide ((-)-Ambroxide) 是龙涎香的一种关键成分,是天然存在的萜类化合物。 | |||
T6212 |
Combretastatin A4
CA4,康普瑞汀,Z)-3,4,5,4',-四甲氧基-3'-羟基二苯乙烯,CRC 87-09 |
Microtubule Associated | Cytoskeletal Signaling |
Combretastatin A4 (CA4) 是一种微管靶向剂,可结合 β-tubulin,Kd 值为 0.4 μM。 | |||
T5710 |
Pinocembrin-7-O-β-D-glucopyranoside
Pinocembrin 7-O-beta-D-glucoside,乔松素7-O-Β-D葡萄糖苷,乔松苷 |
Others | Others |
Pinocembrin-7-O-β-D-glucopyranoside (Pinocembrin 7-O-beta-D-glucoside) 是黄酮类化合物,能够提高脂质过氧化。 | |||
TN2077 |
(+/-)-Pinocembrin
NSC 43318,(±)-5,7-Dihydroxyflavanone |
GPR; Others | Endocrinology/Hormones; GPCR/G Protein; Others |
(+/-)-Pinocembrin (NSC-43318) 是一种来自腋松的天然产物,它是一种 GPR120 配体,能促进 HaCaT 细胞系的伤口愈合。 | |||
TN4250 | Imbricatolic acid | p53 | Apoptosis |
Imbricatolic acid can prevent cell cycle progression in p53-null CaLu-6 cells. | |||
TN5787 |
Imbricatin
|
||
Imbricatin 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5787,CAS号为 84504-71-2。 | |||
TN5509 |
(2S)-Pinocembrin 7-O-[2''-O-(5'''-O-trans-cinnamoyl)-β-D-apiofuranosyl]-β-D-glucoside
(2S)-Pinocembrin 7-O-[cinnamoyl(1→5)-β-D-apiosyl(1→2)]-β-D-glucoside |
||
(2S)-Pinocembrin 7-O-[2''-O-(5'''-O-trans-cinnamoyl)-β-D-apiofuranosyl]-β-D-glucoside 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5509,CAS号为 773899-29-9。 | |||
T28019 |
(-)-Mesembrine
Mesembrin,Mesembrine,Mesembranone |
||
Mesembrine is a serotonin reuptake inhibitor and is also a weak inhibitor of the enzyme phosphodiesterase 4 (PDE4). | |||
T83379 |
2-Hydroxypinocembrin
|
||
2-Hydroxypinocembrin 是一种具有 C-糖基转移酶活性的2-羟基黄烷酮类黄酮底物。 | |||
TN4792 | Pinocembrin diacetate | Others | Others |
Pinocembrin diacetate 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN4792,CAS号为 111441-88-4。 | |||
TN6135 |
Methoxyimbricatin
|
||
Methoxyimbricatin 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN6135,CAS号为 233759-30-3。 | |||
T73857 |
Mesembrine
|
||
Mesembrine ((+)-Mesembrine) 一种主要的生物碱,具有芳基八氢吲哚骨架。Mesembrine 是一种5-HT 转运蛋白抑制剂,Ki 为 1.4 nM。Mesembrine 还抑制磷酸二酯酶 4B (PDE4B),IC50为 7.8 μM。 | |||
T72856 |
(+)-Cembrene A
|
||
(+)-Cembrene A 是一种α-glucosidase 抑制剂,IC50为 30.31 μM。(+)-Cembrene A 对人正常肝细胞 (LO2) 无毒性。 | |||
TN4791 |
Pinocembrin 7-acetate
|
Others | Others |
Pinocembrin 7-acetate has antitumor activity. | |||
T72742 |
(-)-Pinocembrin
(-)-乔松素 |
||
(-)-Pinocembrin 对 H37Ra 结核分枝杆菌展示了抗菌活性,无论是休眠还是活跃期,其 IC50 值分别为1.11 mg/mL 和 1.21 mg/mL。作为一种抗增殖剂,(-)-Pinocembrin 对于 THP-1、A549、Panc-1、HeLa 和 MCF7 细胞系,IC50 值范围为 1.88 至 11.00 mg/mL。 | |||
TN1522 |
Combretol
|
Antifection | Microbiology/Virology |
Combretol has leishmanicidal activity, it showed moderate activity (growth inhibition 87.3 and 73.0 %, respectively, at 50 μM) against a multidrug-resistant L. tropica line. Combretol also shows weakly active cytotoxic activity. | |||
T19772 |
Mesembrenone
(+)-Mesembrenone |
||
Mesembrenone is a selective the serotonin transporter (SERT) inhibitor. Mesembrenone is the main alkaloid of Sceletium tortuosum. |