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抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T29981 Amidochlor

Caswell No. 005B,EPA Pesticide Chemical Code 128001,MON 4620,MON 4621,Limit

Amidochlor is a growth regulator.
T77336 PLH2058

Others Others
PLH2058 是一种可用于调节、限制或抑制AVIL(advillin)表达的化合物,可用于治疗癌症。
T77335 PLH1215

Others Others
PLH1215 是一种可用于调节、限制或抑制 AVIL(advillin)表达的化合物,可用于治疗癌症。
T24115 GSK854

GSK-854,GSK 854

Apoptosis Apoptosis
GSK854 是一种具有高选择性和有效性的肌钙蛋白 I 相互作用激酶 (TNNI3K) 抑制剂,抑制小鼠心肌梗死损伤细胞焦亡和细胞凋亡,可限制缺血性心脏的氧化应激、损伤和不良重塑。
T3615 Evofosfamide

艾伏磷酰胺,TH-302

Apoptosis; Others Apoptosis; Others
Evofosfamide (TH-302) 是一种缺氧激活前药,在缺氧 (N2) 和常氧 (21% O2) 环境下,IC50分别为 10 μM 和 1000 μM。
T39234 BODIPY-TS

Thiol-green 2,BODIPY-TS

BODIPY-TS (also known as Thiol-green 2) is a highly efficient thiol-specific turn-on probe with a fast response. It incorporates a thiosulfonate scaffold as its thiol recognition unit. BODIPY-TS displays excellent selectivity, low detection limit, and quantitative reactivity towards thiols. Moreover, it exhibits low toxicity. Notably, BODIPY-TS exhibits excitation at 490 nm and emission at 515 nm.
T1271 Pronetalol

Pronethalol ((±)-Pronethalo) 是一种非选择性的 β-肾上腺素 (β-adrenergic) 拮抗剂。 Pronethalol 是 Sox2表达的有效抑制剂。Pronethalol 可预防和逆转洋地黄引起的室性心律失常,并限制脑动静脉畸形 (AVMs)。
T7553L PD 128907

PD-128907,PD128907

PD 128907 is a potent and selective agonist of dopamine D2 and D3 receptors. It is used for studying the role of these receptors in the brain, in roles such as inhibitory autoreceptors that act to limit further dopamine release, as well as release of othe
T78439 1,2-Diaminoanthraquinone

1,2-Diaminoanthraquinone是一种敏感、特异且无毒的一氧化氮(NO)荧光探针,适用于活细胞和生物体内NO生成的检测。该化合物的λmax约为540 nm,对NO的检测极限达到5 μM。
T25910 Oxilorphan

Oxilorfano,Oxilorphane,Bristol laboratories BC 2605,levo-BC-2605

Oxilorphan acts as a μ-opioid receptor (MOR) antagonist but a κ-opioid receptor (KOR) partial agonist and has similar effects to naloxone and around the same potency as a MOR antagonist. Oxilorphan has some weak partial agonist actions at the MOR and can
T82272 Gol-NTR

Gol-NTR是一种针对高尔基体的选择性和灵敏度极高的探针,由硝基还原酶(NTR)激活,用于可视化急性肺损伤(ALI)及其修复。该探针的检测限低至54.8 ng/mL,适用于监测和评估脓毒症引发的ALI反应。
T36104 Citrulline-specific Probe-Rhodamine

Protein arginine deiminases (PADs) catalyze the posttranslational modification of arginine residues on proteins to form citrulline, which plays a large role in regulating gene expression. Abnormally high PAD activity has been observed in a host of human diseases. Citrulline-specific probe-rhodamine is a highly sensitive, rhodamine phenylglyoxal-based fluorophore that specifically detects protein citrullination via a chemoselective reaction between glyoxal and citrulline. This chemical probe (com...
T38117 WSP-5

Washington State Probe-5,WSP-5

Hydrogen sulfide (H2S) is an important gaseous mediator, like nitric oxide, that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. WSP-5 is a reactive disulfide-containing, fluorescent probe designed for fast detection of H2S in biological samples and cells. Through a reaction-based fluorescent turn-on strategy, WSP-5 selectively and rapidly reacts with H2S, generating a fluorophore with excitation and emission maxima of 502 and 525 nm, ...
T81276 Rhodamine B hydrazide

Rhodamine B hydrazide 是一优良的亚硫酸盐探针,呈现无色且不荧光。其荧光强度与亚硫酸盐浓度呈正相关(5-800 ng/mL;检测限=1.4 ng/mL (3σ))。在亚硫酸盐作用下,Rhodamine B hydrazide 与还原的溶解氧形成的超氧自由基反应,生成荧光产物 Rhodamine B。Tween 80 表面活性剂的胶束能够增强荧光信号。Rhodamine B hydrazide 在 554 nm 处有最大吸收峰,在 574 nm 处有最高荧光发射峰。
T31194 Dalapon

Basfapon B,Dowpon M,Dawpon-Rae

Dalapon is a selective herbicide used to control perennial grasses. The major use of dalapon is on food crops including sugarcane and sugar beets. Its use is no longer authorized in France. The National Institute for Occupational Safety and Health in the
T37880 OPC-167832

OPC-167832 is a potent and orally active dprE1 Inhibitor with an IC50 of 0.258 μM. OPC-167832 has antituberculosis activity and can be used for the research of tuberculosis caused by Mycobacterium tuberculosis[1]. OPC-167832 exhibits very low MICs against laboratory strains of M. tuberculosis H37Rv (MIC: 0.0005 μg/ml) and Kurono (MIC: 0.0005 μg/ml) and strains with monoresistance to rifampin (RIF), isoniazid (INH), ethambutol (EMB), streptomycin (STR), and pyrazinamide (PZA) (MIC: 0.00024-0.001 ...

化合物

Amidochlor
Cat.No: T29981
Synonym: Caswell No. 005B,EPA Pesticide Chemical Code 128001,MON 4620,MON 4621,Limit
Target:
PLH2058
Cat.No: T77336
Synonym:
Target: Others
PLH1215
Cat.No: T77335
Synonym:
Target: Others
GSK854
Cat.No: T24115
Synonym: GSK-854,GSK 854
Target: Apoptosis
Evofosfamide
Cat.No: T3615
Synonym: 艾伏磷酰胺,TH-302
Target: Apoptosis, Others
BODIPY-TS
Cat.No: T39234
Synonym: Thiol-green 2,BODIPY-TS
Target:
Pronetalol
Cat.No: T1271
Synonym:
Target:
PD 128907
Cat.No: T7553L
Synonym: PD-128907,PD128907
Target:
1,2-Diaminoanthraquinone
Cat.No: T78439
Synonym:
Target:
Oxilorphan
Cat.No: T25910
Synonym: Oxilorfano,Oxilorphane,Bristol laboratories BC 2605,levo-BC-2605
Target:
Gol-NTR
Cat.No: T82272
Synonym:
Target:
Citrulline-specific Probe-Rhodamine
Cat.No: T36104
Synonym:
Target:
WSP-5
Cat.No: T38117
Synonym: Washington State Probe-5,WSP-5
Target:
Rhodamine B hydrazide
Cat.No: T81276
Synonym:
Target:
Dalapon
Cat.No: T31194
Synonym: Basfapon B,Dowpon M,Dawpon-Rae
Target:
OPC-167832
Cat.No: T37880
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T0791 Reserpine

利血平,Serpalan,Serpasil,Serpivite

Others; Potassium Channel; MRP; Monoamine Transporter; Autophagy Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Others
Reserpine (Serpalan) 是一种从催吐萝芙木的根中发现的生物碱。它抑制去甲肾上腺素吸收到储存囊泡中,导致中枢和外周轴突末端的儿茶酚胺和血清素耗尽。它可作为抗高血压药和抗精神病药以及研究工具。
TN5639 Rocaglaol

Ferrugin,Aglaiastatin A

Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylation of Cdc2. Rocaglaol can reduce tis
TN2775 2-Methoxystypandrone

MMP; BCL; IκB/IKK; GSK-3; TNF; NOS; NF-κB; Wnt/beta-catenin; COX; JAK; STAT Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitant
T21772 Reserpine hydrochloride

Reserpine hydrochloride 是一种从催吐萝芙木的根中发现的生物碱。它抑制去甲肾上腺素吸收到储存囊泡中,导致中枢和外周轴突末端的儿茶酚胺和血清素耗尽。它可作为抗高血压药和抗精神病药以及研究工具。

天然产物

Reserpine
Cat.No: T0791
Synonym: 利血平,Serpalan,Serpasil,Serpivite
Target: Others, Potassium Channel, MRP, Monoamine Transporter, Autophagy
Rocaglaol
Cat.No: TN5639
Synonym: Ferrugin,Aglaiastatin A
Target:
2-Methoxystypandrone
Cat.No: TN2775
Synonym:
Target: MMP, BCL, IκB/IKK, GSK-3, TNF, NOS, NF-κB, Wnt/beta-catenin, COX, JAK, STAT
Reserpine hydrochloride
Cat.No: T21772
Synonym:
Target:
TargetMol Loading
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