首页工具

登录

搜索结果

Search Results for " tool compound "

88

抑制剂 & 化合物

4

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T4314	EPZ020411 EPZ020411 2HCl	Histone Methyltransferase	Chromatin/Epigenetic
	EPZ020411是一种特异性有效的 PRMT6 抑制剂， IC50 为 10 nM，比作用于 PRMT1 和 PRMT8 的选择性高10倍多。
T40350	HPK1-IN-4 HPK1-IN-4	MAPK	MAPK
	HPK1-IN-4是一种HPK1（MAPK41）抑制剂，IC 50为0.061 nM。HPK1-IN-4常被作为临床前免疫治疗工具化合物。
T63788	PCLX-001	Others	Others
	PCLX-001 is a small-molecule compound that acts as an orally active inhibitor of N-myristoyltransferase (NMT), specifically targeting NMT1 and NMT2 with IC50 values of 5 nM and 8 nM, respectively. This compound demonstrates anti-tumor effects and effectively inhibits the early signaling of B-cell receptor (BCR). Consequently, PCLX-001 is a valuable tool for researching B-cell malignancies [1] [2].
T22180	3F8 3F 8,3F-8	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	3F8 是一种具有选择性的 GSK-3β抑制剂，可用作 GSK3 相关疾病的新工具和潜在治疗候选化合物，可用于研究神经系统疾病和癌症。
T9314	CC214-1	mTOR; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	CC214-1 是一种 mTOR 抑制剂，具有潜在的抗癌活性，抑制蛋白翻译，可诱导自噬 (autophagy)。 CC214-1 是探索 mTOR 激酶生物学的体外工具化合物，可用于研究骨髓瘤。
T9361	5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione 5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	Others	Others
	5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione (5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) 是一种合成化合物。它已被用作催化剂以及酶动力学研究中的工具；还被用于酶抑制的研究，以及药物受体相互作用的研究。
T64355	TDI-10229	cAMP	GPCR/G Protein
	TDI-10229 是一种口服有效的可溶性腺苷酸环化酶 (sAC, ADCY10) 抑制剂 (IC50 值为 195 nM)。TDI-10229 在生化和细胞分析中都显示出对 sAC 的纳摩尔级抑制，并表现出足以保证其用作体内工具化合物的小鼠药代动力学特性。
T38955	β-Lactamase-IN-4
	β-Lactamase-IN-4 (WO2013149121A1, compound 708) is a potent β-lactamase inhibitor. It serves as a valuable tool in the investigation of bacterial infections.
T30216	AV-105 AV105,AV 105
	Av-105 is the precursor of florbetapir (18F). It is a radiopharmaceutical compound scanned by pet, which can be used as a diagnostic tool for Alzheimer's disease.
T39270	2-NP-AMOZ
	2-NP-AMOZ is a 2-nitrophenyl derivative of AMOZ, which is a metabolite of the antibiotic Furaltadone. This chemical compound specifically serves as a reliable tool for protein bound AMOZ detection.
T61423	Transthyretin-IN-1
	Transthyretin-IN-1 (Compound 1d) is a potent inhibitor of transthyretin (TTR) fibril formation, making it a valuable tool for investigating Alzheimer’s disease [1].
T39729	HIV Protease Substrate 1
	HIV Protease Substrate 1 is a fluorogenic compound that offers insights into the enzymatic activity of HIV protease, making it a valuable tool for studying this aspect.
T38938	Antibacterial agent 37
	Antibacterial agent 37 is an effective antimicrobial compound. It holds potential as a valuable tool for researching bacterial infections.
T61868	Antitumor agent-66
	Antitumor agent-66 (Compound 4) is a derivative of (-)-cleistenolide, showcasing potential as a research tool for cancer diseases [1].
T61592	Thalidomide-piperazine hydrochloride
	Thalidomide-piperazine hydrochloride is a chemical compound with potential applications in the research of leprosy and multiple myeloma. It serves as a valuable tool in developmental biology, facilitating significant discoveries in the biochemical pathways of limb development [1].
T69922	EPZ020411 HCl
	EPZ020411 is a potent and selective PRMT6 inhibitor tool compound. EPZ020411 shows good bioavailability following subcutaneous dosing in rats making it a suitable tool for in vivo studies. EPZ020411 suppresses RCC1 arginine methylation and improves the cytotoxic activity of radiotherapy against GSC brain tumor xenografts.
T18373	N-(Amino-PEG4)-N-Biotin-PEG4-acid	Others	Others
	N-(Amino-PEG4)-N-Biotin-PEG4-acid is a PEG-based PROTAC linker that incorporates biotin for labeling purposes. This compound serves as a versatile tool in the synthesis of PROTACs[1].
T39629	BRD4 ligand-Linker Conjugate 1 BRD4 ligand-Linker Conjugate 1
	BRD4 Ligand-Linker Conjugate 1 is a compound consisting of a ligand and a linker, specifically designed to bind to the target protein BRD4. This conjugate serves as a valuable tool for synthesizing PROTACs, molecules utilized for targeted protein degradation.
T61341	A-908292
	A-908292 is a highly potent and selective inhibitor of acetyl-CoA carboxylase 2 (ACC2), displaying an impressive IC50 of 38 nM. This compound serves as a valuable tool in the investigation of fatty acid metabolism [1].
T61073	KH-259
	KH-259 (compound 1) is a highly potent, selective, and CNS-penetrant HDAC6 inhibitor, demonstrating an IC50 of 0.26 μM. It exerts its antidepressant effects in mice by inhibiting HDAC6 within the brain. Therefore, KH-259 holds promise as a valuable tool for neurodegenerative diseases research [1].
T40452	N-Acetylpsychosine N-Acetylpsychosine,C2 Galactosylceramide (d18:1/2:0)
	N-Acetylpsychosine, also known as α-galactosylated C2-ceramide (d18:1/2:0), exhibits immunostimulatory properties. This compound, N-Acetylpsychosine, holds potential as a valuable tool for studying the mechanisms of apoptosis and immune responses activated by dendritic cells (DCs).
T61502	Antifungal agent 32
	Antifungal agent 32 (compound 1a) is a highly effective antifungal compound. It displays strong inhibitory activity against Candida albicans filamentation and biofilm formation, as well as inhibiting the morphological switching of Candida albicans and its adherence to epithelial cells. This makes Antifungal agent 32 a valuable tool for research on Candida albicans infections [1].
T74959	Antifungal agent 41
	Antifungal agent 41 (compound B01) 是一种抗真菌剂。Antifungal agent 41 在体内外表现出对白假丝酵母菌的抗性。Antifungal agent 41 可以用于侵袭性真菌感染的研究。
T61565	KDM5B-IN-3
	KDM5B-IN-3 (Compound 5) is an inhibitor of histone lysine-specific demethylase 5B (KDM5B) or JARID1B. It effectively inhibits the activity of KDM5B with an IC50 value of 9.32 μM. Consequently, KDM5B-IN-3 serves as a valuable tool in gastric cancer research [1].
T61796	MtTMPK-IN-1
	MtTMPK-IN-1 (compound 3) is a highly effective inhibitor of Mycobacterium tuberculosis thymidylate kinase (Mt TMPK), exhibiting an IC50 value of 2.5 μM. It displays moderate to weak activity against Mtb H37Rv while demonstrating low cytotoxicity in human fibroblast cells MRC-5. MtTMPK-IN-1 is a valuable tool for tuberculosis research [1].
T79131	KAT modulator-1	Histone Acetyltransferase	Chromatin/Epigenetic
	KAT modulator-1 (Compound 3)为一种KAT调节剂, 能够与全长p300进行相互作用，但不影响催化结构域。该化合物主要应用于表观遗传学研究领域。
T39791	Mal-amide-PEG2-oxyamine-Boc Mal-amide-PEG2-oxyamine-Boc
	Mal-amide-PEG2-oxyamineBoc is a polyethylene glycol (PEG)-based linker molecule that possesses a Boc-protected oxyamine functionality. This compound serves as a valuable tool in the efficient synthesis of PROTACs (proteolysis targeting chimeras), offering a versatile and straightforward approach for constructing these targeted protein degradation agents.
T18552	Pomalidomide-amido-C1-Br	Others	Others
	Pomalidomide-amido-C1-Br is a synthesized conjugate consisting of the Pomalidomide-based cereblon ligand and a linker, functioning as an E3 ligase ligand-linker. This compound serves as a tool for designing a B-Raf PROTAC degrader, specifically PROTAC B-Raf degrader 1, which exhibits anti-cancer activity[1].
T17884	cIAP1 Ligand-Linker Conjugates 11 Hydrochloride E3 ligase Ligand-Linker Conjugates 33 Hydrochloride	Others	Others
	cIAP1 Ligand-Linker Conjugates 11 Hydrochloride is a chemical compound consisting of an IAP ligand that targets the E3 ubiquitin ligase, along with a PROTAC linker. It is primarily utilized in the development of SNIPERs, a molecular tool for targeted protein degradation[1].
T61777	Anticancer agent 42
	Anticancer agent 42 (compound 10d) is an orally active, potent anticancer agent with demonstrated efficacy against MDA-MB-231 cells, exhibiting an IC50 of 0.07 μM. It exerts its anticancer activity through the activation of apoptotic pathways and p53 expression. Anticancer agent 42 is a valuable tool for investigating metastatic breast cancer [1].
T39578	TPh A Triphenyl Compound A
	Triphenyl Compound A (TPh A) is an effective inhibitor of nuclear protein pirin, showing specific binding to pirin with a Ki value of 0.6 uM. Its mechanism of action involves disturbing the formation of the bcl3–pirin complex. TPh A serves as a valuable small molecule tool for the regulation of pirin in cellular environments.
T61543	CLK1/4-IN-1
	CLK1/4-IN-1 (compound 31) is a highly potent and selective inhibitor of Clk1 and Clk4, with IC50 values of 9.7 nM and 6.6 nM, respectively. It effectively inhibits the growth of T24 cancer cells, with a GI50 value of 1.1 μM. CLK1/4-IN-1 has shown promising potential as an anticancer research tool [1].
T74339	DNA crosslinker 3 dihydrochloride
	DNA crosslinker 3 (dihydrochloride) (compound 1) 为一种与DNA结合的小沟结合剂，其结合亲和力(ΔTm)达1.4°C，常用于抗癌研究。
T38980	Mg(II) protoporphyrin IX
	Mg(II) protoporphyrin IX is a crucial compound in the synthesis of chlorophyll in Chlorella. It also serves as a negative regulator of nuclear photosynthetic gene expression. Additionally, Mg(II) protoporphyrin IX is employed as a valuable research tool for investigating the signaling molecule involved in plastid-to-nucleus communication.
T61275	TRPM4-IN-2 NBA	TRP/TRPV Channel	Membrane transporter/Ion channel
	TRPM4-IN-2 (NBA), also known as NBA, is a highly effective inhibitor of transient receptor potential melastatin 4 (TRPM4). Its inhibitory potency is represented by an IC 50 value of 0.16 μM. This compound serves as a valuable tool in the investigation of prostate cancer and colorectal cancer [1] [2].
T61573	MtTMPK-IN-5
	MtTMPK-IN-5 (compound 17) is a highly effective inhibitor of M. tuberculosis thymidylate kinase (Mtb TMPK), demonstrating remarkable enzyme inhibitory activity with an IC50 value of 34 μM. Additionally, MtTMPK-IN-5 exhibits notable activity against M. tuberculosis, as evidenced by a minimum inhibitory concentration (MIC) of 12.5 μM. Given its potent properties, MtTMPK-IN-5 serves as a valuable tool for tuberculosis research [1].
T61732	EGFR/HER2-IN-6
	EGFR/HER2-IN-6 (compound 43) is a dual EGFR/HER2 and DHFR inhibitor with potent activity against EGFR kinase, HER2 kinase, and DHFR, characterized by IC50 values of 0.122 μM, 0.078 μM, and 0.585 μM, respectively. This compound displays notable anticancer properties in various cancer cell lines, while demonstrating a favorable safety profile and selectivity indices. Consequently, EGFR/HER2-IN-6 holds promise as a valuable tool in cancer research [1].
T61579	BuChE-IN-5
	BuChE-IN-5 (compound 25b) is a highly potent BuChE inhibitor, displaying an IC50 value of 1.94 μM. It effectively inhibits aggregation of Aβ and tau protein in Escherichia coli. Furthermore, BuChE-IN-5 exhibits considerable free radical scavenging capacity and antioxidant activity. Given these properties, it holds promise as a valuable tool for Alzheimer's disease research [1].
T39074	(Rac)-Zevaquenabant (Rac)-MRI-1867,(Rac)-Zevaquenabant
	(Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a potent and selective antagonist of the cannabinoid receptor type 1 (CB1R) and inducible nitric oxide synthase (iNOS), exhibiting a binding affinity (Ki) of 5.7 nM specifically for CB1R. Due to its characteristics, (Rac)-Zevaquenabant holds promise as an investigative tool in liver fibrosis research.
T61785	BChE-IN-6
	BChE-IN-6 (compound 12) is a highly effective inhibitor of BChE, showcasing a Ki value of 0.182 μM. Notably, BChE-IN-6 exhibits significant chelating abilities towards Zn 2+. Due to these characteristics, BChE-IN-6 serves as a valuable tool for researchers in the field of Alzheimer's disease (AD) [1].
T14593	Biotin-PEG3-Mal	Others	Others
	Biotin-PEG3-Mal is a biotinylated polyethylene glycol (PEG) derivative used as a linker in the synthesis of proteolysis targeting chimeras (PROTACs). By introducing the biotin moiety, it enables specific recognition and binding to target proteins. Additionally, the PEG spacer contributes to improved solubility and flexibility of the linker. This compound offers a valuable tool for constructing PROTACs, which hold great potential in targeted protein degradation strategies[1].
T82801	C12 NBD Galactosylceramide
	C12 NBD galactosylceramide，一种荧光染料，作为半乳糖神经酰胺的生物活性衍生物，具有标记的荧光C12硝基苯并恶二唑（C12 NBD）基团。该化合物主要用于成像研究。
T40131	SGC-CK2-1 SGC-CK2-1
	SGC-CK2-1 is an ATP-competitive chemical compound that acts as a highly potent and cell-active CK2 inhibitor. It demonstrates excellent selectivity towards both isoforms of human CK2, with IC50 values of 36 nM for CK2α and 16 nM for CK2α′ in the nanoBRET assay. Given its properties, SGC-CK2-1 is a suitable tool for the investigation of neurodegenerative diseases.
T79315	PROTAC TG2 degrader-2	PROTACs	PROTAC
	PROTACTG2 degrader-2（compound 7）是一种针对Transglutaminase 2（TG2）的选择性竞争性降解剂，其Kd值大于100 μM。该化合物能有效抑制卵巢癌细胞的迁移，并降低其TG2表达水平，因此可作为卵巢癌研究的工具。
T61739	Dyrk1A-IN-5
	Dyrk1A-IN-5 (compound 5j) is a highly potent and selective inhibitor of DYRK1A, exhibiting an IC50 of 6 nM. It dose-dependently diminishes the phosphorylation of Thr434 in SF3B1, with an IC50 of 0.5 μM. Moreover, Dyrk1A-IN-5 effectively inhibits the phosphorylation of tau at Thr212, with an IC50 of 2.1 μM. Given these properties, Dyrk1A-IN-5 is a valuable tool for Down syndrome research [1].
T39109	ML338 ML338
	ML338 is a selective small molecule inhibitor probe specifically targeting non-replicating Mycobacterium tuberculosis bacilli. It exhibits potent activity against non-replicating M. tuberculosis, with IC90 and IC99 values of 1 μM and 4 μM, respectively, as determined by CFU. This compound, ML338, is an invaluable tool for identifying essential functions and vulnerabilities of M. tuberculosis bacilli under nutrient deprivation conditions. Additionally, ML338 is highly useful for studying M. tuber...
T61601	TLR7/8 antagonist 2
	TLR7/8 antagonist 2 (Compound 15) is a highly potent and orally active agonist of TLR7/8, exhibiting IC50 values of 4.9 and 0.6 nM for TLR7 and TLR8, respectively. Its strong affinity for these receptors makes it a promising candidate for the treatment and investigation of autoimmune diseases, including lupus erythematosus, which is associated with inappropriate activation of TLR7 and TLR8. Consequently, TLR7/8 antagonist 2 represents a valuable tool for research in the field of autoimmune disea...
T39772	BRK inhibitor P21d hydrochloride BRK inhibitor P21d hydrochloride
	BRK inhibitor P21d hydrochloride is a highly potent inhibitor of breast tumor kinase (BRK/PTK6), displaying an IC50 of 30 nM. Additionally, it effectively suppresses p-SAM68 with an IC50 value of 52 nM. This compound, BRK inhibitor P21d hydrochloride, serves as a valuable tool for evaluating the efficacy of BRK inhibitors in xenograft breast tumor models, enabling the assessment of their in vivo activity.
T77967	MS159	PROTACs	PROTAC
	MS159为一有效的NSD2 (核受体结合SET结构域蛋白2) PROTAC降解剂，能够抑制肿瘤细胞生长，是探究NSD2在健康与疾病中作用的重要化学工具。
T24692	QAQ dichloride
	QAQ dichloride is a photoswitchable compound that blocks voltage-gated Na v and K v channels. Its channel-blocking activity is observed in the trans form of the azobenzene photoswitch, while the cis form does not exhibit this effect. This compound is membrane-impermeant and selectively enters pain-sensing neurons expressing endogenous import channels. QAQ dichloride functions as a light-sensitive analgesic and provides a valuable tool for investigating signaling mechanisms involved in acute and ...

化合物

Cat.No: T4314

Synonym: EPZ020411 2HCl

Target: Histone Methyltransferase

Cat.No: T40350

Synonym: HPK1-IN-4

Target: MAPK

Cat.No: T63788

Target: Others

Cat.No: T22180

Synonym: 3F 8,3F-8

Target: GSK-3

Cat.No: T9314

Target: mTOR, Autophagy

5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

Cat.No: T9361

Synonym: 5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Target: Others

Cat.No: T64355

Target: cAMP

β-Lactamase-IN-4

Cat.No: T38955

Cat.No: T30216

Synonym: AV105,AV 105

Cat.No: T39270

Transthyretin-IN-1

Cat.No: T61423

HIV Protease Substrate 1

Cat.No: T39729

Antibacterial agent 37

Cat.No: T38938

Antitumor agent-66

Cat.No: T61868

Thalidomide-piperazine hydrochloride

Cat.No: T61592

Cat.No: T69922

N-(Amino-PEG4)-N-Biotin-PEG4-acid

Cat.No: T18373

Target: Others

BRD4 ligand-Linker Conjugate 1

Cat.No: T39629

Synonym: BRD4 ligand-Linker Conjugate 1

Cat.No: T61341

Cat.No: T61073

N-Acetylpsychosine

Cat.No: T40452

Synonym: N-Acetylpsychosine,C2 Galactosylceramide (d18:1/2:0)

Antifungal agent 32

Cat.No: T61502

Antifungal agent 41

Cat.No: T74959

Cat.No: T61565

Cat.No: T61796

KAT modulator-1

Cat.No: T79131

Target: Histone Acetyltransferase

Mal-amide-PEG2-oxyamine-Boc

Cat.No: T39791

Synonym: Mal-amide-PEG2-oxyamine-Boc

Pomalidomide-amido-C1-Br

Cat.No: T18552

Target: Others

cIAP1 Ligand-Linker Conjugates 11 Hydrochloride

Cat.No: T17884

Synonym: E3 ligase Ligand-Linker Conjugates 33 Hydrochloride

Target: Others

Anticancer agent 42

Cat.No: T61777

Cat.No: T39578

Synonym: Triphenyl Compound A

Cat.No: T61543

DNA crosslinker 3 dihydrochloride

Cat.No: T74339

Mg(II) protoporphyrin IX

Cat.No: T38980

Cat.No: T61275

Synonym: NBA

Target: TRP/TRPV Channel

Cat.No: T61573

Cat.No: T61732

Cat.No: T61579

(Rac)-Zevaquenabant

Cat.No: T39074

Synonym: (Rac)-MRI-1867,(Rac)-Zevaquenabant

Cat.No: T61785

Biotin-PEG3-Mal

Cat.No: T14593

Target: Others

C12 NBD Galactosylceramide

Cat.No: T82801

Cat.No: T40131

Synonym: SGC-CK2-1

PROTAC TG2 degrader-2

Cat.No: T79315

Target: PROTACs

Cat.No: T61739

Cat.No: T39109

Synonym: ML338

TLR7/8 antagonist 2

Cat.No: T61601

BRK inhibitor P21d hydrochloride

Cat.No: T39772

Synonym: BRK inhibitor P21d hydrochloride

Cat.No: T77967

Target: PROTACs

Cat.No: T24692

Cat. No.	Product Name	Target	Signaling Pathways
T39277	D-Hexamannuronic acid
	D-Hexamannuronic acid, an alginate oligomer, is derived from marine brown algae and a restricted group of Gram negative bacteria. This compound serves as a valuable tool for investigating pain and vascular dementia[4].
T40966	D-Heptamannuronic acid
	D-Heptamannuronic acid, an alginate oligomer, is derived from marine brown algae and a select group of Gram-negative bacteria. This compound serves as a valuable research tool in the study of pain and vascular dementia[4].
T38954	L-Glyceric acid sodium
	L-Glyceric acid sodium is a urinary metabolite predominantly found in individuals with the rare inherited metabolic disorder, L-glyceric aciduria. This compound serves as a diagnostic tool for identifying primary hyperoxaluria type 2 (PH2) and can be used to differentiate between PH1 and PH2 based on its excretion pattern.
T73068	Mammea A/BA
	Mammea A/BA 对克氏锥虫 (T. cruzi) 显示出有效抗性。通过诱导线粒体功能障碍、产生活性氧 (ROS)、DNA 片段化以及增加酸性液泡数量，Mammea A/BA 触发细胞死亡机制，包括细胞凋亡 (apoptosis)、细胞自噬 (autophagy) 和细胞坏死，对于南美锥虫病的研究具有潜在应用价值。

天然产物

D-Hexamannuronic acid

Cat.No: T39277

D-Heptamannuronic acid

Cat.No: T40966

L-Glyceric acid sodium

Cat.No: T38954

Cat.No: T73068

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼