Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NGP555 是 γ-分泌酶调节剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 615 | 现货 | ||
2 mg | ¥ 898 | 现货 | ||
5 mg | ¥ 1,810 | 现货 | ||
10 mg | ¥ 2,730 | 现货 | ||
25 mg | ¥ 4,580 | 现货 | ||
50 mg | ¥ 6,530 | 现货 | ||
100 mg | ¥ 8,890 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,890 | 现货 |
产品描述 | NGP555 is a modulator of γ-secretase. |
体外活性 | NGP555 effectively lowers Aβ42 in cell cultures (9 nM) and increasing shorter forms of Aβ at the same time . |
体内活性 | NGP555 also shows good oral bioavailability and is brain-penetrant with a brain: plasma ratio of ~0.93 in mice. NGP555-treated Tg mice show significant protection from a decline in performance with >65% less decline (P<0.005) when comparing the differential of Tg to non-Tg vehicle-treated mice. NGP555 obviously lowers Aβ42 in the cerebrospinal fluid (CSF) at time points from 8 to10 hours post-dose. When combining the reduction of Aβ42 with an increase in Aβ38, NGP555 is effective at raising CSF Aβ38/42 ratio at 1.87 mg/kg and above . |
分子量 | 406.52 |
分子式 | C23H23FN4S |
CAS No. | 1304630-27-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (61.50 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.4599 mL | 12.2995 mL | 24.599 mL | 61.4976 mL |
5 mM | 0.492 mL | 2.4599 mL | 4.9198 mL | 12.2995 mL | |
10 mM | 0.246 mL | 1.23 mL | 2.4599 mL | 6.1498 mL | |
20 mM | 0.123 mL | 0.615 mL | 1.23 mL | 3.0749 mL | |
50 mM | 0.0492 mL | 0.246 mL | 0.492 mL | 1.23 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
NGP555 1304630-27-0 Neuroscience Proteases/Proteasome Stem Cells Gamma-secretase Inhibitor γ-secretase inhibit NGP-555 NGP 555 Gamma secretase inhibitor