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Search Results for " glucagon "

Targets Recommended: Glucagon Receptor Glucocorticoid Receptor Glucagon Receptor

164

抑制剂 & 化合物

4

天然产物

17

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T15389L	Glucagon (1-29), bovine, human, porcine hydrochloride 盐酸胰高血糖素,Porcine glucagon hydrochloride,Glucagon hydrochloride	Glucocorticoid Receptor; Glucagon Receptor	Endocrinology/Hormones; GPCR/G Protein
	Glucagon (1-29), bovine, human, porcine hydrochloride 是一种由胰腺 α 细胞产生的多肽激素。它可激活 HNF4α 并促进 HNF4α 磷酸化，促进糖异生。
TP1863L	Glucagon (19-29), human acetate	Glucagon Receptor	GPCR/G Protein
	Glucagon (19-29), human acetate 是一种从胰高血糖素加工而来的 COOH 末端片段，是一种有效的胰岛素分泌抑制剂。
TQ0239	PF-06291874 Glucagon receptor antagonists-4	Glucagon Receptor	GPCR/G Protein
	PF-06291874 (Glucagon receptor antagonists-4) 是口服有活性的胰高血糖素受体非肽类拮抗剂。它正用于研究 2 型糖尿病。
T36638	[Des-His1,Glu9]-Glucagon amide TFA [Des-His1,Glu9]-Glucagon amide TFA
	[Des-His1,Glu9]-Glucagon amide TFA is a potent peptide antagonist targeting the glucagon receptor, featuring a pA2 value of 7.2. It holds potential utility in diabetes pathogenesis research[1].
T15389	Glucagon (1-29), bovine, human, porcine 胰高血糖素,Porcine glucagon,Glucagon	Others	Others
	Glucagon is a peptide hormone, produced by pancreatic α-cells. Glucagon reduces the activity of HNF-4. Glucagon stimulates gluconeogenesis. Glucagon enhances HNF4α phosphorylation.
T37223	Glucagon Receptor Antagonist I
	Glucagon receptor antagonist I is a competitive antagonist of the glucagon receptor (GCGR; IC50 = 181 nM). It blocks glucagon-induced glycogenolysis in primary human hepatocytes and isolated liver. Glucagon receptor antagonist I, at 50 mg/kg, reduces the increase in glucose levels observed after intraperitoneal administration of glucagon in humanized mice. Glucagon receptor antagonist inactive control does not prevent glucagon-mediated actions.
TP2033	[Des-His1,Glu9]-Glucagon amide des-His1-[Glu9]-Glucagon (1-29) amide
	Glucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitro. Blocks added glucagon-induced hy
T78059	Glucagon (Human) Hyperglycemic-glycogenolytic factor,Glukagon	Others	Others
	Glucagon 对蛋白质和氨基酸的代谢产生显著的调节作用。它抑制了氨基酸与肝脏、肌肉以及胰腺蛋白的结合，增加氮的排出，并促进肝脏内尿素的合成。同时，Glucagon 增加了肝脏中转氨酶和尿素循环酶的浓度，提高了肝脏对氨基酸的摄取，并加强了氨基酸与肝糖原之间的结合，从而降低了血液中的氨基酸浓度。
T36580	Glucagon Receptor Antagonist Inactive Control
	Glucagon Receptor Antagonist Inactive Control 是一种 Glucagon 受体拮抗剂，可用于生命科学领域的相关研究。其产品编号为 T36580，CAS号为 362482-00-6。
T11413	Glucagon receptor antagonists-1	Others	Others
	Glucagon receptor antagonist -1 is a highly effective glucagon receptor antagonist.
TP1863	Glucagon (19-29), human
	Glucagon is a 29-amino-acid peptide hormone liberated in the alpha cells of the islets of Langerhans. Glucagon-producing alpha cells represent one of the earliest populations of detectable islet cells in the developing endocrine pancreas.
T11416	Glucagon receptor antagonists-5	Others	Others
	Glucagon receptor antagonists-5 is an orally bioavailable indazole-based glucagon receptor antagonist (Ki: 32 nM). It has potential for the treatment of type 2 diabetes mellitus (T2DM).
T11415	Glucagon receptor antagonists-3	Others	Others
	Glucagon receptor antagonist -3 is a highly effective glucagon receptor antagonist.
T11414	Glucagon receptor antagonists-2	Others	Others
	Glucagon receptor antagonist -2 is a highly effective glucagon receptor antagonist.
TP1148L	Glucagon-like peptide 1 (1-37), human acetate	Glucagon Receptor	GPCR/G Protein
	Glucagon-like peptide 1 (1-37), human acetate 是一种高效的 GLP-1 受体激动剂。
TP1487	Glucagon-Like Peptide (GLP) II, human
	Glucagon-like peptide 2 (GLP-2) is a recently identified intestinal epithelium-specific growth factor that has been shown to reduce the severity of inflammatory disorders of the intestine in rodent models. Currently Glucagon-Like Peptide 2 is used as a po
T80030	Oxyntomodulin (bovine, porcine) (TFA) Glucagon-37 (bovine, porcine) (TFA)
	Oxyntomodulin (bovine, porcine) TFA为含37个氨基酸的肽类激素，作为胰高血糖素样肽1 (GLP-1) 受体的激动剂。
TQ0124	BETP	Glucagon Receptor	GPCR/G Protein
	BETP 是胰高血糖素样肽 (GLP-1) 受体激动剂，能够抑制人和大鼠的GLP-1受体，其EC50值分别为 0.66 μM 和 0.755 μM。
TP1148	Glucagon-like peptide 1 (1-37), human HuGLP-1
	Glucagon-like peptide 1 (1-37), human is a highly potent agonist of the GLP-1 receptor.Pancreatic hormone synthesized by post-translational processing of proglucagon. Unlike truncated forms of GLP-1, it has no effect on food intake in rats and does not en
T82306	Glucagon (22-29)
	Glucagon (22-29) 作为Glucagon (19–29)的部分激动剂，能特异性抑制肝质膜 Ca2+泵，其作用机制与腺苷酸环化酶激活无关。
TP1147	Glucagon-like peptide 1 (1-37), human TFA HuGLP-1 TFA
	Glucagon-like peptide 1 (1-37), human (TFA) is a highly potent agonist of the GLP-1 receptor, it is a kind of pancreatic hormone synthesized by post-translational processing of proglucagon.
T11845	LGD-6972	Glucagon Receptor	GPCR/G Protein
	LGD-6972 是口服有活性的胰高血糖素受体选择性拮抗剂，能够用于研究 2 型糖尿病。
T80453	GLP-1 (1-36) amide (human, rat) Glucagon-like Peptide 1 (1-36) amide (human, rat)
	GLP-1(1-36) amide (human, rat)（人类及大鼠的胰高血糖素样肽1（1-36）酰胺）是GLP-1(7-36)酰胺的一种分子变体。该化合物能激发[14C]氨基吡啶在大鼠胃壁细胞的酶分散体中积累。
T7364	NNC-0640	Glucagon Receptor	GPCR/G Protein
	NNC-0640 是人类胰高血糖素受体阴性变构调节剂(IC50:69.2 nM)。
T76326	[Des-His1,Glu9] Glucagon
	[Des-His1,Glu9] Glucagon 是一种有效的胰高血糖素受体系统多肽拮抗剂。[Des-His1,Glu9] Glucagon 增强胰岛细胞在葡萄糖刺激下释放胰岛素。[Des-His1,Glu9] Glucagon 可用于糖尿病的研究。
TP1157	GLP-2(1-33)(human) GLP-2 (human),Glucagon-like peptide 2 (human)
	GLP-2(1-33) (human) is an enteroendocrine hormone which stimulates the growth of the intestinal epithelium.
T8748	Exendin-4 acetate	Glucagon Receptor	GPCR/G Protein
	Exendin-4 acetate 是一种长效的 glucagon-likepeptide-1 受体激动剂(IC50:3.22 nM)，是一种由39个氨基酸组成的多肽。。
T82309	GLP-1 (1-36) amide (human, rat) (TFA) Glucagon-like Peptide 1 (1-36) amide (human, rat) (TFA)
	GLP-1(1-36) amide (human, rat) TFA为胰高血糖素样肽1(GLP-1)-(7-36)酰胺的分子变体，能够促进[14C]氨基吡啶在大鼠壁细胞的酶分散体中的积累。
TP2252	GLP-1 (9-36) amide	Glucagon Receptor	GPCR/G Protein
	GLP-1(9-36)amide 是胰高血糖素样肽-1 (7-36) amide 的主要代谢产物，对人胰腺 GLP-1受体具有拮抗作用。
T83550	(Asp28)-Glucagon (1-29) (human, rat, porcine)
	'(Asp28)-Glucagon (1-29) (human, rat, porcine)' 为胰高血糖素的一种改良型结构，在第28位氨基酸残基上天冬氨酸（Asp）替换原有残基，显著提高了该化合物在生理pH条件下的溶解性，且保持了与天然胰高血糖素相同的生物活性。
T76332	Biotinyl-Glucagon (1-29), human, bovine, porcine
	Biotinyl-Glucagon (1-29), human, bovine, porcine 为带生物素标记的Glucagon衍生物，此肽类激素由胰腺α细胞分泌，功能是提升血液中的葡萄糖与脂肪酸浓度。
T19850	Semaglutide 索玛鲁肽,司美格鲁肽,索马鲁肽	Glucagon Receptor	GPCR/G Protein
	Semaglutide 是人胰高血糖素样肽-1受体激动剂，是一种人胰高血糖素样肽-1 的长效类似物。它有用于 2 型糖尿病研究的潜力。
T0178	Saxagliptin hydrate 沙格列汀单水化合物,Onglyza hydrate,BMS-477118 hydrate	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Saxagliptin hydrate (Onglyza hydrate) 是一种选择性，竞争性，可逆性和口服活性的二肽基肽酶 4 (DPP-4) (Ki= 0.6-1.3 nM) 抑制剂。Saxagliptin hydrate 能够用于 2 型糖尿病的研究。
T3984	GLP-1(7-36), amide MKC 253,胰高血糖素样肽-1,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide	Glucagon Receptor	GPCR/G Protein
	GLP-1(7-36), amide (MKC 253) 是一种生理性肠降血糖素，能够刺激胰岛素分泌。
T6203	Saxagliptin BMS-477118,沙克列汀,Onglyza,沙格列汀	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Saxagliptin (BMS-477118) 是一种选择性，可逆性，竞争性和口服活性的二肽基肽酶 4 (DPP-4) (Ki= 0.6-1.3 nM) 抑制剂。Saxagliptin 能够用于 2 型糖尿病的研究。
T76628	(Met(O)27)-Glucagon (1-29) (human, rat, porcine)
	'(Met(O)27)-Glucagon (1-29) (human, rat, porcine) 为修饰版胰高血糖素。在大鼠肝细胞内，其促进葡萄糖合成的活性虽与天然胰高血糖素相似，但呈现出较低效率，暗示蛋氨酸对于胰高血糖素与其肝脏受体绑定具有关键性作用。'
T3422	GRA Ex-25 GRA-Ex-25	Glucagon Receptor	GPCR/G Protein
	GRA Ex-25 (GRA-Ex-25) 是glucagon 受体抑制剂，其对大鼠和人的 glucagon 受体的IC50值分别为 56 和 55 nM。
T3967	Exendin-4 艾塞那肽,Exenatide,Exenatide Acetate	Glucagon Receptor	GPCR/G Protein
	Exendin-4 (Exenatide) 是一种长效的 glucagon-likepeptide-1 受体激动剂(IC50: 3.22 nM)，是一种由 39 个氨基酸组成的多肽。
T76330	Human glucagon-like peptide-1-(7-36)-Lys(Biotin) amide
	Human glucagon-like peptide-1-(7-36)-Lys(Biotin) amide 是一种带有生物素标签的Glucagon-like peptide-1-(7-36)，后者为一种具备提升胰岛素释放功能，从而表现出抗糖尿病活性的胃肠道肽。
TP1039	Secretin (33-59), rat 大鼠SECRETIN肽,Secretin (rat)	Glucagon Receptor	GPCR/G Protein
	Secretin (33-59), rat (Secretin (rat)) 是由 27 个氨基酸组成的多肽。Secretin (33-59), rat 可作用于分泌素受体，能够增强胰腺的碳酸盐、酶和钾离子的分泌。
T26712	AZD-1656 AZD 1656	Glucokinase	Metabolism
	AZD-1656 是口服有效的葡萄糖激酶选择性激活剂，EC50为 60 nM。AZD1656在2 型糖尿病中有研究的价值。
T6876	Liraglutide 利拉鲁肽,Liraglutidum,利拉糖肽,Victoza,Liraglutida,NN2211	Glucagon Receptor	GPCR/G Protein
	Liraglutide (Liraglutida) 是胰高血糖素样肽-1 受体激动剂，用于 2 型糖尿病的研究。
TP1469	Lixisenatide acetate (320367-13-3 free base) Lixisenatide acetate	Glucagon Receptor	GPCR/G Protein
	Lixisenatide acetate 是一种胰高血糖素样肽 1 受体的激动剂，可用于研究 2 型糖尿病。
T76085	Glucagon-Like Peptide 1 (GLP-1) (7-36)-Lys (Biotin), amide, human
	Glucagon-Like Peptide 1 (GLP-1) (7-36)-Lys (Biotin), amide, human 是一种被 C 端标记的生物素化 GLP-1(7-36) 酰胺。
TP2100	Avexitide Exendin-3 (9-39) amide,Exendin (9-39),艾塞那肽	Glucagon Receptor	GPCR/G Protein
	Avexitide (Exendin-3 (9-39) amide) 是一种特异竞争性的glucagon-like peptide-1 (GLP-1)受体拮抗剂。
T2316	Omarigliptin MK-3102,奥格列汀	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Omarigliptin (MK-3102) 是高效选择性 DPP4抑制剂，IC50=为1.6nM。
TP1376	GLP-1(7-37) acetate(106612-94-6 free base) GLP-1(7-37) acetate	Others; Glucagon Receptor	GPCR/G Protein; Others
	GLP-1(7-37) acetate 是肠道胰岛素激素，能够促进葡萄糖诱导的胰岛素分泌。
T60047	V-0219	Glucagon Receptor	GPCR/G Protein
	V-0219 是 GLP-1 的正变构调节剂，可用于肥胖相关糖尿病的研究。
T9579	GLP-1 receptor agonist 9	Glucagon Receptor	GPCR/G Protein
	1H-Benzimidazole-6-carboxylic acid 是GLP-1 receptor 激动剂。
T8947	dasiglucagon acetate dasiglucagon acetate(1544300-84-6 free base)	Others	Others
	dasiglucagon acetate 是一种用于糖尿病低血糖治疗的新型胰高血糖素类似物。它已证明在水性制剂中的溶解度和稳定性。药代动力学研究表明，与传统的重组胰高血糖素相比，它的胰高血糖素具有更高的吸收率和更长的血浆消除半衰期。

化合物

Glucagon (1-29), bovine, human, porcine hydrochloride

Cat.No: T15389L

Synonym: 盐酸胰高血糖素,Porcine glucagon hydrochloride,Glucagon hydrochloride

Target: Glucocorticoid Receptor, Glucagon Receptor

Glucagon (19-29), human acetate

Cat.No: TP1863L

Target: Glucagon Receptor

Cat.No: TQ0239

Synonym: Glucagon receptor antagonists-4

Target: Glucagon Receptor

[Des-His1,Glu9]-Glucagon amide TFA

Cat.No: T36638

Synonym: [Des-His1,Glu9]-Glucagon amide TFA

Glucagon (1-29), bovine, human, porcine

Cat.No: T15389

Synonym: 胰高血糖素,Porcine glucagon,Glucagon

Target: Others

Glucagon Receptor Antagonist I

Cat.No: T37223

[Des-His1,Glu9]-Glucagon amide

Cat.No: TP2033

Synonym: des-His1-[Glu9]-Glucagon (1-29) amide

Glucagon (Human)

Cat.No: T78059

Synonym: Hyperglycemic-glycogenolytic factor,Glukagon

Target: Others

Glucagon Receptor Antagonist Inactive Control

Cat.No: T36580

Glucagon receptor antagonists-1

Cat.No: T11413

Target: Others

Glucagon (19-29), human

Cat.No: TP1863

Glucagon receptor antagonists-5

Cat.No: T11416

Target: Others

Glucagon receptor antagonists-3

Cat.No: T11415

Target: Others

Glucagon receptor antagonists-2

Cat.No: T11414

Target: Others

Glucagon-like peptide 1 (1-37), human acetate

Cat.No: TP1148L

Target: Glucagon Receptor

Glucagon-Like Peptide (GLP) II, human

Cat.No: TP1487

Oxyntomodulin (bovine, porcine) (TFA)

Cat.No: T80030

Synonym: Glucagon-37 (bovine, porcine) (TFA)

Cat.No: TQ0124

Target: Glucagon Receptor

Glucagon-like peptide 1 (1-37), human

Cat.No: TP1148

Synonym: HuGLP-1

Glucagon (22-29)

Cat.No: T82306

Glucagon-like peptide 1 (1-37), human TFA

Cat.No: TP1147

Synonym: HuGLP-1 TFA

Cat.No: T11845

Target: Glucagon Receptor

GLP-1 (1-36) amide (human, rat)

Cat.No: T80453

Synonym: Glucagon-like Peptide 1 (1-36) amide (human, rat)

Cat.No: T7364

Target: Glucagon Receptor

[Des-His1,Glu9] Glucagon

Cat.No: T76326

GLP-2(1-33)(human)

Cat.No: TP1157

Synonym: GLP-2 (human),Glucagon-like peptide 2 (human)

Exendin-4 acetate

Cat.No: T8748

Target: Glucagon Receptor

GLP-1 (1-36) amide (human, rat) (TFA)

Cat.No: T82309

Synonym: Glucagon-like Peptide 1 (1-36) amide (human, rat) (TFA)

GLP-1 (9-36) amide

Cat.No: TP2252

Target: Glucagon Receptor

(Asp28)-Glucagon (1-29) (human, rat, porcine)

Cat.No: T83550

Biotinyl-Glucagon (1-29), human, bovine, porcine

Cat.No: T76332

Cat.No: T19850

Synonym: 索玛鲁肽,司美格鲁肽,索马鲁肽

Target: Glucagon Receptor

Saxagliptin hydrate

Cat.No: T0178

Synonym: 沙格列汀单水化合物,Onglyza hydrate,BMS-477118 hydrate

Target: Proteasome, DPP-4

GLP-1(7-36), amide

Cat.No: T3984

Synonym: MKC 253,胰高血糖素样肽-1,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide

Target: Glucagon Receptor

Cat.No: T6203

Synonym: BMS-477118,沙克列汀,Onglyza,沙格列汀

Target: Proteasome, DPP-4

(Met(O)27)-Glucagon (1-29) (human, rat, porcine)

Cat.No: T76628

Cat.No: T3422

Synonym: GRA-Ex-25

Target: Glucagon Receptor

Cat.No: T3967

Synonym: 艾塞那肽,Exenatide,Exenatide Acetate

Target: Glucagon Receptor

Human glucagon-like peptide-1-(7-36)-Lys(Biotin) amide

Cat.No: T76330

Secretin (33-59), rat

Cat.No: TP1039

Synonym: 大鼠SECRETIN肽,Secretin (rat)

Target: Glucagon Receptor

Cat.No: T26712

Synonym: AZD 1656

Target: Glucokinase

Cat.No: T6876

Synonym: 利拉鲁肽,Liraglutidum,利拉糖肽,Victoza,Liraglutida,NN2211

Target: Glucagon Receptor

Lixisenatide acetate (320367-13-3 free base)

Cat.No: TP1469

Synonym: Lixisenatide acetate

Target: Glucagon Receptor

Glucagon-Like Peptide 1 (GLP-1) (7-36)-Lys (Biotin), amide, human

Cat.No: T76085

Cat.No: TP2100

Synonym: Exendin-3 (9-39) amide,Exendin (9-39),艾塞那肽

Target: Glucagon Receptor

Cat.No: T2316

Synonym: MK-3102,奥格列汀

Target: Proteasome, DPP-4

GLP-1(7-37) acetate(106612-94-6 free base)

Cat.No: TP1376

Synonym: GLP-1(7-37) acetate

Target: Others, Glucagon Receptor

Cat.No: T60047

Target: Glucagon Receptor

GLP-1 receptor agonist 9

Cat.No: T9579

Target: Glucagon Receptor

dasiglucagon acetate

Cat.No: T8947

Synonym: dasiglucagon acetate(1544300-84-6 free base)

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3896	Shanzhiside methyl ester 三栀子甙甲酯,山芝皂苷甲酯	Glucagon Receptor	GPCR/G Protein
	Shanzhiside methyl ester 是一种小分子胰高血糖素样肽 1 受体激动剂，分离自轮状乳杆菌，能够诱导抗异常性痛觉耐受。
T37526	2-Oleoylglycerol 2-Oleoyl Glycerol,2-OG,2-Monoolein	GPR	Endocrinology/Hormones; GPCR/G Protein
	2-Oleoylglycerol 是一种存在于棕榈仁、葵花籽和米糠中的脂质。2-Oleoylglycerol 可当作一种 GPR119 激动剂，具有神经保护作用，可诱导胰高血糖素样肽 1 (GLP-1) 分泌。2-Oleoylglycerol 可用于非酒精性脂肪性肝炎造模。
T37298	Spinacine	Endogenous Metabolite	Metabolism
	Spinacine 是人内源性代谢产物。
TN4997	Serpentine	IGF-1R	Tyrosine Kinase/Adaptors
	Serpentine 是一种玫瑰花根中的生物碱，可用作胰岛素增敏剂，以协助胰岛素降低血糖。Serpentine 可激活 AMPK 磷酸化，从而刺激C2C12细胞对葡萄糖的摄取。Serpentine 可增加了肌肉组织中GSK-3β mRNA的表达，从而增强葡萄糖摄取。Serpentine 显著增加胰高血糖素分泌和肝糖异生。在高脂肪饮食/链脲佐菌素（HFD/STZ）诱导的糖尿病小鼠中，Serpentine 显著延长了胰岛素的降血糖时间，显著降低了外源性胰岛素的使用，抑制了内源性胰岛素的分泌。

天然产物

Shanzhiside methyl ester

Cat.No: T3896

Synonym: 三栀子甙甲酯,山芝皂苷甲酯

Target: Glucagon Receptor

2-Oleoylglycerol

Cat.No: T37526

Synonym: 2-Oleoyl Glycerol,2-OG,2-Monoolein

Target: GPR

Cat.No: T37298

Target: Endogenous Metabolite

Cat.No: TN4997

Target: IGF-1R

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-06864	GLP1R Protein, Human, Recombinant (His & Avi) glucagon-like peptide 1 receptor	Human	HEK293 Cells
	Glucagon-like peptide (GLP)-1 receptor is encoded by GLP1R. GLP1R plays a critical role in mediating the biological actions of GLP1 in mammals and fish. The neuronal GLP1Rs mediate body weight and anorectic effects of liraglutide, but are not required for glucose-lowering effects. Glucagon-like peptide 1 receptor (GLP1R) signaling has been shown to have antipsychotic properties in animal models and to impact glucose-dependent insulin release, satiety, memory, and learning in man. Glucagon-like p...
TMPJ-00742	GCG Protein, Human, Recombinant (His) Glicentin,GRPP,GLP-2,Glucagon-Like Peptide 1,OXM,	Human	HEK293 Cells
	Glucagon is a secreted protein and belongs to the glucagon family. Glucagon can be cleved into 8 chains, playing an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon can regulates blood glucose by decreasing glycolysis and increasing gluconeogenesis. In addition, Glucagon is involved in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin....
TMPH-02628	Cathepsin C Protein, Mouse, Recombinant (His & Myc) Dipeptidyl transferase,Dipeptidyl peptidase I,Cathepsin J,DP...	Mouse	E. coli
	Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function.
TMPH-01386	GLP2R Protein, Human, Recombinant (His)	Human	HEK293 Cells
	This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. GLP2R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-10xHis tag. The predicted molecular weight is 22.0 kDa and the accession number is O95838.
TMPH-03583	Extracellular elastase Protein, S. epidermidis, Recombinant (His & Myc)	Staphylococcus epidermidis	E. coli
	Protease that has a low substrate specificity. Glucagon is preferentially cleaved between aromatic (Phe) and hydrophobic (Val) amino acids. Hydrolyzes casein and elastin. Extracellular elastase Protein, S. epidermidis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 37.7 kDa and the accession number is P0C0Q4.
TMPJ-00851	IDE Protein, Human, Recombinant (His) Insulysin,Insulinase,Insulin-Degrading Enzyme,IDE,Abeta-Degr...	Human	HEK293 Cells
	Insulin-Degrading Enzyme (IDE) is a secreted enzyme that belongs to the peptidase M16 family. IDE is a large zinc-binding protease and cleaves multiple short polypeptides that vary considerably in sequence. IDE plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling. IDE degrades amyloid formed by APP and IAPP. IDE may participate in the degradation and clearance of naturally secreted...
TMPY-03597	VIP Protein, Human, Recombinant (His) PHM27,vasoactive intestinal peptide	Human	HEK293 Cells
	VIP, or vasoactive intestinal peptide, is a neuropeptide of 28 amino acid residues that belongs to a glucagon/secretin superfamily, and it exerts its actions through three G-protein-coupled receptors (PAC1, VPAC1, and VPAC2). VIP is synthesized by trophoblast cells; it regulates trophoblast cell function and interaction with the major immune cell populations present in the pregnant uterus.
TMPH-01385	GLP1R Protein, Human, Recombinant (His)	Human	HEK293 Cells
	G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 18.3 kDa and the accession number is P43220.
TMPH-03301	GLP1R Protein, Rat, Recombinant (E. coli, His)	Rat	E. coli
	G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Rat, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 17.1 kDa and the accession number is P32301.
TMPH-02676	GLP1R Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 30.4 kDa and the accession number is O35659.
TMPH-01384	GLP1R Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18.3 kDa and the accession number is P43220.
TMPK-00036	GIP Protein, Human, Recombinant (His) Incretin,GIP	Human	HEK293 Cells
	The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes has been controversial. Initial interest in the therapeutic use of GIP was dampened by evidence that its insulinotropic activity was reduced in type 2 diabetes and by reports that it increased glucagon secretion and adipose deposition in non-diabetic individuals. GIP Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cell...
TMPK-00890	GIP Protein, Mouse, Recombinant (hFc) Incretin,GIP	Mouse	HEK293 Cells
	The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes has been controversial. Initial interest in the therapeutic use of GIP was dampened by evidence that its insulinotropic activity was reduced in type 2 diabetes and by reports that it increased glucagon secretion and adipose deposition in non-diabetic individuals. GIP Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cell...
TMPK-00891	GIP Protein, Mouse, Recombinant (His) GIP,Incretin	Mouse	HEK293 Cells
	The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes has been controversial. Initial interest in the therapeutic use of GIP was dampened by evidence that its insulinotropic activity was reduced in type 2 diabetes and by reports that it increased glucagon secretion and adipose deposition in non-diabetic individuals. GIP Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cell...
TMPH-02675	GCGR Protein, Mouse, Recombinant (GST)	Mouse	E. coli
	G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. ...
TMPY-02979	HMGN3 Protein, Human, Recombinant (His) PNAS-24,TRIP7,PNAS-25,high mobility group nucleosomal bindin...	Human	E. coli
	HMGN3 belongs to the HMGN family and is expressed in the kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate, and uterus. Members of the HMGN family bind to nucleosomes without any specificity for the underlying DNA sequence. They affect the global and local structure of chromatin, as well as the levels of histone modifications, and thus play a role in epigenetic regulation of gene expression. HMGN3 regulates the expression of the glucose transporter ...
TMPY-02640	FAM3B Protein, Human, Recombinant (hFc) PANDER,ORF9,PRED44,C21orf11,C21orf76,42056,family with seque...	Human	HEK293 Cells
	Pancreatic derived factor, also known as FAM3B, is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. FAM3B protein is present in alpha- and beta- cells of pancreatic islets, insulin-secreting beta-TC3 cells, and glucagon-secreting alpha-TC cells. FAM3B causes apoptosis of beta-cells as assessed by electron microscopy, annexin Ⅴ fluorescent staining, and flow-cytometric terminal deoxynucleotidyl transferase-mediated dU...

重组蛋白

GLP1R Protein, Human, Recombinant (His & Avi)

Cat.No: TMPY-06864

Species: Human

Expression System: HEK293 Cells

GCG Protein, Human, Recombinant (His)

Cat.No: TMPJ-00742

Species: Human

Expression System: HEK293 Cells

Cathepsin C Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02628

Species: Mouse

Expression System: E. coli

GLP2R Protein, Human, Recombinant (His)

Cat.No: TMPH-01386

Species: Human

Expression System: HEK293 Cells

Extracellular elastase Protein, S. epidermidis, Recombinant (His & Myc)

Cat.No: TMPH-03583

Species: Staphylococcus epidermidis

Expression System: E. coli

IDE Protein, Human, Recombinant (His)

Cat.No: TMPJ-00851

Species: Human

Expression System: HEK293 Cells

VIP Protein, Human, Recombinant (His)

Cat.No: TMPY-03597

Species: Human

Expression System: HEK293 Cells

GLP1R Protein, Human, Recombinant (His)

Cat.No: TMPH-01385

Species: Human

Expression System: HEK293 Cells

GLP1R Protein, Rat, Recombinant (E. coli, His)

Cat.No: TMPH-03301

Species: Rat

Expression System: E. coli

GLP1R Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02676

Species: Mouse

Expression System: E. coli

GLP1R Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01384

Species: Human

Expression System: E. coli

GIP Protein, Human, Recombinant (His)

Cat.No: TMPK-00036

Species: Human

Expression System: HEK293 Cells

GIP Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00890

Species: Mouse

Expression System: HEK293 Cells

GIP Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00891

Species: Mouse

Expression System: HEK293 Cells

GCGR Protein, Mouse, Recombinant (GST)

Cat.No: TMPH-02675

Species: Mouse

Expression System: E. coli

HMGN3 Protein, Human, Recombinant (His)

Cat.No: TMPY-02979

Species: Human

Expression System: E. coli

FAM3B Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02640

Species: Human

Expression System: HEK293 Cells

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