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Search Results for " ddr1 "

Targets Recommended: Discoidin Domain Receptor (DDR)

17

抑制剂 & 化合物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T5402	DDR1-IN-2 DDR1 inhibitor 7rh	Discoidin Domain Receptor (DDR)	Tyrosine Kinase/Adaptors
	DDR1-IN-2 (DDR1 inhibitor 7rh) 是盘状结构域受体 1 抑制剂 (IC50:13.1 nM)，对 DDR2 的抑制作用相对较弱 (IC50:203 nM)。
T3337	Ddr1-In-1	Discoidin Domain Receptor (DDR)	Tyrosine Kinase/Adaptors
	DDR1-IN-1 是一种特异性的 DDR1 受体酪氨酸激酶抑制剂，选择性是 DDR2 的 3 倍左右。
T40061	DDR1-IN-6 DDR1-IN-6
	DDR1-IN-6 is a potent and selective inhibitor of Discoidin Domain Receptor family member 1 (DDR1), exhibiting remarkable inhibitory activity at an IC50 of 9.72 nM. It effectively suppresses the auto-phosphorylation of DDR1b (Y513) with an IC50 value of 9.7 nM. Furthermore, DDR1-IN-6 displays strong anti-cancer activity.
T40062	DDR1-IN-5 DDR1-IN-5
	DDR1-IN-5 is a potent and selective inhibitor of the Discoidin Domain Receptor family, member 1 (DDR1). It effectively inhibits the phosphorylation of DDR1b (Y513) with an IC 50 value of 4.1 nM. Furthermore, DDR1-IN-5 demonstrates remarkable anti-cancer activity. Its inhibitory potency against DDR1 (IC 50 = 7.36 nM) makes it a promising compound for targeted therapy in cancer treatment.
T39572	DDR1-IN-4 DDR1-IN-4
	DDR1-IN-4 (Compound 2.45) is a highly potent inhibitor that selectively targets Discoidin Domain Receptor 1 (DDR1) autophosphorylation. This compound demonstrates exceptional efficacy with IC50 values of 29 nM and 1.9 μM for DDR1 and DDR2, respectively.
T70202	DDR1-IN-1 dihydrochloride
	DDR1-IN-1 dihydrochloride 是 DDR1受体酪氨酸激酶抑制剂，IC50值为105 nM，而对 DDR2的 IC50为413 nM。
T79811	DDR1/2 inhibitor-2
	DDR1/2 inhibitor-2 (Example 31)，作为一种DDR1/DDR2抑制剂，其IC50值小于100 nM，适用于癌症和纤维化疾病的研究领域。
T70201	S 16020-2
	S 16020-2 is an olivacine derivative, and DNA topoisomerase II inhibitor endowed with a remarkable antitumor activity against various experimental tumors.
T4646	TA-02	p38 MAPK; Autophagy	Autophagy; MAPK
	TA02 是一种Adezmapimod 类似物，是p38 MAPK 的抑制剂，其IC50值为 20 nM。它和Adezmapimod、SB 202190 具有相似的心源活性，可抑制 TGFBR-2。
T4349	Sitravatinib MG516,MGCD516	Discoidin Domain Receptor (DDR); VEGFR; FLT; Trk receptor; TAM Receptor; c-Kit; Ephrin Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	Sitravatinib (MGCD516) 是一种有口服活性的受体酪氨酸激酶抑制剂。它单独使用即具有有效的抗肿瘤功效，且通过促进抗肿瘤免疫微环境增强了 PD-1 阻断的活性。
T10984	DDR-TRK-1	Discoidin Domain Receptor (DDR)	Tyrosine Kinase/Adaptors
	DDR-TRK-1 是 DDR1的一个选择性抑制剂，其 IC50 值为 9.4 nM。DDR-TRK-1 也抑制 TRK 激酶家族。
T7862	VU6015929	Discoidin Domain Receptor (DDR)	Tyrosine Kinase/Adaptors
	VU6015929 是一种活性双盘状结构域受体 1/2 (DDR1/2) 的抑制剂（IC50 分别为 4.67 nM 和 7.39 nM）。
T10985	DDR Inhibitor	Discoidin Domain Receptor (DDR)	Tyrosine Kinase/Adaptors
	DDR Inhibitor 是一种高效的盘状结构域受体 (discoidin domain receptor) 抑制剂，对 DDR2 的 IC50 值为 3.3 nM，在浓度为 1.5 nM 时，对 DDR1 有 53% 的抑制作用。
T60805	JNK3 inhibitor-2
	JNK3 inhibitor-2 是一种有效的选择性JNK3抑制剂。JNK3 inhibitor-2 对 JNK1、JNK2、 JNK3的IC50值分别为 >100, >100, 0.25 μM。JNK3 inhibitor-2也抑制 DDR1 和 EGFR (T790M, L858R)。
T12925	Sitravatinib malate MGCD516 malate,MG-516 malate	TAM Receptor	Tyrosine Kinase/Adaptors
	Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively.) , shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment.
T15808	Merestinib dihydrochloride LY2801653 dihydrochloride	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), RO
T10801	CHMFL-ABL/KIT-155 CHMFL-ABL-KIT-155	c-Kit	Tyrosine Kinase/Adaptors
	CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induces apoptosis.

化合物

Cat.No: T5402

Synonym: DDR1 inhibitor 7rh

Target: Discoidin Domain Receptor (DDR)

Cat.No: T3337

Target: Discoidin Domain Receptor (DDR)

Cat.No: T40061

Synonym: DDR1-IN-6

Cat.No: T40062

Synonym: DDR1-IN-5

Cat.No: T39572

Synonym: DDR1-IN-4

DDR1-IN-1 dihydrochloride

Cat.No: T70202

DDR1/2 inhibitor-2

Cat.No: T79811

Cat.No: T70201

Cat.No: T4646

Target: p38 MAPK, Autophagy

Cat.No: T4349

Synonym: MG516,MGCD516

Target: Discoidin Domain Receptor (DDR), VEGFR, FLT, Trk receptor, TAM Receptor, c-Kit, Ephrin Receptor

Cat.No: T10984

Target: Discoidin Domain Receptor (DDR)

Cat.No: T7862

Target: Discoidin Domain Receptor (DDR)

DDR Inhibitor

Cat.No: T10985

Target: Discoidin Domain Receptor (DDR)

JNK3 inhibitor-2

Cat.No: T60805

Sitravatinib malate

Cat.No: T12925

Synonym: MGCD516 malate,MG-516 malate

Target: TAM Receptor

Merestinib dihydrochloride

Cat.No: T15808

Synonym: LY2801653 dihydrochloride

Target: ROCK

CHMFL-ABL/KIT-155

Cat.No: T10801

Synonym: CHMFL-ABL-KIT-155

Target: c-Kit

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01289	DDR1 Protein, Human, Recombinant (His) RTK6,DDR,TRKE,PTK3,NTRK4,NEP,PTK3A,MCK10,E...	Human	HEK293 Cells
	DDR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is A0A024RCQ1.
TMPH-01297	DDR1 Protein, Human, Recombinant (aa 21-417, His) EDDR1,MCK-10,Epithelial discoidin...	Human	HEK293 Cells
	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell...
TMPY-03313	DDR1 Protein, Rat, Recombinant (His) discoidin domain receptor tyrosine kinase 1,Drd...	Rat	HEK293 Cells
	DDR1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.3 kDa and the accession number is Q6MG19.
TMPY-02310	DDR1 Protein, Mouse, Recombinant (His) CD167a,discoidin domain receptor tyrosine kinase	Mouse	HEK293 Cells
	DDR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.4 kDa and the accession number is Q03146-1.
TMPY-04442	DDR1 Protein, Mouse, Recombinant (His & GST) 6030432F18,Nep,Cak,AI323681,CD167...	Mouse	Baculovirus Insect Cells
	DDR1 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 75.8kDa and the accession number is Q03146-2.
TMPY-03541	DDR1 Protein, Rat, Recombinant (hFc) Drd1,Cak,discoidin domain receptor tyrosine kinase ...	Rat	HEK293 Cells
	DDR1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 70.9 kDa and the accession number is Q6MG19.
TMPY-02506	DDR1 Protein, Mouse, Recombinant (hFc) AI323681,CD167a,Nep,Cak,PTK3A,6030432F...	Mouse	HEK293 Cells
	DDR1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 71 kDa and the accession number is Q03146-1.
TMPY-04382	DDR1 Protein, Human, Recombinant (aa 444-913, His & GST) discoidin domain receptor tyrosine kinase 1,NEP,TRK...	Human	Baculovirus Insect Cells
	DDR1 Protein, Human, Recombinant (aa 444-913, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 80 kDa and the accession number is Q08345-1.

重组蛋白

DDR1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01289

Species: Human

Expression System: HEK293 Cells

DDR1 Protein, Human, Recombinant (aa 21-417, His)

Cat.No: TMPH-01297

Species: Human

Expression System: HEK293 Cells

DDR1 Protein, Rat, Recombinant (His)

Cat.No: TMPY-03313

Species: Rat

Expression System: HEK293 Cells

DDR1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02310

Species: Mouse

Expression System: HEK293 Cells

DDR1 Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-04442

Species: Mouse

Expression System: Baculovirus Insect Cells

DDR1 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-03541

Species: Rat

Expression System: HEK293 Cells

DDR1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02506

Species: Mouse

Expression System: HEK293 Cells

DDR1 Protein, Human, Recombinant (aa 444-913, His & GST)

Cat.No: TMPY-04382

Species: Human

Expression System: Baculovirus Insect Cells

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