keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GW791343 dihydrochloride (GW791343 (HCl)) 是有种属特异性的 P2X7变构调节剂,对人 P2X7的 pIC50为6.9-7.2。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 343 | 现货 | ||
2 mg | ¥ 497 | 现货 | ||
5 mg | ¥ 822 | 现货 | ||
10 mg | ¥ 1,160 | 现货 | ||
25 mg | ¥ 2,420 | 现货 | ||
50 mg | ¥ 3,590 | 现货 | ||
100 mg | ¥ 5,190 | 现货 | ||
200 mg | ¥ 7,370 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 885 | 现货 |
产品描述 | GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator. |
体外活性 | GW791343 were non-competitive inhibitors of human P2X(7) receptors.?Receptor protection studies using decavanadate and pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS) showed that neither compound-17 nor GW791343 competitively interacted at the ATP binding site and so were probably negative allosteric modulators of the P2X(7) receptor.?GW791343 prevented the slowly reversible blockade of the human P2X(7) receptor produced by compound-17 and inhibited [(3)H]-compound-17 binding to the P2X(7) receptor suggesting they may bind to similar or interacting sites[1]. |
别名 | GW791343 (HCl) |
分子量 | 447.35 |
分子式 | C20H26Cl2F2N4O |
CAS No. | 1019779-04-4 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 42 mg/mL (93.89 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2354 mL | 11.1769 mL | 22.3539 mL | 55.8847 mL |
5 mM | 0.4471 mL | 2.2354 mL | 4.4708 mL | 11.1769 mL | |
10 mM | 0.2235 mL | 1.1177 mL | 2.2354 mL | 5.5885 mL | |
20 mM | 0.1118 mL | 0.5588 mL | 1.1177 mL | 2.7942 mL | |
50 mM | 0.0447 mL | 0.2235 mL | 0.4471 mL | 1.1177 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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