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Search Results for " retinoic acid receptor "

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抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3955	AR7	Retinoid Receptor	Metabolism
	AR7 是一种非典型的 RARA/RARα(视黄酸受体 α) 拮抗剂，能够特异性激活伴侣介导的自噬活性，对自噬无影响。
T16832	S18-000003	ROR	Metabolism
	S18-000003 是口服有活性的维甲酸相关孤儿受体 (RORγt) 选择性抑制剂，在竞争性结合试验中，对 hRORγt 的 IC50值小于 30 nM。它对 RORγt 的选择性比其他 ROR 家族成员 (IC50>10 μM)更高。它可用于银屑病的研究，胸腺畸变风险较低。
T7894	Tazarotenic acid 6-[2-(3,4-二氢-4,4-二甲基-2H-1-苯并噻喃-6-基)乙炔基]-3-吡啶甲酸,AGN-190299	Others	Others
	Tazarotenic acid (AGN-190299) 是 Tazarotene 的代谢物。它与视黄酸受体 (RAR) 的结合位点是类视黄醇作用的可能的分子靶点。它对疣状角化不良具有潜在的研究价值。
T15811	LY2955303	Others; Retinoid Receptor	Metabolism; Others
	LY2955303 是一种有效的特异性视黄酸受体 γ 拮抗剂（RARγ，Ki = 1.09 nM）。
T4538	palovarotene Ro 3300074,R 667,帕罗伐汀	Retinoid Receptor; Autophagy	Autophagy; Metabolism
	Palovarotene (Ro 3300074) 是核视网膜酸受体γ 的激动剂。
T4371	CD437 AHPN,O-Desmethyl Adapalene,6-[3-(1-金刚烷基)-4-羟基苯基]-2-萘甲酸,Apoptosis Activator VI	Retinoid Receptor; Autophagy	Autophagy; Metabolism
	CD437 (AHPN) 是一种特异性视黄酸受体激动剂。
T16425	PA452	Retinoid Receptor; RAR/RXR	Metabolism
	PA452 是视黄酸 X 受体 (RXR) 的选择性拮抗剂，可抑制视黄酸对 Th1/Th2 发育的影响。
T14689	BMS493 BMS-493	Phospholipase; Retinoid Receptor	Metabolism
	BMS493 是泛维甲酸受体（RAR）的逆激动剂，可抑制维甲酸诱导的分化，增强核共抑制因子与 RARs 的相互作用，减弱 RA 信号传导，增强了 TPP 诱导的毒性，抑制磷脂酶 A2 活性的增加。
T5854	AM580 NSC608001,CD336,Ro 40-6055	Retinoid Receptor; Autophagy	Autophagy; Metabolism
	AM580 (CD336) 是一种视黄酸受体激动剂，对 RARα 具有选择性，IC50和EC50分别为 8 和 0.36 nM。
T22767	ER 50891	Retinoid Receptor	Metabolism
	ER-50891是一种强效的视黄酸受体α（RARα）拮抗剂。ER-50891能减少全价视黄酸的抑制作用并恢复骨形态生成蛋白2诱导的成骨细胞分化。
T22049	BMS 753	Retinoid Receptor	Metabolism
	BMS 753是亚型选择性的视黄酸受体α（RARα，Ki=2nM）的激动剂。
T4594	SR1078 SR 1078	ROR	Metabolism
	SR1078 是视黄酸受体相关孤儿受体 (RORα/RORγ) 激动剂。它能够与 RORα 和 RORγ 的配体结合区直接结合，增强该受体的转录活性，促使 RORα/γ 靶基因的转录。
T4050	GSK2981278 ROR gama modulator 1	ROR	Metabolism
	GSK2981278 (ROR gama modulator 1) 是 RORγ的选择性反向激动剂。它能够抑制 il17启动子的激活，并且干扰 RORγ-DNA 结合。
T61588	AGN 192870	Apoptosis; Retinoid Receptor	Apoptosis; Metabolism
	AGN 192870 是一种有效的维甲酸受体（RAR）拮抗剂，，对 RARα、RARβ 和 RARγ 亲和力很高。AGN 192870 可用于研究细胞生长停滞，分化和凋亡。
T78575	KCL-286	Retinoid Receptor	Metabolism
	KCL-286是一种可口服且具有有效性的视黄酸受体β激动剂，可用于改善脊髓损伤(SCI)。
T14911	CD2665	Retinoid Receptor	Metabolism
	CD2665 是一种具有口服活性的视黄酸受体 (RAR) 拮抗剂。对于 RARγ 和 RARβ，Kis 为 110 nM 和 306 nM。
T5341	WYC-209 WYC209	Apoptosis; Retinoid Receptor; Autophagy	Apoptosis; Autophagy; Metabolism
	WYC-209 是一种合成类视黄醇，是维甲酸受体激动剂。它主要通过 caspase 3途径抑制恶性鼠黑色素瘤肿瘤再生细胞的增殖，IC50值为 0.19 μM。
T12516	Polyinosinic-polycytidylic acid sodium 双链聚肌胞,Poly(I:C) sodium	Apoptosis; Others; TLR	Apoptosis; Immunology/Inflammation; Others
	Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) 是双链 RNA 的合成类似物，是TLR3和视黄酸诱导型基因 I 受体激动剂。它可以用作疫苗佐剂，直接触发癌细胞发生凋亡，还增强先天性和适应性免疫反应，并改变肿瘤的微环境。
T37587	ML 209	ROR	Metabolism
	ML-209 是一种视黄酸相关的孤儿受体 RORγ 拮抗剂 (IC50= 1.1 μM)。ML-209 抑制 HEK293t 细胞中 RORγt 转录活性(IC50= 300 nM)。ML-209 不抑制细胞中 RORα。ML-209 对鼠 Th17 细胞分化具有选择性抑制，而不影响幼稚 CD4+ T 细胞分化为 Th1 和调节性 T 细胞。
T26053	Re 80 Re80,Re-80
	Re 80 is a retinoic acid receptor (RAR) agonist.
T26846	BMS270394 BMS 189961,BMS-270394,BMS 270394
	BMS270394 is an agonist of nuclear retinoic acid receptor (RAR-γ).
T10246	Adapalene sodium salt CD 271 sodium salt,阿达帕林钠	Others	Others
	Adapalene (CD 271; Differin) sodium salt is a synthetic retinoid and a Retinoic acid receptor agonist.
T22611	BMS 961	Others	Others
	BMS961 is a potent and selective retinoic acid receptor gamma (RARγ) agonist (IC50: 30 nM).
T67921	Retinoic acid-d5 all-trans-Retinoic acid-d5,Isotretinoin-d5,Vitamin A acid-d5,Accutane-d5,ATRA-d5	Retinoid Receptor	Metabolism
	Retinoic acid-d5 (Vitamin A acid-d5)是视黄酸的氘标记形式。视黄酸是一种天然的RAR 核受体激动剂，对 RARα/β/γ 的 IC50 为 14 nM，与 PPARβ/δ 结合的Kd 为 17 nM。视黄酸是维生素a 的代谢物，在细胞生长、分化和器官发育中起着重要作用。视黄酸通过激活视黄酸受体α作为转录因子Nrf2的抑制剂来发挥作用。
T70031	ER-38925
	ER-38925 is a retinoic acid receptor (rar) subtype α-selective agonist
T12750	ROR agonist-1	Others	Others
	ROR agonist-1 is a potent and orally bioavailable the retinoic acid receptor-related orphan receptor C2 (RORC2) inverse agonist(inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5).
T70976	AGN-190121
	AGN-190121 is a retinoic acid receptor (RAR) agonist. RAR and Retinoid X Receptor (RXR) ligands can act synergistically to induce hypertriglyceridemia through distinct mechanisms of action.
T13067	TAK-828F	ROR	Metabolism
	TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC50=6.1 nM).
T39720	RORγt inverse agonist 23
	RORγt inverse agonist 23, an orally available novel retinoic acid receptor-related orphan receptor γt inverse agonist, is a potent and selective RORγt inverse agonist.
T79772	RARα antagonist 1
	RARα拮抗剂1（化合物21）为一种选择性且具口服活性的retinoic acid receptor α (RARα)拮抗剂，其IC50值为4.6 nM。
T16495	PF-06747711	Others	Others
	PF-06747711 is an effective and selective retinoic acid receptor-related orphan C2 inverse agonist (IC50: 4.1 nM). PF-06747711 also has anti-skin inflammatory activity.
T62242	Retezorogant
	Retezorogant 是一种维甲酸受体相关孤儿受体γ（RORγ）拮抗剂。
T70647	CD2019
	CD2019 is a retinoic acid receptor beta (rarbeta) agonist, overcoming inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord.
T11308	FM26	ROR	Metabolism
	FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26 is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM.
T78102	ER 50891 quarterhydrate
	ER 50891 quarterhydrate为效效的视黄酸受体α(RARα)拮抗剂，可显著削弱ATRA对BMP 2诱导成骨细胞生成的抑制效果。
T37414	CAY10771
	CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 μM, respectively) and is selective for these receptors over retinoic acid receptor α (RARα), retinoid X receptor α (RXRα), PPARα, PPARγ, and liver X receptor α (LXRα) at 10 μM. 1.Schierle, S., Neumann, S., Heitel, P., et al.Design and structural optimization of dual FXR/PPARδ activatorsJ. Med. Ch...
T79470	RORγt inverse agonist 31	ROR	Metabolism
	RORγt inverse agonist 31 (14g) 为一有效RORγt反向激动剂，具备0.428 μM的IC50值。该化合物能够缓解Imiquimod诱发的小鼠牛皮癣症状。
T71933	GNE-3500
	GNE-3500 is a Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C (RORc or RORγ) Inverse Agonist. Retinoic acid receptor-related orphan receptor C (RORc, RORγ, or NR1F3) is a nuclear receptor that plays a major role in the production of interleukin (IL)-17. Considerable efforts have been directed toward the discovery of selective RORc inverse agonists as potential treatments of inflammatory diseases such as psoriasis and rheumatoid arthritis. GNE-3500 poss...
T40043	RORγt Inverse agonist 10
	RORγt Inverse agonist 10 is a highly potent and orally bioavailable compound that acts as an antagonist for the retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt). With an IC50 of 51 nM, it effectively inhibits the activity of RORγt, a prominent transcription factor involved in the regulation of genes associated with the pathogenesis of psoriasis, including IL-17A, IL-22, and IL-23R.
T69055	PD153035 nitrate
	PD153035 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also...
T74052	Polyinosinic-polycytidylic acid potassium
	Polyinosinic-polycytidylic acid potassium (Poly(I:C) potassium) 是双链 RNA 的合成类似物，是一种TLR3和视黄酸诱导型基因 I 受体 (RIG-I 和MDA5) 的激动剂。Polyinosinic-polycytidylic acid potassium 可以用作疫苗佐剂，以增强先天性和适应性免疫反应，并改变肿瘤的微环境，还可以直接触发癌细胞发生凋亡 (Apoptosis)。
T69671	SR1903 TFA
	SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor γ (PPAR) but does not activate it. SR-1903 inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1). It also inhibits LPS-induced expression of the LXR target genes IL-6 and IL-33 and increases expression of ABCG1, FASN, and SCD-1. SR-190...
T36998	7β,27-dihydroxy Cholesterol 7β,27-DHC,7β,27-dihydroxy Cholesterol
	7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 &#181M. It increases IL-17A production in Th17-polarized isolated hum...
T35638	SR 1903
	SR 1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR).1 It is an inverse agonist of RORγ (IC50 = ~100 nM in a cell-based reporter assay) and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor γ (PPARγ; IC50 = 209 nM) but does not activate it. SR 1903 (10 μM) inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1) in RAW 264.7 cells. It also inhibits LPS-induced expression of th...

化合物

Cat.No: T3955

Target: Retinoid Receptor

Cat.No: T16832

Target: ROR

Tazarotenic acid

Cat.No: T7894

Synonym: 6-[2-(3,4-二氢-4,4-二甲基-2H-1-苯并噻喃-6-基)乙炔基]-3-吡啶甲酸,AGN-190299

Target: Others

Cat.No: T15811

Target: Others, Retinoid Receptor

Cat.No: T4538

Synonym: Ro 3300074,R 667,帕罗伐汀

Target: Retinoid Receptor, Autophagy

Cat.No: T4371

Synonym: AHPN,O-Desmethyl Adapalene,6-[3-(1-金刚烷基)-4-羟基苯基]-2-萘甲酸,Apoptosis Activator VI

Target: Retinoid Receptor, Autophagy

Cat.No: T16425

Target: Retinoid Receptor, RAR/RXR

Cat.No: T14689

Synonym: BMS-493

Target: Phospholipase, Retinoid Receptor

Cat.No: T5854

Synonym: NSC608001,CD336,Ro 40-6055

Target: Retinoid Receptor, Autophagy

Cat.No: T22767

Target: Retinoid Receptor

Cat.No: T22049

Target: Retinoid Receptor

Cat.No: T4594

Synonym: SR 1078

Target: ROR

Cat.No: T4050

Synonym: ROR gama modulator 1

Target: ROR

Cat.No: T61588

Target: Apoptosis, Retinoid Receptor

Cat.No: T78575

Target: Retinoid Receptor

Cat.No: T14911

Target: Retinoid Receptor

Cat.No: T5341

Synonym: WYC209

Target: Apoptosis, Retinoid Receptor, Autophagy

Polyinosinic-polycytidylic acid sodium

Cat.No: T12516

Synonym: 双链聚肌胞,Poly(I:C) sodium

Target: Apoptosis, Others, TLR

Cat.No: T37587

Target: ROR

Cat.No: T26053

Synonym: Re80,Re-80

Cat.No: T26846

Synonym: BMS 189961,BMS-270394,BMS 270394

Adapalene sodium salt

Cat.No: T10246

Synonym: CD 271 sodium salt,阿达帕林钠

Target: Others

Cat.No: T22611

Target: Others

Retinoic acid-d5

Cat.No: T67921

Synonym: all-trans-Retinoic acid-d5,Isotretinoin-d5,Vitamin A acid-d5,Accutane-d5,ATRA-d5

Target: Retinoid Receptor

Cat.No: T70031

Cat.No: T12750

Target: Others

Cat.No: T70976

Cat.No: T13067

Target: ROR

RORγt inverse agonist 23

Cat.No: T39720

RARα antagonist 1

Cat.No: T79772

Cat.No: T16495

Target: Others

Cat.No: T62242

Cat.No: T70647

Cat.No: T11308

Target: ROR

ER 50891 quarterhydrate

Cat.No: T78102

Cat.No: T37414

RORγt inverse agonist 31

Cat.No: T79470

Target: ROR

Cat.No: T71933

RORγt Inverse agonist 10

Cat.No: T40043

PD153035 nitrate

Cat.No: T69055

Polyinosinic-polycytidylic acid potassium

Cat.No: T74052

Cat.No: T69671

7β,27-dihydroxy Cholesterol

Cat.No: T36998

Synonym: 7β,27-DHC,7β,27-dihydroxy Cholesterol

Cat.No: T35638

Cat. No.	Product Name	Target	Signaling Pathways
T1051	Retinoic acid 维生素A酸,Vitamin A acid,ATRA,all-trans-Retinoic acid,Tretinoin	Retinoid Receptor; Endogenous Metabolite; PPAR; Autophagy	Autophagy; DNA Damage/DNA Repair; Metabolism
	Retinoic acid (Tretinoin) 是维生素 A 的代谢产物，是一种视黄酸受体 RAR 的天然激动剂，抑制 RARα/β/γ (IC50=14 nM)。Retinoic acid 可以诱导细胞分化、减少细胞增殖和抑制肿瘤发生。

天然产物

Retinoic acid

Cat.No: T1051

Synonym: 维生素A酸,Vitamin A acid,ATRA,all-trans-Retinoic acid,Tretinoin

Target: Retinoid Receptor, Endogenous Metabolite, PPAR, Autophagy

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