Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Esaxerenone (XL-550) 是高效的、选择性的非类固醇盐皮质激素受体拮抗剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 663 | 现货 | ||
5 mg | ¥ 1,490 | 现货 | ||
10 mg | ¥ 2,390 | 现货 | ||
25 mg | ¥ 4,660 | 现货 | ||
50 mg | ¥ 7,390 | 现货 | ||
100 mg | ¥ 9,870 | 现货 | ||
500 mg | ¥ 20,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,630 | 现货 |
产品描述 | Esaxerenone (XL-550) is a highly potent and selective non-steroidal antagonist of the mineralocorticoid receptor. |
体内活性 | After Esaxerenone (0.1, 0.3, 1, and 3?mg/kg, intravenous administration) treatment, the total body clearance (CL) and distribution volume at steady state (Vss) are 3.53 to 6.69?mL/min/kg and 1.47 to 2.49?L/kg, respectively, in rats, and 2.79 to 3.69?mL/min/kg and 1.34 to 1.54?L/kg, respectively, in cynomolgus monkeys. After Esaxerenone (0.1, 0.3, 1, and 3?mg/kg, single oral administration) treatment, maximum plasma concentration (Cmax) and the area under the plasma concentration versus time curve (AUC) are increased with dose. Time to reach the maximum plasma concentration of Esaxerenone ranges from 2.0 to 4.5?h. After Up to 168?h after administration, 3.9% and 91.4% of dosed radioactivity are excreted in rat urine and feces, respectively, and 95.2% in total. In monkeys, the excreted radioactivity up to 168?h is 11.5% in urine, 82.3% in feces, and 93.9% in total[1]. |
别名 | 艾沙利酮, XL-550, CS-3150 |
分子量 | 466.47 |
分子式 | C22H21F3N2O4S |
CAS No. | 1632006-28-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (214.38 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1438 mL | 10.7188 mL | 21.4376 mL | 53.594 mL |
5 mM | 0.4288 mL | 2.1438 mL | 4.2875 mL | 10.7188 mL | |
10 mM | 0.2144 mL | 1.0719 mL | 2.1438 mL | 5.3594 mL | |
20 mM | 0.1072 mL | 0.5359 mL | 1.0719 mL | 2.6797 mL | |
50 mM | 0.0429 mL | 0.2144 mL | 0.4288 mL | 1.0719 mL | |
100 mM | 0.0214 mL | 0.1072 mL | 0.2144 mL | 0.5359 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Esaxerenone 1632006-28-0 Endocrinology/Hormones Glucocorticoid Receptor Inhibitor Mineralocorticoid Receptor inhibit CS 3150 XL550 XL 550 CS3150 艾沙利酮 XL-550 CS-3150 inhibitor