25
3
Cat. No. | Product Name | Target | Signaling Pathways |
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T1783 |
LXR-623
LXR623,WAY 252623 |
Liver X Receptor | Metabolism |
LXR-623 (WAY 252623) 是一种LXRα部分激动剂和LXRβ完全激动剂,可透过血脑屏障,IC50分别为 179 nM 和 24 nM 。 | |||
T7832 |
Ibrolipim
NO-1886 |
LPL Receptor | GPCR/G Protein |
Ibrolipim (NO-1886) 是口服具有活力的脂蛋白脂肪酶 (LPL) 激活剂。它能够降低血浆甘油三酸酯,增加高密度脂蛋白胆固醇水平,具有肾保护和降血脂的作用。 | |||
T63723 | LXR agonist 1 | ||
LXR (Liver X receptor) agonist 1 是 LXR 的有效激动剂,能够作用于 LXR-α (AC50: 1.5 nM) 和 LXR-β (AC50: 12 nM)。LXR agonist 1 对动脉粥样硬化表现出研究潜力。 | |||
T6690 |
T0901317
N-(2,2,2-三氟乙基)-N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]苯磺酰胺 |
Apoptosis; FXR; Liver X Receptor; ROR | Apoptosis; Metabolism |
T0901317 是一种口服有效且高度选择性的LXR 激动剂,对 LXRα 的EC50为 20 nM。它激活FXR,EC50为 5 μM。它是RORα和RORγ双重反向激动剂,Ki 值分别为 132 nM 和 51 nM。它诱导细胞凋亡,并抑制低密度脂蛋白受体缺失小鼠动脉粥样硬化的发展。 | |||
T64171 | LXR antagonist 2 | ||
LXR antagonist 2 (compound 10rr) 是一种有效的 LXR (肝 X 受体) 反向激动剂,能够作用于 LXRβ (IC50: 0.36 μM) 和 LXRα (IC50: 2.25 μM)。 LXR antagonist 2 是一种脂肪生成抑制剂,能够下调 LXR 靶基因 SREBP-1c、ACC、FAS 和 SCD-1。LXR antagonist 2 对 Triton WR-1339 诱导的高脂血症小鼠表现出降脂活性。 | |||
T64148 |
LXR agonist 2
|
||
LXR agonist 2 是 LXR (肝 X 受体) 的有效激动剂。LXR agonist 2 能够稳定 NCOA1 (助激活剂),进而激动 LXR。 | |||
T63989 | LXRβ agonist-3 | ||
LXRβ agonist-3 是一种强效的、选择性的 LXRβ (肝 X 受体 β) 激动剂 (EC50: 0.095 μM)。LXRβ agonist-3 可以有效抑制 U87EGFRvIII 细胞 (IC50: 3.75 μM)。LXRβ agonist-3 表现出抗肿瘤作用,能够抑制恶性胶质瘤。 | |||
T83128 | Aminooxy CatB-LXR | ||
Aminooxy CatB-LXR (compound 10) 是一种用于抗体药物偶联体(ADC)的药物连接分子。 | |||
T3970 |
BMS-779788
XL652,EXEL04286652,XL 652,XL-652,BMS-788 |
Liver X Receptor | Metabolism |
BMS-779788 (XL-652) 是一种 LXR 的部分激动剂,能够作用于 LXRα (IC50:68 μM) 和 LXRβ (IC50:14 μM)。 | |||
T16930 |
SR9238
|
Liver X Receptor | Metabolism |
SR9238 是有效的肝 X 受体(LXR)反向激动剂,对LXRα和LXRβ的IC50分别为 214 nM 和 43 nM。 | |||
T63896 |
BE1218
|
Liver X Receptor | Metabolism |
BE1218 是一种肝 X 受体 (LXR) 反向激动剂,对 LXRα 和 LXRβ有活性,IC50 分别为 9 nM 和 7 nM。 | |||
T15427 |
GSK2033
|
Liver X Receptor | Metabolism |
GSK2033 是LXR 的有效拮抗剂,抑制LXRα和LXRβ的pIC50分别为 7 和 7.4。 | |||
T7796 |
TUG-1375
|
GPR | Endocrinology/Hormones; GPCR/G Protein |
TUG-1375 是游离脂肪酸受体 2 (FFA2/GPR43) 激动剂(pKi:6.69)。它对 FFA3,FFA4,PPARα,PPARγ,PPARδ,LXRα 或 LXRβ 无作用。 | |||
T7621 |
6-Thioinosine
6-Mercaptopurine riboside,6-疏基嘌呤核苷,6TI |
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
6-Thioinosine (6TI) 是一种嘌呤抗代谢物,是抗脂肪形成剂,能降低PPAR γ和C/EBPα及其目标基因 aP2、CD36、LPL 和 LXRα 的 mRNA 水平。 | |||
T5178 |
AZ876
|
Liver X Receptor | Metabolism |
AZ876 是高亲和力的 LXR 激动剂。它在人的 (h)LXRα 和 hLXRβ 比 GW3965 要分别强 25 和 2.5 倍。 | |||
T27478 |
GSK3987
|
Liver X Receptor | Metabolism |
GSK3987 是广谱LXRα/β激动剂,EC50分别为 50 nM 和 40 nM。GSK3987增加 ABCA1 和 SREBP-1c 蛋白的表达,诱导细胞甘油三酯的积累和胆固醇流出。 | |||
T68696 |
AZ-2
|
||
AZ-2 is an inducer of ABCA1 and apoE. It enhances ABCA1 activity and decreases P2X7 receptor activity. AZ-2 activates endogenous LXR signaling but shows no direct LXRα or LXRβ agonist activity. | |||
T25528 |
IMB-808
|
||
IMB-808 is an effective partial dual agonist of liver X receptor α and β (LXRα/β) that promotes the expression of genes related to reverse cholesterol transport (including ABCA1 and ABCG1). | |||
T68668 |
AZ-1
|
||
AZ-1 is an inducer of ABCA1 and apoE. It enhances ABCA1 activity and decreases P2X7 receptor activity. AZ-1 activates endogenous LXR signaling but shows no direct LXRα or LXRβ agonist activity. | |||
T6310 |
GW3965 hydrochloride
GW3965 HCl |
Liver X Receptor | Metabolism |
GW3965 hydrochloride (GW3965 HCl) 是一种肝 X 受体 (LXR) 激动剂,主要作用于 hLXRα (EC50:190 nM) 和 hLXRβ (EC50:30 nM) | |||
T37414 |
CAY10771
|
||
CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 μM, respectively) and is selective for these receptors over retinoic acid receptor α (RARα), retinoid X receptor α (RXRα), PPARα, PPARγ, and liver X receptor α (LXRα) at 10 μM. 1.Schierle, S., Neumann, S., Heitel, P., et al.Design and structural optimization of dual FXR/PPARδ activatorsJ. Med. Ch... | |||
T37408 |
Bischloroanthrabenzoxocinone
|
||
Bacterial type II fatty acid synthesis (FAS-II) is mediated by a series of enzymes, each of which may be targeted by potential antibiotics. Bischloroanthrabenzoxocinone (BABX) is an inhibitor of FAS-II, blocking fatty acid synthesis in S. aureus and E. coli with IC50 values of 11.4 and 35.3 μg/ml, respectively. It inhibits the growth of S. aureus and permeable E. coli strains with minimum inhibitory concentrations ranging from 0.2-0.4 μg/ml. BABX also displays binding to liver X receptors (LXRs)... | |||
T83765 |
Dendrogenin A
DDA |
||
Dendrogenin A (DDA) 作为一种选择性肝X受体(LXR)调节剂(SLiM)、胆固醇环氧水解酶(ChEH; Ki = 120 nM)的抑制剂及胆固醇的活性代谢产物,通过DDA合成酶将5,6α-环氧胆固醇与组胺结合形成。DDA在非癌性人乳腺上皮细胞和上皮黑色素细胞中存在,但在多种乳腺癌细胞或黑色素瘤细胞中未发现,且在分离的人乳腺肿瘤组织中仅以低水平存在。它抑制22(R)-羟基胆固醇诱导的LXRβ和LXRα激活(分别以IC50 = 76和362 nM),但也是LXR的部分激动剂,在B16/F10小鼠黑色素瘤细胞中增加Nur77、NOR-1、LC3-I和LC3-II的蛋白水平。DDA选择性调节LXRα和LXRβ,而非孕烯X受体(PXR)、芳香烃受体(AhR)、维生素D受体(VDR)、维甲酸X受体γ(RXRγ)、维甲酸受体α(RARα)、过氧化物酶体增殖物激活受体α(PPARα)、PPARγ、糖皮质激素受体、雄激素受体、雌激素受体α(ERα)及ERβ在2.5 µM下。此外,DDA在2.5和5 µM的浓度下增加B16/F10和SK-MEL-28癌细胞中LC3-II的蛋白水平,并在2... | |||
T36130 |
22(S)-hydroxy Cholesterol
22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol |
||
22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22... | |||
T11899 |
LXRβ agonist-2
|
Others | Others |
LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2810 |
(20S)-Protopanaxatriol
原人参三醇,20(S)-APPT,20 (S)-原人参三醇,g-PPT |
Apoptosis; Estrogen Receptor/ERR; Glucocorticoid Receptor; Estrogen/progestogen Receptor; Liver X Receptor | Apoptosis; Endocrinology/Hormones; Metabolism |
(20S)-Protopanaxatriol (g-PPT) 是人参皂苷的代谢物,通过糖皮质激素受体和雌激素受体起作用,同时为LXRα的抑制剂,具有广泛的抗癌活性。 | |||
T2768 |
Saikosaponin A
柴胡皂苷A,柴胡皂苷 A |
NF-κB; Antibacterial; Liver X Receptor | Metabolism; Microbiology/Virology; NF-κB |
Saikosaponin A 是银柴胡中的主要活性成分,有抗炎活性,可上调 LXRα的表达。 | |||
TN1719 |
Gymnestrogenin
匙羹藤苷元,(3BETA,4ALPHA,16BETA,21BETA)-齐墩果-12-烯-3,16,21,23,28-五醇 |
Liver X Receptor | Metabolism |
Gymnestrogenin has a dual LXRα±/α2 antagonistic profile. |