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43

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0850	Primaquine diphosphate Primaquine phosphate,磷酸伯氨喹,Primaquine bisphosphate,磷酸伯安喹	Antibiotic; Parasite	Microbiology/Virology
	Primaquine diphosphate 是一种合成的 8-氨基喹啉衍生物，具有抗疟特性。它是一种能破坏间日疟原虫和卵形疟原虫肝脏晚期和潜在组织形态的化合物。
T37072	Nitroxynil 4-Hydroxy-3-iodo-5-nitrobenzonitrile,Trodax,Dovenix	Parasite	Microbiology/Virology
	Nitroxynil (4-Hydroxy-3-iodo-5-nitrobenzonitrile) is an anthelmintic compound that effectively targets parasites in both adult and immature stages. It is extensively employed in investigations pertaining to Fasciola hepatica infection.
T9000	Pyrimorph	Antifungal	Microbiology/Virology
	Pyrimorph 是一种杀真菌剂，对 oomycetes 具有良好抑菌活性。
T3628	Madrasin DDD00107587	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Madrasin (DDD00107587) 是剪接抑制剂，在体外能够阻止剪接中间体和产物的形成，并干扰剪接体组装途径中的一个或多个早期步骤。它能在体外抑制 pre-mRNA 的剪接，并修饰细胞中内源性 pre-mRNA 的剪接。
T3266	Lumefantrine Benflumetol,dl-Benflumelol,苯芴醇	Others; Parasite; Autophagy	Autophagy; Microbiology/Virology; Others
	Lumefantrine (dl-Benflumelol) 是一种抗疟药，用于治疗急性单纯性疟疾。与Artemether 联用，可提高疗效。
T6437	Cefoperazone 头孢哌酮,Cefob,Medocef	Antibacterial; Antibiotic	Microbiology/Virology
	Cefoperazone (Medocef) 是一种半合成的头孢菌素，有抗菌活性。
T64297	Triton X-100
	Triton X-100 是一种溶解脂膜的非变性洗涤剂。Triton X-100 通常用于实验室，并在生产过程的不同阶段应用于疫苗。Triton X-100 被列为某些疫苗,包括裂解病毒流感疫苗的赋形剂。Triton X-100 是一种非离子表面活性剂。
T1228	Cefonicid sodium Monocid sodium,头孢尼西钠,Cefonicid disodium salt	Antibacterial; Antibiotic	Microbiology/Virology
	Cefonicid sodium (Monocid sodium) 是一种广谱头孢类抗生素, 能抑制细菌细胞壁的形成。
T1213	Piperacillin sodium 哌拉西林钠,Sodium piperacillin,CL227193,Piperacillin sodium salt	Antibacterial; Antibiotic	Microbiology/Virology
	Piperacillin sodium salt(CL227193) )是一种β-内酰胺类广谱抗生素。
T1122	Cephalothin sodium 头孢噻吩钠,Cefalotin sodium,Cephalothin,Cefalotin	Antibacterial; Antibiotic	Microbiology/Virology
	Cephalothin sodium (Cefalotin) 是一种头孢类抗生素, 具有广泛的抗菌活性，抑制革兰氏阳性和阴性菌。
T9574	PF-07304814 Lufotrelvir,卢夫特韦
	Lufotrelvir (PF-07304814) 是 PF-00835231 的磷酸盐前药，是一种有效的3CLpro 蛋白酶 (Mpro) 抑制剂，具有抗SARS-CoV-2 病毒活性。Lufotrelvir 结合并抑制 SARS-CoV-2 3CLpro 活性，Ki 为 174nM。Lufotrelvir 是一种很有前途的单一抗病毒试剂，也可用于与针对冠状病毒生命周期其他关键阶段的其他抗病毒试剂的联合研究。
T30214	Austrocortirubin NSC626307,(+)-Austrocortirubin,NSC 626307,NSC-626307
	Austrocortirubin is a DNA damage inducer at the G0/G1, S, and G2 cell cycle stages distinct from other DNA damage agents.
T20730	Cyclanilide RPA 90946,Finish,RPA90946,RPA-90946
	Cyclanilide is a plant growth regulator. It is used in cotton at different stages of growth.
T19256	Cyhalofop Cyhalofop acid,氰氟草酸	Others	Others
	Cyhalofop (Cyhalofop acid) is a recently registered herbicide in the Indian aryloxyphenoxypropionate group, which can control a variety of grass weeds at different growth stages of rice crops.
T25815	Mirincamycin HCl U24,729A,U-24,729A,U-24729 A,U 24729 A,U 24,729A,Mirincamycin hydrochloride
	Mirincamycin HCl is a close analog of the drug clindamycin used for the treatment of Plasmodium falciparum blood stages.
T27400	Ganaplacide KAF 156,KAF-156,GNF-156,GNF 156,GNF156,KAF156
	Ganaplacide is an antimalarials with activity against asexual and sexual blood stages and the preerythrocytic liver stages of malarial parasites. KAF156 showed antimalarial activity without evident safety concerns in a small number of adults with uncompli
T32014	GTC365 GTC 365,NSC 177365,GTC-365,NSC-177365,NSC177365
	GTC365 is an hTERT transcriptional repressor that acts in the early stages of the G-quadruplex folding pathway.
T20960	Luxabendazole HOE 216V
	Luxabendazole is a benzimidazole carbamate broad-spectrum anthelmintic agent. It has proved to be effective against immature and adult stages of the major gastrointestinal nematodes, cestodes, and trematodes.
T40560	Benzyl selenocyanate
	Benzyl selenocyanate is a chemopreventive agent that effectively inhibits chemically induced tumors at both initiation and postinitiation stages in animal models. It acts as a potent inhibitor of DNA (cytosine-5)-methyltransferase (Mtase), with an IC50 of 8.4 μM.
T70507	KAI-407
	KAI407 is a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. KAI407 showed an activity profile similar to that of primaquine (PQ), efficiently killing the earliest stages of the parasites that become either primary hepatic schizonts or hypnozoites (50% inhibitory concentration [IC50] for hypnozoites, KAI407, 0.69 μM, and PQ, 0.84 μM; for developing liver stages, KAI407, 0.64 μM, and PQ, 0.37 μM). KAI407 may represent a new compou...
T82005	JNJ-8003	RSV	Microbiology/Virology
	JNJ-8003 为 RSVPolymerase 高效抑制剂，能在 RNA 转录与复制初期阶段抑制核苷酸的聚合作用。
T37715	Galactosylcerebrosides (bovine)
	Galactosylcerebrosides (SGal-CB) 在髓鞘形成的早期阶段可由周围神经系统 (PNS) 中的 Schwann 细胞 (SC) 表达，在鞘中的持续存在对于长期维持其结构完整性至关重要。
T25258	Clazuril R62690,R 62690,R-62690
	Clazuril 是苯乙腈衍生物。它是一种合成抗球虫药物，用于动物，尤其是家禽，以治疗球虫病。它对艾美耳球虫物种内源阶段具有杀灭作用。
T73546	WM382
	WM382为一种通过口服生效的PMIX/X（双血浆蛋白酶IX/X）抑制剂，其IC50值分别为1.4 nM和0.03 nM。该化合物在疟原虫生命周期多个阶段表现出优异的体内疗效及抗药性。
T21735	NNGH
	NNGH 是基质分解素-1 (MMP-3) 抑制剂。 MMP-3 既是直接转录靶蛋白，也是 Wnt/β-catenin 信号通路的必要组成。基质金属蛋白酶 (MMP) 在肿瘤进展的晚期发挥着明确的作用。
T79460	Antimalarial agent 28	Parasite	Microbiology/Virology
	Antimalarial agent 28 (Compound 2i)为具有针对P. berghei三个发育阶段活性的化合物。该化合物的IC50s针对肝期P. berghei为0.561 μM，对早期配子体为0.14 μM，以及对环期P. berghei为4.34 μM，表明其具有抑制该寄生虫的潜力。
T38895	Zanapezil free base TAK-147 free base,Zanapezil free base
	Zanapezil (TAK-147) is a powerful and selective inhibitor of acetylcholine esterase (AChE). It demonstrates significant and reversible inhibition of AChE activity in rat cerebral cortex homogenates (IC50 = 51.2 nM). Furthermore, Zanapezil exhibits moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. This compound holds promise for the investigation of the initial stages of Alzheimer's disease (AD).
T62004	(Rac)-Nebivolol
	(Rac)-Nebivolol ((Rac)-R 065824) 是 Nebivolol 的外消旋异构体。Nebivolol 是一种选择性的β1 肾上腺素能受体拮抗剂（IC50= 0.8 nM）。Nebivolol 显示血管舒张活性。在乙醇引起心脏毒性的早期阶段，Nebivolol 能预防 Nox2/NADPH 氧化酶上调和脂质过氧化。
T62677	Ganaplacide hydrochloride
	Ganaplacide (KAF156) hydrochloride 是一种首创的、口服具有活力的咪唑哌嗪类抗疟药 (antimalarial)。Ganaplacide hydrochloride 对多种疟原虫（包括耐药寄生虫）有作用。Ganaplacide hydrochloride 对无性和有性血液阶段以及肝脏阶段均具有杀虫效果。
T75067	Antimalarial agent 19	Parasite	Microbiology/Virology
	Antimalarial agent 19（compound 6e）是一种活性抗疟疾化合物，对K1型恶性疟原虫和伯氏疟原虫展现出较强的抑制效果，其EC50值分别为0.3 µM和15.3 µM。相较于γ-肝硫平，该化合物具有更好的水溶性、肠道渗透性以及微粒体稳定性。
T83044	Antimalarial agent 33	Parasite	Microbiology/Virology
	Antimalarial agent 33 (compound 5g) 显示针对红细胞期和肝期疟原虫的抗活性，特别是对 K1 恶性疟原虫株，其EC50为1.1 μM。Antimalarial agent 33 还展示出提升的微粒体稳定性（T1/2=29分钟），并且对原代肝细胞未表现出明显的细胞毒效应。
T22856	IgG light chain variable region [Homo sapiens]/IgM/kappa antibody [Mus musculus]	Others	Others
	IgG has four forms, provides the majority of antibody-based immunity against invading pathogens. The only antibody capable of crossing the placenta to give passive immunity to the fetus. Eliminates pathogens in the early stages of B cell-mediated (humoral
T74425	Nepuvibart
	Nepuvibart (ZRC3308-B10) 是一种靶向 SARS-CoV-2的单克隆抗体 (IgG1 型)。Nepuvibart 对 SARS-CoV-2穗状蛋白的 RBD 上的非竞争性表位显示出良好的结合亲和力。Nepuvibart 可按 1:1 与 ZRC3308-A7 联合使用，对 COVID-19 的预防以及尚未发展为严重疾病的早期 COVID-19 有效。
T9763	MMV666810
	MMV666810 是一种类似于 MMV390048 的2-氨基吡嗪，5.94 nM 的 MMV666810 对无性寄生虫有效。与早期相比，MMV666810 对晚期配子体细胞的选择性是早期的3.3倍（早期配子体:IC50603 ± 88 nM; 晚期配子体:IC50179 ± 8 nM）。
T28937	Tebuquine WR-228,258,WR 228,258,CI 897,CI897,CI-897
	Tebuquine is an antimalarial agent. Tebuquine is active against P. falciparum in vitro. Tebuquine in vitro shows a chloroquine-like effect, but not in vivo, suggesting that its mode of action in vivo is different from that of chloroquine. Tebuquine has no
T74424	Masavibart
	Masavibart (ZRC3308-A7) 是一种靶向SARS-CoV-2的单克隆抗体 (IgG1 型)。Masavibart 对SARS-CoV-2穗状蛋白的RBD 上的非竞争性表位显示出良好的结合亲和力。Masavibart 可按 1:1 与ZRC3308-B10 联合使用，对 COVID-19 的预防以及尚未发展为严重疾病的早期 COVID-19 有效。
T37040	DiIC1(5) DiIC1(5)
	DiIC1(5) is a signal-off fluorescent probe for the detection of mitochondrial membrane potential disruption. It accumulates in mitochondria and its fluorescence intensity decreases when the mitochondrial membrane potential is disrupted. DilC1(5) has been used in combination with a variety of cell damage and cell death markers to classify nine stages of cell death using flow cytometry. It has also been used as a quencher for the detection of serine phosphorylation and tyrosine dephosphorylation p...
T61063	SEN177
	SEN177 在亨廷顿病的研究中显示出潜力。它是谷氨酰胺环化酶 (QPCT) 的有效抑制剂，对谷氨酰胺肽环转移酶 (QPCTL) 的 IC50值为 0.013 μM。SEN177 对人谷氨酰胺环化酶 (hQC) 的 Ki 值为 20 nM。SEN177 显著降低了突变 HTT 寡聚化的早期阶段，并降低了具有 Q80 聚集体的神经元的百分比。
T76845	Sotrovimab
	Sotrovimab (VIR 7831)为一种人源化IgG1κ泛冠状病毒(sarbecvirus)单克隆抗体，能够中和SARS-CoV-2、SARS-CoV-1以及其他多种冠状病毒。该药物基于S309研发，拥有较长半衰期，在呼吸道黏膜中展现出较高的生物利用度。Sotrovimab有助于免疫介导的病毒清除，预防Covid-19早期发展。
T69266	Cefcanel free acid
	Cefcanel is a semisynthetic third-generation cephalosporin with antibacterial activity. Cefcanel is active against the species E. coli, K. aerogenes and Proteus mirabilis; H. influenzae and M. catarrhalis has reasonable susceptibility. Cefcanel inhibits 90% of S. aureus strains at 2 µg/ml, irrespective of the presence of a β-lactamase. Cefcanel binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the te...
T38218	1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC
	1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 是一种在生物膜中的磷脂，在 sn-1 和 sn-2 位置分别含有硬脂酸和二十二碳六烯酸。它已被用于研究脂膜的组织和动力学。在超氧化物歧化酶 1 突变体转基因小鼠肌萎缩性脊髓侧索硬化症（ALS）模型中1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 的水平在疾病晚期会在 L5 前角下降。1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 可用于研究生物膜。
T79567	Antiviral agent 35	Influenza Virus	Microbiology/Virology
	Antiviralagent 35 (compound 4d) 作为一种口服抗流感病毒药物，针对流感病毒复制的早期阶段有效。该化合物能够阻断流感病毒引发的ROS积聚、自噬及细胞凋亡，同时在肺部感染的小鼠模型中，抑制RIG-1通路所介导的炎症响应。Antiviralagent 35展现出低细胞毒性（CC50>800 μM，MDCK细胞）且对H1N1（A/Weiss/43）展现出显著的抗病毒活性，EC50为2.28 μM。
T61572	FNDR-20123 free base
	FNDR-20123 free base 是一种有效、安全、首创的抗疟疾HDAC 抑制剂，对疟原虫和人类 HDAC 的IC50分别为 31 nM 和 3 nM。FNDR-20123 free base 对恶性疟原虫 (Plasmodium falciparum) 无性期 (IC50=41 nM) 和性血期 (雄性配子体 IC50=190 nM) 具有抗疟疾活性。FNDR-20123 free base 抑制 HDAC1，HDAC2，HDAC3，HDAC6，HDAC8 的 IC50分别为 25，29，2，11，282 nM，并在纳摩尔浓度下抑制 III 类 HDAC 亚型。

化合物

Primaquine diphosphate

Cat.No: T0850

Synonym: Primaquine phosphate,磷酸伯氨喹,Primaquine bisphosphate,磷酸伯安喹

Target: Antibiotic, Parasite

Cat.No: T37072

Synonym: 4-Hydroxy-3-iodo-5-nitrobenzonitrile,Trodax,Dovenix

Target: Parasite

Cat.No: T9000

Target: Antifungal

Cat.No: T3628

Synonym: DDD00107587

Target: DNA/RNA Synthesis

Cat.No: T3266

Synonym: Benflumetol,dl-Benflumelol,苯芴醇

Target: Others, Parasite, Autophagy

Cat.No: T6437

Synonym: 头孢哌酮,Cefob,Medocef

Target: Antibacterial, Antibiotic

Cat.No: T64297

Cefonicid sodium

Cat.No: T1228

Synonym: Monocid sodium,头孢尼西钠,Cefonicid disodium salt

Target: Antibacterial, Antibiotic

Piperacillin sodium

Cat.No: T1213

Synonym: 哌拉西林钠,Sodium piperacillin,CL227193,Piperacillin sodium salt

Target: Antibacterial, Antibiotic

Cephalothin sodium

Cat.No: T1122

Synonym: 头孢噻吩钠,Cefalotin sodium,Cephalothin,Cefalotin

Target: Antibacterial, Antibiotic

Cat.No: T9574

Synonym: Lufotrelvir,卢夫特韦

Austrocortirubin

Cat.No: T30214

Synonym: NSC626307,(+)-Austrocortirubin,NSC 626307,NSC-626307

Cat.No: T20730

Synonym: RPA 90946,Finish,RPA90946,RPA-90946

Cat.No: T19256

Synonym: Cyhalofop acid,氰氟草酸

Target: Others

Mirincamycin HCl

Cat.No: T25815

Synonym: U24,729A,U-24,729A,U-24729 A,U 24729 A,U 24,729A,Mirincamycin hydrochloride

Cat.No: T27400

Synonym: KAF 156,KAF-156,GNF-156,GNF 156,GNF156,KAF156

Cat.No: T32014

Synonym: GTC 365,NSC 177365,GTC-365,NSC-177365,NSC177365

Cat.No: T20960

Synonym: HOE 216V

Benzyl selenocyanate

Cat.No: T40560

Cat.No: T70507

Cat.No: T82005

Target: RSV

Galactosylcerebrosides (bovine)

Cat.No: T37715

Cat.No: T25258

Synonym: R62690,R 62690,R-62690

Cat.No: T73546

Cat.No: T21735

Antimalarial agent 28

Cat.No: T79460

Target: Parasite

Zanapezil free base

Cat.No: T38895

Synonym: TAK-147 free base,Zanapezil free base

(Rac)-Nebivolol

Cat.No: T62004

Ganaplacide hydrochloride

Cat.No: T62677

Antimalarial agent 19

Cat.No: T75067

Target: Parasite

Antimalarial agent 33

Cat.No: T83044

Target: Parasite

IgG light chain variable region [Homo sapiens]/IgM/kappa antibody [Mus musculus]

Cat.No: T22856

Target: Others

Cat.No: T74425

Cat.No: T9763

Cat.No: T28937

Synonym: WR-228,258,WR 228,258,CI 897,CI897,CI-897

Cat.No: T74424

Cat.No: T37040

Synonym: DiIC1(5)

Cat.No: T61063

Cat.No: T76845

Cefcanel free acid

Cat.No: T69266

1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC

Cat.No: T38218

Antiviral agent 35

Cat.No: T79567

Target: Influenza Virus

FNDR-20123 free base

Cat.No: T61572

Cat. No.	Product Name	Target	Signaling Pathways
T2P2806	Hederacolchiside A1 黑海常春藤苷A1,革叶常春藤皂苷 A1,Raddeanoside R13	Apoptosis; ERK; MEK; Akt; PI3K; Parasite; mTOR	Apoptosis; Cytoskeletal Signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Hederacolchiside A1 (Raddeanoside R13) 是从白头翁中分离的一种有抗利什曼原虫和抗肿瘤增殖活性的天然产物。
TN3899	Drupacine	Others	Others
	Drupacine and a crude alkaloid extract suppress nematode hatch, activity of mixed life stages, and population numbers on plant roots.
TN4695	Odorine	Others	Others
	Odorine has potent anti-carcinogenic effect by inhibiting both the initiation and promotion stages of two-stage skin carcinogenesis. It was found to inhibit the growth of the vinblastine-resistant KB cells by enhancing the anticancer activity of vinblastine.
TN4696	Odorinol	Antifection	Microbiology/Virology
	Odorine and odorinol inhibit both the initiation and promotion stages of two-stage skin carcinogenesis. (+)-Odorinol exhibits strong antiviral activity against Ranikhet disease virus (RVD) in chick embryo.
T38515	Ascr#7
	Ascr#7, an ascaroside-based hormonal compound, plays a significant role in nematode physiology. It is specifically expressed throughout the various stages of nematode development. Notably, ascarosides exhibit the capability to initiate the formation of dauer larvae, which are characterized by their long lifespan and exceptional stress resistance.
T4415	Katacine	Others	Others
	Katacine 抑制氧气消耗，并抑制电子通过线粒体呼吸链从氧化底物转移到分子氧的速度。 Katacine 是来自蓼科蓼科蓼属的 A 型原花青素聚合物在不同聚合阶段的混合物。 Katacine 是一种抗缺氧药。

天然产物

Hederacolchiside A1

Cat.No: T2P2806

Synonym: 黑海常春藤苷A1,革叶常春藤皂苷 A1,Raddeanoside R13

Target: Apoptosis, ERK, MEK, Akt, PI3K, Parasite, mTOR

Cat.No: TN3899

Target: Others

Cat.No: TN4695

Target: Others

Cat.No: TN4696

Target: Antifection

Cat.No: T38515

Cat.No: T4415

Target: Others

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