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33

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T5000	Diflucortolone valerate Afusona,戊酸双氟可龙,Diflucortolone 21-valerate	Others; Antibacterial; Antifungal	Microbiology/Virology; Others
	Diflucortolone valerate (Diflucortolone 21-valerate) 是一种强效皮质类固醇，可研究各种皮肤疾病。
T4050	GSK2981278 ROR gama modulator 1	ROR	Metabolism
	GSK2981278 (ROR gama modulator 1) 是 RORγ的选择性反向激动剂。它能够抑制 il17启动子的激活，并且干扰 RORγ-DNA 结合。
T16802	Lonapalene RS4317,氯萘帕林	Others	Others
	Lonapalene is a topically effective inhibitor of 5-lipoxygenase.
T0367	Fluocinolone (Acetonide) Fluocinolone acetonide,醋酸肤轻松,Flucort-N	Glucocorticoid Receptor	Endocrinology/Hormones
	Fluocinolone Acetonide (Flucort-N) 是一种糖皮质激素衍生物，能够作用于各种皮肤病的研究。
T0344	Miconazole R18134,咪康唑	Potassium Channel; NOS; Antibacterial; Antibiotic; Antifection; Antifungal	Immunology/Inflammation; Membrane transporter/Ion channel; Microbiology/Virology
	Miconazole (R18134) 是一种具有抗菌作用的咪唑类抗真菌剂。
T8777	Beclometasone 倍氯米松,BecloMethasone	Glucocorticoid Receptor	Endocrinology/Hormones
	Beclometasone 是糖皮质激素受体激动剂。
T1440	Ethacridine lactate monohydrate 乳酸依沙吖啶一水物,利凡诺	Antibacterial; Antibiotic	Microbiology/Virology
	Ethacridine lactate monohydrate 是一种聚 (ADP-核糖) 糖基水解酶 (PARG) 抑制剂，有抗金黄色葡萄球菌和其他革兰氏阳性球菌的活性。它也是抗菌剂和流产剂。
T0087L	Sulfacetamide sodium Sulamyd sodium,磺乙酰胺钠盐,磺胺醋酰钠	Antibacterial; Antibiotic; Autophagy	Autophagy; Microbiology/Virology
	Sulfacetamide sodium (Sulamyd sodium) 是磺胺类抗感染剂，可局部用于口服治疗尿路感染和皮肤感染。
T1536	Promestriene 3-propyl ethyl,舒经劳,17B-methyl estradiol,Promestriano	Estrogen/progestogen Receptor	Endocrinology/Hormones
	Promestriene (3-propyl ethyl) 是局部有效的雌激素，是合成的雌二醇二乙醚。它对阴道萎缩有作用，但吸收量小。
T0858	Flufenamic acid Arlef,Nichisedan,氟灭酸,氟芬那酸,Achless	Potassium Channel; Calcium Channel; Chloride channel; COX; AMPK; Parasite	Chromatin/Epigenetic; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling
	Flufenamic acid (Arlef) 是一种非甾体类抗炎剂，是一种邻氨基苯甲酸衍生物，具有镇痛、抗炎和解热的特性。它用于肌肉骨骼和关节疾病。
T0314	Hexylresorcinol 己雷锁辛,4-己基间苯二酚,4-Hexylresorcinol	Apoptosis; Tyrosinase; Antibacterial; Parasite	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Hexylresorcinol (4-Hexylresorcinol) 是在植物中发现的一种天然产物，具有抗菌、驱虫、防腐和抗肿瘤活性。它是一种可逆、非竞争性的 α-葡萄糖苷酶抑制剂，有抗 DNA 氧化损伤的保护作用。它可诱导鳞癌细胞凋亡。
T1198	Tetracaine hydrochloride 盐酸丁卡因,Amethocaine hydrochloride,Amethocalne HCl,Tetracaine HCl	Calcium Channel; Sodium Channel	Membrane transporter/Ion channel; Metabolism
	Tetracaine hydrochloride (Amethocalne HCl) 是一种钙通道蛋白抑制剂，可阻断肌浆网中 Ca2+的电压敏感释放。它主要用作眼科的止痒剂和局部用药，可用于表面和脊髓麻醉。
T0820	Triamcinolone acetonide 曲安奈德,Aristogel,Azmacort,Aristoderm	Glucocorticoid Receptor	Endocrinology/Hormones
	Triamcinolone acetonide (Azmacort) 是皮质类固醇。它是皮质类固醇激素受体激动剂。它是抗炎糖皮质激素，局部用于治疗各种皮肤疾病。它的有效性是 prednisone 的八倍。
T25048	Algestone acetophenide Neolutin,苯甲孕酮	Others	Others
	Algestone acetophenide (Neolutin) 是用于发情同步的孕酮，已被评估为与庚酸雌二醇联合使用的注射避孕药。它在治疗上也用作局部抗炎药，并在治疗痤疮时局部应用。
T32699	Levobunolol Levobunololum,Liquifilm,AK-Beta,Betegan
	Levobunolol is a nonselective beta-blocker. It is used topically to treat glaucoma.
T33218	Mazipredone Mazipredonum,Mazipredona
	Mazipredone is a water-soluble, long-acting prednisolone derivative used topically for skin conditions & parenterally as a glucocorticoid.
T13955	Unoprostone	Others	Others
	Unoprostone is a prostaglandin F2α analogs (PGAs), and reduces intraocular pressure and is used topically for glaucoma or ocular hypertension.
T32113	Hydrocortamate Hydrochloride UNII-9QM8U7R83W,Ulcort,Hydrocortamate HCl,Magnacort,Ethamicort
	Hydrocortamate Hydrochloride is a synthetic glucocorticoid that has anti-inflammatory and immunosuppressive properties. It is used topically to treat inflammation caused by corticosteroid-responsive skin diseases.
T29693	Aftobetin HCl ANCA11,NCE 11,NCE11,NCE-11
	Aftobetin, also known as ANCA11 and NCE-11, is a novel amyloid–binding compound applied topically in the form of an ophthalmic ointment. Aftobetin may be of useful as an aid in the diagnosis Alzheimer's disease.
T16955	Sulfiram	Others	Others
	Sulfiram is an ectoparasiticide and is a drug applied topically to treat scabies.
T22862	Imiquimod maleate	Others	Others
	Imiquimod maleate is an immune response modifier. It acts as a toll-like receptor 7 agonists and is commonly used topically to treat warts on the skin of the genital and anal areas.
T25202	Candicidin Levorinum,NSC 94219,NSC94219,Candizidin,NSC-94219
	Candicidin is an antifungal heptaene macrolides from Streptomyces griseus or Actinomyces levoris used topically in candidiasis. The antibiotic is composed of candicidins A, B, C, and D, of which D is the major component.
T70294	KAA-276 free base
	KAA-276 free base is a novel potent and long-lasting histamine HI-receptor antagonist with less-topical irritation, and can be topically administered by inhalation for the treatment of bronchial asthma.
T70293	KAA-276 HCl
	KAA-276 HCl is the salt form of KAA-276 free base, a novel potent and long-lasting histamine HI-receptor antagonist with less-topical irritation, and can be topically administered by inhalation for the treatment of bronchial asthma.
T70311	Demecarium Free Base
	Demecarium Free Base is a quaternary ammonium compound that serves as a long-acting cholinesterase inhibitor with parasympathomimetic activity. When used topically, demecarium inactivates both pseudocholinesterase and acetylcholinesterase, thereby preventing acetylcholine breakdown and increasing acetylcholine activity.
T36908	Bimatoprost grenod 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α
	Bimatoprost grenod(15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2α) is a nitric oxide-donating derivative of 17-phenyl trinor PGF2α.1It increases cGMP levels in rabbit aqueous humor and iris ciliary body when topically administered at a concentration of 0.042%. Topical administration of 15-(6-nitroxylhexanoyl)-17-phenyl trinor PGF2α(0.14%) reduces intraocular hypertension (IOP) in a rabbit model of hypertonic saline-induced transient ocular pressure. It also reduces IOP in a cynomolgus monkey mode...
T38196	Prostaglandin F2α isopropyl ester Prostaglandin F2α isopropyl ester
	PGF2α isopropyl ester is an ester prodrug of PGF2α with enhanced lipid solubility. Due to better membrane penetration, PGF2α isopropyl ester is more suitable than PGF2α or PGF2α tromethamine salt for topical application in studies on intraocular pressure. The ester functionality is readily hydrolyzed in vivo to release the active compound PGF2α. When administered topically to the eyes of cynomolgus monkeys, a 5 μg dose reduces intraocular pressure by 68% after the fourth day of treatment.
T62654	Fluocortin butyl ester
	Fluocortin butyl ester 是一种发达的皮质类固醇化合物，局部使用时无法检测到全身性的皮质类固醇活性。Fluocortin butyl ester 似乎是一种有效的、耐受性良好的局部类固醇，能够用于常年性鼻炎的研究。
T36234	5(Z),11(Z),14(Z)-Eicosatrienoic Acid
	5(Z),11(Z),14(Z)-Eicosatrienoic acid is a polyunsaturated fatty acid found in various natural sources including maritime pine (Pinus pinaster) seed oil (MPSO), gymnospermae leaves and seeds, and freshwater gastropods. A diet containing MPSO lowered high-density lipoprotein and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to diminish cholesterol efflux in vitro. 5(Z),11(Z),14(Z)-Eicosatrienoic acid methyl ester, when topically applied, reduces inflammatory processes, pot...
T36059	Dichlorphenamide-13C6 Dichlorphenamide-13C6
	Dichlorphenamide-13C6is intended for use as an internal standard for the quantification of dichlorphenamide by GC- or LC-MS. Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively).1It lowers intraocular pressure in rabbits when 50 μl of a 10% solution is applied topically to the eye.2Dichlorphenamide rescues the potassium deficiency and prevents insulin-induc...
T37831	CAY10641
	Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from thesn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process.1CAY10641 is an inactive alcohol derivative of a highly potent (IC50= 12 nM) cPLA2α inhibitor.2The parent compound demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in...
T83744	Tiger17 TFA H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2
	Tiger17是一种环状肽，属于tigerinin-RC1和tigerinin-RC2的衍生物，这两种化合物是在螃蟹吃蛙（F. cancrivora）皮肤分泌物中发现的抗微生物肽。在5至20µg/ml的浓度范围内使用时，Tiger17能增加HaCaT角质形成细胞和人类皮肤成纤维细胞的增殖，并且在20µg/ml的浓度下增加HaCaT细胞的迁移。此外，Tiger17还能增加RAW 264.7巨噬细胞的招募及其TGF-β1和IL-6的分泌。在全层皮肤创伤的小鼠模型中，局部应用20µg/ml的Tiger17能加速伤口闭合和重新上皮化的速度。
T38100	Betamethasone 21-phosphate (sodium salt hydrate)
	Betamethasone 21-phosphate is a synthetic glucocorticoid.1It prevents increases in macrophage and eosinophil numbers in bronchoalveolar lavage fluid (BALF) and decreases in blood leukocyte numbers in a guinea pig model of parainfluenza-3 viral infection when administered at a dose of 8 mg/kg but does not prevent airway hyperresponsiveness after infection.2Betamethasone 21-phosphate inhibits cell infiltration into the aqueous humor in a rat model of endotoxin-induced uveitis when administered top...

化合物

Diflucortolone valerate

Cat.No: T5000

Synonym: Afusona,戊酸双氟可龙,Diflucortolone 21-valerate

Target: Others, Antibacterial, Antifungal

Cat.No: T4050

Synonym: ROR gama modulator 1

Target: ROR

Cat.No: T16802

Synonym: RS4317,氯萘帕林

Target: Others

Fluocinolone (Acetonide)

Cat.No: T0367

Synonym: Fluocinolone acetonide,醋酸肤轻松,Flucort-N

Target: Glucocorticoid Receptor

Cat.No: T0344

Synonym: R18134,咪康唑

Target: Potassium Channel, NOS, Antibacterial, Antibiotic, Antifection, Antifungal

Cat.No: T8777

Synonym: 倍氯米松,BecloMethasone

Target: Glucocorticoid Receptor

Ethacridine lactate monohydrate

Cat.No: T1440

Synonym: 乳酸依沙吖啶一水物,利凡诺

Target: Antibacterial, Antibiotic

Sulfacetamide sodium

Cat.No: T0087L

Synonym: Sulamyd sodium,磺乙酰胺钠盐,磺胺醋酰钠

Target: Antibacterial, Antibiotic, Autophagy

Cat.No: T1536

Synonym: 3-propyl ethyl,舒经劳,17B-methyl estradiol,Promestriano

Target: Estrogen/progestogen Receptor

Flufenamic acid

Cat.No: T0858

Synonym: Arlef,Nichisedan,氟灭酸,氟芬那酸,Achless

Target: Potassium Channel, Calcium Channel, Chloride channel, COX, AMPK, Parasite

Hexylresorcinol

Cat.No: T0314

Synonym: 己雷锁辛,4-己基间苯二酚,4-Hexylresorcinol

Target: Apoptosis, Tyrosinase, Antibacterial, Parasite

Tetracaine hydrochloride

Cat.No: T1198

Synonym: 盐酸丁卡因,Amethocaine hydrochloride,Amethocalne HCl,Tetracaine HCl

Target: Calcium Channel, Sodium Channel

Triamcinolone acetonide

Cat.No: T0820

Synonym: 曲安奈德,Aristogel,Azmacort,Aristoderm

Target: Glucocorticoid Receptor

Algestone acetophenide

Cat.No: T25048

Synonym: Neolutin,苯甲孕酮

Target: Others

Cat.No: T32699

Synonym: Levobunololum,Liquifilm,AK-Beta,Betegan

Cat.No: T33218

Synonym: Mazipredonum,Mazipredona

Cat.No: T13955

Target: Others

Hydrocortamate Hydrochloride

Cat.No: T32113

Synonym: UNII-9QM8U7R83W,Ulcort,Hydrocortamate HCl,Magnacort,Ethamicort

Cat.No: T29693

Synonym: ANCA11,NCE 11,NCE11,NCE-11

Cat.No: T16955

Target: Others

Imiquimod maleate

Cat.No: T22862

Target: Others

Cat.No: T25202

Synonym: Levorinum,NSC 94219,NSC94219,Candizidin,NSC-94219

KAA-276 free base

Cat.No: T70294

Cat.No: T70293

Demecarium Free Base

Cat.No: T70311

Bimatoprost grenod

Cat.No: T36908

Synonym: 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α

Prostaglandin F2α isopropyl ester

Cat.No: T38196

Synonym: Prostaglandin F2α isopropyl ester

Fluocortin butyl ester

Cat.No: T62654

5(Z),11(Z),14(Z)-Eicosatrienoic Acid

Cat.No: T36234

Dichlorphenamide-13C6

Cat.No: T36059

Synonym: Dichlorphenamide-13C6

Cat.No: T37831

Cat.No: T83744

Synonym: H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2

Betamethasone 21-phosphate (sodium salt hydrate)

Cat.No: T38100

Cat. No.	Product Name	Target	Signaling Pathways
TN1049	Ingenol-5,20-acetonide	Others	Others
	Ingenol-5,20-acetonide 是一种天然化合物，Ingenol 3-Angelate 的类似物，当局部用于治疗光化性角化病时具有抗肿瘤活性。
T0281	Meclocycline sulfosalicylate salt 磺基水杨酸甲氯环素,Meclutin,Mecloderm,甲环素磺基水杨酸盐,Meclan Cream	Antibacterial; Antibiotic	Microbiology/Virology
	Meclocycline sulfosalicylate salt (Mecloderm) 是一种具有广谱抗菌活性的四环素抗生素，可预防皮肤细菌感染。
T2952	Camphor 樟脑,(±)-Camphor,Bornan-2-one,2-Camphanone,2-Bornanone,Formosa	Influenza Virus; TRP/TRPV Channel	Membrane transporter/Ion channel; Microbiology/Virology
	Camphor (2-Camphanone) 是一种双环单萜酮，广泛存在于植物中，尤其是樟脑。它是一种激动剂，局部用作皮肤止痒剂和抗感染剂，具有抗病毒，镇咳和抗癌活性。
T0744	10-Undecenoic acid zinc salt Zinc diundec-10-enoate,Zinc 10-undecenoate,Zinc undecylenate,十一烯酸锌	Antibiotic; Antifungal	Microbiology/Virology
	10-Undecenoic acid zinc salt (Zinc undecylenate) 是一种天然的或合成的抗真菌脂肪酸, 在乳膏中可局部用于治疗湿疹、真菌感染、癣和其他皮肤病。锌具有收敛作用。
T0884	1-Docosanol Behenic alcohol,Behenyl alcohol,n-Docosanol,二十二醇,Docosanol	Antifection; HSV	Microbiology/Virology
	1-Docosanol (Behenic alcohol) 是一种具有抗病毒活性的饱和 22 碳脂肪醇，局部用于治疗复发性单纯性唇疱疹发作并缓解相关疼痛并可能有助于更快地治愈疮。
T1437	D-Panthenol D-泛醇,D-Pantothenyl alcohol,Ilopan,Dexpanthenol,Pantothenol	Endogenous Metabolite	Metabolism
	D-Panthenol (D-Pantothenyl alcohol) 是 D-pantothenic acid 和胆碱能剂的酒精类似物。D-Panthenol 作为乙酰化反应所必需的辅酶A的前体，参与乙酰胆碱的合成。虽然 D-Panthenol 作用的确切机制尚不清楚，但它可能增强乙酰胆碱的作用。D-Panthenol 作用于胃肠道，增加下肠蠕动。它也适用于局部皮肤，以缓解瘙痒和促进愈合。

天然产物

Ingenol-5,20-acetonide

Cat.No: TN1049

Target: Others

Meclocycline sulfosalicylate salt

Cat.No: T0281

Synonym: 磺基水杨酸甲氯环素,Meclutin,Mecloderm,甲环素磺基水杨酸盐,Meclan Cream

Target: Antibacterial, Antibiotic

Cat.No: T2952

Synonym: 樟脑,(±)-Camphor,Bornan-2-one,2-Camphanone,2-Bornanone,Formosa

Target: Influenza Virus, TRP/TRPV Channel

10-Undecenoic acid zinc salt

Cat.No: T0744

Synonym: Zinc diundec-10-enoate,Zinc 10-undecenoate,Zinc undecylenate,十一烯酸锌

Target: Antibiotic, Antifungal

Cat.No: T0884

Synonym: Behenic alcohol,Behenyl alcohol,n-Docosanol,二十二醇,Docosanol

Target: Antifection, HSV

Cat.No: T1437

Synonym: D-泛醇,D-Pantothenyl alcohol,Ilopan,Dexpanthenol,Pantothenol

Target: Endogenous Metabolite

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