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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1792L |
Regorafenib monohydrate
|
Raf; VEGFR; c-RET; PDGFR; c-Kit; Autophagy | Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors |
Regorafenib monohydrate 是一种新型口服多激酶抑制剂,对VEGFR1/2/3、PDGFRβ、Kit、RET 和Raf-1的IC50分别为 13、4.2、46、22、7、1.5 和 2.5 nM。 | |||
T1792 |
Regorafenib
BAY 73-4506,瑞戈非尼,Fluoro-Sorafenib,瑞格非尼 |
Raf; VEGFR; c-RET; PDGFR; c-Kit; Autophagy | Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors |
Regorafenib (BAY 73-4506) 是一种多靶点受体酪氨酸激酶抑制剂,抑制 RET、C-RAF、VEGFR2、c-Kit、VEGFR1 和 PDGFRβ (IC50=1.5/2.5/4.2/7/13/22 nM),具有口服活性。Regorafenib 具有抗肿瘤和抗血管生成活性。 | |||
T79797 |
PHD-IN-1
|
HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism |
PHD-IN-1(compound 80)作为PHD2的抑制剂,显示出 IC50 ≤5 nM 的高效活性。在Caco2-HIFla-HiBiT-clone-1和Hep3B细胞系中进行的EPO Elisa实验中,其EC50值均为2.5 μM。 | |||
T61968 | PD-1/PD-L1-IN 6 | ||
PD-1/PD-L1-IN 6 (compound A13) 是有效的PD-1/PD-L1相互作用抑制剂(IC50为 132.8 nM)。PD-1/PD-L1-IN 6 显示出显著的免疫调节活性。 在 Hep3B/OS-8/hPD-L1 与 CD3 T 细胞共培养模型中,PD-1/PD-L1-IN 6显著提高干扰素 -γ 分泌,且无明显毒性作用。 在 T 细胞-肿瘤共培养模型中,PD-1/PD-L1-IN 6恢复免疫应答。 | |||
T79737 |
Menin-MLL inhibitor 29
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
Menin-MLL inhibitor 29(Compound C1)是一种选择性Menin-MLLPPI抑制剂。该化合物与Menin紧密结合,具有138 nM的KD值,并以46 nM的IC50值明显抑制Menin与MBM1(Menin结合motif 1)的相互作用。在体外条件下,Menin-MLL inhibitor 29对HepG2和Hep3B肝癌细胞系表现出抑制增殖的作用(IC50s分别为0.31 μM和0.71 μM),也能有效抑制肿瘤生长。 | |||
T35771 | Destruxin B2 | ||
Destruxin B2 is a cyclic hexadepsipeptide mycotoxin that has been found in M. anisopliae and has antiviral, insecticidal, and phytotoxic activities.1,2,3 It inhibits secretion of hepatitis B virus surface antigen (HBsAg) by Hep3B cells expressing hepatitis B virus (HBV) DNA (IC50 = 1.3 μM).1 Destruxin B2 is toxic to Sf9 insect cells in an electric cell-substrate impedance sensing (ECIS) test with a 50% inhibitory concentration (ECIS50) value of 92 μM.4 It is also phytotoxic to B. napus leaves.3 ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4S0145 |
Corylifol A
Corylinin,补骨脂异黄酮A |
hCE; STAT; UGT | JAK/STAT signaling; Metabolism; Stem Cells |
Corylifol A (Corylinin) 是补骨脂中的一种天然产物,可抑制IL-6 诱导的STAT3激活和磷酸化,IC50值为0.81 μM。 | |||
T4964 |
steviolbioside
CCRIS-6025,菊双糖甙,甜菊双糖苷 |
Others | Others |
Steviolbioside (CCRIS-6025) 是一种存在于甜菊叶中的罕见甜味剂。它对几种人类癌细胞有抑制作用,对乳腺癌具有潜在的研究价值。 | |||
T80942 |
Triptonoditerpenic acid
|
||
Triptonoditerpenic acid 为一芳香族松香烷二萜类化合物,源自Tripterygium wilfordii。该化合物对HepG2、Hep3B 及 Bcap37细胞株展现细胞毒性作用,其IC50值依次为42.53 μM、29.74 μM 与37.63 μM。 | |||
TN2685 |
2,3,24-Trihydroxy-12-ursen-28-oic acid
|
Antifection | Microbiology/Virology |
2α,3α,24-Trihydroxyurs-12-en-28-oic acid, a triterpenoid phytoalexin, shows antifungal activity against the fungus mentioned. It also shows in vitro cytotoxic activity against tumor cell lines including PLC,Hep3B,HepG2,HeLa,SW480,MCF-7 and Bel7402. | |||
TN4490 | Manassantin B | ERK; BCL; p38 MAPK; TNF; NF-κB; JNK; STAT; Antifection | Apoptosis; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells |
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-EBV lytic replication activity. Manassantin B inhibits interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells, it has potential as a potent anti-inflammatory drug for use in pathological processes such as sepsis or acute lung injury. Manassantin B exerts antifibrotic activity in HSC-T6 cells, in pa... |