Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3709 |
XMD8-87
ACK1-B19 |
Tyrosinase; PPAR | DNA Damage/DNA Repair; Metabolism; Proteases/Proteasome |
XMD8-87 (ACK1-B19)是TNK2抑制剂,对于D163E 和R806Q 突变体的IC50值分别为38和113 nM。 | |||
T3196 |
GNF-7
GNF7 |
Bcr-Abl; ACK; AChR | Angiogenesis; Cytoskeletal Signaling; Neuroscience; Tyrosine Kinase/Adaptors |
GNF-7 是一种多重激酶抑制剂。它对ACK1和GCK 具有抑制活性,IC50分别为 25 nM 和 8 nM。它是一种 Bcr-Abl 的抑制剂,对 Bcr-AblWT 和 Bcr-AblT315I 作用的IC50值分别为 133 nM 和 61 nM。它可用于研究血液恶性肿瘤。 | |||
T5092 |
AIM-100
AIM100 |
ACK | Tyrosine Kinase/Adaptors |
AIM-100 是选择性的 Ack1 抑制剂 (IC50:21.58 nM)。它还抑制 Tyr267磷酸化,但不抑制其他激酶,包括 PI3K 和 AKT 亚家族成员。它具有抗癌活性。 | |||
T2641 |
KRCA-0008
KRCA 0008,KRCA0008 |
ACK; ALK | Angiogenesis; Tyrosine Kinase/Adaptors |
KRCA-0008 是高效的、选择性的 ALK/Ack1 抑制剂,对ALK 和Ack1的IC50值分别为12nM 和4nM,显示出非hERG 依赖性药物活性。 | |||
TP1971 |
Pseudo RACK1
|
||
Activator of protein kinase C; attached to cell permeabilization Antennapedia domain vector peptide. Consists of peptide derived from the C2 domain of PKC β linked by a disulfide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide i | |||
T68740 |
NVP-TAC544
|
||
NVP-TAC544 is a novel focal adhesion kinase (FAK) inhibitor, potently blocking kinase activity of FAK along with Aurora A, activated Cdc42-associated kinase 1 (ACK1), Met, insulin receptor (IR), TrkA, and IGF-1R. | |||
T2382 |
Vemurafenib
RO5185426,RG7204,维罗非尼,PLX4032 |
Raf; MAPK; ACK; Src; Autophagy | Angiogenesis; Autophagy; MAPK; Tyrosine Kinase/Adaptors |
Vemurafenib (RG7204) 是一种 B-RAF 抑制剂,可以抑制 RAFV600E 和 c-RAF-1 (IC50=31/48 nM),具有选择性和有效性。Vemurafenib 具有抗肿瘤活性,用于 BRAF V600E 突变阳性的黑色素瘤治疗。 | |||
T13564L2 |
AZ7550 trimesylate salt
AZ7550 Mesylate,AZ7550 trimesylate salt (1421373-99-0 free base) |
MLK | MAPK |
AZ7550 trimesylate salt (AZ7550 Mesylate) 是奥希替尼的活性代谢产物,AZ7550 trimesylate salt 抑制 IGF1R 活性,可用于研究非小细胞肺癌。 | |||
T13564 |
AZ7550
|
MLK; FAK; EGFR; FLT; Tyrosine Kinases; PYK2; MNK; IGF-1R; ACK; BTK; ALK; Drug Metabolite | Angiogenesis; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; Metabolism; Tyrosine Kinase/Adaptors |
AZ7550 是 AZD9291 的活性代谢物,可抑制 IGF1R 活性,IC50为 1.6 μM。 | |||
T13564L |
AZ7550 hydrochloride
AZ7550 hydrochloride (1421373-99-0 free base) |
EGFR; IGF-1R | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
AZ7550 hydrochloride (AZ7550 hydrochloride ) 是 AZD9291 的活性代谢物,可抑制 IGF1R 活性,IC50为 1.6 μM。 |