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24

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0081	Lafutidine 拉呋替丁,FRG-8813	5-HT Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Lafutidine (FRG-8813) 是一种组胺受体 H2RA 拮抗剂，可抑制胃酸分泌，具有胃粘膜保护作用，可用于研究胃食管反流疾病。
T3267	Potassium guaiacolsulfonate hemihydrate 愈创木酚磺酸钾水合物,Potassium guaiacolsulfonate,Potassium 4-guaiacolsulfonate hemihydrate,愈创木酚磺酸钾	Antibacterial; Antibiotic	Microbiology/Virology
	Potassium guaiacolsulfonate hemihydrate (Potassium guaiacolsulfonate) 是一种芳香族磺酸，在医药中用作祛痰剂，可治疗急性呼吸道感染。它可松弛粘液，与其他药物合用，可治疗普通感冒、感染或过敏引起的咳嗽。
T6710	Troxipide 曲昔派特,曲昔匹特,Aplace	Others	Others
	Troxipide (Aplace) 是非分泌型胃保护剂，是口服具有活力的胃炎和胃溃疡的防御因子的增强剂，具有抗溃疡、抗炎和粘液分泌作用。
T1547	L-Cysteine methyl ester hydrochloride L-半胱氨酸甲酯盐酸盐,L-Cysteine methyl ester hydrochloride(Acdrile)	Amino Acids and Derivatives	Metabolism
	L-Cysteine methyl ester hydrochloride (L-Cysteine methyl ester hydrochloride (Acdrile)) 是一种粘痰溶解剂，是镇咳药，可用于缓解大量粘痰引起的呼吸困难。
TP1365L	Parasin I acetate(219552-69-9 free base)	Antibacterial	Microbiology/Virology
	Parasin I acetate(219552-69-9 free base) 是一种从受伤鲶鱼 (Parasilurus asotus) 的皮肤粘液中分离出来的 19 个残基的强效抗菌肽。
T6858	Hydroxyprogesterone caproate Primolut Depot,Delalutin,Hormofort,己酸孕酮,17α-Hydroxyprogesterone hexanoate,17α-Hydroxyprogesterone caproate	Autophagy	Autophagy
	Hydroxyprogesterone caproate (Delalutin) 是一种甾体，是一种人工合成的孕激素。
T1229	Erdosteine 厄多司坦,RV 144,KW-9144	NF-κB; Antibacterial; Adenosine deaminase	Metabolism; Microbiology/Virology; NF-κB
	Erdosteine (RV 144) 抑制脂多糖诱导的NF-κB 激活，具有粘液调节、抗菌、抗炎、抗氧化和自由基清除作用。
T0828	Bromhexine hydrochloride Bromhexine HCl,Auxit,盐酸溴己新,Bisolvon	SARS-CoV; HIV Protease; Autophagy	Autophagy; Microbiology/Virology; Proteases/Proteasome
	Bromhexine hydrochloride (Bisolvon) 是TMPRSS2蛋白酶的一种特异性有效抑制剂，IC50为 0.75 μM。它可预防和控制SARS-CoV-2感染。它是一种粘液溶解剂，用于治疗与粘稠或过多粘液相关的呼吸系统疾病。
T2597	Norgestrel 甲基炔诺酮,SH-850,FH 122-A,炔诺孕酮,WY-3707,SH-70850	Estrogen/progestogen Receptor; Reactive Oxygen Species	Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
	Norgestrel (WY-3707) 是一种孕酮的合成类似物，是一种口服避孕药中常见的化合物，也是一种神经保护性强抗氧化剂，能够防止光诱导的感光细胞中的ROS 的生成以及细胞死亡。
T0920	Ambroxol 氨溴索,氨溴索碱,Ambroxolum,NA-872	P450; Autophagy	Autophagy; Metabolism
	Ambroxol (NA-872) 是前药溴己辛的活性代谢产物，是一种分泌溶解剂，具有强效祛痰作用，用于治疗与粘液或过多粘液相关的呼吸道疾病。它可诱导肺组织细胞自噬，有用于帕金森氏病和神经性戈谢病的研究潜力。它是一种葡糖脑苷脂酶伴侣，可增加葡糖脑苷脂酶的活性。
T60522	Letosteine Viscotiol	Others	Others
	Letosteine (Viscotiol) 是具有口服活性、有效且安全的祛痰剂，可用于研究急性或慢性呼吸道疾病，如支气管肺炎。Letosteine 能够溶解支气管粘液并减轻呼吸道炎症症状，从而实现恢复肺部气体交换和自然防御机制。
T0910	Terpin hydrate Terpin Monohydrate,cis-Terpin hydrate,萜品(水合结晶)	Others	Others
	Terpin hydrate 是一种祛痰药，可除去急慢性支气管炎病人的黏液。
T30835	Cgp 45715A Cgp45715A,Cgp-45715A
	CGP 45715A (irukostat) is a potent peptide-leukotriene antagonist used to treat respiratory diseases by antagonizing the bronchial constriction, mucus secretion, and inflammatory effects of these leukotrienes.
T3034L	Eprazinone
	Erazinone is a mucus dissolver and bronchospasm reliever.
T22281	Bromhexine	Others	Others
	Bromhexine is an expectorant/mucolytic agent which can be used in the treatment of respiratory disorders associated with excessive mucus or viscid.
TP1365	Parasin I
	Parasin I is a potent 19-residue antimicrobial peptide isolated from the skin mucus of wounded catfish (Parasilurus asotus).
T69341	Tramazoline hydrochloride
	Tramazoline hydrochloride is commonly used in nasal spray as a nasal decongestant by acting as an α-adrenergic receptor agonist that inhibits secretion of nasal mucus.
T10992	Delamanid D4 OPC-67683 D4	Others	Others
	Delamanid D4 is deuterium-labeled Delamanid. Delamanid is a newer mycobacterial cell wall synthesis inhibitor that inhibits the synthesis of mucus acid.
T32656	Lerimazoline ST-71,Trimizoline,Trimazoline,ST 71,ST71
	Lerimazoline(Trimazoline, Trimizoline, ST-71) is used in the form of tramazoline hydrochloride in nasal decongestant preparations. It is used to inhibits the secretion of nasal mucus as an α-adrenergic receptor agonist.
T26090	Rioprostil TR 4698,TR4698,Rioprostilum,TR-4698
	Rioprostil is a methyl prostaglandin E1 analog that decreases gastric acid secretion and enhances the gastric mucus-bicarbonate barrier. It is effective in the treatment of gastric ulcers and gives significant protection against NSAID-induced gastric muco
T78380	Desacetyl bisacodyl	Others	Others
	Desacetyl bisacodyl为泻药比沙可啶的活性代谢产物，可诱导大鼠结肠及直肠上皮Cl(-)分泌增加，对结肠或直肠产生多种作用，包括促进粘液及氯化物的分泌。
T78510	Zolimidine	Others	Others
	Zolimidine是一种咪唑并吡啶衍生物，可作为口服抗溃疡剂。它能刺激肠粘膜细胞分泌粘液，增强肠壁的抗溃疡能力，并在十二指肠溃疡研究中显示出胃保护效果。
T71286	Guaifenesin-d3
	Guaifenesin-d3 is intended for use as an internal standard for the quantification of guaifenesin by GC- or LC-MS. Guaifenesin is an expectorant. It inhibits production of mucin 5AC (MUC5AC), reduces mucus viscosity and elasticity, and increases the mucociliary transport rate of endogenous particles in primary human tracheobronchial epithelial cells in a concentration-dependent manner. Guaifenesin increases phenol red secretion, a marker of expectorant activity, in rats.3 Formulations containing ...
T70763	KR-67607
	KR-67607, also known as NTX-101 is novel selective 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor. KR-67607 decreased 4-hydroxynonenal expression and increased antioxidant and mucus secretion in BAC-treated rat eyes. KR-67607 showed its protective effects against ischemia-reperfusion-induced eye injury. KR-67607 effectively reduced cortisol levels in mouse eyes and maintained the trabecular meshwork (TM) structure in the presence of transient ischemic stress. Furthermore, KR-67607 rever...

化合物

Cat.No: T0081

Synonym: 拉呋替丁,FRG-8813

Target: 5-HT Receptor, Histamine Receptor

Potassium guaiacolsulfonate hemihydrate

Cat.No: T3267

Synonym: 愈创木酚磺酸钾水合物,Potassium guaiacolsulfonate,Potassium 4-guaiacolsulfonate hemihydrate,愈创木酚磺酸钾

Target: Antibacterial, Antibiotic

Cat.No: T6710

Synonym: 曲昔派特,曲昔匹特,Aplace

Target: Others

L-Cysteine methyl ester hydrochloride

Cat.No: T1547

Synonym: L-半胱氨酸甲酯盐酸盐,L-Cysteine methyl ester hydrochloride(Acdrile)

Target: Amino Acids and Derivatives

Parasin I acetate(219552-69-9 free base)

Cat.No: TP1365L

Target: Antibacterial

Hydroxyprogesterone caproate

Cat.No: T6858

Synonym: Primolut Depot,Delalutin,Hormofort,己酸孕酮,17α-Hydroxyprogesterone hexanoate,17α-Hydroxyprogesterone caproate

Target: Autophagy

Cat.No: T1229

Synonym: 厄多司坦,RV 144,KW-9144

Target: NF-κB, Antibacterial, Adenosine deaminase

Bromhexine hydrochloride

Cat.No: T0828

Synonym: Bromhexine HCl,Auxit,盐酸溴己新,Bisolvon

Target: SARS-CoV, HIV Protease, Autophagy

Cat.No: T2597

Synonym: 甲基炔诺酮,SH-850,FH 122-A,炔诺孕酮,WY-3707,SH-70850

Target: Estrogen/progestogen Receptor, Reactive Oxygen Species

Cat.No: T0920

Synonym: 氨溴索,氨溴索碱,Ambroxolum,NA-872

Target: P450, Autophagy

Cat.No: T60522

Synonym: Viscotiol

Target: Others

Cat.No: T0910

Synonym: Terpin Monohydrate,cis-Terpin hydrate,萜品(水合结晶)

Target: Others

Cat.No: T30835

Synonym: Cgp45715A,Cgp-45715A

Cat.No: T3034L

Cat.No: T22281

Target: Others

Cat.No: TP1365

Tramazoline hydrochloride

Cat.No: T69341

Cat.No: T10992

Synonym: OPC-67683 D4

Target: Others

Cat.No: T32656

Synonym: ST-71,Trimizoline,Trimazoline,ST 71,ST71

Cat.No: T26090

Synonym: TR 4698,TR4698,Rioprostilum,TR-4698

Desacetyl bisacodyl

Cat.No: T78380

Target: Others

Cat.No: T78510

Target: Others

Cat.No: T71286

Cat.No: T70763

Cat. No.	Product Name	Target	Signaling Pathways
T0875	Acetylcysteine 乙酰半胱氨酸,N-Acetyl-L-cysteine,LNAC,NAC,易咳净	Apoptosis; TNF; Ferroptosis; Influenza Virus; Reactive Oxygen Species; ROS; Endogenous Metabolite	Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Acetylcysteine (NAC) 是半胱氨酸的 N-乙酰衍生物，是一种 ROS 抑制剂和粘液溶解剂。Acetylcysteine 可诱导细胞凋亡，可用于减少粘液的厚度，还具有抗流感病毒活性。
T4S1619	L-Hyoscyamine sulfate Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate,硫酸天仙子胺水合物,L-莨菪碱硫酸盐	AChR	Neuroscience
	L-Hyoscyamine sulfate (Levsin Sulfate) 是来自山莨菪的一种托烷生物碱，是竞争性的毒蕈碱受体拮抗剂。它是 Atropine 的左旋异构体。
T0962	L-Hyoscyamine Daturine,Hyoscyamine,L-莨菪碱,L-天仙子胺	AChR	Neuroscience
	L-Hyoscyamine (Daturine) 是从山莨菪中提取的一种托烷生物碱，是竞争性的毒蕈碱受体拮抗剂。它是 Atropine 的左旋异构体。
T25687	Leukotriene C4 白三烯C4,LTC4,Leukotriene C
	Leukotriene C4 is the conjugation product of Leukotriene A4 and glutathione. It is the major arachidonic acid metabolite in human mast cells, macrophages, and antigen-sensitized lung tissue. It stimulates mucus secretion in the lung and produces contracti

天然产物

Cat.No: T0875

Synonym: 乙酰半胱氨酸,N-Acetyl-L-cysteine,LNAC,NAC,易咳净

Target: Apoptosis, TNF, Ferroptosis, Influenza Virus, Reactive Oxygen Species, ROS, Endogenous Metabolite

L-Hyoscyamine sulfate

Cat.No: T4S1619

Synonym: Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate,硫酸天仙子胺水合物,L-莨菪碱硫酸盐

Target: AChR

Cat.No: T0962

Synonym: Daturine,Hyoscyamine,L-莨菪碱,L-天仙子胺

Target: AChR

Cat.No: T25687

Synonym: 白三烯C4,LTC4,Leukotriene C

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