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Cat. No. | Product Name | Target | Signaling Pathways |
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T4637 |
R-7050
TNF-α Antagonist III |
TNF | Apoptosis |
R-7050 (TNF-α Antagonist III) 是一种肿瘤坏死因子受体拮抗剂,对 TNFα具有更高选择性。 | |||
T8692 |
(Rac)-Benpyrine
|
TNF | Apoptosis |
(Rac)-Benpyrine 是一种有效且具有口服活性的 TNF-α 抑制剂,是Benpyrine 的外消旋体。它可研究TNF-α介导的炎症和自身免疫性疾病。 | |||
T14975 |
CJ-42794
CJ-042794 |
Others | Others |
CJ-42794 (CJ-042794)是前列腺素受体 EP4的选择性拮抗剂, 抑制[3H]-PGE2与 EP4受体结合的平均 pKi 为8.5, 对 EP4选择性比 EP1, EP2和 EP3高200多倍。 | |||
T4403 |
AX-024 hydrochloride
AX-024 HCl |
IL Receptor; TNF; COX; IFNAR; Interleukin | Apoptosis; Immunology/Inflammation; Neuroscience |
AX-024 hydrochloride (AX-024 HCl) 是一种细胞因子释放抑制剂,可强烈抑制 IL-6、TNFα、IFN-γ、IL-10 和 IL-17A 的产生。它是口服可利用的 TCR-Nck 相互作用抑制剂,可选择性地抑制 TCR 触发的 T 细胞活化。它通过靶向 SH3结构域调节细胞信号传导,具有低毒、高效和高选择性的特点。 | |||
T19584L |
TNF-α (31-45), human acetate
TNF-α (31-45), human acetate(144796-71-4 free base) |
Others | Others |
TNF-α (31-45), human acetate(144796-71-4 free base) 是一种肿瘤坏死因子-α 的肽。 | |||
T9921 |
Infliximab
|
TNF | Apoptosis |
Infliximab 是一种与 TNF-α特异性结合的嵌合单克隆 IgG1 抗体,可阻止 TNF-α与 TNFR1和 TNFR2 的相互作用,用于治疗克罗恩病和类风湿性关节炎。 | |||
T67924 |
ABzOH
|
||
ABzOH 是一种苯甲酸衍生物,结构类似于阿司匹林等非甾体抗炎药,具有抗炎、抗肿瘤和抗增殖作用。ABzOH 不仅可以抑制肿瘤坏死因子- α (TNF-a)、白细胞介素-1β (IL-1β)和白细胞介素-6 (IL-6)等促炎细胞因子的表达还对乳腺癌、肺癌和胰腺癌具有抑制作用。 | |||
T19584 |
TNF-α (31-45), human
|
Others | Others |
TNF-α (31-45), human is a peptide of tumor necrosis factor-α. | |||
T30531 |
BMS-561392
DPC333,DPC 333,DPC-333,BMS561392,BMS 561392 |
TNF | Apoptosis |
BMS-561392 (DPC333)是一种肿瘤坏死因子-α(TNF-α)转化酶抑制剂。 | |||
T76026 |
TNF-α (31-45), human TFA
|
||
TNF-α (31-45), human TFA 是人肿瘤坏死因子-α 的多肽片段。TNF α 是一种炎性细胞因子,可诱导坏死或凋亡。 | |||
TP1636 |
TNF-α (31-45), human TFA (144796-71-4 free base)
TNF-α (31-45), human TFA |
||
TNF-α (31-45), human (TFA) is a peptide of tumor necrosis factor-α. | |||
T33802 |
Ono 4007
Ono-4007,Ono4007 |
||
ONO 4007 is a novel synthetic low-toxicity lipid A analog that stimulates the production of tumor necrosis factor-α in tumor tissues, resulting in the rejection of transplanted rat hepatocellular carcinoma cells. ONO-4007 has been shown to have a therapeu | |||
T69914 |
Variegatic acid
|
||
Variegatic acid is a natural inhibitor of β-hexosaminidase release and tumor necrosis factor (TNF)-α secretion from rat basophilic leukemia (RBL 2H3) cells, with IC50 values of 10.4 μM and 16.8 μM, respectively, also inhibiting PKC β1 activity with an IC50 value of 36.2 μM. | |||
T81606 |
Onercept
|
||
Onercept为重组可溶性人类肿瘤坏死因子-α p55受体,用于Crohn's disease研究。 | |||
T14312 |
Apratastat
|
MMP; TNF | Apoptosis; Proteases/Proteasome |
Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) and it also can potently inhibit the release of TNF-α in vitro, ex vivo, and in vivo with IC50s of 144 ng/mL in vitro and 81.7 ng/mL ex vivo, respectively[1]. | |||
T76983 | Tengonermin | ||
Tengonermin (ARENEGYR) 是一种血管靶向剂,由与CNGRCG 肽结合的人肿瘤坏死因子-α (TNF-α) 组成。Tengonermin 通过改变肿瘤微环境来增加肿瘤内化疗的渗透和 T 细胞浸润。 | |||
T77179 | Remtolumab | ||
Remtolumab (ABT-122) 是一种双变量域免疫球蛋白,可以中和肿瘤坏死因子α (TNFα) 和IL-17A。Remtolumab 显示出对 TNFα 和IL-17A 的双重抑制。Remtolumab 可用于类风湿关节炎 (RA) 研究。 | |||
T36097 | TNF-α-IN-2 | ||
TNF-α-IN-2 is a highly potent and orally bioavailable inhibitor of tumor necrosis factor alpha (TNFα), exhibiting an IC50 of 25 nM in the HTRF assay. It exerts its inhibitory effects by inducing conformational changes in the TNFα trimer upon binding, resulting in disrupted signaling when the trimer interacts with TNFR1. TNF-α-IN-2 holds promise as a valuable tool for investigating the pathogenesis of rheumatoid arthritis[1]. | |||
T76963 |
Certolizumab pegol
|
||
Certolizumab pegol (Certolizumab) 是经过重组和聚乙二醇化处理的人源化单克隆抗体抗原结合片段,它选择性地靶向并中和肿瘤坏死因子-α (TNF-α)。适用于类风湿关节炎和克罗恩病的研究领域。 | |||
T79256 |
DPP-4-IN-8
|
||
DPP-4-IN-8 (compound 27) 是一种高效的选择性DPP4抑制剂,具有 0.96 μM 的 Ki。该化合物能够抑制 Caco-2 和 HepG-2 细胞中的 DPP4 二肽酶活性,并剂量依赖性地降低 TNF-α、IL-6 和 IL-1β 的表达水平[1]。 | |||
T72687 | Keap1-Nrf2-IN-11 | ||
Keap1-Nrf2-IN-11为Keap1-Nrf2抑制剂,KD2值达0.21 nM。该化合物可有效抑制ROS及NO的生成,并降低TNF-α的表达。通过促进Nrf2的核内转移,Keap1-Nrf2-IN-11对炎症具有调节作用,适用于抗炎研究。 | |||
T80973 |
TNF-α-IN-8
|
||
TNF-α-IN-8 (compound I-42) 作为一种TNF-α抑制剂,属于异吲哚-亚胺类化合物,适用于肿瘤、心脏病、骨质疏松、炎症、过敏及自身免疫性疾病的研究。作为点击化学试剂,其Azide基团能与含Alkyne的分子配对,通过铜催化的叠氮-炔环加成反应(CuAAc)产生反应,也可与含DBCO或BCN基团的分子进行菌株促进的炔-叠氮环加成反应(SPAAC)。 | |||
T38039 |
(E)-C-HDMAPP (ammonium salt)
|
||
Synthetic and natural alkyl phosphates, also known as phosphoantigens, stimulate the proliferation of γδ-T lymphocytes. Isopentenyl pyrophosphate, and related derivatives including (E)-hydroxy-dimethyl-allyl pyrophosphate ((E)-HDMAPP), are particularly effective activators of γδ-T cells. (E)-C-HDMAPP is the pyrophosphonate form of (E)-HDMAPP. The pyrophosphonate moiety in (E)-C-HDMAPP is much less susceptible to chemical or enzymatic hydrolysis than its pyrophosphate counterpart. As a result, (E... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2893 |
Muscone
3-Methylcyclopentadecanone,Methylexaltone,麝香酮 |
MMP; TNF; NF-κB; NOD-like Receptor (NLR); P-gp; Interleukin | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; NF-κB; Proteases/Proteasome |
Muscone (3-Methylcyclopentadecanone) 是中药麝香的一种主要活性单体。它抑制NF-κB 和NLRP3炎性小体的活化,显著降低炎性细胞因子水平,并最终改善心脏功能和存活率。 | |||
TWA2417 |
Sodium taurocholate
牛黄胆酸钠(牛胆酸钠,牛胆酸钠盐,牛磺膽酸鈉,牛磺胆酸钠,牛磺胆酸钠盐,牛胆酸钠水合物,水合牛磺胆酸钠,牛胆酸钠(混合物),牛黄胆酸钠(水合),牛磺胆酸钠(标准品)),Taurocholate Sodium |
Others | Others |
Sodium taurocholate (Taurocholate Sodium) hydrate 具有显著的生物学效应,例如通过上调 VEGF-A 的表达抑制肝动脉结扎所致的胆道损伤。对免疫系统具有一定的调节作用。 | |||
TN1163 |
2'-Hydroxychalcone
|
Others | Others |
2'-Hydroxychalcone 是一种药物合成中间体,可用于合成黄酮类化合物。负载在纳米乳液中的2'-Hydroxychalcone 在Danio rerio 模型对副球孢子菌显示出杀真菌活性。2'-Hydroxychalcone 通过负载脂质的Hepg2细胞中的氧化应激诱导细胞毒性。2'-Hydroxychalcone 抑制通过逆转录聚合酶链反应确定的肿瘤坏死因子-α诱导ICAM-1,VCAM-1和E-选择素的稳态转录水平,因此可能会干扰其基因的转录。 | |||
T0131 |
Cepharanthine
NSC-623442,千金藤碱,千金藤素 |
Apoptosis; TNF; HIV Protease; Autophagy | Apoptosis; Autophagy; Microbiology/Virology; Proteases/Proteasome |
Cepharanthine (NSC-623442) 是从Stephania cepharanthaHayata 中提取的一种生物碱,具有抗炎、抗氧化作用。它可抑制肿瘤坏死因子 (TNF)-α 介导的 NFκB 刺激、质膜脂质过氧化和血小板聚集,并抑制细胞因子的产生。 | |||
TN2259 |
Taurocholic acid
N-Choloyltaurine |
TNF; PI3K | Apoptosis; PI3K/Akt/mTOR signaling |
Taurocholic acid (N-Choloyltaurine) 是一种胆汁酸,参与脂肪的乳化。Taurocholic acid 具有细胞保护作用,可通过 PI3K 介导的途径防止肿瘤坏死因子-α 诱导的胆管细胞损伤。 | |||
T6S1597 |
Mulberroside A
桑皮苷 A,桑皮苷A |
TNF; Tyrosinase; Interleukin | Apoptosis; Immunology/Inflammation; Proteases/Proteasome |
Mulberroside A 是桑中的一种主要活性成分,可降低TNF-α、IL-1β和IL-6的表达,抑制 NALP3、caspase-1 和 NF-κB 的激活以及 ERK、JNK 和 p38 的磷酸化 。它抑制蘑菇酪氨酸酶,具有抗炎和抗细胞凋亡作用。 | |||
T6S1579 |
Monotropein
水晶兰苷,Monotropeine |
Others | Others |
Monotropein (Monotropeine) 是从Morinda officinalis 中获得,能够抑制硫酸葡聚糖硫酸钠诱导的结肠炎小鼠模型中炎性因子的表达。 | |||
T2S2264 |
Linalool
Linalol,(±)-Linalool,Phantol,沉香醇 |
Apoptosis; IL Receptor; TNF; Endogenous Metabolite; iGluR | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Linalool (Linalol) 是存在芫荽等植物中的单萜类天然产物,是竞争性NMDA 受体拮抗剂,具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤,具有镇痛、抗菌和抗炎的特性。 | |||
TN4409 |
Lansiumarin C
|
TNF | Apoptosis |
Lansiumarin C can decrease nitric oxide (NO) and tumor necrosis factor-α (TNF-α) production in lipopolysaccharide (LPS)-induced macrophages. | |||
TMA2576 |
Episappanol
|
IL Receptor; TNF | Apoptosis; Immunology/Inflammation |
Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis factor-alpha (TNF-α). | |||
TN5238 |
Viscidulin II
|
IL Receptor; TNF | Apoptosis; Immunology/Inflammation |
Viscidulin II can be potential therapeutic agents against P. acnes-induced skin inflammation, it can significantly suppress P. acnes-induced IL-8 and IL-1β production in THP-1 cells, concomitant intradermal injection of viscidulin II with P. acnes can effectively attenuate P. acnes-induced ear swelling, and decrease the production of IL-6 and tumor necrosis factor-α in ear homogenates. | |||
TN4190 | Hedycoronen A | IL Receptor; TNF | Apoptosis; Immunology/Inflammation |
Hedycoronen A and hedycoronen B have the potential anti-inflammatory benefits, they are potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, with IC(50) ranging from 4.1±0.2 to 9.1±0.3 uM, they also show moderate inhibitory activity on | |||
T35741 |
Gliovirin
|
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Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the parasiteT. brucei brucei(IC50= 90 ng/ml), but has no effect on the plant pathogenic fungiR. solani,P. omnivorum,T. basicola,R. arrhizus, andV. dahliaeor the bacteriaB. thuringiensis,P. fluorescens, andX. malvacearumwhen used at concentrations up to 1,000 ng/ml.2,3Gliovirin decrease... |