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Search Results for " pro-inflammatory cytokine "

23

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T16111	ML604086	CCR	Immunology/Inflammation; Microbiology/Virology
	ML604086 是选择性CCR8抑制剂，抑制循环T 细胞上 CCL1 与 CCR8 结合，还抑制 CCL1 介导的趋化性并提高细胞内 Ca2 浓度。
T15784	LP99	Epigenetic Reader Domain	Chromatin/Epigenetic
	LP99 是一种表观遗传探针，可破坏 BRD7 和 BRD9 与细胞中染色质的结合。它是一种选择性的 BRD7 和 BRD9 溴结构域抑制剂，对 BRD9 的 Kd 为 99 nM。
T24154	I942 I 942,I-942	cAMP	GPCR/G Protein
	I942 是一种新型且具有选择性的非环核苷酸 (NCN) EPAC1 激动剂，可激活交换蛋白调节人脐血管中的炎症基因表达，可抑制与心血管疾病相关的促炎细胞因子信号传导。
T70277	Cynandione A	Others	Others
	Cynandione A 是从 Cynanchum wilfordii 中提取的苯乙酮，具有抗炎活性，可通过巨噬细胞 α7 nAChR 激活和随后的 IL-10 表达来显着减少促炎细胞因子的过表达。
T77484	Atibuclimab	TNF	Apoptosis
	Atibuclimab 是一种靶向 CD14 的嵌合单克隆抗体，由小鼠可变区和人类 IgG4 Fc 区构成。Atibuclimab 可用于治疗肌萎缩侧索硬化症。Atibuclimab 可减少 LPS 诱导的病症，并对 LPS 诱导的促炎细胞因子释放有抑制作用，可延迟抗炎细胞因子可溶性 TNF 受体 I 型的释放，
T79365	TIM-3-IN-2	Immunology/Inflammation related	Immunology/Inflammation
	TIM-3-IN-2 是 Tim3 抑制剂，可以抑制TIM-3与PtdSer、CEACAM1和Gal-9的结合，抑制TIM-3发挥作用。TIM-3-IN-2能够逆转TIM-3介导的促炎细胞因子的作用。
T11473	GSK-5498A	Others	Others
	GSK-5498A is a selective blocker of CARC (IC50, 1 μM). It inhibits mediator release from mast cells, and pro-inflammatory cytokine release from T-cells in a variety of species.
T69453	APC-0576
	APC-0576 is an (S,S)-isomer which inhibits NF-kappaB-dependent gene activation. APC-0576 may prevent pro-inflammatory cytokine-induced chemokine production in human endothelial cells.
TP1537	TNF-α (10-36), human
	TNF-α (10-36), human is a potent pro-inflammatory cytokine involved in the acute phase stress response.
T11357	Gamma-glutamylcysteine TFA γ-glutamylcysteine (TFA),Gamma-glutamylcysteine (TFA)	IL Receptor	Immunology/Inflammation
	Gamma-glutamylcysteine (TFA) also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes. Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA)), an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx).
T78754	COX-2-IN-33	COX	Immunology/Inflammation; Neuroscience
	COX-2-IN-33（化合物5f）作为一种COX-2抑制剂（IC50=45.5 nM），同样具备潜在抗炎作用。该化合物能抑制促炎细胞因子的生成，同时确保胃部安全。
T62674	LSD1-IN-21
	LSD1-IN-21 是一种有效的、具有血脑屏障通透性的 LSD1 (赖氨酸特异性去甲基化酶-1) 抑制剂 (IC50: 0.956 μM)。LSD1-IN-21 能够明显减少促炎细胞因子 TNF-α，表现出良好的抗癌和抗炎效果。
T80954	TREM-1 inhibitory peptide M3
	TREM-1 inhibitory peptide M3为一种配体依赖的TREM-1拮抗剂。该化合物能够有效抑制全身及肺部促炎细胞因子与趋化因子的产生，有助于缓解急性肺损伤。
T78923	DDO-8926	Epigenetic Reader Domain	Chromatin/Epigenetic
	DDO-8926 是一种高效的选择性BET抑制剂，其通过抑制促炎细胞因子表达和降低神经兴奋性，显著减缓机械性超敏反应，被应用于神经性疼痛的研究领域。
T78762	SIKs-IN-1
	SIKs-IN-1（compound 8h）为一种嘧啶-5-羧酰胺衍生物，并充当盐诱导激酶（SIKs）的抑制剂。该化合物通过抑制SIK活性，上调IL-10抗炎细胞因子，下调IL-12促炎细胞因子，调控M1/M2巨噬细胞的极化，并在DSS诱导的结肠炎模型中展现出明显的抗炎效果。
T37633	17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
	17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).
T79447	IRAK4-IN-25	IRAK	Immunology/Inflammation; NF-κB
	IRAK4-IN-25（化合物38）是口服活性IRAK4抑制剂，具有低清除率（Cl=12 mL/min/kg）和IC50值为7.3 nM。它能抑制促炎细胞因子产生，表现出良好的体外安全性和ADME特性。IRAK4-IN-25主要用于研究炎症和自身免疫性疾病。
T37634	17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
	Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils. 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DPA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).
T74779	JNJ-28583113
	JNJ-28583113 是一种具有脑透性的 TRPM2拮抗剂。JNJ-28583113 抑制 TRPM2 阻断 GSK3α和β亚基的磷酸化。JNJ-28583113 保护细胞免受氧化应激诱导的细胞死亡。JNJ-28583113 还抑制小胶质细胞响应促炎刺激而释放细胞因子。
T35593	Semapimod tetrahydrochloride CPSI-2364 tetrahydrochloride	TLR; MAPK	Immunology/Inflammation; MAPK
	Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) 是一种合成鸟腙丝裂原活化蛋白激酶阻滞剂,也是促炎细胞因子生成抑制剂，干扰巨噬细胞和小胶质细胞功能。Semapimod tetrahydrochloride 可抑制 TLR4 信号传导，抑制 TNF-α、IL-1β 和 IL-6，可用于研究克罗恩病和其他炎症。
T78803	SIRT5 inhibitor 7	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	SIRT5 inhibitor7 (compound 58) 是一种底物竞争性且选择性的SIRT5抑制剂，展现出抗炎活性。它在调节蛋白质琥珀酰化和抑制促炎细胞因子释放方面具有潜在的肾功能保护效果。此外，在LPS和CLP诱导的脓毒症相关急性肾损伤小鼠模型中，SIRT5 inhibitor7已证实具备体内有效性。
T81360	PSMα3 TFA
	PSMα3 TFA 作为一种肽类化合物，主要用于诱导生成耐受性的树突细胞（DC），以应用于DC疫苗接种。该化合物能对TLR2和TLR4诱导的DC成熟过程进行调节，抑制促炎和消炎细胞因子的产生，降低抗原摄取，并影响人单核细胞来源DC的渗透和调节能力。此外，PSMα3 TFA 是耐甲氧西林金黄色葡萄球菌（MRSA）中最有毒株释放的关键毒素之一。
T36401	DCVC
	DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.Target: TNF-αin vitro: DCVC inhibits pathogen stimulated cytokine release from tissue punch cultures. DCVC (5-50 μM) significantly inhibits LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4 h (P ≤ 0.05). In contrast, TCA (up to 500 μM) does not inhibit LTA-stimulated cytokine release from tissue punches. DCVC effects on LTA-stimulated and LPS-stimulated TNF-α release from tissue p...

化合物

Cat.No: T16111

Target: CCR

Cat.No: T15784

Target: Epigenetic Reader Domain

Cat.No: T24154

Synonym: I 942,I-942

Target: cAMP

Cat.No: T70277

Target: Others

Cat.No: T77484

Target: TNF

Cat.No: T79365

Target: Immunology/Inflammation related

Cat.No: T11473

Target: Others

Cat.No: T69453

TNF-α (10-36), human

Cat.No: TP1537

Gamma-glutamylcysteine TFA

Cat.No: T11357

Synonym: γ-glutamylcysteine (TFA),Gamma-glutamylcysteine (TFA)

Target: IL Receptor

Cat.No: T78754

Target: COX

Cat.No: T62674

TREM-1 inhibitory peptide M3

Cat.No: T80954

Cat.No: T78923

Target: Epigenetic Reader Domain

Cat.No: T78762

17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid

Cat.No: T37633

Cat.No: T79447

Target: IRAK

17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid

Cat.No: T37634

Cat.No: T74779

Semapimod tetrahydrochloride

Cat.No: T35593

Synonym: CPSI-2364 tetrahydrochloride

Target: TLR, MAPK

SIRT5 inhibitor 7

Cat.No: T78803

Target: Sirtuin

Cat.No: T81360

Cat.No: T36401

Cat. No.	Product Name	Target	Signaling Pathways
TN1131	Handelin	NF-κB; Immunology/Inflammation related	Immunology/Inflammation; NF-κB
	Handelin 是一种来自 Chrysanthemum boreale 的愈创木酚内酯二聚体，它能够阻碍 NF-κB 活化和促炎细胞因子产生，具有抗炎作用。
TN1475	Caulophyllogenin Segetalic acid	IL Receptor; TNF; PPAR; Immunology/Inflammation related	Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism
	Caulophyllogenin 是一种部分 PPARγ 激动剂 (EC50 = 12.6 μM)，来源于 Kalopanax pictus (五加科) 的茎皮。 Caulophyllogenin 抑制促炎细胞因子分泌，可用于预防和治疗炎症性疾病、2 型糖尿病、肥胖和代谢综合征的研究。
T4S1943	Kirenol 奇壬醇,奇任醇,Kirel	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Kirenol (Kirel) 是分离自 Siegesbeckia orientalis 中的，具有抗氧化、抗炎、抗过敏、抗关节炎活性，可用于缓解疼痛的研究。
T4S2063	Tetrahydrocoptisine 人血草碱,STYLOPINE	ERK; p38 MAPK; NF-κB	MAPK; NF-κB
	Tetrahydrocoptisine (STYLOPINE) 具有抑制炎症的有效作用。它通过抑制 NF-κB 信号通路对 LPS 诱导的 ALI 具有保护作用，这可能涉及抑制肺部炎症过程。它具有胃保护活性，归因于减少 NO 产生和调节促炎细胞因子，抑制中性粒细胞积累和 NF-κB 表达。它是一种活性抗炎成分，通过下调 NF-κB 活化、磷酸化 ERK1/2 和磷酸化-p38MAPK 信号通路抑制 TNF-α、IL-6 和 NO 的产生。
T0798	Triamcinolone Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone	Glucocorticoid Receptor; COX	Endocrinology/Hormones; Immunology/Inflammation; Neuroscience
	Triamcinolone (Aristocort) 是一种皮质类固醇激素受体激动剂，也是一种合成的长效糖皮质激素，具有抗炎活性。
TN2327	Zedoarondiol 蓬莪二醇	NOS; NF-κB; COX	Immunology/Inflammation; Neuroscience; NF-κB
	Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPKs, and by subsequently inactivating the NF-kappaB pathway.
T27282	Erucin AR 1G3839,AR-1G3839,CCRIS-9056,CCRIS9056,AR1G3839,CCRIS 9056
	Erucin is a sulforaphane analog found in cruciferous vegtables. Erucin is a telomerase inhibitor. It induces phase II enzyme activity, suppresses cellular proliferation in hepatocellular carcinoma cells, prevents 6-OHDA-induced neurodegenration, and inhib

天然产物

Cat.No: TN1131

Target: NF-κB, Immunology/Inflammation related

Caulophyllogenin

Cat.No: TN1475

Synonym: Segetalic acid

Target: IL Receptor, TNF, PPAR, Immunology/Inflammation related

Cat.No: T4S1943

Synonym: 奇壬醇,奇任醇,Kirel

Target: Wnt/beta-catenin

Tetrahydrocoptisine

Cat.No: T4S2063

Synonym: 人血草碱,STYLOPINE

Target: ERK, p38 MAPK, NF-κB

Cat.No: T0798

Synonym: Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone

Target: Glucocorticoid Receptor, COX

Cat.No: TN2327

Synonym: 蓬莪二醇

Target: NOS, NF-κB, COX

Cat.No: T27282

Synonym: AR 1G3839,AR-1G3839,CCRIS-9056,CCRIS9056,AR1G3839,CCRIS 9056

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