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Cat. No. | Product Name | Target | Signaling Pathways |
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T7692 |
2,4-DPD
|
HIF | Angiogenesis; Chromatin/Epigenetic |
2,4-DPD 是氧感应酶 HIF-α 脯氨酰羟化酶 (HIF-PH) 的竞争性抑制剂。 | |||
T11847L |
Liarozole
R75251 dihydrochloride,利阿唑 |
P450; Retinoid Receptor | Metabolism |
Liarozole (R75251 dihydrochloride) 是一种咪唑衍生物,是一种具有口服活性的维甲酸 (RA) 代谢阻断剂(RAMBA),具有抗肿瘤作用。它能够抑制维甲酸依赖的细胞色素P450(CYP26) 4- 羟基化 (IC50=7 μM),导致组织维甲酸水平增加。 | |||
T21653 |
1,4-DPCA
|
HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism |
1,4-DPCA 是一种脯氨酰羟化酶抑制剂,对人源包皮成纤维细胞中胶原羟基化的 IC50 为 2.4 μM,对因子抑制 HIF (FIH) 的 IC50 为 60 μM。 | |||
T9624 |
iron chloride hexahydrate
|
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iron chloride hexahydrate 促进了苯基酮衍生物的选择性羟基化和氯化反应,用于构建杂四元骨架。 | |||
TQ0121 |
VH-298
|
Others; HIF; Ligand for E3 Ligase | Angiogenesis; Chromatin/Epigenetic; Others; PROTAC |
VH-298 是一种高效的 VHL:HIF-α 相互作用抑制剂(Kd:80-90 nM)。它可用于PROTAC 技术中。 | |||
T11277 |
FG 7142
ZK 39106,LSU-65 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
FG 7142 (LSU-65) 是一种非选择性苯二氮卓类反向激动剂,对含 α1 亚基的 GABAA 受体具有高亲和力,Ki 为 91 nM。它还调节 GABA 诱导的 GABAA 受体上的氯离子通量,表达 α1 亚基,EC50为 137 nM。它可增加酪氨酸羟基化并导致小鼠大脑皮层中 β-肾上腺素受体的上调。 | |||
T1055 |
Ifosfamide
NSC109724,Isophosphamide,异环磷酰胺 |
DNA Alkylator/Crosslinker; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Ifosfamide (NSC-109724) 是一种烷化剂,具有抗肿瘤活性。它烷基化并形成 DNA 交联,从而防止 DNA 链分离和 DNA 复制。它是一种前药,必须通过肝微粒体酶的羟基化来激活。 | |||
T32743 |
Licodione
|
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Licodione is a Cytochrome P450 Monooxygenase Catalyzing 2-Hydroxylation of 5-Deoxyflavanone. | |||
T33370 |
Metyrapol
SU 5236,SU-5236,SU5236 |
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Metyrapol is a competitive inhibitor of 11-deoxycorticosterone hydroxylation by 11β-hydroxylase. | |||
T19773 |
Diethyl bipy55'DC
|
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Diethyl bipy55'DC inhibits CP4H activity in cultured cells. The stability of collagen relies on post-translational modifications, the most prevalent being the hydroxylation of collagen strands by collagen prolyl 4-hydroxylases. | |||
T83919 |
Hydroxy Darunavir
R-426857 |
||
Hydroxy darunavir是HIV-1蛋白酶抑制剂darunavir的一种代谢产物,通过异丁基脂肪族羟基化作用从darunavir形成。 | |||
T19610 |
(24S)-24,25-Dihydroxyvitamin D3
(24S)-24,25-Dihydroxycholecalciferol |
Others | Others |
(24S)-24,25-Dihydroxyvitamin D3 undergoes various levels of hydroxylation to form active vitamin D3 analogs. | |||
T83243 |
7'-Hydroxy ABA
7'-OH ABA |
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7'-Hydroxy ABA (7'-OH ABA) 是由 Abscisic acid (Abscisic acid) 通过羟基化其7'-碳原子形成的代谢产物,具备显著的激素活性。 | |||
T36237 |
5-hydroxy Propranolol
|
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5-hydroxy Propranolol is a metabolite of propranolol , a β-adrenergic receptor antagonist. Propranolol is primarily metabolized in the liver, with cytochrome P450 isoform 2D6 directing ring hydroxylation and the generation of 5-hydroxy propranolol and related metabolites. | |||
T36920 |
16α-hydroxy Dehydroepiandrosterone
|
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16α-hydroxy Dehydroepiandrosterone is a metabolite of the endogenous steroid hormone dehydroepiandrosterone .116α-hydroxy Dehydroepiandrosterone is formed from dehydroepiandrosteronevia16-hydroxylation by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in adult human liver microsomes, as well as by fetal recombinant CYP3A7. It is a precursor to fetal estrogens, including estriol .2 1.Miller, K.K.M., Cai, J., Ripp, S.L., et al.Stereo- and regioselectivity account for the diversity of dehydro... | |||
T36840 |
(R)-Omeprazole (sodium salt)
|
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(R)-Omeprazole is the inactive isomer of omeprazole , a gastric proton-pump inhibitor. A stereoselective hydroxylation of (R)-omeprazole is mediated primarily by cytochrome P450 (CYP) 2C19, whereas CYP3A4 favors sulfoxidation of the active (S)-enantiomer . (R)-Omeprazole has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19 in pooled human liver microsomes (IC50 = 8.1 μM). | |||
T10661 |
Calcifediol-D6
骨化二醇 D6 |
Others | Others |
Calcifediol-D6 is the deuterated form of Calcifediol, which is a prehormone that is produced in the liver by hydroxylation of vitamin D3 by the enzyme cholecalciferol 25-hydroxylase. | |||
T35681 |
MeIQx
|
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MeIQx (MeIQx) is a food-derived carcinogen that has been found in high temperature-cooked fish and meats.1It is activated by hydroxylation and subsequent O-acetylationviathe cytochrome P450 (CYP) isoform CYP1A2 and N-acetyltransferase 2, respectively, in UV5 cells expressing the human enzymes to a metabolite that reacts with DNA to form adducts.2MeIQx (200 and 400 ppm in the diet) induces tumor formation in rats.3 | |||
T35708 | N-acetyl-5-Aminosalicylic Acid | ||
N-acetyl-5-Aminosalicylic acid is a metabolite of the anti-inflammatory agent 5-aminosalicylic acid and its prodrug form, sulfasalazine . It is formed in the liver, intestinal lumen, and colonic epithelial cells via N-acetyltransferases. It reduces IFN-γ binding to colonic epithelial cells by 24% when used at a concentration of 10 mM. N-acetyl-5-Aminosalicylic acid (100 μM) scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay and inhibits base hydroxylation in DNA stimulated by ... | |||
T75141 | Aflatoxin Q1 | ||
Aflatoxin Q1是Aflatoxin B1 (AFB1)的羟基化代谢产物,后者由黄曲霉 (A. flavus) 产生的一种霉菌毒素。在人肝微粒体中,不论底物浓度高低,Aflatoxin B1的8,9-氧化物及Aflatoxin Q1均为其主要氧化产物。将Aflatoxin B1 3α-羟基化生成Aflatoxin Q1被视为一条重要的解毒途径。 | |||
T36384 |
DL-Tyrosine-13C9,15N
L-Tyrosine-13C9,15N |
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L-Tyrosine-13C9,15N is intended for use as an internal standard for the quantification of L-tyrosine by GC- or LC-MS. L-Tyrosine is a non-essential amino acid.1It is produced by hydroxylation of phenylalanine by phenylalanine hydroxylase but can also be obtained from dietary sources or degradation of endogenous proteins, resulting in L-tyrosine release.1,2L-Tyrosine is a precursor in the biosynthesis of catecholamine neurotransmitters, melanins, and thyroid hormones.3Plasma, skeletal muscle, and... | |||
T78135 |
Nicotelline
Nicotellin |
||
Nicotelline(Nicotellin)是一种与尼古丁相关的生物碱,作为人类cDNA表达的细胞色素P-450 2A6(CYP2A6)的弱抑制剂,不显著抑制该酶介导的香豆素7-羟基化反应,在300 μM浓度下效果更是如此。此外,Nicotelline还被用作烟草烟雾中颗粒物(PM)的示踪剂和生物标记物。 | |||
T37361 |
6β-hydroxy Dexamethasone
|
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6β-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound. Dexamethasone is metabolized by CYP3A4; therefore, quantification of the dexamethasone metabolites, 6α- and 6β-hydroxy dexamethasone, can be used to determine CYP3A4 enzyme activity in humans., The formation of 6-hydroxy dexamethasone metabolites is species-specific, with hamsters producing the highest amount. In rats, dexamethasone hydroxylation is sex-specific, with male rats producing ... | |||
T79343 |
hCYP3A4-IN-1
|
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hCYP3A4-IN-1(化合物C6)是一种经口服时具有活性的hCYP3A4抑制剂,其对hCYP3A4的IC50值在人肝微粒体(HLM)为43.93 nM,在CHO-3A4稳定转染细胞系中为153.00 nM。hCYP3A4-IN-1通过竞争性抑制机制,有效抑制CYP3A4催化的N-乙基-1,8-萘二甲酰亚胺(NEN)羟基化反应,其Ki值为30.00 nM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3S0804 |
Worenine
甲基黄连碱,Worenin |
Others | Others |
Worenine (Worenin) 是一种从黄连中提取的物质。它在大鼠体内第一阶段代谢中显示出脱氢,氢化,羟基化和脱亚甲基反应。在大鼠体内 II 期代谢中显示为硫酸化和葡萄糖醛酸化反应。 | |||
T3696 |
polygalaxanthone III
|
Others; P450 | Metabolism; Others |
Polygalaxanthone III 提取自远志polygala tenuifolia wild,可抑制CYP450酶。它能够抑制由 CYP2E1 催化的氯唑沙宗 6-羟基化(IC50:50.56μM)。 | |||
T3397 |
Epmedin C
淫羊霍定C,Baohuoside-VI,Epimedin C |
Others | Others |
Epmedin C (Baohuoside-VI) 是天然化合物,在切除卵巢的小鼠体内与雌性激素作用相似。 | |||
T3881 |
Vaccarin
|
Integrin; Akt; PERK; AMPK | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Vaccarin 是从王不留行中提取的一种黄酮糖苷,可显著促进伤口愈合以及伤口部位的内皮和成纤维细胞增殖。它通过激活 AMPK 信号通路改善胰岛素抵抗和脂肪变性。 | |||
T2S2211 |
Tenuifoliside C
|
Dehydrogenase | Metabolism |
Tenuifoliside C 是从野生的 polygala tenuifolia 中分离得到的。它对 CYP2E1 催化氯唑酮 6-羟基化反应具有抑制作用。 | |||
T4A2458 |
Resibufogenin
酯蟾毒配基,Bufogenin,Recibufogenin,酯蟾毒配基,蟾力苏 |
Others | Others |
Resibufogenin (Bufogenin) 是华蟾素的成分之一,表现出抑制氧化应激及肿瘤再生的活性。 | |||
T3818 |
Fraxinol
|
Others; P450 | Metabolism; Others |
Fraxinol 是一种分离自半边莲中的化合物。 | |||
T83241 |
7-Hydroxy-TSU-68
|
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7-Hydroxy-TSU-68为TSU-68的衍生物,该化合物为TSU-68在人类肝微粒体内经生物转化途径形成的代谢产物,其含量标识了TSU-68自身诱导的羟基化程度。 | |||
T19394 |
L-hydroxylysine dihydrochloride
(2S,5R)-5-Hydroxylysine dihydrochloride |
Others | Others |
L-hydroxylysine dihydrochloride , is formed by posttranslational hydroxylation of some lysine residues. It is an amino acid, is exclusive to collagen protein. | |||
TN2144 | Resveratroloside | P450; NO Synthase | Immunology/Inflammation; Metabolism |
Resveratroloside 是α-glucosidase 的竞争性抑制剂,可以对血糖水平进行调节,对心脏具有保护作用。 | |||
TMA2106 | (-)-Sparteine | P450 | Metabolism |
Sparteine is a class 1a antiarrhythmic agent, a sodium channel blocker. The deficient debrisoquine hydroxylation of Sparteine is due to the absence of P-450IID1 protein in the livers of poor metabolizers. | |||
T38557 | Chitotriose trihydrochloride | ||
Chitotriose trihydrochloride is an orally active chitooligosaccharide known for its antioxidant properties. It effectively inhibits the hydroxylation of benzoate to salicylate by H 2 O 2 in the presence of Cu 2+, with an IC 50 value of 80 μM. | |||
T36915 |
21-Deoxycortisol
|
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21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations inCYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies. 1.Fiet, J., Villette, J.-M., Galons, H., et al.The application of a new highly-sensitive... | |||
T83264 |
6-Hydroxy-TSU-68
|
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6-Hydroxy-TSU-68为TSU-68的衍生物,此化合物为TSU-68在人肝微粒体生物转化路径中的代谢产物,其含量反映TSU-68的自诱导羟基化程度。 |