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Search Results for " ly3 "

Targets Recommended: Adrenergic Receptor

49

抑制剂 & 化合物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T15819	LY377604	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	LY377604 是一种人类 β3 肾上腺素能受体激动剂（EC50：2.4 nM）和β1/2-肾上腺素能受体拮抗剂,可用于研究肥胖。
T15815	LY3295668 AK-01	Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	LY3295668 (AK-01) 是 Aurora A 的选择性抑制剂，对 Aurora A 和 B 的 Kis 分别为 0.8 nM 和 1038 nM。
T27949	LY382884 LY-382884,LY 382884	GluR	Neuroscience
	LY382884 是一种具有选择性和有效性的 GLU(K5)受体拮抗剂，具有抗焦虑活性。LY382884可阻断阻断苔藓纤维LTP的诱导。
T4266	LY334370 4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐,LY 334370	5-HT Receptor	GPCR/G Protein; Neuroscience
	LY334370 是一种选择性5-HT1F 受体激动剂，Ki 值为 1.6 nM。
T27947L	LY339434 HCl LY339434 HCl(219566-62-8 Free base)	GluR; NMDAR	Neuroscience
	LY339434 HCl是一种亲和力很低的GluR5红氨酸受体激动剂。LY339434 HCl 主要通过影响 N-甲基-D-天冬氨酸（NMDA）受体来快速的神经元死亡。
T61661	LY3372689 Formulaic Ia	Microtubule Associated	Cytoskeletal Signaling
	LY3372689 (Formulaic Ia) 是一种具有口服活性的O-GlcNAcase (OGA)酶抑制剂,可用于包括阿尔茨海默病在内的 tau 蛋白类疾病。
T5125	LY3200882	TGF-beta/Smad	Stem Cells
	LY3200882 是一种高度选择性的、口服活性的、具有 ATP 竞争性的 TGF-β 受体 1 型 (ALK5) 抑制剂(IC50:38.2 nM)。它能够抑制多种促肿瘤活性，可用作免疫调节剂。
T15816	LY341495	GluR	Neuroscience
	LY341495 是高效的代谢型谷氨酸受体拮抗剂，对多种谷氨酸受体的亚型表现除很高的活性，可用于研究神经系统疾病。
T27951	LY392098 LY-392098,LY 392098,AMPA receptor modulator-3	GluR; iGluR	Membrane transporter/Ion channel; Neuroscience
	LY392098 (AMPA receptor modulator-3) 是 AMPA 受体的变构调节剂，EC50 为 4.4 μM，可用于哺乳动物神经系统的研究。
T2688	LY310762 LY310762 HCl	5-HT Receptor	GPCR/G Protein; Neuroscience
	LY310762 是 5-HT1D 受体拮抗剂，Ki 为 249 nM。
T9064	LY3143921 hydrate	CDK	Cell Cycle/Checkpoint
	LY3143921 ((S)-Example 2) hydrate 是一种具有口服活性的 CDC7激酶抑制剂。LY3143921 hydrate 表现出广泛的体外抗癌活性。
T9078	LY3405105 1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester	CDK	Cell Cycle/Checkpoint
	LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester) 是一种新型 CDK7 抑制剂。
T6882	LY3009120 DP-4978	Raf; Autophagy	Autophagy; MAPK
	LY3009120 (DP-4978) 是一种泛RAF 抑制剂，其抑制BRAFV600E、BRAFWT 和CRAFWT 的IC50分别为 5.8、9.1和15 nM。
T7810	LY3177833 LY-3177833	CDK	Cell Cycle/Checkpoint
	LY3177833 抑制CDC7和pMCM2，IC50值分别为 3.3 nM 和 290 nM。
T78626	LY393615 NCC1048	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	LY393615 (NCC1048) 是新型神经元 Ca2+ 与 Na+ 通道阻断剂，具备优良的脑渗透性，并在脑缺血模型中显示神经保护效果，适用于神经性疾病研究。
T60355	LY367385 hydrochloride
	LY367385 hydrochloride 是一种高效且选择性的mGluR1a 拮抗剂，抑制喹喹啉诱导的磷酸肌醇水解的IC50值为 8.8 μM，而对 mGlu5a 的IC50值大于 100 μM。LY367385 hydrochloride 具有神经保护，抗惊厥和抗癫痫作用。
T18246	Mal-C2-Gly3-EDA-PNU-159682	Others	Others
	Mal-C2-Gly3-EDA-PNU-159682, a drug-linker conjugate for antibody-drug conjugates (ADC), combines the cleavable ADC linker Mal-C2-Gly3-EDA with the potent ADC cytotoxin PNU-159682.
T72384	(S)-LY3177833 hydrate
	(S)-LY3177833 ((S)-Example 2) hydrate，是一种具口服活性的CDC7激酶抑制剂，展现了广泛的体外抗癌活性。
T11911	LY3020371 hydrochloride	GluR	Neuroscience
	LY3020371 hydrochloride exerts an antidepressant-like signature in vivo. LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, potently blocks cAMP formation with IC50 of 16.2 nM.
T77828	Fmoc-Gly3-Val-Cit-PAB
	Fmoc-Gly3-Val-Cit-PAB为一种可降解（cleavable）的ADC linker，其用途在于抗体偶联活性分子（ADC）的合成。
T70005	LY3325656
	LY3325656 is a GPR142 agonist suitable for clinical testing in human. LY3325656 demonstrated anti-diabetic benefits in pre-clinical studies and ADME/PK properties suitable for human dosing. LY3325656 is the first GPR142 agonist molecule advancing to phase 1 clinic trials for the treatment of Type 2 diabetes.
T38791	LY3020371
	LY3020371 is a highly potent and selective antagonist targeting the glutamate (mGlu) 2/3 receptor, showcasing excellent inhibition at Ki values of 5.26 nM and 2.50 nM for hmGluR2 and hmGluR3, respectively. With its remarkable affinity and specificity, LY3020371 serves as a valuable tool in depression research.
T27947	LY339434 LY 339434,LY-339434
	LY339434 is a potent and selective agonist of the kainate receptor GluK1, GluR5.
T39406	(±)-LY367385 (±)-LY367385
	(±)-LY367385 is the racemic form of LY367385, and LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 exhibits a high inhibitory activity against quisqualate-induced phosphoinositide (PI) hydrolysis, with an IC50 value of 8.8 μM. In contrast, its inhibitory activity against mGlu5a is greater than 100 μM.
T15818	LY367385	FXR	Metabolism
	LY367385 is a highly effective and selective mGluR1a antagonist. LY367385 has neuroprotective, anticonvulsant, and antiepileptic effects. Compared with > 100 μM for mGlu5a, LY367385 has an IC50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis.
T27944	LY3202626 LY 3202626,LY-3202626
	LY3202626, an amyloid precursor protein secretase (BACE protein) inhibitor, is used for the treatment of Alzheimer's disease.
T60747	LY3143921
	LY3143921 ((S)-Example 2) 具有广泛的体外抗癌活性，是口服有效的CDC7激酶抑制剂。
T18247	Mal-C2-Gly3-EDA	Others	Others
	Mal-C2-Gly3-EDA is a cleavable antibody-drug conjugate (ADC) linker equipped with a Maleimide moiety. It serves the purpose of facilitating the synthesis of ADCs.
T82384	Fmoc-Gly3-VC-PAB-MMAE
	Fmoc-Gly3-VC-PAB-MMAE 是一款用于 ADC 的药物-连接子偶联物，由 MonomethylauristatinE 和连接子构成。
T33013	LY334362 LY 334362,LY-334362
	LY334362 is a bioactive chemical.
T15814	LY3130481	Others	Others
	LY3130481 is an AMPA receptor antagonist. It is dependent upon transmembrane AMPA receptor regulatory protein (TARP) γ-8 and selectively inhibits AMPA/TARP γ-8 (IC50: 65 nM).
T38790	LY3027788 hydrochloride
	LY3027788 hydrochloride is a diester analog of LY3020371, a selective antagonist of the metabotropic glutamate 2 and 3 receptors (mGlu2/3). It serves as a highly potent and orally bioavailable prodrug of LY3020371. Notably, LY3027788 hydrochloride exhibits antidepressant efficacy.
T27943	LY314228 LY-314228,LY 314228
	LY314228 is an antagonist of 5-HT2A receptor.
T27950	LY389795 LY-389795,LY 389795
	LY389795 is an agonist of group II (mGlu2/3) metabotropic glutamate receptor, it is used in inflammatory pain models.
T62610	LY3154885
	LY3154885 是一种口服具有活力的多巴胺 D1 受体正变构调节剂 (PAM)。LY3154885 对药物-药物相互作用 (DDI) 的风险具有改善作用。
T24422	LY3104607 LY 3104607,LY-3104607
	LY3104607 is a G Protein-Coupled Receptor 40 agonist. It is active in oral treatment for patients with type 2 diabetes mellitus and is a glucose-lowering drug candidate.
T40308	Gly3-VC-PAB-MMAE Gly3-VC-PAB-MMAE
	Gly3-VC-PAB-MMAE is a chemical compound comprised of a cleavable antibody-drug conjugate (ADC) linker, Gly3-VC-PAB, and a potent inhibitor of tubulin, MMAE. It is utilized in the synthesis of ADCs.
T22951	LY320135 LY 320135	Others	Others
	CB1 receptor antagonist/inverse agonist
T27942	LY307452 LY 307452,LY-307452
	LY307452 is a selective antagonist of mGluR2/3.
T11912	LY3154207	Others	Others
	LY3154207 is a subtype selective, potent, and orally available human dopamine D1 receptor positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50=3 nM).
T15813	LY309887	LTR	Immunology/Inflammation
	LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.
T27945	LY320954 LY 320954,PDSP1_001629,LY-320954
	LY320954 is an antagonist of 5-HT2A receptor.
T27941	LY303336 LY-303336,LY 303336
	LY303336 is an antagonist of AT1 receptor.
T27940	LY301875 LY 301875,LY-301875
	LY301875 is an antagonist of nonpeptide angiotensin receptor.
T61610	NPEC-caged-LY379268
	NPEC-caged-LY379268 是第二组 mGluR 激动剂。
T38792	LY3027788 LY3027788
	LY3027788, a diester analog of LY3020371, an mGlu2/3 receptor antagonist, is a highly potent and orally active prodrug of LY3020371. Notably, LY3027788 exhibits significant antidepressant efficacy.
T63051	(R)-MALT1-IN-3
	(R)-MALT1-IN-3 (compound 121) 是一种 MALT1 蛋白酶的有效抑制剂 (IC50: 20 nM)，对于 OCI-LY3 细胞中的人 IL6/IL10 的 IC50 值分别为 60 nM 和 40 nM。
T63053	MALT1-IN-3
	MALT1-IN-3 是一种 MALT1 蛋白酶的有效抑制剂 (IC50: 0.06 μM)，对 OCI-LY3 细胞中人 IL6 和 IL10 的 IC50 值分别为 0.14 和 0.13 μM。
T62533	MALT1-IN-8
	MALT1-IN-8 是一种 MALT1 蛋白酶的有效抑制剂 (IC50: 2 nM)。MALT1-IN-8 对 OCI-LY3 淋巴瘤细胞的生长具有抑制作用 (IC50: 1.16 μM)，表现出抗癌活性。

化合物

Cat.No: T15819

Target: Adrenergic Receptor

Cat.No: T15815

Synonym: AK-01

Target: Aurora Kinase

Cat.No: T27949

Synonym: LY-382884,LY 382884

Target: GluR

Cat.No: T4266

Synonym: 4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐,LY 334370

Target: 5-HT Receptor

Cat.No: T27947L

Synonym: LY339434 HCl(219566-62-8 Free base)

Target: GluR, NMDAR

Cat.No: T61661

Synonym: Formulaic Ia

Target: Microtubule Associated

Cat.No: T5125

Target: TGF-beta/Smad

Cat.No: T15816

Target: GluR

Cat.No: T27951

Synonym: LY-392098,LY 392098,AMPA receptor modulator-3

Target: GluR, iGluR

Cat.No: T2688

Synonym: LY310762 HCl

Target: 5-HT Receptor

LY3143921 hydrate

Cat.No: T9064

Target: CDK

Cat.No: T9078

Synonym: 1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester

Target: CDK

Cat.No: T6882

Synonym: DP-4978

Target: Raf, Autophagy

Cat.No: T7810

Synonym: LY-3177833

Target: CDK

Cat.No: T78626

Synonym: NCC1048

Target: Calcium Channel

LY367385 hydrochloride

Cat.No: T60355

Mal-C2-Gly3-EDA-PNU-159682

Cat.No: T18246

Target: Others

(S)-LY3177833 hydrate

Cat.No: T72384

LY3020371 hydrochloride

Cat.No: T11911

Target: GluR

Fmoc-Gly3-Val-Cit-PAB

Cat.No: T77828

Cat.No: T70005

Cat.No: T38791

Cat.No: T27947

Synonym: LY 339434,LY-339434

Cat.No: T39406

Synonym: (±)-LY367385

Cat.No: T15818

Target: FXR

Cat.No: T27944

Synonym: LY 3202626,LY-3202626

Cat.No: T60747

Mal-C2-Gly3-EDA

Cat.No: T18247

Target: Others

Fmoc-Gly3-VC-PAB-MMAE

Cat.No: T82384

Cat.No: T33013

Synonym: LY 334362,LY-334362

Cat.No: T15814

Target: Others

LY3027788 hydrochloride

Cat.No: T38790

Cat.No: T27943

Synonym: LY-314228,LY 314228

Cat.No: T27950

Synonym: LY-389795,LY 389795

Cat.No: T62610

Cat.No: T24422

Synonym: LY 3104607,LY-3104607

Gly3-VC-PAB-MMAE

Cat.No: T40308

Synonym: Gly3-VC-PAB-MMAE

Cat.No: T22951

Synonym: LY 320135

Target: Others

Cat.No: T27942

Synonym: LY 307452,LY-307452

Cat.No: T11912

Target: Others

Cat.No: T15813

Target: LTR

Cat.No: T27945

Synonym: LY 320954,PDSP1_001629,LY-320954

Cat.No: T27941

Synonym: LY-303336,LY 303336

Cat.No: T27940

Synonym: LY 301875,LY-301875

NPEC-caged-LY379268

Cat.No: T61610

Cat.No: T38792

Synonym: LY3027788

Cat.No: T63051

Cat.No: T63053

Cat.No: T62533

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04925	CD8 beta Protein, Human, Recombinant, Biotinylated LY3,LYT3,CD8b molecule,P...	Human	HEK293 Cells
	CD8 beta Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 17.6 kDa and the accession number is P10966-1.
TMPY-02925	CD8 beta Protein, Human, Recombinant LEU2,P37,CD8b molecule,LYT3,CD8B1...	Human	HEK293 Cells
	CD8 beta Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 17.6 kDa and the accession number is P10966-1.
TMPY-02703	CD8 beta Protein, Human, Recombinant (hFc) LYT3,CD8 β,CD8b molecule,LY3<...	Human	HEK293 Cells
	CD8 beta Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44 kDa and the accession number is P10966-1.

重组蛋白

CD8 beta Protein, Human, Recombinant, Biotinylated

Cat.No: TMPY-04925

Species: Human

Expression System: HEK293 Cells

CD8 beta Protein, Human, Recombinant

Cat.No: TMPY-02925

Species: Human

Expression System: HEK293 Cells

CD8 beta Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02703

Species: Human

Expression System: HEK293 Cells

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