首页工具

登录

搜索结果

Search Results for " mineralocorticoid "

29

抑制剂 & 化合物

7

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T14301	Apararenone MT-3995	Glucocorticoid Receptor	Endocrinology/Hormones
	Apararenone (MT-3995) 是一种新型的、非甾体类盐皮质激素受体 (mineralocorticoid receptor) 拮抗剂，正在开发用于糖尿病性肾病和非酒精性脂肪性肝炎的研究。
T9022	AZD9977 AZD 9977	Glucocorticoid Receptor	Endocrinology/Hormones
	AZD9977 是一种选择性的，有效的，具有口服活性的盐皮质激素受体 (MR) 调节剂，可用于研究心力衰竭和慢性肾病。
T4277	Osilodrostat LCI699	Glucocorticoid Receptor; Others; Hydroxylase	Endocrinology/Hormones; Metabolism; Others
	Osilodrostat (LCI699) 是一种有效的人11β-羟化酶和醛固酮合成酶抑制剂，IC50分别值为2.5 和0.7nM。
T15246	Esaxerenone 艾沙利酮,XL-550,CS-3150	Glucocorticoid Receptor	Endocrinology/Hormones
	Esaxerenone (XL-550) 是高效的、选择性的非类固醇盐皮质激素受体拮抗剂。
T0476	Spironolactone 安体舒通,螺内酯,SC9420,Abbolactone	Glucocorticoid Receptor; Androgen Receptor; Autophagy	Autophagy; Endocrinology/Hormones
	Spironolactone (SC9420) 是一种可口服的醛固酮盐皮质激素受体拮抗剂，IC50值为 24 nM。它也是雄激素受体拮抗剂，促进足细胞自噬，IC50值为 77 nM。
T0083	Eplerenone Epoxymexrenone,CGP 30083,依普利酮,SC-66110	Glucocorticoid Receptor	Endocrinology/Hormones
	Eplerenone (CGP 30083) 是一种竞争性的、选择性的、具有口服活性的醛固酮 (aldosterone) 拮抗剂，IC50=138 nM。它对孕酮，雄激素，雌激素和糖皮质激素受体的亲和力低，可用于研究高血压和心肌梗死后的心力衰竭。
T17217	Vamorolone 地塞米松EP杂质E,VBP15	Glucocorticoid Receptor; NF-κB	Endocrinology/Hormones; NF-κB
	Vamorolone (VBP15) 是一种首创的，具有口服活性的解离性类固醇 (dissociative steroidal) 抗炎药和膜稳定剂。它抑制 (NF-κB) 抑制作用，并降低了激素的影响。它改善肌营养不良，无副作用。
T3096	Canrenoate potassium 坎利酸钾,Potassium aldadiene,Canrenoic acid potassium salt,Potassium canrenoate,Soldactone	Glucocorticoid Receptor	Endocrinology/Hormones
	Canrenoate potassium (Soldactone) 是一种有效的竞争性盐皮质激素受体 (mineralocorticoid receptor) 拮抗剂，是一种释放 canrenone 的前药。它作为一种利尿剂，用于高血压的研究。
T1666L	Fludrocortisone 9α-fluorocortisol,9α-Fludrocortisone,Florinef,9α-fluorohydrocortisone,氟氢可的松,Fludrocortisone acetate,Astonin,9α-Fluorcortisol	Others	Others
	Fludrocortisone (Florinef) 是一种合成皮质类固醇，具有中等的糖皮质激素效力和更大的盐皮质激素效力。Fludrocortisone (Florinef) 可用于治疗低血压的研究。
T1666	Fludrocortisone acetate 9α-Fluorcortisol acetate,9α-Fludrocortisone acetate,醋酸氟氢可的松,9α-fluorocortisol acetate	Glucocorticoid Receptor; Autophagy	Autophagy; Endocrinology/Hormones
	Fludrocortisone acetate (9α-Fludrocortisone acetate) 是一种合成的盐皮质激素，可减少尿液中钠丢失量，也用于增加血压，有用于阿狄森氏病的研究潜力。
T21395	Finerenone BAY948862,BAY-948862,BAY94-8862,非奈利酮,BAY 94-8862,BAY-94-8862,BAY 948862	Glucocorticoid Receptor	Endocrinology/Hormones
	Finerenone (BAY-948862) 是一种选择性、具有口服活性的、非甾体类盐皮质激素受体拮抗剂 (IC50=18 nM)。与糖皮质激素受体、雄激素受体和孕酮受体相比，它表现出良好的选择性 (>500-fold)。它在心肾疾病研究中具有潜在的应用前景，如 2 型糖尿病和慢性肾脏疾病。
T1541	Drospirenone ZK 3059,屈螺酮,Dihydrospirorenone	Glucocorticoid Receptor; Estrogen/progestogen Receptor; Progesterone Receptor; Androgen Receptor; COX	Endocrinology/Hormones; Immunology/Inflammation; Neuroscience; Others
	Drospirenone (ZK 3059) 是spironolactone 的类似物，是一种合成的孕酮。
T32368	KB-74935 KB 74935	Others	Others
	KB-74935是一种酶抑制剂，是一种矿物皮质激素受体拮抗剂，可用于治疗胆固醇、低血脂、神经系统疾病和阿尔茨海默病。
T13881	Dicirenone SC26304	ATPase; Glucocorticoid Receptor	Endocrinology/Hormones; Membrane transporter/Ion channel
	Dicirenone (SC26304) 对盐皮质激素受体（MR）有抑制作用，对醛固酮对尿 K+:Na+ 比例的调节和醛固酮与肾细胞质和核受体结合有抑制作用。
T0094	Budesonide Entocort,Pulmicort,布地奈德,Rhinocort	Glucocorticoid Receptor	Endocrinology/Hormones
	Budesonide (Pulmicort) 是吸入型糖皮质类固醇，是一种口服具有活性的糖皮质激素受体激动剂。它能够减小肺部肿瘤的体积，逆转 DNA 低度甲基化，调节基因的 mRNA 表达。它是能够用于哮喘的抗炎药。
T17291	ZK 216348 (+)-ZK 216348	Others	Others
	ZK 216348 also binds to Progesterone and mineralocorticoid receptors (IC50s: 20.4 nM and 79.9 nM, respectively). ZK 216348 is a nonsteroidal selective glucocorticoid receptor agonist (IC50: 20.3 nM). ZK 216348 has an anti-inflammatory activity similar to
T23272	RU 28318, potassium salt	Others	Others
	mineralocorticoid receptor (MR) antagonist
T16502	PF-3882845	Others	Others
	PF-3882845 also binds to the progesterone receptor (the binding IC50: 310 nM). PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for hypertension and nephropathy.
T68699	Oxprenoate Free Base
	Oxprenoate Free Base is a mineralocorticoid receptor (MR) antagonist, inhibiting aldosterone production and secretion.
T26157	RU 752 RU-752,RU752
	RU 752 is an antagonist of mineralocorticoid receptor that inhibits aldosterone synthesis.
T36129	21-hydroxy Eplerenone
	21-hydroxy Eplerenone is a major metabolite of the mineralocorticoid receptor antagonist eplerenone . It is formed from eplerenone by the cytochrome P450 (CYP) isoform CYP3A4.
TC0008	Desoxycorticosterone pivalate DOCP	Others	Others
	Deoxycorticosterone (DOCP) is a mineralocorticoid and is an analog of deoxycorticosterone. Deoxycorticosterone pivalate is used in the treatment of canine low adrenal cortex hormones.
T37064	6β-hydroxy Eplerenone
	6β-hydroxy Eplerenone is a major metabolite of the mineralocorticoid receptor antagonist eplerenone .1 It is formed from eplerenone by the cytochrome P450 (CYP) isoform CYP3A4. \|1. Cook, C.S., Berry, L.M., Kim, D.H., et al. Involvement of CYP3A in the metabolism of eplerenone in humans and dogs: Differential metabolism by CYP3A4 and CYP3A5. Drug Metab. Dispos. 30(12), 1344-1351 (2002).
T69323	Dexamethasone sodium succinate
	Dexamethasone sodium succinate is the acetate salt form of dexamethasone, which is a synthetic glucocorticoid; it combines high anti-inflammatory effects with low mineralocorticoid activity. At high doses (e.g. 40 mg), it reduces the immune response. Dexamethasone acetate (NEOFORDEX®) is indicated in adults for the treatment of symptomatic multiple myeloma in combination with other medicinal products. Dexamethasone has been shown to induce multiple myeloma cell death (apoptosis) via a down-regul...
T38448	(Rac)-Finerenone (Rac)-Finerenone,(Rac)-BAY 94-8862
	Rac-Finerenone, also known as (Rac)-BAY 94-8862, is the racemate derivative of Finerenone, a selective third-generation nonsteroidal mineralocorticoid receptor antagonist (MR) that is taken orally. With an IC50 value of 18 nM, Finerenone exhibits exceptional selectivity against the glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold).
T36381	Aldosterone 21-sulfate (sodium salt)
	Aldosterone 21-sulfate is a metabolite of the steroid hormone aldosterone .1It reduces the sodium-to-potassium ratio in rat urine when administered at doses ranging from 10 to 100 μg, indicating mineralocorticoid activity that is less than 1% that of aldosterone.2 1.Grose, J.H., Nowaczynski, W., Kuchel, O., et al.Isolation of aldosterone urinary metabolites, glucuronides and sulfateJ. Steroid Biochem.4(6)551-566(1973) 2.Jowett, T.P., and Slater, J.D.H.Aldosterone 21-sulphate in manJ. Steroid. Bi...
T68765	Spirorenone
	Spirorenone is an androstadienone derivative as a highly effective aldosterone antagonist. Spirorenone is 8.6 times as potent as spironolactone, but showed a lower affinity for the mineralocorticoid receptors. In phase I clinical trials Spirorenone was absorbed with a half-life of 20-30 min, achieving maximum concentrations of about 100 ng/ml (10 mg) and 260 ng/ml (40 mg) after 1-2 h. Disposition of the parent drug was biphasic with half-lives of 50-60 min (distribution) and 5-6 h (elimination)....
T68808	11-Dehydrocorticosterone
	11-Dehydrocorticosterone is an endogenous mineralocorticoid. It increases Na+/K+-ATPase mRNA expression in vascular smooth muscle cells and inhibits aldosterone action in B. marinus toad bladder tissue in a concentration-dependent manner. 11-Dehydrocorticosterone decreases the sodium/creatine ratio and increases the potassium/creatine ratio in rat urine in a dose-dependent manner in a model of 11β-hydroxysteroid dehydrogenase inhibition induced by carbenoxolone. Chronic administration 11-dehydro...
T68009	prorenoate
	Prorenoate 是一种甾体醛固酮拮抗剂，具有保钾利尿作用。Prorenoate 可拮抗醛固酮在肾元中盐皮质激素受体的活性，从而阻止钠的重吸收。这会干扰钠/钾交换器，导致钠和水排泄，同时减少钾排泄。

化合物

Cat.No: T14301

Synonym: MT-3995

Target: Glucocorticoid Receptor

Cat.No: T9022

Synonym: AZD 9977

Target: Glucocorticoid Receptor

Cat.No: T4277

Synonym: LCI699

Target: Glucocorticoid Receptor, Others, Hydroxylase

Cat.No: T15246

Synonym: 艾沙利酮,XL-550,CS-3150

Target: Glucocorticoid Receptor

Cat.No: T0476

Synonym: 安体舒通,螺内酯,SC9420,Abbolactone

Target: Glucocorticoid Receptor, Androgen Receptor, Autophagy

Cat.No: T0083

Synonym: Epoxymexrenone,CGP 30083,依普利酮,SC-66110

Target: Glucocorticoid Receptor

Cat.No: T17217

Synonym: 地塞米松EP杂质E,VBP15

Target: Glucocorticoid Receptor, NF-κB

Canrenoate potassium

Cat.No: T3096

Synonym: 坎利酸钾,Potassium aldadiene,Canrenoic acid potassium salt,Potassium canrenoate,Soldactone

Target: Glucocorticoid Receptor

Fludrocortisone

Cat.No: T1666L

Synonym: 9α-fluorocortisol,9α-Fludrocortisone,Florinef,9α-fluorohydrocortisone,氟氢可的松,Fludrocortisone acetate,Astonin,9α-Fluorcortisol

Target: Others

Fludrocortisone acetate

Cat.No: T1666

Synonym: 9α-Fluorcortisol acetate,9α-Fludrocortisone acetate,醋酸氟氢可的松,9α-fluorocortisol acetate

Target: Glucocorticoid Receptor, Autophagy

Cat.No: T21395

Synonym: BAY948862,BAY-948862,BAY94-8862,非奈利酮,BAY 94-8862,BAY-94-8862,BAY 948862

Target: Glucocorticoid Receptor

Cat.No: T1541

Synonym: ZK 3059,屈螺酮,Dihydrospirorenone

Target: Glucocorticoid Receptor, Estrogen/progestogen Receptor, Progesterone Receptor, Androgen Receptor, COX

Cat.No: T32368

Synonym: KB 74935

Target: Others

Cat.No: T13881

Synonym: SC26304

Target: ATPase, Glucocorticoid Receptor

Cat.No: T0094

Synonym: Entocort,Pulmicort,布地奈德,Rhinocort

Target: Glucocorticoid Receptor

Cat.No: T17291

Synonym: (+)-ZK 216348

Target: Others

RU 28318, potassium salt

Cat.No: T23272

Target: Others

Cat.No: T16502

Target: Others

Oxprenoate Free Base

Cat.No: T68699

Cat.No: T26157

Synonym: RU-752,RU752

21-hydroxy Eplerenone

Cat.No: T36129

Desoxycorticosterone pivalate

Cat.No: TC0008

Synonym: DOCP

Target: Others

6β-hydroxy Eplerenone

Cat.No: T37064

Dexamethasone sodium succinate

Cat.No: T69323

(Rac)-Finerenone

Cat.No: T38448

Synonym: (Rac)-Finerenone,(Rac)-BAY 94-8862

Aldosterone 21-sulfate (sodium salt)

Cat.No: T36381

Cat.No: T68765

11-Dehydrocorticosterone

Cat.No: T68808

Cat.No: T68009

Cat. No.	Product Name	Target	Signaling Pathways
T3033	Deoxycorticosterone acetate 醋酸去氧皮质酮,DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate,醋酸脱氧皮质酮	Glucocorticoid Receptor; Endogenous Metabolite; Adrenergic Receptor	Endocrinology/Hormones; GPCR/G Protein; Metabolism; Neuroscience
	Deoxycorticosterone acetate (Cortexone acetate) 是肾上腺产生的类固醇激素，具有盐皮质激素活性，并作为醛固酮的前体。
T0354	Canrenone 6,7-Dehydro-7α-desthioacetylspironolactone,SC9376,Aldadiene,坎利酮,RP-11614,SC14266	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Canrenone (SC14266) 是一种醛固酮 (aldosterone) 拮抗剂，广泛用作利尿剂。
TN3910	Ecdysone	Apoptosis; ATPase; Glucocorticoid Receptor; Potassium Channel; Sodium Channel; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Endocrinology/Hormones; Membrane transporter/Ion channel; Metabolism
	Ecdysone 是存在于昆虫和草药中的主要类固醇激素，可以激活盐皮质激素受体并诱导细胞凋亡。Ecdysone 的活性代谢物 20-羟基蜕皮激素在协调发育过渡和体内稳态睡眠调节中起重要作用。
T20302	Deoxycorticosterone Desoxycorticosterone,去氧皮质酮,Desoxycorticosteronum,Desoxycortone	Endogenous Metabolite	Metabolism
	Deoxycorticosterone (Desoxycortone) 是由肾上腺产生的类固醇代谢物。 Deoxycorticosterone 是醛固酮前体，具有盐皮质激素活性。
T39991	18-Oxocortisol
	18-Oxocortisol is a cortisol derivative generated by aldosterone synthase (CYP11B2). It acts as a naturally occurring mineralocorticoid agonist and serves as a biomarker in adrenal vein sampling.
T19186	Aldosterone	Others	Others
	Aldosterone is the primary mineralocorticoid. Aldosterone is synthesized and secreted in response to renin-angiotensin system activation or high dietary potassium by the zona glomerulosa of the adrenal cortex.
TCA2511	11Beta-hydroxyprogesterone	Sodium Channel	Membrane transporter/Ion channel
	The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro and can confer mineralocorticoid activity on corticosterone in the rat in vivo. 11beta-Hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells.

天然产物

Deoxycorticosterone acetate

Cat.No: T3033

Synonym: 醋酸去氧皮质酮,DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate,醋酸脱氧皮质酮

Target: Glucocorticoid Receptor, Endogenous Metabolite, Adrenergic Receptor

Cat.No: T0354

Synonym: 6,7-Dehydro-7α-desthioacetylspironolactone,SC9376,Aldadiene,坎利酮,RP-11614,SC14266

Target: Glucocorticoid Receptor, Endogenous Metabolite

Cat.No: TN3910

Target: Apoptosis, ATPase, Glucocorticoid Receptor, Potassium Channel, Sodium Channel, Endogenous Metabolite, Autophagy

Deoxycorticosterone

Cat.No: T20302

Synonym: Desoxycorticosterone,去氧皮质酮,Desoxycorticosteronum,Desoxycortone

Target: Endogenous Metabolite

Cat.No: T39991

Cat.No: T19186

Target: Others

11Beta-hydroxyprogesterone

Cat.No: TCA2511

Target: Sodium Channel

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼