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28

抑制剂 & 化合物

47

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T14523	Beauvericin	Others; Acyltransferase	Metabolism; Others
	Beauvericin 是一种镰刀菌霉菌毒素。Beauvericin 在大鼠肝微粒体酶实验中对酰基-CoA：胆固醇酰基转移酶（ACAT）有抑制作用，其 IC50 值为 3 μM。
T124797	Ochratoxin B	Endogenous Metabolite	Metabolism
	Ochratoxin B 由多种曲霉和青霉菌产生的，是霉菌毒素 Ochratoxin A 的类似物，会对农产品造成污染。
T26164	Rubratoxin A
	Rubratoxin A is a classical mycotoxin used as a PP2A-specific inhibitor.
T71798	Demethoxyviridiol
	Demethoxyviridiol is a mycotoxin that inhibits phosphatidylinositol 3-kinase (PI3K).
T33468	Monoacetoxyscirpenol 4-Acetoxyscirpenol
	Monoacetoxyscirpenol is a mycotoxin produced by Fusarium roseum Gibbosum.
T32259	Janthitrem C
	Janthitrem c is a type of naphthopyran. Janthitrem C is obtained form Penicillium janthinellum. Tremorgenic mycotoxin.
T26165	Rubratoxin B
	Rubratoxin B is a mycotoxin that causes hypoglycemia and fatty liver and has exhibited anticancer activity.
T71774	Territrem B
	Territrem B is a mycotoxin that irreversibly inhibits acetylcholinesterase (AChE). It is toxic to mice, inducing tremors with a median tremulous dose of 0.21 mg/kg.
T34535	Satratoxin G Satratoxin-G
	Satratoxin G is a trichothecene mycotoxin of Stachybotrys chartarum and has been shown to selectively induces apoptosis in olfactory sensory neurons (OSNs) of the nose and brain.
T36852	Phalloidin-AMCA Conjugate
	Phalloidin-AMCA conjugate is a blue fluorophore that specifically labels filamentous actin (F-actin). It consists of aminomethylcoumarin (AMCA; ex/em max = 350/450 nm) conjugated with phalloidin , a mycotoxin that binds F-actin. Phalloidin-AMCA conjugate is used in fixed and permeabilized tissue sections, cell cultures, or cell-free experiments.
T35515	3-Acetyldeoxy Nivalenol-13C17 3-Acetyldeoxy Nivalenol-13C17
	3-Acetyldeoxy nivalenol-13C17is intended for use as an internal standard for the quantification of 3-acetyldeoxy nivalenol by GC- or LC-MS. 3-Acetyldeoxy nivalenol is a mycotoxin that has been found inF. graminearum.1In vivo, 3-acetyldeoxy nivalenol (40 mg/kg) induces duodenal and splenic cell necrosis, as well as lethality (LD50= 70 mg/kg) in mice.2 1.Jiao, F., Kawakami, A., and Nakajima, T.Effects of different carbon sources on trichothecene production and Tri gene expression by Fusarium grami...
T35521	Aflatoxin G2-13C17 Aflatoxin G2-13C17
	Aflatoxin G2-13C17is intended for use as an internal standard for the quantification of aflatoxin G2by GC- or LC-MS. Aflatoxin G2is a mycotoxin that has been found inAspergillus.1It is lethal to ducklings (LD50= 2.83 mg/kg) but is non-toxic to rats when administered at a dose of 200 mg/kg.2 1.Bennett, J.W., and Klich, M.MycotoxinsClin. Microbiol. Rev.16(3)497-516(2003) 2.Wogan, G.N., Edwards, G.S., and Newberne, P.M.Structure-activity relationships in toxicity and carcinogenicity of aflatoxins a...
T35776	Janthitrem A
	Janthitrem A is a mycotoxin that has been found inP. janthinellum.1It induces tremors in mice and decreases the time to fall from the rotarod when administered at a dose of 4 mg/kg.2Janthitrem A (20 μg/g) also reducesW. cervinatalarvae weight gain and food consumption. 1.Gallagher, R.T., Latch, G.C., and Keogh, R.G.The janthitrems: Fluorescent tremorgenic toxins produced by Penicillium janthinellum isolates from ryegrass pasturesAppl. Environ. Microbiol.39(1)272-273(1980) 2.Babu, J.V., Popay, A....
T35520	Aflatoxin G1-13C17 Aflatoxin G1-13C17
	Aflatoxin G1-13C17is intended for use as an internal standard for the quantification of aflatoxin G1by GC- or LC-MS. Aflatoxin G1is a mycotoxin that has been found inA. terricola.1In vivo, aflatoxin G1is lethal to ducklings (LD50= 1.18 mg/kg).2It induces hepatocellular carcinoma tumor formation and lethality in rats when administered at doses of 1.4 and 3 mg/animal, respectively. Aflatoxin G1also inhibits liver and kidney succinate dehydrogenase and fumarase, as well as kidney cytochrome oxidase...
T35907	Paraherquamide A
	Paraherquamide A is a mycotoxin anthelmintic originally isolated from P. paraherquei. It binds to acetylcholine receptors (IC50 = 0.5 nM for head homogenates of M. domestica) and acts as an antagonist. Paraherquamide A is toxic to C. elegans (LD50 = 2.5 μg/ml) and effective against T. colubriformis infection in gerbils when used at doses ranging from 0.39 to 200 mg/kg. It is toxic to mice (LD50 = 14.9 mg/kg).
T35513	13C15-Nivalenol 13C15-Nivalenol
	13C15-Nivalenol is intended for use as an internal standard for the quantification of nivalenol by GC- or LC-MS. Nivalenol is a trichothecene mycotoxin that has been found inFusarium.1It is lethal to mice (LD50= 6.9 mg/kg).2Nivalenol (5, 10, and 15 mg/kg) also induces thymic, splenic, and Peyer's patch cell apoptosis in mice.3 1.Yang, Z., Concannon, J., Ng, K.S., et al.Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulationSci. Rep.63026...
T37006	Previridicatumtoxin
	Previridicatumtoxin is a fungal metabolite that has been found inP. aethiopicumand has diverse biological activities.1,2It is an intermediate in the biosynthesis of the mycotoxin viridicatumtoxin . Previridicatumtoxin is active against methicillin-resistantS. aureus(MRSA) and vancomycin-resistantE. faecalis(IC50s = 4.4 and 4.8 μM, respectively), as well asC. albicansandS. cerevisiae(MIC = 32 μg/ml for both).2,1It is cytotoxic to NCI H460, KB-3-1, and SW620 cancer cells (IC50s = 5.3, 4.1, and 6 μ...
T35775	HT-2 Toxin-13C22 HT-2 Toxin-13C22
	HT-2 toxin-13C22is intended for use as an internal standard for the quantification of HT-2 toxin by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin .1,2Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.2HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50values ranging from 3.1 to 23 ng/ml and human...
T35773	Gliotoxin-13C13 Gliotoxin-13C13
	Gliotoxin-13C13is intended for use as an internal standard for the quantification of gliotoxin by GC- or LC-MS. Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains ofAspergillusand other fungi with diverse biological activities.1,2,3,4,5,6,7,8It inhibits 20S proteasomal chymotrypsin activity (IC50= 10 μM), blocking the degradation of IκBα and preventing the activation of NF-κB.2,3Gliotoxin induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutr...
T35519	Aflatoxin B2-13C17 Aflatoxin B2-13C17
	Aflatoxin B2-13C17(AFB2-13C17) is intended for use as an internal standard for the quantification of AFB2by GC- or LC-MS. AFB2is a mycotoxin that has been found inA. terricola.1It induces hepatic autophagy and apoptosis in broiler chickens when administered at doses of 0.2, 0.4, and 0.8 mg/kg.2AFB2(0.5 and 1 mg/animal) also induces parenchymal cell hyperplasia in rats.3 1.Moubasher, A.H., el-Kady, I.A., and Shoriet, A.Toxigenic Aspergilli isolated from different sources in EgyptAnn. Nutr. Alimen...
T75141	Aflatoxin Q1
	Aflatoxin Q1是Aflatoxin B1 (AFB1)的羟基化代谢产物，后者由黄曲霉 (A. flavus) 产生的一种霉菌毒素。在人肝微粒体中，不论底物浓度高低，Aflatoxin B1的8,9-氧化物及Aflatoxin Q1均为其主要氧化产物。将Aflatoxin B1 3α-羟基化生成Aflatoxin Q1被视为一条重要的解毒途径。
T35771	Destruxin B2
	Destruxin B2 is a cyclic hexadepsipeptide mycotoxin that has been found in M. anisopliae and has antiviral, insecticidal, and phytotoxic activities.1,2,3 It inhibits secretion of hepatitis B virus surface antigen (HBsAg) by Hep3B cells expressing hepatitis B virus (HBV) DNA (IC50 = 1.3 μM).1 Destruxin B2 is toxic to Sf9 insect cells in an electric cell-substrate impedance sensing (ECIS) test with a 50% inhibitory concentration (ECIS50) value of 92 μM.4 It is also phytotoxic to B. napus leaves.3 ...
T35783	Zearalenone-13C18 Zearalenone-13C18
	Zearalenone-13C18is intended for use as an internal standard for the quantification of zearalenone by GC- or LC-MS. Zearalenone is a mycotoxin that has been found inFusariumand has estrogenic activities.1It binds to human estrogen receptor α (ERα) and ERβ (IC50s = 9 and 5.8 nM, respectively).2Zearalenone induces precocious development of mammary tissues in young female pigs and prepucial enlargement in young male pigs.3Zearalenone (1.5-5 mg/kg of diet) induces hyperestrogenism in pigs. It also i...
T35772	Emestrin
	Emestrin is a mycotoxin originally isolated from E. striata that has antimicrobial, immunomodulatory, and cytotoxic activities.1,2,3,4,5 It is active against the fungi C. albicans and C. neoformans, as well as the bacteria E. coli, S. aureus, and methicillin-resistant S. aureus (MRSA; IC50s = 3.94, 0.6, 2.21, 4.55, and 2.21 μg/ml, respectively).2 Emestrin is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50 = 5.4 μM in a radioligand binding assay using isolated human monocytes).3 Emestr...
T35778	Ochratoxin A-13C20 Ochratoxin A-13C20
	Ochratoxin A-13C20is intended for use as an internal standard for the quantification of ochratoxin A by GC- or LC-MS. Ochratoxin A is a mycotoxin that has been found inAspergillusandPenicillium.1It increases lipid peroxide levels and the number of apoptotic cells, as well as reduces superoxide dismutase activity in rat kidney when administered at a dose of 120 μg/kg.2Topical application of ochratoxin A (80 μg/mouse) induces DNA damage, cell cycle arrest at the G0/G1phase, and apoptosis in mouse ...
T35437	(-)-Viriditoxin
	(-)-Viriditoxin is a mycotoxin originally isolated from A. viridinutans that has antibacterial and antiproliferative activity. It is active against methicillin-sensitive and -resistant S. aureus (MSSA and MRSA, respectively), tetracycline-sensitive and -resistant Staphylococcus, vancomycin-sensitive and -resistant Enterococcus, and penicillin-sensitive and -resistant S. pneumoniae (MICs = 2-32 μg/ml). (-)-Viriditoxin is also active against fish pathogens, including S. iniae and S. parauberis (MI...
T41240	Verrucarin A
	Verrucarin A (Muconomycin A) 是一种 D 型大环真菌毒素。Verrucarin A 是一种蛋白质合成 (protein synthesis) 的抑制剂，来源于Myrothecium verrucaria，可抑制白血病细胞系生长，并激活巨噬细胞 caspases、凋亡和炎症信号。Verrucarin A 能有效提高 p38 MAPK 的磷酸化，降低 ERK/Akt 的磷酸化。Verrucarin A 通过 p21 和 p53 的诱导引起细胞周期调控的解除。
T35517	4-deoxy Nivalenol-13C15 4-deoxy Nivalenol-13C15
	4-deoxy Nivalenol-13C15is intended for use as an internal standard for the quantification of 4-deoxy nivalenol by GC- or LC-MS. 4-deoxy Nivalenol is a trichothecene mycotoxin that has been found inFusarium.1It binds to eukaryotic ribosomes and inhibits protein synthesis in mice when administered at doses ranging from 5 to 25 mg/kg. 4-deoxy Nivalenol (0.1 and 0.2 mg/kg) induces emesis in pigs and decreases feed consumption in pigs when administered at a dose of 40 ppb in the diet.2It induces leth...

化合物

Cat.No: T14523

Target: Others, Acyltransferase

Cat.No: T124797

Target: Endogenous Metabolite

Cat.No: T26164

Demethoxyviridiol

Cat.No: T71798

Monoacetoxyscirpenol

Cat.No: T33468

Synonym: 4-Acetoxyscirpenol

Cat.No: T32259

Cat.No: T26165

Cat.No: T71774

Cat.No: T34535

Synonym: Satratoxin-G

Phalloidin-AMCA Conjugate

Cat.No: T36852

3-Acetyldeoxy Nivalenol-13C17

Cat.No: T35515

Synonym: 3-Acetyldeoxy Nivalenol-13C17

Aflatoxin G2-13C17

Cat.No: T35521

Synonym: Aflatoxin G2-13C17

Cat.No: T35776

Aflatoxin G1-13C17

Cat.No: T35520

Synonym: Aflatoxin G1-13C17

Paraherquamide A

Cat.No: T35907

13C15-Nivalenol

Cat.No: T35513

Synonym: 13C15-Nivalenol

Previridicatumtoxin

Cat.No: T37006

HT-2 Toxin-13C22

Cat.No: T35775

Synonym: HT-2 Toxin-13C22

Gliotoxin-13C13

Cat.No: T35773

Synonym: Gliotoxin-13C13

Aflatoxin B2-13C17

Cat.No: T35519

Synonym: Aflatoxin B2-13C17

Cat.No: T75141

Cat.No: T35771

Zearalenone-13C18

Cat.No: T35783

Synonym: Zearalenone-13C18

Cat.No: T35772

Ochratoxin A-13C20

Cat.No: T35778

Synonym: Ochratoxin A-13C20

(-)-Viriditoxin

Cat.No: T35437

Cat.No: T41240

4-deoxy Nivalenol-13C15

Cat.No: T35517

Synonym: 4-deoxy Nivalenol-13C15

Cat. No.	Product Name	Target	Signaling Pathways
T5625	Zearalenone 玉米,Mycotoxin F2,玉米烯酮,RAL,F2 toxin,Toxin F2	Others	Others
	Zearalenone (F2 toxin) 是真菌毒素，主要由食物和饲料中的 Fusarium 产生。它会引起幼龄母猪乳房发育早熟或其它雌激素效应。它在猪、牛、羊体内具有雌激素活性，急性毒性低。
T13053	T-2 Toxin T-2 Mycotoxin	Others	Others
	T- 2 Toxin is a toxic trichothecene mycotoxin produced by various Fusarium species in feedstuffs and cereal grains,( LD50 are 5.2 and 1.5 mg/kg BWa in mice and rats,respectively ).
T3208	Brevianamide F Cyclo-L-tryptophyl-L-proline,cyclo-(L-Trp-L-Pro),Cyclo(L-Pro-L-Trp)	BCRP; PI3K; Antibacterial	Membrane transporter/Ion channel; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Brevianamide F (Cyclo(L-Pro-L-Trp)) 是一种从Colletotrichum gloeosporioides 中分离得到的真菌毒素，属于天然存在的 2,5-二酮哌嗪类，具有抗菌活性。它具有PI3Kα抑制活性，IC50值为 4.8 µM。
T7097	Cytochalasin B Phomin,细胞松弛素 B,细胞松弛素B	Arp2/3 Complex	Cytoskeletal Signaling
	Cytochalasin B is a mycotoxin binding to the barbed end of actin filaments. It can disrupt the formation of actin polymers (Kd: 1.4-2.2 nM for F-actin).
T13815	Penicillic acid	Apoptosis; Caspase; Antibacterial; Antibiotic	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Penicillic acid, a polyketide mycotoxin, synthesized by various species of Aspergillus and Penicillium, acts as an inhibitor of Fas ligand-induced apoptosis by impeding self-processing of caspase-8. Additionally, in vitro studies have shown that Penicillic acid displays cytotoxic properties in rat alveolar macrophages.
T3936	PATULIN Expansin,Claviform,散毒素,Clavacin,棒曲霉素	Apoptosis; Others; Antibacterial; Antibiotic; Autophagy	Apoptosis; Autophagy; Microbiology/Virology; Others
	Patulin (Claviform) 是由 Aspergillus、Penicillium 和 Byssochlamys 几种真菌属产生的霉菌毒素，有致染色体断裂、突变，致畸和细胞毒性作用。它通过溶酶体-线粒体轴诱导自噬依赖性细胞凋亡，能造成 DNA 损伤。
TN1979	Neocnidilide 新蛇床内酯,新蛇床内酯,新川芎内酯	Antifungal	Microbiology/Virology
	Neocnidilide 是一种从川芎中提取的烷基邻苯二甲酸酯，具有抑制产生真菌毒素的真菌生长和杀虫。Neocnidilide 对 D. melanogaster 幼虫的LC50 值为 9.9 μmol/mL。它可以增强苯甲酸的皮肤渗透性。
T13493	3-Acetyldeoxynivalenol	Others	Others
	3-Acetyldeoxynivalenol is a trichothecene mycotoxin deoxynivalenol acetylated derivative and a blood-brain barrier (BBB) permeable mycotoxin.
T19330	Fumonisin B3 伏马菌素	Others	Others
	Fumonisin B3 is a mycotoxin derived from fusarium fungi, a member of fumonisins.
T13777	Moniliformin sodium salt	Others	Others
	Moniliformin sodium salt is water-soluble mycotoxin isolate from Fusarium moniliforme.
T16285	Neosolaniol	Potassium Channel	Membrane transporter/Ion channel
	Neosolaniol, a type A trichothecene mycotoxin produced by Fusarium species, strongly induces an anorectic (loss of appetite) response.
T13577	β-Zearalenol	Others	Others
	β-Zearalenol, a non-steroidal estrogenic mycotoxin synthesized by Fusarium species, potentially influences transcription and affects gene expression on the translational level.
T31134	Cyclochlorotine CCRIS 1316
	Cyclochlorotine is a mycotoxin produced by Penicillium insularum, which can cause liver injury and has carcinogenic properties.
T13391	Zearalanone	Others	Others
	Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains.
T34536	Satratoxin H Satratoxin-H
	Satratoxin H is an air- and food-borne mycotoxin, which has been implicated in human health damage.
T12373	Paxilline	Others	Others
	Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline possesses significant anticonvulsant activity.
T12448	Phomopsin A	Others	Others
	Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis.
T13729	Hydrolyzed Fumonisin B1 Aminopentol	Others	Others
	Hydrolyzed Fumonisin B1 is the backbone and the main hydrolysis product of the mycotoxin fumonisin B1 (FB1), can weakly inhibit ceramide synthase.
T13533	Aflatoxin G2 黄曲霉毒素 G2	Others	Others
	Aflatoxin G2 is a major naturally produced aflatoxin. It is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus.
T10825	Citrinin NSC 186,桔霉素	Others	Others
	Citrinin is a mycotoxin that causes contamination in the food and is associated with different toxic effects. Citrinin also possesses a broad spectrum of bioactivities, including antifungal, antibacterial, and potential anticancer and neuroprotective effe
T13531	Aflatoxicol 黄曲霉毒醇,Aflatoxin R0	Others	Others
	Aflatoxin (Aflatoxin R0) is a mutagenic and carcinogenic mycotoxin derived from aflatoxin B1 through metabolic processes facilitated by Rhizopus spp.
T13544	Altertoxin I Dihydroalterperylenol	Others	Others
	Altertoxin I (Dihydroalterperylenol) is a quinone-type mycotoxin produced by Alternaria alternata fungi. It is mutagenic and cytotoxic and can weakly disrupt metabolic communication.
T13678	Enniatin A
	Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 22 μM in an enzyme assay using rat liver microsomes.
T81014	Territrem A
	Territrem A，一种由土曲霉菌分离提取的致震霉菌毒素。
T14548	Beta-Zearalanol	Others	Others
	Beta-Zearalenol, a derivative of zearalenone (ZEA) capable of conjugating with glucuronic acid[2], is a mycotoxin produced by Fusarium spp. It induces apoptosis and oxidative stress in mammalian reproductive cells[1].
T15355	Fumitremorgin C 烟曲霉毒素c,12α-Fumitremorgin C	BCRP; Antibacterial; Antibiotic; ABC	Membrane transporter/Ion channel; Microbiology/Virology
	Fumitremorgin C (12α-Fumitremorgin C) 是ABCG2/BRCP 的选择性抑制剂。
T17037	Tenuazonic acid	Others	Others
	Tenuazonic acid is a putative nonhost-selective mycotoxin isolated from Alternaria alternate. Tenuazonic acid blocks electron transport beyond primary quinone acceptor (QA) by interacting with D1 protein and it is a broad-spectrum and effective photosyste
T15357	Fumonisin B2 伏马菌素B2	Others	Others
	Fumonisin B2 is a mycotoxin produced by Fusarium moniliforme in various grains. It also is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase). Which disrupts de novo sphingolipid biosynthesis.
T15111	Diacetoxyscirpenol	Others	Others
	Diacetoxyscirpenol, a trichothecene mycotoxin, is a secondary metabolite product of fungi. Diacetoxyscirpenol consumption induces hematological disorders in humans and animals.
T83159	Agistatin B
	Agistatin B是从真菌中分离出的霉菌毒素，能够抑制胆固醇合成(cholesterolsynthesis)。
T13679	Enniatin B	ERK	MAPK
	Enniatins B decreases the activation of ERK (p44/p42). Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 113 μM in an enzyme assay using rat liver microsomes.
T13535	Aflatoxin M2 黄曲霉毒素 M2	Others	Others
	Aflatoxin M2 is a major metabolite of Aflatoxin B1. It is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus.
T13534	Aflatoxin M1 黄曲霉毒素 M1	Others	Others
	Aflatoxin M1, a significant metabolite of Aflatoxin B1, is a mycotoxin synthesized by Aspergillus flavus and Aspergillus parasiticus fungi. Toxicity levels of Aflatoxins follow the order: Aflatoxin B1 > Aflatoxin M1 > Aflatoxin G1 > Aflatoxin B2 > Aflatoxin M2 > Aflatoxin G2.
T15356	Fumonisin B1 伏马菌素B1	Others	Others
	Fumonisin B1 is the most abundant and toxic fumonisin and is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is also a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis.
T13628	Curvularin (S)-Curvularin	NOS	Immunology/Inflammation
	Curvulin, naturally isolated from Campylobacter curvulans, is a fungal metabolite and a potent mycotoxin that inhibits cytokine-induced nitric oxide synthase (iNOS) with IC50 of 9.5 µM.
T19569	T-2 Tetraol	Others	Others
	T- 2 Tetraol is a T-2 toxin metabolite, and also a trichothecene mycotoxin, with less toxicity and is unable to induce apoptosis.
T14196	Alternariol	Others	Others
	Alternariol (AOH), a mycotoxin synthesized by Alternaria species, displays numerous therapeutic and biological effects, including phytotoxic, cytotoxic, anti-HIV, anti-cancer, and anti-microbial properties. It functions by inhibiting the catalytic activity of topoisomerase I and II enzymes.
T73913	Fumigaclavine A
	Fumigaclavine A 是一种棒麦角素型生物碱，是由烟曲霉 (Aspergillus fumigatus) 产生的真菌毒素。可以从污染发霉的青贮饲料中分离出 A. fumigatus。
T13680	Enniatin B1 恩镰孢菌素 B1	ERK	MAPK
	Enniatin B1 crosss the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation.Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes.
T16942	Sterigmatocystine	Others	Others
	Sterigmatocystine is an inhibitor of G1 Phase and DNA synthesis and is used to inhibit p21 activity. Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor.
TN3351	Aflatrem	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Aflatrem is a tremorgenic mycotoxin with acute neurotoxic effects, a single low dose of aflatrem is able to induce degeneration of neuronal processes in hippocampal neurotransmitter systems. Aflatrem potentiates the gamma-aminobutyric acid (GABA)-induced
TN4937	Sambutoxin	Others	Others
	Sambutoxin, a new mycotoxin produced by toxic Fusarium isolates obtained from rotted potato tubers, it can cause toxic effects in rats, including body weight loss, feed refusal, hemorrhage in the stomach and intestines, and, finally, death when rats were
T15097	Deoxynivalenol Vomitoxin,4-Deoxynivalenol
	Deoxynivalenol (Vomitoxin) 是一种单端孢菌素家族镰刀菌属产生的霉菌毒素，常见于受到污染的食物和饲料中。Deoxynivalenol 通过紧密连接处的细胞旁路来穿过肠粘膜。Deoxynivalenol 转运不受P-糖蛋白 (PgP) 或多药耐药相关蛋白 (MRP) 抑制剂的影响。Deoxynivalenol 通常会导致人类和动物腹泻、呕吐和胃肠道炎症。
TN4084	Fumitremorgin B	Antifection	Microbiology/Virology
	Fumitremorgen B is a mycotoxin, it exhibits a certain degree of genotoxicity, it can cause DNA damage in human lymphocytes; it shows an inhibitory activity on the cell cycle progression of mouse tsFT210 cells in the M phase, with the MIC value of 26.1 mic
TN3401	Altenuene	Antifection	Microbiology/Virology
	Altenuene 是一种霉菌毒素，经常出现在被链格孢属真菌侵染的食物和饲料中。 Altenuene 表现出对金黄色葡萄球菌的中等活性。 Altenuene 还表现出对肺癌细胞系 A549、乳腺癌细胞系 MDA-MB-231 和胰腺癌细胞系 PANC-1 的细胞毒活性。
TN1694	Gliotoxin	Apoptosis; NF-κB; Wnt/beta-catenin; COX; PKA; Antibacterial; Antifection	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Gliotoxin 是一种次生代谢产物，由A. fumigatus 分泌，可以抑制巨噬细胞的吞噬作用和其他免疫细胞的免疫功能。它通过阻止 IκB 降解来抑制诱导型NF-κB 活性，从而诱导宿主细胞凋亡。它可以激活PKA 并增加细胞内 cAMP 浓度，调节肌动蛋白细胞骨架重排以促进A. fumigatus 内化到肺上皮细胞。
T35779	Oosporein
	Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ...

天然产物

Cat.No: T5625

Synonym: 玉米,Mycotoxin F2,玉米烯酮,RAL,F2 toxin,Toxin F2

Target: Others

Cat.No: T13053

Synonym: T-2 Mycotoxin

Target: Others

Cat.No: T3208

Synonym: Cyclo-L-tryptophyl-L-proline,cyclo-(L-Trp-L-Pro),Cyclo(L-Pro-L-Trp)

Target: BCRP, PI3K, Antibacterial

Cat.No: T7097

Synonym: Phomin,细胞松弛素 B,细胞松弛素B

Target: Arp2/3 Complex

Penicillic acid

Cat.No: T13815

Target: Apoptosis, Caspase, Antibacterial, Antibiotic

Cat.No: T3936

Synonym: Expansin,Claviform,散毒素,Clavacin,棒曲霉素

Target: Apoptosis, Others, Antibacterial, Antibiotic, Autophagy

Cat.No: TN1979

Synonym: 新蛇床内酯,新蛇床内酯,新川芎内酯

Target: Antifungal

3-Acetyldeoxynivalenol

Cat.No: T13493

Target: Others

Cat.No: T19330

Synonym: 伏马菌素

Target: Others

Moniliformin sodium salt

Cat.No: T13777

Target: Others

Cat.No: T16285

Target: Potassium Channel

Cat.No: T13577

Target: Others

Cyclochlorotine

Cat.No: T31134

Synonym: CCRIS 1316

Cat.No: T13391

Target: Others

Cat.No: T34536

Synonym: Satratoxin-H

Cat.No: T12373

Target: Others

Cat.No: T12448

Target: Others

Hydrolyzed Fumonisin B1

Cat.No: T13729

Synonym: Aminopentol

Target: Others

Cat.No: T13533

Synonym: 黄曲霉毒素 G2

Target: Others

Cat.No: T10825

Synonym: NSC 186,桔霉素

Target: Others

Cat.No: T13531

Synonym: 黄曲霉毒醇,Aflatoxin R0

Target: Others

Cat.No: T13544

Synonym: Dihydroalterperylenol

Target: Others

Cat.No: T13678

Cat.No: T81014

Beta-Zearalanol

Cat.No: T14548

Target: Others

Fumitremorgin C

Cat.No: T15355

Synonym: 烟曲霉毒素c,12α-Fumitremorgin C

Target: BCRP, Antibacterial, Antibiotic, ABC

Tenuazonic acid

Cat.No: T17037

Target: Others

Cat.No: T15357

Synonym: 伏马菌素B2

Target: Others

Diacetoxyscirpenol

Cat.No: T15111

Target: Others

Cat.No: T83159

Cat.No: T13679

Target: ERK

Cat.No: T13535

Synonym: 黄曲霉毒素 M2

Target: Others

Cat.No: T13534

Synonym: 黄曲霉毒素 M1

Target: Others

Cat.No: T15356

Synonym: 伏马菌素B1

Target: Others

Cat.No: T13628

Synonym: (S)-Curvularin

Target: NOS

Cat.No: T19569

Target: Others

Cat.No: T14196

Target: Others

Fumigaclavine A

Cat.No: T73913

Cat.No: T13680

Synonym: 恩镰孢菌素 B1

Target: ERK

Sterigmatocystine

Cat.No: T16942

Target: Others

Cat.No: TN3351

Target: GABA Receptor

Cat.No: TN4937

Target: Others

Cat.No: T15097

Synonym: Vomitoxin,4-Deoxynivalenol

Fumitremorgin B

Cat.No: TN4084

Target: Antifection

Cat.No: TN3401

Target: Antifection

Cat.No: TN1694

Target: Apoptosis, NF-κB, Wnt/beta-catenin, COX, PKA, Antibacterial, Antifection

Cat.No: T35779

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