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M-CSF/CSF1 Protein, Cynomolgus, Rhesus, Recombinant (hFc)

产品编号 TMPY-04704

别名: 集落刺激因子, colony stimulating factor 1 (macrophage)

M-CSF/CSF1 Protein, Cynomolgus, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.1 kDa and the accession number is XP_005542489.1.

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M-CSF/CSF1 Protein, Cynomolgus, Rhesus, Recombinant (hFc)

规格	价格/CNY		货期	数量
50 μg	￥ 4,420		5日内发货

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参考文献

生物活性	Measured in a cell proliferation assay using M-NFS-60 mouse myelogenous leukemia lymphoblast cell. The ED50 for this effect is typically 25-140 ng/mL.
产品描述	M-CSF/CSF1 Protein, Cynomolgus, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.1 kDa and the accession number is XP_005542489.1.

种属	Cynomolgus,Rhesus
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	XP_005542489.1
别名	集落刺激因子, colony stimulating factor 1 (macrophage)
蛋白构建	The cynomolgus / rhesus CSF1 (XP_005542489.1) (Met1-Asn190) was expressed with the Fc region of Human IgG1 at the C-terminus. Cynomolgus and Rhesus CSF1 sequences are identical.
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	45.1 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, Lanimostim and CSF1, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF/CSF-1 may also be involved in development of the placenta. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression.

参考文献

1. Pandit J. et al., 1992, Science. 258: 1358-62. 2. Tokai M. et al., 2000, J Bacteriol. 182 (10): 2865-8. 3. Fan X. et al., 2001, Am J Physiol Endocrinol Metab. 280 (1): E103-11. 4. Frangogiannis NG. et al., 2003, Am J Physiol Heart Circ Physiol. 285 (2): H483-92. 5. Cupp JS. et al., 2007, Am J Surg Pathol. 31 (6): 970-6.

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Keywords

M-CSF/CSF1 Protein, Cynomolgus, Rhesus, Recombinant (hFc) macrophage 集落刺激因子 colony stimulating factor 1 (macrophage) colony stimulating factor 1 recombinant recombinant-proteins proteins protein

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