store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SR9238 是有效的肝 X 受体(LXR)反向激动剂,对LXRα和LXRβ的IC50分别为 214 nM 和 43 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 273 | 现货 | ||
2 mg | ¥ 389 | 现货 | ||
5 mg | ¥ 617 | 现货 | ||
10 mg | ¥ 1,110 | 现货 | ||
25 mg | ¥ 2,390 | 现货 | ||
50 mg | ¥ 3,580 | 现货 | ||
100 mg | ¥ 5,180 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 837 | 现货 |
产品描述 | SR9238 is a synthetic agonist of liver X receptor inverse (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively). |
靶点活性 | LXRβ:43 nM, LXRα:214 nM |
体外活性 | SR9238 effectively suppresses transcription from a fatty acid synthase promoter-driven luciferase reporter. SR9238 is a synthetic LXR inverse agonist (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively). SR9238-induced recruitment of CoRNR box peptides is dose-dependent for both LXRα and LXRβ. It is found that SR9238 induces increased interaction of CoRNR box peptides derived from NCoR with both LXRα and LXRβ while causing decreased interaction with a coactivator NR box peptide derived from TRAP220. HepG2 cells treated with SR9238 cause a significant decrease in Fasn and Srebp1c mRNA expression[1]. |
体内活性 | SR9238 treatment inhibits diet-induced hepatosteatosis, hepatic inflammation, and hepatocellular injury. SR9238 is also detected in the intestine with either i.p. or oral administration. Approximately SR9238 (6 μM) is detected in the liver 2h after the injection of SR9238, but no compound is detected in the plasma. SR9238-treated mice show greatly reduced lipid content in the liver. Both Tnfa and Il1b expression are substantially reduced (~80% and >95%, respectively) in the SR9238-treated mice when compared to the vehicle-treated mice. SR9238-treated DIO mice display a considerably lower intensity of F4/80 staining versus vehicle-treated DIO mice consistent with a beneficial effect of SR9238 on non-alcoholic steatohepatitis. SR9238 treatment does not alter body weight or percent body fat composition relative to vehicle-treated animals during the experiment [1]. |
分子量 | 595.73 |
分子式 | C31H33NO7S2 |
CAS No. | 1416153-62-2 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (83.93 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.6786 mL | 8.3931 mL | 16.7861 mL | 41.9653 mL |
5 mM | 0.3357 mL | 1.6786 mL | 3.3572 mL | 8.3931 mL | |
10 mM | 0.1679 mL | 0.8393 mL | 1.6786 mL | 4.1965 mL | |
20 mM | 0.0839 mL | 0.4197 mL | 0.8393 mL | 2.0983 mL | |
50 mM | 0.0336 mL | 0.1679 mL | 0.3357 mL | 0.8393 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
SR9238 1416153-62-2 Metabolism Liver X Receptor SR 9238 Liver X receptor LXR inhibit SR-9238 Inhibitor inhibitor