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39

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8599	Betazole dihydrochloride 盐酸倍他唑,Betazole hydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Betazole dihydrochloride (Betazole hydrochloride) 是吡唑类组胺，是一种口服活性 H2受体激动剂，能诱导胃酸分泌，导致胆总管压力立即显著升高。它作为一种诊断剂，用于研究胃酸分泌能力。
T2044	Varespladib LY315920,伐瑞拉地,伐瑞拉迪	Phospholipase	Metabolism
	Varespladib (LY315920) 是选择性group IIA, secretory phospholipase A2(sPLA2)抑制剂，其IC50=9 nM。它对大鼠，兔，豚鼠和人等各种物种血清的sPLA2活性具有明显的抑制作用，IC50分别为 8.1 nM，5.0 nM，3.2 nM 和 6.2 nM。
T22665	PD 128042 CI 976	Acyltransferase	Metabolism
	PD 128042 (CI 976) 是口服有效的ACAT (酰基辅酶 A: 胆固醇酰基转移酶)选择性抑制剂。它也是LPAT(溶血磷脂酰基转移酶) 抑制剂。它抑制高尔基体相关 LPAT 活性 (IC50=15 μM)。它抑制多种膜运输步骤，包括在内吞和分泌途径中发现的步骤。
T6928	Pantoprazole SKF96022,泮托拉唑,BY1023	Apoptosis; Proton pump; Autophagy	Apoptosis; Autophagy; Membrane transporter/Ion channel
	Pantoprazole (BY1023) 是一种质子泵抑制剂，用于短期治疗由胃食管反流病引起的食管糜烂和溃疡。它联合阿霉素可显著增加肿瘤生长延迟。它是一种取代的苯并咪唑，是H+/K+-ATPase 抑制剂，可改善 pH 值稳定性，具有抗分泌和抗溃疡的作用。
T0161	Pantoprazole Sodium Hydrate SKF96022 sodium hydrate,泮托拉唑钠水合物,BY1023 (sodium hydrate),SKF96022 (sodium hydrate)	Apoptosis; Potassium Channel; Proton pump; Autophagy	Apoptosis; Autophagy; Membrane transporter/Ion channel
	Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) 是一种具有口服活性的质子泵抑制剂。它是取代的苯并咪唑，是H+/K+-ATPase 抑制剂。它可改善 pH 值稳定性，具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。
T6929	Pantoprazole sodium Pantecta,泮托拉唑钠盐,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),泮托拉唑钠,BY-1023 sodium,Pantoloc	Apoptosis; Others; Proton pump; HIF; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Membrane transporter/Ion channel; Others
	Pantoprazole sodium (Pantecta) 是一种具有口服活性的质子泵抑制剂，是一种取代的苯并咪唑，是H+/K+-ATPase 抑制剂，IC50为 6.8 μM。它可以改善 pH 值稳定性，具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。
T17218	Varespladib methyl A-002,LY333013	Others; Phospholipase	Metabolism; Others
	Varespladib methyl (LY333013) 是 Varespladib 的生物可利用前药，是一种特异性 II 组分泌型磷脂酶 A2 抑制剂。
T4192	hnps-PLA Inhibitor	Phospholipase; LTR	Immunology/Inflammation; Metabolism
	hnps-PLA Inhibitor 是人类非胰腺分泌型磷脂酶 A (hnps-PLA) 的抑制剂。
T2486	IOWH-032 IOWH032,IOWH 032	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	IOWH-032 (IOWH032) 是一种合成 CFTR 抑制剂，可用于研究治疗霍乱、腹泻和分泌性腹泻，在T84和CHO-CFTR 细胞实验中IC50为1.01 uM。
T0594	Diphenmanil methylsulfate Diphemanil mesylate,Diphemanil Methylsulfate,甲硫二苯马尼	AChR	Neuroscience
	Diphenmanil methylsulfate (Diphemanil mesylate) 是一种抗胆碱能季铵盐，可与毒蕈碱乙酰胆碱受体结合，从而减少胃酸、汗液和唾液的分泌。
T16865	SCH28080	ATPase; Proton pump	Membrane transporter/Ion channel
	SCH28080 是一种可逆且具有 K+ 竞争性的胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂，IC50 值为 20 nM (家兔微粒体膜)。SCH28080 在体内是有效的酸分泌抑制剂，具有抗溃疡活性、抗分泌和细胞保护活性。
T1756	Ilaprazole sodium IY-81149 sodium,艾普拉唑钠	Proton pump; TOPK	MAPK; Membrane transporter/Ion channel
	Ilaprazole sodium (IY-81149 sodium) 是一种具有口服活性质子泵抑制剂，以剂量依赖性方式不可逆地抑制 H+/K+-ATPase，在兔壁细胞制剂中的 IC50为 6 μM。它也是一种有效的 T 细胞起源蛋白激酶(TOPK)抑制剂，用于胃溃疡的研究。
T30290	Bam 1745 Bam1745,Pyroglutamyl peptide bam-1745,Bam-1745
	Bam 1745 is a significant adrenomedullary secretory vesicles component.
T29056	UK-9040 UK9040,UK 9040
	UK-9040 inhibits gastric secretory.
T23547	YM 26734	Others	Others
	Competitive inhibitor of secretory phospholipase A2 (sPLA2)
T27539	Hexocyclium metilsulfate AB803,AB-803,Traline,AB 803
	Hexocyclium metilsulfate has anti-gastric secretory effects in humans.
T10008	BTM-1086	Others	Others
	BTM-1086 is a potent gastric secretory inhibitor and an anti-ulcer agent.
T15672	KU14R	Others	Others
	KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.
T20755	Trimegestone RU27987,RU-27987,RU 27987
	Trimegestone, a highly effective oral progestogen, is used for endometrial protection, all doses inducing secretory endometrial transformation.
T29288	163-BP3
	163-bp3 is an effective photoaffinity probe and can be used as a target γ Secretory enzyme.
T68573	Tigapotide triflutate
	Tigapotide triflutate is a synthetic peptide corresponding to amino acids 31-45 of PSP94 (prostate secretory protein) that inhibits matrix metalloproteinase-9 secretion.
T68574	Tigapotide Free Base
	Tigapotide Free Base is a synthetic peptide corresponding to amino acids 31-45 of PSP94 (prostate secretory protein) that inhibits matrix metalloproteinase-9 secretion.
T30831	Cgp 43182 Cgp-43182,Cgp43182
	CGP 43182 is an effective inhibitor of group IIA secretory phospholipase A2 (Group IIA sPLA2) activity in vitro, which can be used to prevent the synergistic effect of pro-inflammatory genes stimulated by cytokines mediated by NFkappaB.
T37309	Diadenosine pentaphosphate pentaammonium
	Diadenosine pentaphosphate pentaammonium, an endogenous vasoactive purine dinucleotide isolated from thrombocytes, is one component of the diadenosine polyphosphates (ApnA, n=2-7) family. These compounds are found in secretory vesicles, including those in platelets, chromaffin cells, Torpedo synaptic terminals, and brain synaptosomes[1][2].
T76538	Pancreatic polypeptide
	Pancreatic polypeptide 是由胰腺内分泌的 PP 细胞所分泌的多肽，具有调节胰腺分泌功能、影响肝糖原储存及胃肠分泌的作用。
T41088	Diadenosine pentaphosphate pentalithium
	Diadenosine pentaphosphate pentalithium is an endogenous vasoactive purine dinucleotide, isolated from thrombocytes. It is a member of the diadenosine polyphosphates (ApnA, n=2–7) and is found in secretory vesicles of platelets, chromaffin cells, Torpedo synaptic terminals, and brain synaptosomes.
T39173	Varespladib sodium LY315920 sodium,伐瑞拉迪钠；伐瑞拉地钠
	Varespladib sodium (LY315920 sodium) is a highly potent and selective inhibitor of group IIA secretory phospholipase A2 (sPLA2), with an IC50 of 9 nM. It demonstrates significant inhibitory activity against sPLA2 in serum samples from multiple species, including rat, rabbit, guinea pig, and human, with IC50 values of 8.1 nM, 5.0 nM, 3.2 nM, and 6.2 nM, respectively.
T28331	PD 136450 Cam1189,PD136450,Cam-1189,PD-136450,Cam 1189
	Cholecystokinin type B receptor antagonist PD-136,450 is a partial secretory agonist in the stomach and a full agonist in the pancreas of the rat. Gastrin (cholecystokinin type B (CCK-B)) receptor antagonists may help to elucidate the physiological role o
T37310	Diadenosine pentaphosphate pentasodium
	Diadenosine pentaphosphate pentasodium, an endogenous vasoactive purine dinucleotide isolated from thrombocytes, serves as a key component of secretory vesicles in platelets, chromaffin cells, Torpedo synaptic terminals, and brain synaptosomes. This compound, along with other diadenosine polyphosphates (ApnA, n=2-7), plays a crucial role in physiological processes[1][2].
T81183	Sec61-IN-5
	Sec61-IN-5 (Compound 16c)是一种Sec61抑制剂，在A549细胞中展现出细胞毒性（IC50: 0.27 nM），并且能够抑制Sec61依赖性分泌功能（IC50: 0.08 nM）。
T76480	Amylin (1-37) (human)
	Amylin (1-37) (human) (hIAPP (1-37)) 为胰岛β细胞分泌颗粒中的肽类激素，其C端经酰胺化处理，第2和第7个半胱氨酸残基间形成二硫键。
T61265	Exo2
	Exo2 is a secretion inhibitor that hinders the trafficking of Shiga toxin from endosomes to the trans-Golgi network. It inhibits the exit of secretory cargo from the endoplasmic reticulum (ER) and disrupts the Golgi apparatus. Notably, Exo2 does not impact the morphology of the trans-Golgi network (TGN). Additionally, Exo2 has the ability to induce calcium-dependent exocytosis in permeabilized adrenal chromaffin cells [1] [2].
T72005	Betazole Ametazole
	Betazole (Ametazole) 为一种吡唑类组胺，具有口服活性，作为H2受体激动剂发挥作用。该化合物能诱导胃酸分泌并立即显著提高胆总管压力。Betazole 作为一种称为histalog的诊断剂，应用于评估胃酸分泌功能。
T76320	FIZZ-1 (32-51) (mouse)
	FIZZ-1 (32-51) (mouse) 是一种富含半胱氨酸的分泌性蛋白，主要在过敏性气道炎症中被巨噬细胞、支气管上皮细胞及II型肺泡上皮细胞高度表达，具有对肺成纤维细胞的抗凋亡功能，广泛应用于过敏性肺炎的研究领域。
T74891	Apratoxin S4
	Apratoxin S4（Apra S4）是一种Sec61抑制剂，能够有效阻止分泌蛋白的共翻译转运进入内质网(ER)。它对flaviviruses类病毒显示出抗病毒效果，IC50值在0.46 nM至170 nM不等。此外，Apratoxin S4通过抑制多条血管生成通路，能够抑制视网膜血管细胞活化，适用于病毒感染、血管生成相关疾病和癌症的研究。
T37331	Pyrrophenone
	The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid (AA) from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins (PGs) and leukotrienes (LTs). Pyrrophenone inhibits cPLA2α with an IC50 of 4.2 nM in enzyme assays and potently blocks the release of AA and the production of PGE2 and LTC4 in cells (IC50 = 24, 25, and 14 nM, respectively). Its action is reversible and selective, as py...
T38052	CRA-2059 TFA
	CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2]. Tryptase is a trypsin-like serine protease found as a major protein component in human mast cell secretory granules. CRA-2059 has the potential for inflammatory bowel disease research[1]. [1]. Tremaine WJ, et al. Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study. Aliment Pharmacol Ther. 2002;16...
T38051	CRA-2059 hydrochloride
	CRA-2059 hydrochloride is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2]. Tryptase is a trypsin-like serine protease found as a major protein component in human mast cell secretory granules. CRA-2059 hydrochloride has the potential for inflammatory bowel disease research[1]. [1]. Tremaine WJ, et al. Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study. Ali...
T38286	C26 Sphingomyelin (d18:1/26:0) C26 Sphingomyelin (d18:1/26:0)
	C26 Sphingomyelin is a sphingolipid that has been found in serum and cell or brain extracts.1,2,3C26 sphingomyelin levels are increased in the serum of patients with hemophagocytic lymphohistiocytosis, an inflammatory condition characterized by excessive immune activation.3C26 sphingomyelin has been used a component of monolayers to study the influence of sphingomyelin acyl chain length on sphingomyelin-sterol interactions.4[Matreya, LLC.] 1.Wang, J.-R., Zhang, H., Yau, L.D., et al.Improved sphi...

化合物

Betazole dihydrochloride

Cat.No: T8599

Synonym: 盐酸倍他唑,Betazole hydrochloride

Target: Histamine Receptor

Cat.No: T2044

Synonym: LY315920,伐瑞拉地,伐瑞拉迪

Target: Phospholipase

Cat.No: T22665

Synonym: CI 976

Target: Acyltransferase

Cat.No: T6928

Synonym: SKF96022,泮托拉唑,BY1023

Target: Apoptosis, Proton pump, Autophagy

Pantoprazole Sodium Hydrate

Cat.No: T0161

Synonym: SKF96022 sodium hydrate,泮托拉唑钠水合物,BY1023 (sodium hydrate),SKF96022 (sodium hydrate)

Target: Apoptosis, Potassium Channel, Proton pump, Autophagy

Pantoprazole sodium

Cat.No: T6929

Synonym: Pantecta,泮托拉唑钠盐,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),泮托拉唑钠,BY-1023 sodium,Pantoloc

Target: Apoptosis, Others, Proton pump, HIF, Autophagy

Varespladib methyl

Cat.No: T17218

Synonym: A-002,LY333013

Target: Others, Phospholipase

hnps-PLA Inhibitor

Cat.No: T4192

Target: Phospholipase, LTR

Cat.No: T2486

Synonym: IOWH032,IOWH 032

Target: CFTR, Autophagy

Diphenmanil methylsulfate

Cat.No: T0594

Synonym: Diphemanil mesylate,Diphemanil Methylsulfate,甲硫二苯马尼

Target: AChR

Cat.No: T16865

Target: ATPase, Proton pump

Ilaprazole sodium

Cat.No: T1756

Synonym: IY-81149 sodium,艾普拉唑钠

Target: Proton pump, TOPK

Cat.No: T30290

Synonym: Bam1745,Pyroglutamyl peptide bam-1745,Bam-1745

Cat.No: T29056

Synonym: UK9040,UK 9040

Cat.No: T23547

Target: Others

Hexocyclium metilsulfate

Cat.No: T27539

Synonym: AB803,AB-803,Traline,AB 803

Cat.No: T10008

Target: Others

Cat.No: T15672

Target: Others

Cat.No: T20755

Synonym: RU27987,RU-27987,RU 27987

Cat.No: T29288

Tigapotide triflutate

Cat.No: T68573

Tigapotide Free Base

Cat.No: T68574

Cat.No: T30831

Synonym: Cgp-43182,Cgp43182

Diadenosine pentaphosphate pentaammonium

Cat.No: T37309

Pancreatic polypeptide

Cat.No: T76538

Diadenosine pentaphosphate pentalithium

Cat.No: T41088

Varespladib sodium

Cat.No: T39173

Synonym: LY315920 sodium,伐瑞拉迪钠；伐瑞拉地钠

Cat.No: T28331

Synonym: Cam1189,PD136450,Cam-1189,PD-136450,Cam 1189

Diadenosine pentaphosphate pentasodium

Cat.No: T37310

Cat.No: T81183

Amylin (1-37) (human)

Cat.No: T76480

Cat.No: T61265

Cat.No: T72005

Synonym: Ametazole

FIZZ-1 (32-51) (mouse)

Cat.No: T76320

Cat.No: T74891

Cat.No: T37331

Cat.No: T38052

CRA-2059 hydrochloride

Cat.No: T38051

C26 Sphingomyelin (d18:1/26:0)

Cat.No: T38286

Synonym: C26 Sphingomyelin (d18:1/26:0)

Cat. No.	Product Name	Target	Signaling Pathways
T13206	Tris(2,4-di-tert-butylphenyl)phosphate	Phospholipase	Metabolism
	Tris(2,4-di-tert-butylphenyl)phosphate 是一种从 Vitex negundoL 中分离的活性化合物，能够通过分子对接抑制了分泌性磷脂酶 A2(sPLA2)，具有抗炎作用。
TN1419	Rhamnetin beta-Rhamnocitrin,鼠李素	Others; Phospholipase	Metabolism; Others
	Rhamnetin (beta-Rhamnocitrin) 是一种槲皮素衍生物，在芫荽中被发现，具有抗氧化和抗炎活性。Rhamnetin 可抑制分泌型磷脂酶 A2。
TCS1772	Dehydroabietic acid Dehydroabietate,脱氢松香酸	Antifection	Microbiology/Virology
	Dehydroabietic acid (Dehydroabietate) 是 EBV-EA 活化抑制剂。它是食物衍生化合物，可通过降低血浆葡萄糖、胰岛素水平、血浆甘油三酯 (TG) 和肝 TG 水平来治疗肥胖相关疾病。它的衍生物在动物模型中表现出抗分泌和抗胃蛋白酶作用。
TN5221	(-)-Variabilin
	Variabilin, a novel inhibitor of human platelet aggregation, it is a potent RGD (Arg-Gly-Asp)-containing antagonist of the fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa; αIIbβ3) and the vitronectin receptor αvβ3.Variabilin is also an antimicrobial furanosesterterpene. Variabilin is an inhibitor of human secretory and cytosolic phospholipase A2 (PLA2) activities that controls eicosanoid production in vitro and in vivo, inhibits neutrophil degranulation and superoxide generation in vitro a...
TN4659	Nimbin	COX	Immunology/Inflammation; Neuroscience
	Nimbin is an anti-pyretic, can be used to treat arthritis, hypoglycaemia, peptic ulcers, anti-secretory activity, and it can also be used as an antibiotic. Nimbin requires to elicit a 50% inhibition of this steroid hydroxylase activity in the three insect
T75540	Ipomoeassin F
	Ipomoeassin F 是一种高效且具有选择性的内质网(ER)蛋白转位抑制剂，它通过作用于ER膜上的Sec61复合物（Sec61α）的成孔亚基来实现其功能。此化合物能特异性抑制SARS-CoV-2蛋白在ER膜上的转位，同时阻碍分泌蛋白和I型跨膜蛋白（TMP）的ER转运，但对III型TMP的转运不产生影响。

天然产物

Tris(2,4-di-tert-butylphenyl)phosphate

Cat.No: T13206

Target: Phospholipase

Cat.No: TN1419

Synonym: beta-Rhamnocitrin,鼠李素

Target: Others, Phospholipase

Dehydroabietic acid

Cat.No: TCS1772

Synonym: Dehydroabietate,脱氢松香酸

Target: Antifection

Cat.No: TN5221

Cat.No: TN4659

Target: COX

Cat.No: T75540

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