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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T28883	Sultroponium A118,A-118,A 118
	Sultroponium may be used as an anticholinergic agent or antispasmodic.
T3355	Naloxegol oxalate NKTR-118,NKTR-118 oxalate,AZ 13337019,AZ-13337019 oxalate	P450	Metabolism
	Naloxegol oxalate (NKTR-118) 是一种外周选择性 opioid 样物质拮抗剂，用于治疗 opioid 样物质引起的便秘。
T6735	XL413 hydrochloride BMS-863233 Hydrochloride,XL413,BMS-863233	cholecystokinin; Casein Kinase; Pim; CDK	Cell Cycle/Checkpoint; Chromatin/Epigenetic; GPCR/G Protein; JAK/STAT signaling; Metabolism; Stem Cells
	XL413 hydrochloride (BMS-863233 Hydrochloride) 是一种有效的，选择性的，ATP 竞争性的 Cdc7抑制剂，IC50值为 3.4 nM。XL413 hydrochloride 对 CK2 和 PIM1 的IC50值分别为 215 和 42 nM，对 pMCM 的EC50值为 118 nM。
T6100	Torin 2	Apoptosis; ATM/ATR; DNA-PK; mTOR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Torin 2 是一种特异性 mTOR 抑制剂，IC50值为0.25 nM，并改善了药代动力学特性。它抑制 ATM/ATR/DNA-PK 的 EC50 分别为 28 nM/35 nM/118 nM。
T36374	Naloxegol (NKTR-118)
	Naloxegol (NKTR-118; AZ-13337019) is an opioid-receptor antagonist[1]. [1]. Yoon SC, et al. Naloxegol in opioid-induced constipation: a new paradigm in the treatment of a common problem. Patient Prefer Adherence. 2017 Jul 24;11:1265-1271.
TP1077	Nucleoprotein (118-126) Nucleoprotein 118-126,NP(118-126)
	Nucleoprotein (118-126),a fragment of Nucleoprotein, is a 9-aa peptide .
T82890	bFGF (119-126)
	bFGF (119-126) 为具备生物活性的肽段，对应人类、牛(119-126)、小鼠、大鼠(118-125)以及肝素结合生长因子2(118-125)的相应残基。该肽能够抑制bFGF受体的二聚化及其激活作用。
T61665	Antibacterial agent 118
	Antibacterial agent 118 (also known as compound 20) is a potent antimycobacterial compound with activity against various mycobacterial strains, including Mtb H37Ra, M. aurum, M. smegmatis, Mtb H37Rv, and M. avium. The minimum inhibitory concentration (MIC) values for Antibacterial agent 118 against these strains are 40.7 μM, 10.2 μM, 163.0 μM, 62.5 μM, and 62.5 μM, respectively. This compound holds potential for tuberculosis research [1].
T75886	[Ala107]MBP(104-118) TFA
	[Ala107]MBP(104-118) TFA 为针对protein kinase C (PKC)的非竞争性肽抑制剂，IC50值介于46-145 μM之间。
T79178	WRN inhibitor 2	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	WRN inhibitor 2 (example 118)为一WRN（Werner综合征ATP依赖性解旋酶）的抑制剂，其pIC50值不小于7.0。
T68461	HA-118
	HA-118 is a dopamine receptor agonist.
T65704	2-(Hydroxymethyl)isoindoline-1,3-dione
	2-(Hydroxymethyl)isoindoline-1,3-dione 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65704，CAS号为 118-29-6。
T38050	CP-609754	Transferase	Metabolism
	CP-609754 是高效的、可逆的法尼基转移酶抑制剂，对重组人 H-Ras 和重组 K-Ras 法尼基化的 IC50分别为 0.57 ng/mL 和 46 ng/mL。CP-609754有潜在的抗癌作用。
T69647	UCM-05194
	UCM-05194 is a potent Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA1). UCM-05194 Shows Efficacy in Neuropathic Pain Amelioration. UCM-05194 stands out as the most potent and selective LPA1 receptor agonist described so far (Emax = 118%, EC50 = 0.24 μM, KD = 19.6 nM; inactive at autotaxin and LPA2-6 receptors).
T81605	Ontorpacept TTI-621
	Ontorpacept (TTI-621)为一种由人SIRPα的N端(1-118)与人IgG1的Fc区域构建的可溶性融合蛋白。该N端片段为CD47结合域，而CD47为巨噬细胞吞噬作用的负调控器。作为CD47阻断剂和检查点抑制剂，Ontorpacept展现出抗肿瘤活性。
T75887	[Ala113]MBP(104-118) TFA
	[Ala113]MBP(104-118) TFA 是 protein kinase C (PKC)的非竞争性的肽抑制剂，IC50值范围为 28-62 μM。
T79202	Anticancer agent 118
	Anticanceragent 118是一种N-酰化环丙沙星衍生物，展现了针对革兰氏阳性(bacterial)菌株的高度活性，以及对前列腺癌PC3细胞的抗增殖能力，适用于抗肿瘤研究。
T70844	CM-118
	CM-118 is a potent and selective dual inhibitor of c-Met and ALK which potently abrogates hepatocyte growth factor (HGF)-induced c-Met phosphorylation and cell migration, as well as phosphorylation of ALK, EML4-ALK, and ALK resistance mutants in transfected cells.
T76523	HCV Core Protein (107-114)
	HCVCore Protein (107-114) 是主要线性 HCV 核心区域中免疫原性极低的残基。HCVCore Protein (107-114) 被鉴定为 101-118 区域内的结合位点，其包含基因型 Ⅰ/Ⅱ 和基因型 Ⅲ/Ⅵ 之间不同的两个残基。HCVCore Protein (107-114) 可能是传播 HCV 血清型的潜在位点。
T9669	EST73502 hydrochloride
	EST73502 hydrochloride 是一种选择性的，具有口服活性和血脑屏障渗透性的 μ-opioid 受体 (μ-opioid receptor/MOR) 激动剂和 σ1 受体(σ1R) 拮抗剂，对 MOR 和 σ1R 作用的Ki 值分别为 64 nM 和 118 nM。EST73502 hydrochloride 可用于缓解疼痛研究。
T38030	(R)-AM1241 (R)-AM1241
	(R)-AM1241 binds to cannabinoid (CB) receptors and has greater than 100-fold selectivity for the CB2 over the CB1 receptor (Kis = 15 and 5,000 nM, respectively, in a membrane assay using human receptors). (R)-AM1241 acts as an agonist at human CB2 receptors (EC50 = 118 nM) but an inverse agonist at rat and mouse CB2 receptors (EC50s = 315 and 341 nM, respectively). Similar to the racemate AM1241 , (R)-AM1241 produces antinociception to thermal, but not mechanical, pain in rats. The pain-reducing...
T36693	FD-211
	FD-211 is a δ lactone originally isolated from M. lutea with anticancer activity.1 It is cytotoxic to adriamycin-susceptible P388, T-24, HeLa, A549, and HL-60 cancer cells (IC50s = 4, 0.5, 1, 1, and 0.2 μg/ml, respectively), as well as adriamycin-resistant HL-60/ADR cells (IC50 = 0.1 μg/ml). FD-211 also inhibits DNA, RNA, and protein synthesis in HeLa cells (IC50 = 1.25 μg/ml for all). \|1. Nozawa, O., Okazaki, T., Sakai, N., et al. A novel bioactive δ lactone FD-211. Taxonomy, isolation and char...

化合物

Cat.No: T28883

Synonym: A118,A-118,A 118

Naloxegol oxalate

Cat.No: T3355

Synonym: NKTR-118,NKTR-118 oxalate,AZ 13337019,AZ-13337019 oxalate

Target: P450

XL413 hydrochloride

Cat.No: T6735

Synonym: BMS-863233 Hydrochloride,XL413,BMS-863233

Target: cholecystokinin, Casein Kinase, Pim, CDK

Cat.No: T6100

Target: Apoptosis, ATM/ATR, DNA-PK, mTOR, Autophagy

Naloxegol (NKTR-118)

Cat.No: T36374

Nucleoprotein (118-126)

Cat.No: TP1077

Synonym: Nucleoprotein 118-126,NP(118-126)

Cat.No: T82890

Antibacterial agent 118

Cat.No: T61665

[Ala107]MBP(104-118) TFA

Cat.No: T75886

WRN inhibitor 2

Cat.No: T79178

Target: DNA/RNA Synthesis

Cat.No: T68461

2-(Hydroxymethyl)isoindoline-1,3-dione

Cat.No: T65704

Cat.No: T38050

Target: Transferase

Cat.No: T69647

Cat.No: T81605

Synonym: TTI-621

[Ala113]MBP(104-118) TFA

Cat.No: T75887

Anticancer agent 118

Cat.No: T79202

Cat.No: T70844

HCV Core Protein (107-114)

Cat.No: T76523

EST73502 hydrochloride

Cat.No: T9669

Cat.No: T38030

Synonym: (R)-AM1241

Cat.No: T36693

Cat. No.	Product Name	Target	Signaling Pathways
T38330	Collinin
	Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a...

天然产物

Cat.No: T38330

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