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Search Results for " γ-secretase "

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Cat. No.	Product Name	Target	Signaling Pathways
T40315	γ-Secretase modulator 10
	γ-Secretase modulator 10 is a novel γ-secretase modulator.
T11361	γ-Secretase modulator 4	Others	Others
	γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.017 μM and 0.014 μM in mouse and human, respectively.
T9422	Fosciclopirox CPX-POM	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Fosciclopirox (CPX-POM) 利用靶向γ-分泌酶，抑制尿路上皮癌的生长。静脉给药后，它选择性地将活性代谢物 Ciclopirox 递送至整个尿路。Ciclopirox 在许多实体和血液恶性肿瘤中显示出抗癌活性。
T16294	NGP555	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	NGP555 是 γ-分泌酶调节剂。
T6063	LY-411575 LY411575	Apoptosis; Gamma-secretase	Apoptosis; Neuroscience; Proteases/Proteasome; Stem Cells
	LY-411575 是一种高效的γ-secretase 抑制剂，能够抑制 Aβ40 蛋白的产生，在膜中的 IC50 为 0.078 nM，在细胞中为 0.082 nM。它还抑制 Notch 切割，IC50 为 0.39 nM。
T6249	Avagacestat BMS-708163	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Avagacestat (BMS-708163) 是一种有效的γ-secretase 抑制剂，抑制 Aβ42 (IC50:0.27 nM) 和 Aβ40 (IC50:0.30 nM) 的产生。它同时抑制 Notch 胞内结构域 (NICD) (IC50:0.84 nM) 和 CYP2C19 (IC50:20 nM) 。它可用于阿尔兹海默症的研究。
T6135	YO-01027 gamma-Secretase Inhibitor XX,Dibenzazepine,DBZ,二苯并氮卓	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	YO-01027 (DBZ) 是一种高效的 γ-分泌酶抑制剂，能够裂解 Notch (IC50:2.92 nM) 和 APPL (IC50:2.64 nM)。
T2625	MK-0752	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	MK0752 是一种高效的、特异性的、可穿过血脑屏障的、口服活性的 γ-分泌酶(γ-secretase)抑制剂，对人 SH-SY5Y 细胞 Aβ40 呈剂量依赖性降低(IC50=5 nM)。它能够降低体内新生的中枢神经系统 Aβ。
T3633	Crenigacestat LY3039478	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Crenigacestat (LY3039478) 是一种口服具有活性的Notch 和γ-secretase 的抑制剂，其在多种肿瘤细胞中的IC50为 ∼1nM。
T3521	γ-Secretase-IN-1 Compound E	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	γ-Secretase-IN-1 是一种高效的 γ-secretase 抑制剂，对T-47D 细胞显示部分抗增殖活性且抑制 β-amyloid(40)，β-amyloid(42)，和Notch γ-分泌酶裂解。
T62263	γ-Secretase modulator 13	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	γ-Secretase modulator 13 是一种 γ-分泌酶调节剂 (GSMs)，可以抑制淀粉样蛋白 β 肽Aβ42 的产生，可以用于研究阿尔茨海默病和肿瘤。
T6870	L-685458 L-685,458	Apoptosis; Gamma-secretase	Apoptosis; Neuroscience; Proteases/Proteasome; Stem Cells
	L-685458 (L-685,458) 是一种过渡状态模拟 γ-分泌酶抑制剂，抑制淀粉样 β-蛋白前体 γ-分泌酶活性，选择性高于其他检测的天冬氨酸蛋白酶 50-100 倍。它抑制 γ-分泌酶介导的 APP-C99 和 Notch-100 的裂解，可研究阿尔茨海默病和癌症。
T16133	MRK-560	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	MRK-560 是高效的、口服有效的 γ- 分泌酶抑制剂抑制剂，具有大脑屏障渗透性。
T6274	RO4929097 RG-4733	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	RO4929097 (RG-4733) 是 γ secretase 抑制剂，IC50=4 nM，能够抑制细胞内 Aβ40 (EC50:14 nM) 的产生和 Notch (EC50:5 nM) 活性。
T6125	Semagacestat LY450139,塞美司他	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Semagacestat (LY450139) 是一种γ-secretase 抑制剂，抑制β-amyloid(Aβ42)，Aβ38和Aβ40，IC50分别为 10.9，12 和 12.1 nM，可用于研究阿尔茨海默病。
T2262	Itanapraced CHF5074,CSP-1103	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Itanapraced (CHF5074) 是新型γ-secretase 调节剂，能够降低 Aβ42 (IC50=3.6 nM) 和 Aβ40 (IC50=18.4 nM) 分泌。
T6202	DAPT LY-374973,GSI-IX	Apoptosis; Beta Amyloid; Gamma-secretase; Autophagy	Apoptosis; Autophagy; Neuroscience; Proteases/Proteasome; Stem Cells
	DAPT (LY-374973) 是一种 γ 分泌酶抑制剂，抑制总 Aβ 和 Aβ42 (IC50=115/200 nM)，具有口服活性。DAPT 也是一种 Notch 抑制剂。DAPT 可以诱导细胞分化、诱导细胞自噬和凋亡。
T6935	Nirogacestat PF-03084014,PF-3084014,PF03084014,PF 03084014	Apoptosis; Gamma-secretase	Apoptosis; Neuroscience; Proteases/Proteasome; Stem Cells
	Nirogacestat (PF 03084014) 是一种具有口服活性的，可逆的，非竞争性的，选择性γ-secretase 抑制剂，IC50为 6.2 nM。它抑制 Notch 信号通路，可研究 Notch 受体依赖性肿瘤。
T15184	E 2012 (E)-1-[(1S)-1-(4-氟苯基)乙基]-3-[3-甲氧基-4-(4-甲基-1H-咪唑-1-YL)亚苄基]哌啶-2-酮	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	E 2012 是一种γ 分泌酶调节剂，不会影响 Notch 加工，在胆固醇生物合成的末步抑制 3β-羟基固醇 Δ24-还原酶。它能够减少淀粉样蛋白 β-42 减少阿兹海默氏病，并在大鼠多次重复给药后诱发白内障。
T22678	3,5-Bis(4-nitrophenoxy)benzoic acid 3,5-二(4-硝基苯氧基)苯甲酸,Compound W	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) 是 γ-secretase 抑制剂。它导致 Aβ42 和 notch-1 Aβ-like peptide 25 (Nβ25) 的释放水平降低。它是母体血清中 3,3’-diiodothyronine sulfate (T2S) 的交叉反应物质，可作为胎儿甲状腺功能减退的标志物。
T11362	gamma-Secretase Modulators γ-Secretase Modulators,Amyloid-β production inhibitor	Others	Others
	gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β. Specifically, it acts as a gamma-Secretase Modulators with an IC50 value.
T61881	γ-Secretase modulator 12
	γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM. It is specifically designed for Alzheimer's disease research. Notably, γ-Secretase modulator 12 exhibits a favorable brain/plasma ratio (Kp, brain = 0.72) in mice [1].
T17281	Z-Ile-Leu-aldehyde Z-IL-CHO,GSI-XII,γ-Secretase inhibitor XII	Others	Others
	Z-Ile-Leu-aldehyde is an effective and competitive peptide aldehyde inhibitor of γ-secretase and notch.
T9713	δ-secretase inhibitor 11	Beta Amyloid; Caspase	Apoptosis; Neuroscience; Proteases/Proteasome
	δ-secretase inhibitor 11是一种分泌酶抑制剂，可用作阿尔茨海默病（AD）治疗转化开发的先导化合物。
T63216	γ-Secretase modulator 11
	5-{8-[（3，4'-二氟[1，1'-联苯]-4-基）甲氧基]-2-甲基咪唑并[1，2-a]吡啶-3-基}-N-甲基吡啶-2-甲酰胺（1o）具有较高的体外效力和脑暴露效果，能够使脑Aβ42水平的明显降低，且对细胞色素p450酶无抑制作用。此外，化合物1o 在AD 模型小鼠中表现出优异的抗认知缺陷作用。
T11358	gamma-secretase modulator 1 N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4-phenyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	gamma-secretase modulator 1 是一种 γ 分泌酶的调节剂，可用于治疗阿尔茨海默病的研究。
T63638	γ-Secretase modulator 11 hydrochloride
	γ-Secretase modulator 11 hydrochloride 是有效的、口服具有活力的 γ-secretase 调节剂 (IC50: 0.029 μM)。 γ-Secretase modulator 11 hydrochloride 能够明显降低脑 Aβ42 水平，可挽救 AD 模型小鼠表现出的认知缺陷。γ-Secretase modulator 11 hydrochloride 对阿尔茨海默病表现出研究潜力。
T40260	β-Secretase Inhibitor II
	β-Secretase Inhibitor II is a tripeptide aldehyde compound that acts as an inhibitor of β-Secretase. It exhibits a simple structure and has an inhibitory potency of IC50 = 700 nM against total Aβ and IC50 = 2.5 μM specifically against Aβ 1-42. This compound is particularly useful in research related to Alzheimer's disease.
T39251	β-Secretase Inhibitor I
	β-Secretase Inhibitor I is a highly potent inhibitor of the β-secretase enzyme. This compound exhibits exceptional inhibitory activity while also demonstrating a significant reduction in cardiovascular and liver toxicity.
T3161	β-Secretase inhibitor-STA	Beta-Secretase	Neuroscience
	BACE-IN-1 是淀粉样前体蛋白 β-分泌酶抑制剂。
T62455	β-Secretase Inhibitor III
	β-Secretase Inhibitor III 是一种高度选择性的 BACE1 抑制剂，其 Ki 值为 0.13 nM。
T64258	gamma-secretase modulator 5
	gamma-secretase modulator 5 (compound 22d) 是一种能够透过血脑屏障的 γ-分泌酶调节剂 (GSMs)，对聚集的淀粉样蛋白 β 肽 Aβ42 的产生表现出抑制作用 (IC50: 60 nM)。gamma-secretase modulator 5 能够用于研究阿尔茨海默病。
T21890	JLK6	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	JLK-6 是一种γ分泌酶抑制剂，选择性作用于 HEK293细胞的淀粉样β前体蛋白(APP)的γ-分泌酶裂解 APP，抑制 Aβ的生成，但对不 Notch 受体的裂解无影响。
T14690	BMS 433796 BMS-289948,BMS-299897	Beta Amyloid	Neuroscience
	BMS 433796 是一种在阿尔茨海默病转基因小鼠模型中具有Aβ降低活性的γ分泌酶抑制剂，可有效抑制 Aβ 的产生。
T10532	BI-1408	Others; Gamma-secretase	Neuroscience; Others; Proteases/Proteasome; Stem Cells
	BI-1408 是一种强效的 γ 分泌酶调节剂（对 Aβ42 的 IC50 值为 0.04 μM）。
T9015	LY900009	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	LY900009 是一种通过选择性抑制 γ-分泌酶蛋白来抑制 Notch 信号传导的小分子抑制剂。
T9641	Aβ42-IN-2	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Aβ42-IN-2 是一种 γ-secretase 调节剂。Aβ42-IN-2 对 Αβ42 的 IC50 值为 6.5 nM 。Aβ42-IN-2 可用于阿尔茨海默症相关的研究。
T11178L	ELN318463 racemate ELN318463 (racemate),ELN 318463 racemate	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	ELN318463 racemate (ELN 318463 racemate) 是 ELN318463 的外消旋体，ELN318463 是一种淀粉样前体蛋白 (APP) 选择性 γ-分泌酶抑制剂。
T14673	BMS 299897	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	BMS 299897 是一种磺胺类 γ 分泌酶抑制剂。它在稳定过表达淀粉样前体蛋白（APP）的 HEK293 细胞中抑制 Aβ 生成的 IC50 值为 7 nM。
T11043	Dihydroergocristine mesylate 甲磺酸双氢麦角汀,DHEC (mesylate)	Beta Amyloid	Neuroscience
	Dihydroergocristine mesylate (DHEC (mesylate)) 是一种 γ-secretase (GSI) 的抑制剂，能够阿尔茨海默氏病淀粉样蛋白 β 肽 (amyloid-β) 的产生，与 γ-secretase 和 Nicastrin 结合的平衡解离常数 (Kd) 值分别为 25.7 nM 和 9.8 μM。
T63208	Aβ-IN-1	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Aβ-IN-1 是一种新型有效且具有口服活性的 γ 分泌酶调节剂 (GSM)。 Aβ-IN-1 在不抑制 CYP3A4 的情况下，在培养细胞中有效降低 Aβ42 水平，IC50值为 0.091 μM。Aβ-IN-1 显示出良好的药代动力学特征。
T14680	BMS-906024 Osugacestat,AL-101,BM-0018	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	BMS-906024 (Osugacestat) 是一种可口服且具有选择性的γ 分泌酶抑制剂，是一种小分子 Notch 抑制剂。BMS-906024 对多种人类癌症异种移植具有广谱抗肿瘤活性。BMS-906024 可阻止所有四种 Notch 受体的激活，对 Notch1、-2、-3 和 -4 受体的 IC50 分别为 1.6、0.7、3.4 和 2.9 nM。
T4364	Aftin-4 Aftin 4,Aftin4	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Aftin-4 是一种 β-淀粉样蛋白42(Aβ42) 的诱导剂。
T2470	MDL-28170 Calpain Inhibitor III	Cysteine Protease; Proteasome	Proteases/Proteasome; Ubiquitination
	MDL-28170 (Calpain Inhibitor III) 是一种选择性的、有效的、具有膜渗透性的半胱氨酸蛋白酶 (calpain)抑制剂，可在全身给药后迅速穿过血脑屏障。它还能阻断γ-secretase。
T13037	Sulindac sulfide cis-Sulindac sulfide	Raf; Others; AChR	MAPK; Neuroscience; Others
	Sulindac sulfide (cis-Sulindac sulfide) 是一种非甾体抗炎化合物，对COX-1具有很高的亲和力，是Ras 激活Raf-1的抑制剂。Sulindac sulfide 是 γ-secretase 的一个非竞争性抑制剂， IC50 为 20.2 μM。它是舒林酸的活性代谢物。
T11178	ELN318463 ELN 318463	Others	Others
	ELN 318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN 318463 is 51-fold more selective for PS1.ELN 318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor.
T23431	TC-E 5006	Others	Others
	γ-secretase modulator
T11359	gamma-secretase modulator 2	Others	Others
	gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's disease .γ-secretase modulator is modulation of the action of γ-secretase so as to Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain. γ-secretase modulator is usful in particular Alzheimer's disease.
T26864	BMS-932481 BMS932481
	BMS-932481 is a γ-secretase modulator.
T24116	GSM-1 gamma Secretase modulator 1,GSM 1 (enzyme modulator),J2.559.799K
	GSM-1 is a modulator of γ-Secretase.

化合物

γ-Secretase modulator 10

Cat.No: T40315

γ-Secretase modulator 4

Cat.No: T11361

Target: Others

Cat.No: T9422

Synonym: CPX-POM

Target: Gamma-secretase

Cat.No: T16294

Target: Gamma-secretase

Cat.No: T6063

Synonym: LY411575

Target: Apoptosis, Gamma-secretase

Cat.No: T6249

Synonym: BMS-708163

Target: Gamma-secretase

Cat.No: T6135

Synonym: gamma-Secretase Inhibitor XX,Dibenzazepine,DBZ,二苯并氮卓

Target: Gamma-secretase

Cat.No: T2625

Target: Beta Amyloid, Gamma-secretase

Cat.No: T3633

Synonym: LY3039478

Target: Gamma-secretase

γ-Secretase-IN-1

Cat.No: T3521

Synonym: Compound E

Target: Beta Amyloid, Gamma-secretase

γ-Secretase modulator 13

Cat.No: T62263

Target: Gamma-secretase

Cat.No: T6870

Synonym: L-685,458

Target: Apoptosis, Gamma-secretase

Cat.No: T16133

Target: Gamma-secretase

Cat.No: T6274

Synonym: RG-4733

Target: Beta Amyloid, Gamma-secretase

Cat.No: T6125

Synonym: LY450139,塞美司他

Target: Beta Amyloid, Gamma-secretase

Cat.No: T2262

Synonym: CHF5074,CSP-1103

Target: Beta Amyloid, Gamma-secretase

Cat.No: T6202

Synonym: LY-374973,GSI-IX

Target: Apoptosis, Beta Amyloid, Gamma-secretase, Autophagy

Cat.No: T6935

Synonym: PF-03084014,PF-3084014,PF03084014,PF 03084014

Target: Apoptosis, Gamma-secretase

Cat.No: T15184

Synonym: (E)-1-[(1S)-1-(4-氟苯基)乙基]-3-[3-甲氧基-4-(4-甲基-1H-咪唑-1-YL)亚苄基]哌啶-2-酮

Target: Gamma-secretase

3,5-Bis(4-nitrophenoxy)benzoic acid

Cat.No: T22678

Synonym: 3,5-二(4-硝基苯氧基)苯甲酸,Compound W

Target: Gamma-secretase

gamma-Secretase Modulators

Cat.No: T11362

Synonym: γ-Secretase Modulators,Amyloid-β production inhibitor

Target: Others

γ-Secretase modulator 12

Cat.No: T61881

Z-Ile-Leu-aldehyde

Cat.No: T17281

Synonym: Z-IL-CHO,GSI-XII,γ-Secretase inhibitor XII

Target: Others

δ-secretase inhibitor 11

Cat.No: T9713

Target: Beta Amyloid, Caspase

γ-Secretase modulator 11

Cat.No: T63216

gamma-secretase modulator 1

Cat.No: T11358

Synonym: N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4-phenyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine

Target: Gamma-secretase

γ-Secretase modulator 11 hydrochloride

Cat.No: T63638

β-Secretase Inhibitor II

Cat.No: T40260

β-Secretase Inhibitor I

Cat.No: T39251

β-Secretase inhibitor-STA

Cat.No: T3161

Target: Beta-Secretase

β-Secretase Inhibitor III

Cat.No: T62455

gamma-secretase modulator 5

Cat.No: T64258

Cat.No: T21890

Target: Gamma-secretase

Cat.No: T14690

Synonym: BMS-289948,BMS-299897

Target: Beta Amyloid

Cat.No: T10532

Target: Others, Gamma-secretase

Cat.No: T9015

Target: Gamma-secretase

Cat.No: T9641

Target: Gamma-secretase

ELN318463 racemate

Cat.No: T11178L

Synonym: ELN318463 (racemate),ELN 318463 racemate

Target: Gamma-secretase

Cat.No: T14673

Target: Beta Amyloid, Gamma-secretase

Dihydroergocristine mesylate

Cat.No: T11043

Synonym: 甲磺酸双氢麦角汀,DHEC (mesylate)

Target: Beta Amyloid

Cat.No: T63208

Target: Gamma-secretase

Cat.No: T14680

Synonym: Osugacestat,AL-101,BM-0018

Target: Gamma-secretase

Cat.No: T4364

Synonym: Aftin 4,Aftin4

Target: Beta Amyloid, Gamma-secretase

Cat.No: T2470

Synonym: Calpain Inhibitor III

Target: Cysteine Protease, Proteasome

Sulindac sulfide

Cat.No: T13037

Synonym: cis-Sulindac sulfide

Target: Raf, Others, AChR

Cat.No: T11178

Synonym: ELN 318463

Target: Others

Cat.No: T23431

Target: Others

gamma-secretase modulator 2

Cat.No: T11359

Target: Others

Cat.No: T26864

Synonym: BMS932481

Cat.No: T24116

Synonym: gamma Secretase modulator 1,GSM 1 (enzyme modulator),J2.559.799K

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