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Cat. No. | Product Name | Target | Signaling Pathways |
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T14767 |
BP 897 hydrochloride
|
Dopamine Receptor | GPCR/G Protein; Neuroscience |
BP 897 hydrochloride 是有效的部分多巴胺 D3受体激动剂和弱 D2受体拮抗剂,在多巴胺 D3 受体 (Ki=0.92 nM) 上显示出高亲和力,而在 D2 受体上显示出 70 倍的低亲和力 (Ki=61 nM)。它表现出对可卡因寻求行为的选择性抑制。 | |||
T9100 |
BP 897
2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]- |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
BP 897 (2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-) 是一种有效的部分多巴胺D3受体激动剂和弱D2受体拮抗剂,在多巴胺 D3 受体(Ki=0.92 nM) 上显示出高亲和力,而在 D2 受体上显示出 70 倍的低亲和力 (Ki=61 nM)。它表现出对可卡因寻求行为的选择性抑制。 | |||
T21380 |
Pravadoline
WIN 48098-6,WIN48098-6,普拉朵林,WIN-48098-6 |
Cannabinoid Receptor | GPCR/G Protein |
Pravadoline (WIN48098-6) 是一种 cannabinoid 受体激动剂。 Pravadoline 抑制小鼠大脑中的 PGs 合成,并在受到各种热、化学和机械伤害性刺激的啮齿动物中显示出镇痛活性。 | |||
T29968 |
AMG-0347
UNII-CD7L9290QR |
TRP/TRPV Channel | Membrane transporter/Ion channel |
AMG-0347 (UNII-CD7L9290QR)是一种靶向TRPA1(瞬时受体电位锚蛋白1)离子通道的小分子抑制剂,是一种在感觉神经元中发现的受体,参与疼痛和环境刺激物的检测。AMG-0347通过阻断TRPA1的功能起作用,具有镇痛作用。 | |||
T36310 |
AKT-IN-6
INCB-047775 |
Akt | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
AKT-IN-6 (INCB-047775)对ATK 有抑制作用。Akt 是对生长因子、细胞因子和其他细胞刺激的细胞信号传导的重要组成部分。Akt 的异常激活与2型糖尿病和癌症的发生密切相关。 | |||
T1627 |
Famotidine
MK-208,法莫替丁 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Famotidine (MK-208) 是一种具有抗酸活性的丙脒和组胺 H2 受体拮抗剂。 | |||
T14198 |
ALX-1393
|
GlyT | Neuroscience |
ALX-1393 是一种选择性 GlyT2 抑制剂,通过浓度依赖性的方式有效地降低了神经元动作电位的活性 ,抑制自发网络通过在脊髓腹角诱导甘氨酸能强直电流的活动 。对大鼠急性疼痛模型中的热,机械和化学刺激具有抗伤害作用。 | |||
T35105 |
Way 100252
Way-100252,Way100252 |
||
Way 100252 inhibits evoked [3H]GABA release when tested against a number of release-inducing stimuli. | |||
T35082 |
VU6010608
VU-6010608,VU 6010608 |
||
VU6010608 is an effective mGlu7 NAM with excellent CNS permeability and is powerful in electrophysiological studies in blocking long-term enhancement of high-frequency stimuli. | |||
TP1608 |
PTD-p65-P1 Peptide
|
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PTD-p65-P1 Peptide, a selective inhibitor of the nuclear transcription factor NF-kappaB, consists of a conjugation between a membrane-translocating peptide derived from antennapedia (PTD) and p65-P1. This composition effectively inhibits activation triggered by diverse inflammatory stimuli. | |||
TP1395 |
PTD-p65-P1 Peptide TFA
|
||
Ptd-p65-p1 Peptide TFA is a nuclear transcription factor nf-kappab inhibitor, consisting of a membrane transport Peptide sequence derived from antennapedia linked to p65-p1, selectively inhibiting nf-kappab activity induced by various stimuli. | |||
T26807 |
Bifeprunox Mesylate
Bifeprunox,DU 127090,DU-127090,DU127090 |
||
Bifeprunox is a partial dopamine and serotonin agonist potentially for the treatment of schizophrenia. Bifeprunox suppresses in vivo VTA dopaminergic neuronal activity via D2 and not D3 dopamine autoreceptor activation. Bifeprunox influences nicotine-seek | |||
T70581 | CY208-243 Mandelate | ||
CY208-243 is a D1 agonist. CY208-243 attenuates the pattern electroretinogram to low spatial frequency stimuli in the monkey. CY208-243 stimulates adenylate cyclase in rat striatal homogenates with an EC50 of 125 nM. CY208,243 was superior in improving the strength of neuronal outcome sensitivity to the working memory-related choice behavior in the T-maze. | |||
TP2176 |
amyloid A protein fragment [Homo sapiens]
|
Others | Others |
Amyloid A proteins (H2N-Ala-Gly-Leu-Pro-Glu-Lys-Tyr-OH) are a family of apolipoproteins associated with high-density lipoprotein in plasma. Different isoforms of SAA are expressed constitutively at different levels or in response to inflammatory stimuli. | |||
T67212 |
Ligustrazine HCl
|
||
Ligustrazine Hydrochloride, is a natural substance discovered in the plant Ligusticum chuanxiong Hort. It inhibits platelet aggregation, improves atherosclerosis situation, protects endothelium injury, and has antithrombotic effects.in vivo,ligustrazine hydrochloride at 10 and 20 mg/kg produced significant analgesic effects against mechanical stimuli,and ligustrazine hydrochloride at 80 mg/kg, also significantly alleviated cold hypersensitivity manifested by reduction in cold vocalization temper... | |||
T74779 | JNJ-28583113 | ||
JNJ-28583113 是一种具有脑透性的 TRPM2拮抗剂。JNJ-28583113 抑制 TRPM2 阻断 GSK3α和β亚基的磷酸化。JNJ-28583113 保护细胞免受氧化应激诱导的细胞死亡。JNJ-28583113 还抑制小胶质细胞响应促炎刺激而释放细胞因子。 | |||
T36838 |
(R)-Bromoenol lactone
|
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The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β exce... | |||
T82771 |
CB2-H
|
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CB2-H为一种高特异性双通道荧光探针,专门设计用于HOCl和ONOO-的同时检测。该探针在两个分离的通道中对HOCl和ONOO-无交叉干扰的检测能力使其适用于对活细胞和斑马鱼样本内HOCl及ONOO-的内源性水平进行双通道荧光成像分析,即使在不同生物刺激下也能保持准确性。 | |||
T79556 |
NDBM
|
Autophagy | Autophagy |
NDBM为一种结合Pim-1 kinase的肿瘤特异性探针,具备释放强荧光及细胞毒性,用于筛选及杀伤肿瘤细胞。该化合物特异性地靶向溶酶体并对pH值具有高度敏感性,适用于监测自噬(autophagy)过程及细胞内环境在外部刺激下的pH变化。 | |||
T21750 |
A 784168
|
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A-784168 是一种有效的、口服活性的香草素受体 1 型 (TRPV1) 抑制剂。香草素受体 1 型 (TRPV1) 是一种配体门控非选择性阳离子通道,被认为是各种疼痛刺激 (如内源性脂质、辣椒素、热和低 pH 值) 的重要整合剂。口服给药时,A-784168 具有良好的 CNS 渗透性。 | |||
T83749 |
Tertiapin LQ TFA
TPNLQ |
||
Tertiapin LQ是源自蜜蜂毒素肽tertiapin的肽衍生物,同时也是向内整流钾(Kir)通道的抑制剂。它能够抑制由G蛋白激活的向内整流钾通道1(GIRK1)和GIRK4(即Kir3.1和Kir3.4)组成的异源多聚钾通道,以及向内整流钾通道1(Kir1.1)。在活体内,tertiapin LQ抑制在雪貂中对条件刺激的Purkinje细胞暂停响应。 | |||
T38193 |
β-Endorphin (1-27) (human) (trifluoroacetate salt)
|
||
β-Endorphin (1-27) is an endogenous peptide that binds to μ-, δ-, and κ-opioid receptors (Kis = 5.31, 6.17, and 39.82 nM, respectively, in COS-1 cells expressing rat receptors). It binds to rat and mouse brain membrane preparations (IC50s = 1.1 and 5.7 nM, respectively) and induces chemotaxis of human monocytes in vitro when used at a concentration of 1 nM. Intracerebroventricular administration of β-endorphin (1-27) increases the latency to tail withdrawal in response to thermal stimulation in ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2P2870 |
Damascenone
trans-damascenone,Beta-Damascenone,大马烯酮,大马酮 |
Others; NF-κB; Endogenous Metabolite | Metabolism; NF-κB; Others |
Damascenone (trans-damascenone) 是一种 E-和 Z-异构体大马士革酮的混合物,源于 Epipremnum pinnatum 的具有抗炎特性的特性化合物。 | |||
TN3460 |
Asebogenin
|
Antifungal | Microbiology/Virology |
Asebogenin 是从丹参中分离出来的化合物,具有抗真菌活性,对GPVI 诱导的血小板反应有抑制作用,抑制促炎刺激诱导的 NET 形成。 | |||
TN5131 |
Tetrahydrocannabivarin
THCV,delta9-Tetrahydrocannabivarin,CRM,Tetrahydrocannavarin |
Cannabinoid Receptor | GPCR/G Protein |
Tetrahydrocannabivarin (CRM) 是 cannabinoid type 1 receptor 的中性拮抗剂,对 2 型糖尿病有潜在治疗价值。 | |||
T32614 |
L-Clausenamide
(-)-Clausenamide |
Microtubule Associated | Cytoskeletal Signaling |
L-Clausenamide 是从黄皮 (Clausena lansium (Lour) skeels) 的树叶中提取出来的生物碱,可用于提高认知功能。L-Clausenamide 对β-淀粉样蛋白 (Aβ) 毒性有抑制作用,通过抑制 tau 蛋白磷酸化阻止神经纤维缠结的形成。L-Clausenamide 具有神经保护活性,可用于调节 Aβ25-35 引发的刺激。L-Clausenamide 可用于研究阿尔兹海默症类的神经系统疾病。 | |||
T10109 |
3-Carene
Delta-3-Carene |
COX; Antifungal | Immunology/Inflammation; Microbiology/Virology; Neuroscience |
3-Carene(Delta-3-Carene) 是西部落叶松和花旗松中提取的双环单萜烯,可做为植物杀菌剂。3-Carene 对痛觉刺激引起的炎症浸润和 COX-2 过表达有抑制作用。3-Carene 具有抗伤害作用,能促进成骨细胞分化的早期标志物碱性磷酸酶的活性和表达。 |