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35

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T14766	BPH-715	Others; Parasite	Microbiology/Virology; Others
	BPH-715 抑制恶性疟原虫的肝脏阶段生长，对 HepG2 细胞中的恶性疟原虫外红细胞的形成的 IC50 为 10 μM。
T10586L	BPH-1358 NSC50460	Others; Antibacterial	Microbiology/Virology; Others
	BPH-1358 (NSC-50460) 是一种人 FPPS 和 UPPS 抑制剂，IC50值分别为 1.8 μM 和 110 nM，对金黄色葡萄球菌的 MIC 值大约为 250 ng/mL。
T30567	BPH-675 BPH 675
	BPH-675 is a bioactive chemical.
T30563	BPH-252 BPH 252
	BPH-252 is a bioactive chemical.
T30569	BPH-742 BPH 742,BPH742
	BPH-742 is a bioactive chemical.
T30565	BPH-628 BPH628
	BPH-628 is a bioactive chemical.
T10587	BPH-652	Others	Others
	BPH-652 is an S. aureus dehydrosqualene synthase (CrtM) inhibitor (Ki: 1.5 nM; IC50: 100-300 nM for S. aureus pigment formation).
T30566	BPH-629 BPH629
	BPH-629 is a bioactive chemical.
T30568	BPH-676
	BPH-676 is a bioactive chemical.
T23814	BPH-1218 BPH1218
	BPH-1218 is a SQS inhibitor.
T30564	BPH-608
	BPH-608 is a bioactive chemical.
T30570	BPH-830 BPH830
	BPH-830 is a bioactive chemical.
T72587	BPH-1358 mesylate NSC50460 mesylate
	BPH-1358 mesylate (NSC50460 mesylate) 是一种有效的人FPPS 和UPPS 抑制剂，IC50值分别为 1.8 μM 和 110 nM，在体外对金黄色葡萄球菌的 MIC 值大约为 250 ng/mL。
T23815	BPH-651 BPH651,3ACW,3-ACW,3 ACW
	BPH-651 is a CrtM inhibitor.
T10586	BPH-1358 free base NSC50460 free base	Others	Others
	BPH-1358 (NSC50460) free base is a potent human undecaprenyl diphosphate synthase (UPPS) and farnesyl diphosphate synthase (FPPS) inhibitor (IC50s: 110 nM and 1.8 μM) and is active against S. aureus in vitro (MIC ~250 ng/mL).
T60300	BPH-1086
	BPH-1086 (compound 10) 是一种IspH 抑制剂。IspH 结构域通过与核糖体蛋白 (RPS1) 融合，能够结合 mRNA 或形成细菌核糖体。
T0488	Finasteride 非那雄胺,MK-906	Reductase	Endocrinology/Hormones; Metabolism
	Finasteride (MK-906) 是 5α-还原酶的竞争性抑制剂，对 II 型 5α-还原酶的IC50为 4.2 nM，对 II 型 5α-还原酶的亲和力是 I 型酶的 100 倍。它可用于研究前列腺增生和雄激素性脱发。
T0091	Alfuzosin hydrochloride SL 77499-10,Alfuzosin HCl,盐酸阿夫唑嗪	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Alfuzosin hydrochloride (Alfuzosin HCl) 是一种 α1 肾上腺素受体拮抗剂，可用于良性前列腺增生(BPH)的研究。
T1504	Silodosin 西洛多辛,KAD 3213,KMD 3213	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Silodosin (KAD 3213) 是有选择性的、强效的、口服活性的 α1A-adrenergic receptor 阻滞剂，是一种有效且耐受性良好的试剂，可用于研究 LUTS/BPH。它对 α1A-AR 表现出高度的亲和力，是 α1B-AR 和 α1D-AR 亲和力的 162 和 50 倍。
T21366	Sapropterin free base BPH4,Dapropterin,6R-BH4,Tetrahydro-6-biopterin,THB,Phenoptin
	Sapropterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of dopamine, epinephrine, melatonin, norepinephrine, neurotransmitter
T6461	Dapoxetine hydrochloride LY-210448,LY-210448 hydrochloride,Dapoxetine HCl,盐酸达泊西汀,Priligy	5-HT Receptor; Serotonin Transporter	GPCR/G Protein; Neuroscience
	Dapoxetine hydrochloride (LY-210448 hydrochloride) 是一种具有口服活性的、选择性的血清素再摄取 (serotonin reuptake) 抑制剂 (SSRI)，可用于研究早泄 (PE) 。
T0039	Dapoxetine 达波西汀,Dapoxetina,Dapoxetinum	Others; 5-HT Receptor	GPCR/G Protein; Neuroscience; Others
	Dapoxetine (Dapoxetina) 是一种选择性5-羟色胺再摄取抑制剂，用于治疗早泄。
T36712	BPHA MMP-2/MMP-9 Inhibitor II	MMP	Proteases/Proteasome
	BPHA (MMP-2/MMP-9 Inhibitor II) 是一种有效的、具有选择性和口服活性的抑制剂，对MMP-2、MMP-9 和 MMP-14 具有抑制作用，IC50 分别为 12 nM、16 nM 和 17 nM。BPHA 不抑制 MMP-1、-3 和 -7 (IC50 分别为 974、>1000 和 795 nM)。BPHA 具有抗血管生成和抗肿瘤活性。
T14843	Bifluranol BX341	Androgen Receptor	Endocrinology/Hormones
	Bifluranol (BX341) 具有抗雄激素活性，在体内实验中显示出显著的抗前列腺活性，可用于治疗良性前列腺增生（BPH）。
T6701	Terazosin hydrochloride dihydrate Flotrin dihydrate,Terazosin HCl Dihydrate,Dysalfa dihydrate,Heitrin dihydrate,盐酸特拉唑嗪(二水合物)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Terazosin hydrochloride dihydrate (Heitrin dihydrate) 是一种竞争性和口服活性的 α1-肾上腺素受体(α1-adrenoceptor) 拮抗剂，是一种喹唑啉衍生物，通过舒张血管和打开膀胱的方式起作用。它可用于研究良性前列腺增生 (BPH) 和高血压。
T22232	Alfuzosin
	Alfuzosin 是选择性和竞争性的α1肾上腺素受体拮抗剂，可用于良性前列腺增生（BPH）的研究。
T27798	Lapisteride CS891B,CS-891,CS-891B,CS891	Others	Others
	Lapisteride (CS-891) 一种类固醇5α-还原酶抑制剂，可用于治疗良性前列腺增生(BPH)和雄激素性脱发，可有效预防或治疗AGA 。
T0210L	Tamsulosin LY253351 free base,HSDB7744,(R)-(-)-YM12617 free base,Harnal-D,Flowmax,HSDB 7744,HSDB-7744	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tamsulosin ((R)-(-)-YM12617 free base) 是一种肾上腺素能受体α 1A 拮抗剂，用于良性前列腺增生(BPH)的治疗。Tansulosin 用于治疗排尿困难，这是前列腺肥大的一种常见症状。Tansulosin 和其他被称为α受体阻滞剂的药物通过放松膀胱颈部肌肉和前列腺本身的肌肉纤维来发挥作用，使其更容易排尿。
T0197	Terazosin hydrochloride 盐酸特拉唑嗪,Terazosin HCl,Terazosine,Blavin,Hytrin,Zayasel,Fosfomic	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Terazosin hydrochloride (Hytrin) 是一种竞争性和口服活性的 α1-肾上腺素受体拮抗剂，是一种喹唑啉衍生物。它通过舒张血管和打开膀胱来起作用。它可用于良性前列腺增生和高血压的研究。
T70396	Fexapotide triflutate
	Fexapotide triflutate is a caspase and TNF signaling pathway activator used to treat benign prostatic hyperplasia (BPH).
T71904	Chlormadinone (free base)
	Chlormadinone (free base) is a synthetic steroid hormone and antagonist at androgen and estrogen receptors used to treat BPH and polycystic ovary syndrome. It also promotes osteoblast differentiation and Ca deposition in bone marrow stem cells.
T76275	Fexapotide
	Fexapotide (NX-1207 free acid) 在细胞水平上通过选择性诱导细胞凋亡，降低前列腺体积。它主要用于研究下尿路症状(LUTS)与良性前列腺增生(BPH)。
T69492	Ozarelix
	Ozarelix is a fourth generation GnRH antagonist, induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of death receptors. Mechanistically, LHRH antagonists exert rapid inhibition of luteinizing hormone and follicle stimulating hormone with an accompanying rapid decrease in sex hormones and would therefore be expected to be effective in a variety of hormonally dependent disease states including ovarian cancer, prostate cancer,...
T61729	Terazosin
	Terazosin, a quinazoline derivative, is an orally active and competitive antagonist of α1-adrenoceptors. Its mechanism of action involves relaxing blood vessels and promoting bladder opening. Terazosin exhibits therapeutic potential for treating benign prostatic hyperplasia (BPH) and high blood pressure [1][2][3].
T21668	Finasteride acetate
	Finasteride (MK-906) acetate 是一种高效的5α-还原酶 (5α-reductase) 竞争性抑制剂，其对 II 型 5α-还原酶的IC50值仅为 4.2 nM，其对该型酶的亲和力是对 I 型酶亲和力的约100倍。因此，Finasteride acetate 主要在良性前列腺增生症 (BPH) 和雄激素性脱发研究领域中应用。

化合物

Cat.No: T14766

Target: Others, Parasite

Cat.No: T10586L

Synonym: NSC50460

Target: Others, Antibacterial

Cat.No: T30567

Synonym: BPH 675

Cat.No: T30563

Synonym: BPH 252

Cat.No: T30569

Synonym: BPH 742,BPH742

Cat.No: T30565

Synonym: BPH628

Cat.No: T10587

Target: Others

Cat.No: T30566

Synonym: BPH629

Cat.No: T30568

Cat.No: T23814

Synonym: BPH1218

Cat.No: T30564

Cat.No: T30570

Synonym: BPH830

BPH-1358 mesylate

Cat.No: T72587

Synonym: NSC50460 mesylate

Cat.No: T23815

Synonym: BPH651,3ACW,3-ACW,3 ACW

BPH-1358 free base

Cat.No: T10586

Synonym: NSC50460 free base

Target: Others

Cat.No: T60300

Cat.No: T0488

Synonym: 非那雄胺,MK-906

Target: Reductase

Alfuzosin hydrochloride

Cat.No: T0091

Synonym: SL 77499-10,Alfuzosin HCl,盐酸阿夫唑嗪

Target: Adrenergic Receptor

Cat.No: T1504

Synonym: 西洛多辛,KAD 3213,KMD 3213

Target: Adrenergic Receptor

Sapropterin free base

Cat.No: T21366

Synonym: BPH4,Dapropterin,6R-BH4,Tetrahydro-6-biopterin,THB,Phenoptin

Dapoxetine hydrochloride

Cat.No: T6461

Synonym: LY-210448,LY-210448 hydrochloride,Dapoxetine HCl,盐酸达泊西汀,Priligy

Target: 5-HT Receptor, Serotonin Transporter

Cat.No: T0039

Synonym: 达波西汀,Dapoxetina,Dapoxetinum

Target: Others, 5-HT Receptor

Cat.No: T36712

Synonym: MMP-2/MMP-9 Inhibitor II

Target: MMP

Cat.No: T14843

Synonym: BX341

Target: Androgen Receptor

Terazosin hydrochloride dihydrate

Cat.No: T6701

Synonym: Flotrin dihydrate,Terazosin HCl Dihydrate,Dysalfa dihydrate,Heitrin dihydrate,盐酸特拉唑嗪(二水合物)

Target: Adrenergic Receptor

Cat.No: T22232

Cat.No: T27798

Synonym: CS891B,CS-891,CS-891B,CS891

Target: Others

Cat.No: T0210L

Synonym: LY253351 free base,HSDB7744,(R)-(-)-YM12617 free base,Harnal-D,Flowmax,HSDB 7744,HSDB-7744

Target: Adrenergic Receptor

Terazosin hydrochloride

Cat.No: T0197

Synonym: 盐酸特拉唑嗪,Terazosin HCl,Terazosine,Blavin,Hytrin,Zayasel,Fosfomic

Target: Adrenergic Receptor

Fexapotide triflutate

Cat.No: T70396

Chlormadinone (free base)

Cat.No: T71904

Cat.No: T76275

Cat.No: T69492

Cat.No: T61729

Finasteride acetate

Cat.No: T21668

Cat. No.	Product Name	Target	Signaling Pathways
T1284	Megestrol acetate SC10363,醋酸甲地孕酮,BDH1298	Glucocorticoid Receptor; Estrogen/progestogen Receptor; Progesterone Receptor; HIV Protease; Autophagy	Autophagy; Endocrinology/Hormones; Microbiology/Virology; Others; Proteases/Proteasome
	Megestrol acetate (BDH1298) 是具有口服活性的合成孕激素。它还具有抗雄激素特性，可用于治疗厌食症和恶病质。
TN1061	Ganoderol B	Androgen Receptor	Endocrinology/Hormones
	Ganoderol B is a potent β ±-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of β ±-glucosidase is 119.8 uM. It may be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of andr
TN4164	Grandifloroside	TNF	Apoptosis
	Grandifloroside shows good antioxidative and potent anti-inflammatory activities, it also exhibits potent inhibitory activity against TNF-α and 5α-reductase, suggests that it might be developed as a source of potent anti-oxidative and anti-inflammatory ag

天然产物

Megestrol acetate

Cat.No: T1284

Synonym: SC10363,醋酸甲地孕酮,BDH1298

Target: Glucocorticoid Receptor, Estrogen/progestogen Receptor, Progesterone Receptor, HIV Protease, Autophagy

Cat.No: TN1061

Target: Androgen Receptor

Grandifloroside

Cat.No: TN4164

Target: TNF

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