首页工具

购物车

Dicirenone

产品编号 T13881 CAS 41020-79-5

别名: SC26304

Dicirenone (SC26304) 对盐皮质激素受体（MR）有抑制作用，对醛固酮对尿 K+:Na+ 比例的调节和醛固酮与肾细胞质和核受体结合有抑制作用。

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Dicirenone, CAS 41020-79-5

规格	价格/CNY		货期	数量
1 mg	￥ 4,900		现货
5 mg	￥ 12,600		现货

大包装超大折扣，点击咨询

选择批次

纯度: 99.1%

更多批次查询请联系客服

生物活性

化学信息

存储 & 溶解度

参考文献

相关产品

产品描述

Dicirenone (SC26304) inhibits the Mineralocorticoid receptor (MR), aldosterone regulation of the urinary K+:Na+ ratio, and aldosterone binding to renal cytoplasmic and nuclear receptors.

体内活性

In glycerol density gradients, cytoplasmic [3H]Aldosterone receptor complexes sediment at 8.5 S and 4 S in low concentrations of salt and at 4.5 S in high concentrations of salt. Similarly, cytoplasmic [3H]Dicirenone receptor complexes sediment at 3 S in low concentrations of salt and 4 S in high concentrations of salt. The cytoplasmic binding of [3H]Aldosterone and [3H]Dicirenone is similar in magnitude and involves the same set of sites.
Under three sets of conditions - (i) in the intact rat, (ii) in kidney slices, and (iii) in reconstitution studies (mixing prelabeled cytoplasm with either purified renal nuclei or chromatin) - [3H]Dicirenone does not yield specific nuclear complexes, in contrast to the reproducible generation of these complexes with [3H]Aldosterone. Administration of Dicirenone (SC-26304) alone in doses of 3-600 μg/100 g of body weight has no effect on urinary Na+:creatinine or K+:creatinine ratios, expressed as urinary K+:Na+ ratios. Aldosterone (0.3 μg/100 g of body weight) increases the K+:Na+ ratio 5-fold. This increase is significantly inhibited by 180 μg/100 g of body weight of Dicirenone and completely inhibited by 600 μg/100 g of body weight. To correlate inhibitory action and receptor occupancy, the same doses of Dicirenone are given to rats injected with 0.036 μg of [3H]Aldosterone. A dose of 180 μg/100 g of body weight reduces specific binding of Aldosterone in cytoplasmic and nuclear fractions to less than half of the control levels, and 600 μg/100 g of body weight eliminates specific binding. The dose of Aldosterone used in the physiological studies is about eight times that used in the binding studies, but both doses are well below saturating amounts[1].

别名	SC26304
分子量	428.56
分子式	C26H36O5
CAS No.	41020-79-5

存储

store at low temperature　|　Powder: -20°C for 3 years | In solvent: -80°C for 1 year

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

质量

浓度

容积

分子量

浓度 (起始)

容积 (起始)

浓度 (终)

容积 (终)

溶液体积

质量

配液浓度

参考文献

1. Marver D, et al. Renal aldosterone receptors: studies with (3H)aldosterone and the anti-mineralocorticoid (3H)spirolactone (SC-26304). Proc Natl Acad Sci U S A. 1974 Apr;71(4):1431-5.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO+

% +