69
8
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8747 |
Levofloxacin hydrochloride
|
DNA gyrase; Topoisomerase | DNA Damage/DNA Repair |
Levofloxacin hydrochloride 是一种广谱的第三代氟喹诺酮类抗生素,是氧氟沙星的光学活性 L-异构体,具有抗菌活性。左氧氟沙星通过细菌细胞壁扩散并通过抑制 DNA 促旋酶(细菌拓扑异构酶 II)起作用,这是一种 DNA 复制、RNA 转录和细菌 DNA 修复所需的酶。 DNA 促旋酶活性的抑制导致细菌细胞生长受阻。 | |||
T13231L |
Trovafloxacin mesylate
|
Others; DNA/RNA Synthesis; Topoisomerase; Antibacterial | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others |
Trovafloxacin是一种广谱氟喹诺酮类抗生素,可阻断 DNA 促旋酶 (DNA gyrase) 和拓扑异构酶 IV (topoisomerase IV) 的活性,也是一种有效的特异性 pannexin 1 通道抑制剂 (PANX1, IC50 = 4 μM)。 | |||
T7865 |
Danofloxacin
达氟沙星,达诺沙星,Danofloxacino,Danofloxacin free base,Danofloxacine |
Others; DNA/RNA Synthesis; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others |
Danofloxacin (Danofloxacin free base) free base 是一种具有口服活性第三代氟喹诺酮抗菌剂,对大多数革兰氏阴性和革兰氏阳性细菌,支原体和衣原体物种具有广谱的活性,并通过抑制细菌的 DNA 回转酶发挥抗菌作用。它可用于牛,猪和鸡呼吸道疾病的研究。 | |||
T1451 |
Levofloxacin hydrate
左氧氟沙星半水合物,Levaquin hydrate,Cravit hydrate,Quixin hydrate,Levofloxacin Hemihydrate,Tavanic hydrate,Iquix hydrate |
DNA gyrase; Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Levofloxacin hydrate (Cravit hydrate) 是抗生素化合物,抑制细菌DNA 旋转酶活性。 | |||
T0909L |
Nalidixic acid sodium salt
萘啶酮酸,萘啶酮酸钠,Baktogram,Sodium nalidixate |
Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Nalidixic acid sodium salt (Baktogram) 是一种喹诺酮类抗生素,对革兰氏阳性和革兰氏阴性细菌均有效。它在较低浓度下有抑菌作用,在较高浓度下有杀菌作用。它抑制 DNA 促旋酶和拓扑异构酶IV 的亚基,并可逆地阻止易感细菌中的 DNA 复制。 | |||
T0717L |
Enoxacin
依诺沙星,NSC 629661,AT 2266,Pd107779,CI 919 |
DNA/RNA Synthesis; Topoisomerase; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Enoxacin (NSC-629661) 是一种可干扰DNA 复制的氟喹诺酮,抑制细菌 DNA 促旋酶 (IC50=126 µg/ml) 和拓扑异构酶 IV (IC50=26.5 µg/ml)。它是特异性癌症生长抑制剂,可有效抑制革兰氏阳性和阴性细菌。 | |||
T63442 |
DNA Gyrase-IN-2
|
||
DNA Gyrase-IN-2 是细菌 DNA 促旋酶 B 抑制剂,能作用于大肠杆菌 DNA 促旋酶(IC50: 3.29-10.49 μM)和结核分枝杆菌 DNA 促旋酶(IC50: 4.41-5.61 μM),表现出抗菌和抗结核作用。 | |||
T78866 |
DNA Gyrase-IN-9
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
DNA Gyrase-IN-9 (compound 4j) 是一款抗细菌剂,作用于 DNA gyrase。该化合物对抑制革兰氏阳性菌的最小抑菌浓度(MIC)范围为 0.5-2 μg/mL,最小杀菌浓度(MBC)为 2-8 μg/mL。在金黄色葡萄球菌中,DNA Gyrase-IN-9 的 DNA gyrase 抑制半数有效浓度(IC50)为 6.29 μg/mL。 | |||
T63681 | DNA Gyrase-IN-1 | ||
DNA Gyrase-IN-1 是有效的、选择性的 DNA 促旋酶抑制剂 (IC50: 2.6 μM)。DNA Gyrase-IN-1 能够较好的抑制结核分枝杆菌 (Mtb) 的活性 (MIC: 0.49 μM)。DNA Gyrase-IN-1 能够用于研究结核病。 | |||
T74848 | DNA Gyrase-IN-6 | ||
Antibacterial agent 138 是细菌 DNA 促旋酶和拓扑异构酶 IV 的苯并噻唑抑制剂。Antibacterial agent 138 表现出良好的溶解度和血浆蛋白结合。Antibacterial agent 138 对革兰氏阳性和革兰氏阴性菌株具有抗菌活性。Antibacterial agent 138 是一种双重 GyrB 和 ParE 抑制剂。 | |||
T0717 |
Enoxacin hydrate
CI-919 hydrate,Enoxacin Sesquihydrate,依诺沙星半水合物,AT-2266 hydrate,依诺沙星倍半水合物 |
DNA gyrase; DNA/RNA Synthesis; Topoisomerase; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Enoxacin hydrate (AT-2266 hydrate) 是氟喹诺酮,可干扰DNA 复制,抑制细菌 DNA 促旋酶 (IC50=126 µg/ml) 和拓扑异构酶 IV (IC50=26.5 µg/ml)。它是特异性癌症生长抑制剂,抑制革兰氏阳性和阴性细菌。 | |||
T78712 |
DNA Gyrase-IN-8
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
DNA Gyrase-IN-8是一种高效的DNA gyrase抑制剂,其IC50为8.45 µM,同时展现出了抗菌活性。 | |||
T63395 |
DNA Gyrase-IN-5
|
||
DNA Gyrase-IN-5 是 DNA gyrase 的有效抑制剂 (IC50: 0.10 μM),对野生型和耐药株均有抗细菌(antibacterial)作用。 | |||
T7804 |
Garenoxacin mesylate hydrate
Garenoxacin mesylate [USAN],加雷沙星甲磺酸盐,BMS284756 (Mesylate hydrate) |
Antibacterial | Microbiology/Virology |
Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) 是一种新型口服 des-fluoro(6) 喹诺酮,具有强抗菌活性,抗呼吸道病原体。 | |||
T62895 |
DNA Gyrase-IN-4
|
||
DNA Gyrase-IN-4 (compound 8p) 是一种 DNA 促旋酶的有效抑制剂 (IC50: 0.13 μM)。DNA Gyrase-IN-4 对金黄色葡萄球菌 (MIC: 0.05 μg/ml)、单核增生李斯特菌 (MIC: 0.05 μg/ml)、沙门氏菌 (MIC: 0.05 μg/ml) 和大肠杆菌 (MIC: 8 μg/ml) 具有较好的抗菌作用。 | |||
T61937 | DNA Gyrase-IN-3 | ||
DNA Gyrase-IN-3 (Compound 28) 是细菌DNA 旋转酶 B (bacterial DNA gyrase B) 抑制剂。DNA Gyrase-IN-3抑制大肠杆菌DNA 旋转酶的 IC50为5.41-15.64 μM。DNA Gyrase-IN-3显示出抗结核和抗菌活性。 | |||
T79240 |
DNA gyrase B-IN-2
|
||
DNA gyrase B-IN-2 (Compound E) 是一款基于2-aminobenzothiazole的DNA gyrase B抑制剂,针对ESKAPE病原体显示出强效活性。该化合物在低纳摩尔浓度下表现出优异的DNA gyrase B抑制能力(IC50< 10 nM),具备对多种ESKAPE病原体的广谱抗菌作用。对于大部分革兰氏阳性菌,最低抑菌浓度(MIC)低于0.03 μg/mL;针对革兰氏阴性病原体如E. coli, Acinetobacter baumannii, Pseudomonas aeruginosa和Klebsiella pneumoniae,MIC为4 - 16 μg/mL。此化合物适用于感染性疾病的研究应用。 | |||
T64012 | DNA gyrase B-IN-1 | ||
DNA gyrase B-IN-1 是 DNA gyrase B 的有效抑制剂,表现出良好的结合亲和力和稳定性。DNA gyrase B-IN-1 能够抑制 P. aeruginosa/i> DNA gyrase B (IC50: 2.2 μM)。 | |||
T78776 | DNA gyrase B-IN-3 | DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
DNA gyrase B-IN-3(Compound A),作为一种细菌DNA gyrase B抑制剂(IC50: <10 nM),针对革兰氏阳性菌株表现出抗菌活性。 | |||
T13231 |
Trovafloxacin
|
DNA gyrase; Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Trovafloxacin 是广谱喹诺酮类抗生素,对革兰氏阳性,革兰氏阴性和厌氧菌有活性。它可阻断 DNA 促旋酶 和拓扑异构酶 IV 的活性。它也是口服活性的 Pannexin 1通道选择性抑制剂,对 PANX1内向电流的 IC50为 4 μM。 | |||
T62389 |
14α-Demethylase/DNA Gyrase-IN-2
|
||
14α-Demethylase/DNA Gyrase-IN-2 (Compound 6a) 是一种 14α-Demethylase/DNA Gyrase 的有效抑制剂,具有抗菌作用。 | |||
T62792 | 14α-Demethylase/DNA Gyrase-IN-1 | ||
14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) 是一种 14α-Demethylase/DNA Gyrase 的有效抑制剂,具有抗菌作用。 | |||
T7179 |
Garenoxacin
BMS284756,加雷沙星 |
Antibacterial | Microbiology/Virology |
Garenoxacin (BMS284756) 是一种新型的口服 des-fluoro(6) 喹诺酮,有抗菌活性,可抑制呼吸道病原体。 | |||
T2353 |
BRD7116
BRD7716 |
DNA gyrase; Antibacterial | DNA Damage/DNA Repair; Microbiology/Virology |
BRD7116 与细菌 DNA 促旋酶竞争性结合, 作用于LSCe 细胞,EC50值为200 nM。它具有细胞非自主抗白血病活性。 | |||
T0425L |
Pefloxacin Mesylate Dihydrate
Pefloxacinium mesylate dihydrate,1589 RB,甲磺酸培氟沙星二水合物 |
Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Pefloxacin Mesylate Dihydrate (1589 RB) 是一种抗菌素,能通过抑制DNA 旋转酶阻断细菌DNA 复制。 | |||
T1095 |
Sparfloxacin
AT-4140,PD 131501,Zagam,司帕沙星,CI-978 |
DNA gyrase; Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Sparfloxacin (CI-978) 是一种氟喹诺酮类抗菌素。 | |||
T1640 |
Ciprofloxacin
Ciproxan,环丙沙星,Ciprobay,Bay o 9867,Bay-09867 |
Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Ciprofloxacin (Bay-09867) 是一种有高抗菌活性的氟喹诺酮类抗生素。 | |||
T1294 |
Fleroxacin
AM-833,氟罗沙星,RO 23-6240 |
DNA gyrase; Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Fleroxacin (RO 23-6240) 是一种广谱氟喹诺酮类抗菌素。 | |||
T20510 |
Novobiocin
U-6391,U 6391,U6391,Cathomycin,Albamycin |
Apoptosis; Virus Protease; HSP; DNA gyrase; Antibacterial; Antibiotic | Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Novobiocin 是一种具有口服活性和有效性的的抗生素。Novobiocin 是 DNA 促旋酶抑制剂和热休克蛋白 90 (Hsp90) 拮抗剂,对促旋酶和Hsp90 具有抑制作用。 Novobiocin 具有抗正痘活性,可用于研究高度耐药性肺炎球菌感染。 | |||
T0902 |
Ofloxacin
DL8280,菲宁达,Hoe-280,氧氟沙星,Floxin,Tarivid,Oxaldin |
Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Ofloxacin (Oxaldin) 是可抑制细菌DNA 旋转酶的一种氟喹诺酮类抗生素。 | |||
T8835 |
Tosufloxacin hydrochloride
A-61827 hydrochloride,盐酸妥舒沙星,T-3262 hydrochloride |
Antibacterial | Microbiology/Virology |
Tosufloxacin hydrochloride 是一种氟喹诺酮类抗菌剂,用于治疗细菌感染。 Tosufloxacin hydrochloride 也是一种细菌 Topo(DNA 促旋酶,拓扑异构酶)抑制剂。 | |||
T0116 |
Balofloxacin
|
DNA gyrase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Balofloxacin 是一种具有口服活性的氟喹诺酮类抗生素,可通过干扰 DNA 促旋酶来抑制细菌 DNA 的合成,对革兰氏阴性,革兰氏阳性和厌氧菌具有广谱抗菌活性。它可研究呼吸道,肠道和泌尿道感染。 | |||
T1293 |
Gatifloxacin
BMS 206584-01,PD 135432,CG5501,BMS-206584,AM-1155,加替沙星 |
Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Gatifloxacin (CG5501) 是一种具有广谱抗菌活性的氟喹诺酮类抗生素。它可抑制大肠杆菌 DNA 解旋酶 (IC50=0.109 μg/ml) 和细菌 II 型拓扑异构酶(IC50=13.8 μg/ml)。在动物模型中,它有抗细菌性结膜炎作用。 | |||
T67826 |
Alalevonadifloxacin
|
DNA gyrase; Topoisomerase; Antibacterial | DNA Damage/DNA Repair; Microbiology/Virology |
Alalevonadifloxacin 是一种DNA 回旋酶和DNA 拓扑异构酶抑制剂,是一种喹诺酮类针对Mrsa 的新型抗菌化合物。Alalevonadifloxacin 对治疗细菌性革兰氏阳性、革兰氏阴性和厌氧性感染有潜在作用。 | |||
TQ0063 |
Zoliflodacin
ETX0914,AZD0914 |
DNA gyrase; DNA/RNA Synthesis; Topoisomerase; Antibacterial | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Zoliflodacin (ETX0914) 是一种新型螺旋嘧啶三酮,对革兰氏阳性和阴性生物有抗菌活性,对金黄色葡萄球菌的b>MIC90值为0.25 μg/mL。他也是细菌DNA 促旋酶/拓扑异构酶的抑制剂。 | |||
T1625 |
Lomefloxacin hydrochloride
Lomefloxacin HCl,盐酸洛美沙星,Okacyn,Maxaquin |
Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Lomefloxacin hydrochloride (Okacyn) 是一种广谱喹诺酮类抗生素,具有抗菌活性。它可研究支气管炎、尿路感染、结膜炎、外耳炎和中耳炎。 | |||
T1492 |
Gemifloxacin mesylate
LB-20304a,甲磺酸吉米沙星,SB-265805S,Gemifloxacin mesylate |
DNA gyrase; Topoisomerase; Antibacterial | DNA Damage/DNA Repair; Microbiology/Virology |
Gemifloxacin mesylate (Gemifloxacin mesylate) 是一种喹诺酮类口服广谱抗菌剂,可研究轻中度肺炎和慢性支气管炎的急性细菌性发作。 | |||
T24126 |
Gyramide A
Gyramide-A |
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Gyramide A is an inhibitor of bacterial DNA gyrase. It shows antimicrobial activity and inhibits bacterial cell division. | |||
T23924 |
Cyclothialidine
Ro 09-1437 |
||
Cyclothialidine is an inhibitor of DNA gyrase. | |||
T1451L |
Levofloxacin sodium
|
||
Levofloxacin sodium is a synthetic fluoroquinolones antibacterial. It inhibits the supercoiling activity of bacterial DNA gyrase, so that halting DNA replication. | |||
T22797 |
Gatifloxacin mesylate
|
Others | Others |
Gatifloxacin (mesylate) is an antibiotic of the fourth-generation fluoroquinolone family. It also inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. | |||
T26588 |
Albicidin
|
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Albicidin is a DNA gyrase inhibitor produced by Xanthomonas albilineans. | |||
T25265 |
Clorobiocin
RP18631,RP 18631,RP-18631 |
||
Clorobiocin is an aminocoumarin antibacterial that suppresses the enzyme DNA gyrase. | |||
T26717 |
AZD-5099
AZD5099 |
||
AZD-5099 is a DNA gyrase modulator potentially for the treatment of bacterial infection. | |||
T1293L |
Gatifloxacin sesquihydrate
Gatifloxacin |
||
Gatifloxacin sesquihydrate, a bacterial DNA gyrase inhibitor, is used to treat tuberculosis and pneumonia. | |||
T71982 |
Ofloxacin HCl
|
||
Ofloxacin HCl is a synthetic fluoroquinolone ( FLUOROQUINOLONES) antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION. | |||
T23578 |
(S)-Gyramide A
(S)-Gyramide-A,(S)-534F6,(S)534F6,(S) 534F6 |
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(S)-Gyramide A is a bacterial DNA gyrase inhibitor that acts by exhibiting antimicrobial activity and inhibiting bacterial cell division. | |||
T62866 |
844-TFM
|
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844-TFM 是一种 NBTI (新型细菌拓扑异构酶抑制剂) DNA gyrase 抑制剂 (IC50: 1.5 μM)。844-TFM 对脓肿分枝杆菌的表现出杀菌作用。 | |||
T71459 | PD 163449 | ||
PD 163449 is a bioactive molecule of 4-pyridone group that inhibits bacterial type IIA topoisomerase (DNA gyrase and topoisomerase IV). | |||
T26963 |
CBR-2092
TNP2092,CBR2092,TNP-2092,TNP 2092 |
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CBR-2092 is a DNA-directed RNA polymerase and DNA topoisomerase inhibitor. CBR-2092 exhibited rifampin-like potency as an inhibitor of RNA polymerase, was an equipotent (balanced) inhibitor of DNA gyrase and DNA topoisomerase IV, and retained activity against a prevalent quinolone-resistant variant. Studies of mutant strains that exhibited reduced susceptibility to CBR-2092 further substantiated RNA polymerase as the primary cellular target of CBR-2092, with DNA gyrase and DNA topoisomerase IV b... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6567 |
Levofloxacin
Levaquin,Cravit,Tavanic,Fluoroquinolone,左氧氟沙星,(-)-Ofloxacin |
Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Levofloxacin (Fluoroquinolone) 是合成的氟喹诺酮类抗生素,有抑制细菌DNA 旋转酶的超螺旋活性的作用,能阻止DNA 复制。 | |||
T0909 |
Nalidixic acid
萘啶酸,NSC-82174 |
Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Nalidixic acid (NSC-82174) 是一种喹诺酮类抗生素,对革兰氏阳性和革兰氏阴性细菌有效。它在较低浓度下有抑菌作用,而在较高浓度下有杀菌作用。它抑制 DNA 促旋酶和拓扑异构酶 IV 的亚基,并可逆地阻止易感细菌中的 DNA 复制。 | |||
T7786 |
Tryptanthrin
|
DNA gyrase | DNA Damage/DNA Repair |
Tryptanthrin 是一种口服具有活性的细胞内Leukotriene (LT) biosynthesis 抑制剂。 它能够降低大鼠胸膜炎模型中的 LTB4 水平,并抑制人全血中Leukotriene 的形成 (IC50= 10 µM)。 | |||
T1276 |
Danofloxacin mesylate
甲磺酸达氟沙星,CP 76136-27 |
DNA/RNA Synthesis; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Danofloxacin mesylate (CP 76136-27) 是一种兽医用氟喹诺酮类抗菌素。 | |||
TQ0184 |
Chebulinic acid
|
ATPase; Proton pump; DNA/RNA Synthesis; Antibacterial; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Stem Cells |
Chebulinic acid 是从诃子果中提取的一种天然产物,结核分枝杆菌 DNA 促旋酶的有效抑制剂。它也能抑制 SMAD-3 phosphorylation 和 H+ K+-ATPase 的活性。 | |||
T0974 |
Novobiocin Sodium
Albamycinsodium,新生霉素钠,Cathomycin,Albamycin |
Potassium Channel; DNA gyrase; Topoisomerase; Antibacterial; Antibiotic; ABC; Autophagy | Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology |
Novobiocin Sodium (Albamycinsodium) 是源自 Streptomyces niveus 的抗生素。 它的化学结构类似于香豆素。Novobiocin 与 DNA 促旋酶结合并阻断三磷酸腺苷活性。 | |||
T10838 |
Closthioamide
|
Antibacterial | Microbiology/Virology |
Closthioamide is a potent inhibitor of bacterial DNA gyrase and highly active against MRSA, Ec, VRE, and Mv (MICs: 0.58 μM, 9.00 μM, 0.58 μM and 72.03 μM). | |||
T36303 |
Psammaplin A
|
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Psammaplin A, a marine metabolite, functions as a robust inhibitor of HDAC and DNA methyltransferases, displaying notable potency and selectivity as a DAC1 inhibitor, with an IC50 value of 0.9 nM. It exhibits antimicrobial effects against Gram-positive bacteria and inhibits both DNA synthesis and DNA gyrase activity, also demonstrating antitumor activity[1][2]. |